Reviewed, UniProtKB/Swiss-Prot Q8N961 (ABTB2_HUMAN)

Names and origin

Protein names

Recommended name:
    Ankyrin repeat and BTB/POZ domain-containing protein 2

Gene names

Name:

ABTB2

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	839 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	May be involved in the initiation of hepatocyte growth By similarity.
Sequence similarities	Contains 4 ANK repeats. Contains 1 BTB (POZ) domain.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	ANK repeat Repeat
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	regulation of cell growth Non-traceable author statement. Source: UniProtKB
Molecular function	DNA binding Inferred from electronic annotation. Source: InterPro protein binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 839	839	Ankyrin repeat and BTB/POZ domain-containing protein 2		PRO_0000066887
Regions
	Repeat	335 – 364	30	ANK 1
	Repeat	381 – 410	30	ANK 2
	Repeat	420 – 449	30	ANK 3
	Repeat	463 – 492	30	ANK 4
	Domain	659 – 728	70	BTB
Natural variations
	Natural variant	64	1	H → Q: dbSNP rs1925368.		VAR_022087
	Natural variant	732	1	T → A: dbSNP rs2473928.		VAR_024171

Sequences

	Sequence		Length	Mass (Da)
	Q8N961-1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 0E48EE96F0C85DB2	FASTA	839	93,290
	10 20 30 40 50 60 MSAGDGLRRG KSARCGLTFS VGRFFRWMVD TRISVRIHEY AAISLTACME NLVEEIRARV 70 80 90 100 110 120 MASHSPDGGG AGGGEVSAEA LEMVINNDAE LWGVLQPYEH LICGKNANGV LSLPAYFSPY 130 140 150 160 170 180 NGGSLGHDER ADAYAQLELR TLEQSLLATC VGSISELSDL VSRAMHHMQG RHPLCPGASP 190 200 210 220 230 240 ARQARQPPQP ITWSPDALHT LYYFLRCPQM ESMENPNLDP PRMTLNNERP FMLLPPLMEW 250 260 270 280 290 300 MRVAITYAEH RRSLTVDSGD IRQAARLLLP GLDCEPRQLK PEHCFSSFRR LDARAATEKF 310 320 330 340 350 360 NQDLGFRMLN CGRTDLINQA IEALGPDGVN TMDDQGMTPL MYACAAGDEA MVQMLIDAGA 370 380 390 400 410 420 NLDIQVPSNS PRHPSIHPDS RHWTSLTFAV LHGHISVVQL LLDAGAHVEG SAVNGGEDSY 430 440 450 460 470 480 AETPLQLASA AGNYELVSLL LSRGADPLLS MLEAHGMGSS LHEDMNCFSH SAAHGHRNVL 490 500 510 520 530 540 RKLLTQPQQA KADVLSLEEI LAEGVEESDA SSQGSGSEGP VRLSRTRTKA LQEAMYYSAE 550 560 570 580 590 600 HGYVDITMEL RALGVPWKLH IWIESLRTSF SQSRYSVVQS LLRDFSSIRE EEYNEELVTE 610 620 630 640 650 660 GLQLMFDILK TSKNDSVIQQ LATIFTHCYG SSPIPSIPEI RKTLPARLDP HFLNNKEMSD 670 680 690 700 710 720 VTFLVEGKLF YAHKVLLVTA SNRFKTLMTN KSEQDGDSSK TIEISDMKYH IFQMMMQYLY 730 740 750 760 770 780 YGGTESMEIP TTDILELLSA ASLFQLDALQ RHCEILCSQT LSMESAVNTY KYAKIHNAPE 790 800 810 820 830 LALFCEGFFL KHMKALLEQD AFRQLIYGRS SKVQGLDPLQ DLQNTLAERV HSVYITSRV

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Fetal brain.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 440-839. Tissue: Rectum tumor.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK091560 mRNA. Translation: BAC03697.1. Different initiation. AK095632 mRNA. Translation: BAC04595.1. BC093968 mRNA. Translation: AAH93968.1. BX640841 mRNA. Translation: CAE45913.3.
IPI	IPI00167609.
RefSeq	NP_665803.1.
UniGene	Hs.23361
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q8N961.
Genome annotation databases
Ensembl	ENST00000298992; ENSP00000298992; ENSG00000166016; Homo sapiens. [Genome view]
GeneID	25841.
KEGG	hsa:25841.
UCSC	uc001mvl.1. human.
Organism-specific databases
CTD	25841.
GeneCards	GC11M034129.
H-InvDB	HIX0009548.
HGNC	HGNC:23842. ABTB2.
HPA	HPA020065.
PharmGKB	PA134937734.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q8N961.
HOVERGEN	Q8N961.
OMA	RQLIYGR
OrthoDB	EOG9DJNFQ
Gene expression databases
ArrayExpress	Q8N961.
Bgee	Q8N961.
CleanEx	HS_ABTB2.
Genevestigator	Q8N961.
GermOnline	ENSG00000166016. Homo sapiens.
Family and domain databases
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR000210. BTB/POZ-like. IPR011333. BTB/POZ_fold. IPR013069. BTB_POZ. IPR009072. Histone-fold. IPR013089. Kelch_related. [Graphical view]
Gene3D	G3DSA:1.25.40.20. ANK. 1 hit. G3DSA:3.30.710.10. BTB/POZ_fold. 1 hit. G3DSA:1.10.20.10. Histone-fold. 1 hit.
PANTHER	PTHR23230. Kelch_related. 1 hit.
Pfam	PF00023. Ank. 3 hits. PF00651. BTB. 1 hit. [Graphical view]
SMART	SM00248. ANK. 5 hits. SM00225. BTB. 1 hit. [Graphical view]
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 3 hits. PS50097. BTB. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	47159.

Entry information

Entry name

ABTB2_HUMAN

Accession

Primary (citable) accession number: Q8N961
Secondary accession number(s): Q52LD6, Q6MZW4, Q8NB44

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	October 1, 2002
Last modified:	November 24, 2009
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.