Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8N961

- ABTB2_HUMAN

UniProt

Q8N961 - ABTB2_HUMAN

Protein

Ankyrin repeat and BTB/POZ domain-containing protein 2

Gene

ABTB2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 2 (01 May 2013)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    May be involved in the initiation of hepatocyte growth.By similarity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ankyrin repeat and BTB/POZ domain-containing protein 2
    Gene namesi
    Name:ABTB2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:23842. ABTB2.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: HPA

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134937734.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10251025Ankyrin repeat and BTB/POZ domain-containing protein 2PRO_0000066887Add
    BLAST

    Proteomic databases

    MaxQBiQ8N961.
    PaxDbiQ8N961.
    PRIDEiQ8N961.

    PTM databases

    PhosphoSiteiQ8N961.

    Expressioni

    Gene expression databases

    BgeeiQ8N961.
    CleanExiHS_ABTB2.
    GenevestigatoriQ8N961.

    Organism-specific databases

    HPAiHPA020065.
    HPA030699.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000298992.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N961.
    SMRiQ8N961. Positions 521-738, 841-944.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati521 – 55030ANK 1Add
    BLAST
    Repeati567 – 59630ANK 2Add
    BLAST
    Repeati606 – 63530ANK 3Add
    BLAST
    Repeati649 – 67830ANK 4Add
    BLAST
    Domaini845 – 91470BTBPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 4 ANK repeats.PROSITE-ProRule annotation
    Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    ANK repeat, Repeat

    Phylogenomic databases

    eggNOGiNOG81568.
    HOGENOMiHOG000033776.
    HOVERGENiHBG050447.
    InParanoidiQ8N961.
    KOiK10521.
    OMAiFPWTEGD.
    OrthoDBiEOG773XF8.
    PhylomeDBiQ8N961.
    TreeFamiTF106437.

    Family and domain databases

    Gene3Di1.10.20.10. 2 hits.
    1.25.40.20. 3 hits.
    3.30.710.10. 1 hit.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR009072. Histone-fold.
    [Graphical view]
    PfamiPF00023. Ank. 1 hit.
    PF12796. Ank_2. 1 hit.
    PF00651. BTB. 1 hit.
    [Graphical view]
    SMARTiSM00248. ANK. 5 hits.
    SM00225. BTB. 1 hit.
    [Graphical view]
    SUPFAMiSSF47113. SSF47113. 2 hits.
    SSF48403. SSF48403. 1 hit.
    SSF54695. SSF54695. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 3 hits.
    PS50097. BTB. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8N961-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAGTYSSTLK TLEDLTLDSG YGAGDSCRSL SLSSSKSNSQ ALNSSAQQHR     50
    GAAWWCYSGS MNSRHNSWDT VNTVLPEDPE VADLFSRCPR LPELEEFPWT 100
    EGDVARVLRK GAGGRRLPQF SAEAVRRLAG LLRRALIRVA REAQRLSVLH 150
    AKCTRFEVQS AVRLVHSWAL AESCALAAVK ALSLYSMSAG DGLRRGKSAR 200
    CGLTFSVGRF FRWMVDTRIS VRIHEYAAIS LTACMENLVE EIRARVMASH 250
    SPDGGGAGGG EVSAEALEMV INNDAELWGV LQPYEHLICG KNANGVLSLP 300
    AYFSPYNGGS LGHDERADAY AQLELRTLEQ SLLATCVGSI SELSDLVSRA 350
    MHHMQGRHPL CPGASPARQA RQPPQPITWS PDALHTLYYF LRCPQMESME 400
    NPNLDPPRMT LNNERPFMLL PPLMEWMRVA ITYAEHRRSL TVDSGDIRQA 450
    ARLLLPGLDC EPRQLKPEHC FSSFRRLDAR AATEKFNQDL GFRMLNCGRT 500
    DLINQAIEAL GPDGVNTMDD QGMTPLMYAC AAGDEAMVQM LIDAGANLDI 550
    QVPSNSPRHP SIHPDSRHWT SLTFAVLHGH ISVVQLLLDA GAHVEGSAVN 600
    GGEDSYAETP LQLASAAGNY ELVSLLLSRG ADPLLSMLEA HGMGSSLHED 650
    MNCFSHSAAH GHRNVLRKLL TQPQQAKADV LSLEEILAEG VEESDASSQG 700
    SGSEGPVRLS RTRTKALQEA MYYSAEHGYV DITMELRALG VPWKLHIWIE 750
    SLRTSFSQSR YSVVQSLLRD FSSIREEEYN EELVTEGLQL MFDILKTSKN 800
    DSVIQQLATI FTHCYGSSPI PSIPEIRKTL PARLDPHFLN NKEMSDVTFL 850
    VEGKLFYAHK VLLVTASNRF KTLMTNKSEQ DGDSSKTIEI SDMKYHIFQM 900
    MMQYLYYGGT ESMEIPTTDI LELLSAASLF QLDALQRHCE ILCSQTLSME 950
    SAVNTYKYAK IHNAPELALF CEGFFLKHMK ALLEQDAFRQ LIYGRSSKVQ 1000
    GLDPLQDLQN TLAERVHSVY ITSRV 1025
    Length:1,025
    Mass (Da):113,656
    Last modified:May 1, 2013 - v2
    Checksum:iE0DBA1B9BC0AFB82
    GO
    Isoform 2 (identifier: Q8N961-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-186: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:839
    Mass (Da):93,290
    Checksum:i0E48EE96F0C85DB2
    GO

    Sequence cautioni

    The sequence AAH93968.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAC03697.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAF84433.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAF84433.1 differs from that shown. Reason: Erroneous termination at position 101. Translated as Glu.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti189 – 1891A → D in BAF84433. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti250 – 2501H → Q.1 Publication
    Corresponds to variant rs1925368 [ dbSNP | Ensembl ].
    VAR_022087
    Natural varianti918 – 9181T → A.
    Corresponds to variant rs2473928 [ dbSNP | Ensembl ].
    VAR_024171

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 186186Missing in isoform 2. 1 PublicationVSP_046439Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK091560 mRNA. Translation: BAC03697.1. Different initiation.
    AK095632 mRNA. Translation: BAC04595.1.
    AK291744 mRNA. Translation: BAF84433.1. Sequence problems.
    AC090469 Genomic DNA. No translation available.
    AL035079 Genomic DNA. No translation available.
    AL133294 Genomic DNA. No translation available.
    AL139174 Genomic DNA. No translation available.
    BC093968 mRNA. Translation: AAH93968.1. Different initiation.
    BX640841 mRNA. Translation: CAE45913.3.
    CCDSiCCDS7890.2. [Q8N961-1]
    RefSeqiNP_665803.2. NM_145804.2. [Q8N961-1]
    UniGeneiHs.23361.

    Genome annotation databases

    EnsembliENST00000435224; ENSP00000410157; ENSG00000166016. [Q8N961-1]
    GeneIDi25841.
    KEGGihsa:25841.

    Polymorphism databases

    DMDMi485955977.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK091560 mRNA. Translation: BAC03697.1 . Different initiation.
    AK095632 mRNA. Translation: BAC04595.1 .
    AK291744 mRNA. Translation: BAF84433.1 . Sequence problems.
    AC090469 Genomic DNA. No translation available.
    AL035079 Genomic DNA. No translation available.
    AL133294 Genomic DNA. No translation available.
    AL139174 Genomic DNA. No translation available.
    BC093968 mRNA. Translation: AAH93968.1 . Different initiation.
    BX640841 mRNA. Translation: CAE45913.3 .
    CCDSi CCDS7890.2. [Q8N961-1 ]
    RefSeqi NP_665803.2. NM_145804.2. [Q8N961-1 ]
    UniGenei Hs.23361.

    3D structure databases

    ProteinModelPortali Q8N961.
    SMRi Q8N961. Positions 521-738, 841-944.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000298992.

    PTM databases

    PhosphoSitei Q8N961.

    Polymorphism databases

    DMDMi 485955977.

    Proteomic databases

    MaxQBi Q8N961.
    PaxDbi Q8N961.
    PRIDEi Q8N961.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000435224 ; ENSP00000410157 ; ENSG00000166016 . [Q8N961-1 ]
    GeneIDi 25841.
    KEGGi hsa:25841.

    Organism-specific databases

    CTDi 25841.
    GeneCardsi GC11M034129.
    H-InvDB HIX0009548.
    HGNCi HGNC:23842. ABTB2.
    HPAi HPA020065.
    HPA030699.
    neXtProti NX_Q8N961.
    PharmGKBi PA134937734.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG81568.
    HOGENOMi HOG000033776.
    HOVERGENi HBG050447.
    InParanoidi Q8N961.
    KOi K10521.
    OMAi FPWTEGD.
    OrthoDBi EOG773XF8.
    PhylomeDBi Q8N961.
    TreeFami TF106437.

    Miscellaneous databases

    ChiTaRSi ABTB2. human.
    GenomeRNAii 25841.
    NextBioi 13640301.
    PROi Q8N961.

    Gene expression databases

    Bgeei Q8N961.
    CleanExi HS_ABTB2.
    Genevestigatori Q8N961.

    Family and domain databases

    Gene3Di 1.10.20.10. 2 hits.
    1.25.40.20. 3 hits.
    3.30.710.10. 1 hit.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR009072. Histone-fold.
    [Graphical view ]
    Pfami PF00023. Ank. 1 hit.
    PF12796. Ank_2. 1 hit.
    PF00651. BTB. 1 hit.
    [Graphical view ]
    SMARTi SM00248. ANK. 5 hits.
    SM00225. BTB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47113. SSF47113. 2 hits.
    SSF48403. SSF48403. 1 hit.
    SSF54695. SSF54695. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 3 hits.
    PS50097. BTB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT GLN-250.
      Tissue: Fetal brain and Placenta.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 626-1025 (ISOFORM 1/2).
      Tissue: Rectum tumor.

    Entry informationi

    Entry nameiABTB2_HUMAN
    AccessioniPrimary (citable) accession number: Q8N961
    Secondary accession number(s): A8K6S9
    , E9PRW7, Q52LD6, Q6MZW4, Q8NB44
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2005
    Last sequence update: May 1, 2013
    Last modified: October 1, 2014
    This is version 106 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3