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Q8N961

- ABTB2_HUMAN

UniProt

Q8N961 - ABTB2_HUMAN

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Protein

Ankyrin repeat and BTB/POZ domain-containing protein 2

Gene

ABTB2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May be involved in the initiation of hepatocyte growth.By similarity

GO - Biological processi

  1. cellular response to toxic substance Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and BTB/POZ domain-containing protein 2
Gene namesi
Name:ABTB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:23842. ABTB2.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: HPA
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134937734.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10251025Ankyrin repeat and BTB/POZ domain-containing protein 2PRO_0000066887Add
BLAST

Proteomic databases

MaxQBiQ8N961.
PaxDbiQ8N961.
PRIDEiQ8N961.

PTM databases

PhosphoSiteiQ8N961.

Expressioni

Gene expression databases

BgeeiQ8N961.
CleanExiHS_ABTB2.
GenevestigatoriQ8N961.

Organism-specific databases

HPAiHPA020065.
HPA030699.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000298992.

Structurei

3D structure databases

ProteinModelPortaliQ8N961.
SMRiQ8N961. Positions 521-738, 841-944.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati521 – 55030ANK 1Add
BLAST
Repeati567 – 59630ANK 2Add
BLAST
Repeati606 – 63530ANK 3Add
BLAST
Repeati649 – 67830ANK 4Add
BLAST
Domaini845 – 91470BTBPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 4 ANK repeats.PROSITE-ProRule annotation
Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiNOG81568.
GeneTreeiENSGT00550000074669.
HOGENOMiHOG000033776.
HOVERGENiHBG050447.
InParanoidiQ8N961.
KOiK10521.
OMAiFPWTEGD.
OrthoDBiEOG773XF8.
PhylomeDBiQ8N961.
TreeFamiTF106437.

Family and domain databases

Gene3Di1.10.20.10. 2 hits.
1.25.40.20. 3 hits.
3.30.710.10. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR009072. Histone-fold.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 1 hit.
PF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 5 hits.
SM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 2 hits.
SSF48403. SSF48403. 1 hit.
SSF54695. SSF54695. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
PS50097. BTB. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8N961-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGTYSSTLK TLEDLTLDSG YGAGDSCRSL SLSSSKSNSQ ALNSSAQQHR
60 70 80 90 100
GAAWWCYSGS MNSRHNSWDT VNTVLPEDPE VADLFSRCPR LPELEEFPWT
110 120 130 140 150
EGDVARVLRK GAGGRRLPQF SAEAVRRLAG LLRRALIRVA REAQRLSVLH
160 170 180 190 200
AKCTRFEVQS AVRLVHSWAL AESCALAAVK ALSLYSMSAG DGLRRGKSAR
210 220 230 240 250
CGLTFSVGRF FRWMVDTRIS VRIHEYAAIS LTACMENLVE EIRARVMASH
260 270 280 290 300
SPDGGGAGGG EVSAEALEMV INNDAELWGV LQPYEHLICG KNANGVLSLP
310 320 330 340 350
AYFSPYNGGS LGHDERADAY AQLELRTLEQ SLLATCVGSI SELSDLVSRA
360 370 380 390 400
MHHMQGRHPL CPGASPARQA RQPPQPITWS PDALHTLYYF LRCPQMESME
410 420 430 440 450
NPNLDPPRMT LNNERPFMLL PPLMEWMRVA ITYAEHRRSL TVDSGDIRQA
460 470 480 490 500
ARLLLPGLDC EPRQLKPEHC FSSFRRLDAR AATEKFNQDL GFRMLNCGRT
510 520 530 540 550
DLINQAIEAL GPDGVNTMDD QGMTPLMYAC AAGDEAMVQM LIDAGANLDI
560 570 580 590 600
QVPSNSPRHP SIHPDSRHWT SLTFAVLHGH ISVVQLLLDA GAHVEGSAVN
610 620 630 640 650
GGEDSYAETP LQLASAAGNY ELVSLLLSRG ADPLLSMLEA HGMGSSLHED
660 670 680 690 700
MNCFSHSAAH GHRNVLRKLL TQPQQAKADV LSLEEILAEG VEESDASSQG
710 720 730 740 750
SGSEGPVRLS RTRTKALQEA MYYSAEHGYV DITMELRALG VPWKLHIWIE
760 770 780 790 800
SLRTSFSQSR YSVVQSLLRD FSSIREEEYN EELVTEGLQL MFDILKTSKN
810 820 830 840 850
DSVIQQLATI FTHCYGSSPI PSIPEIRKTL PARLDPHFLN NKEMSDVTFL
860 870 880 890 900
VEGKLFYAHK VLLVTASNRF KTLMTNKSEQ DGDSSKTIEI SDMKYHIFQM
910 920 930 940 950
MMQYLYYGGT ESMEIPTTDI LELLSAASLF QLDALQRHCE ILCSQTLSME
960 970 980 990 1000
SAVNTYKYAK IHNAPELALF CEGFFLKHMK ALLEQDAFRQ LIYGRSSKVQ
1010 1020
GLDPLQDLQN TLAERVHSVY ITSRV
Length:1,025
Mass (Da):113,656
Last modified:May 1, 2013 - v2
Checksum:iE0DBA1B9BC0AFB82
GO
Isoform 2 (identifier: Q8N961-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-186: Missing.

Note: No experimental confirmation available.

Show »
Length:839
Mass (Da):93,290
Checksum:i0E48EE96F0C85DB2
GO

Sequence cautioni

The sequence AAH93968.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC03697.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAF84433.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAF84433.1 differs from that shown. Reason: Erroneous termination at position 101. Translated as Glu.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti189 – 1891A → D in BAF84433. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti250 – 2501H → Q.1 Publication
Corresponds to variant rs1925368 [ dbSNP | Ensembl ].
VAR_022087
Natural varianti918 – 9181T → A.
Corresponds to variant rs2473928 [ dbSNP | Ensembl ].
VAR_024171

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 186186Missing in isoform 2. 1 PublicationVSP_046439Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091560 mRNA. Translation: BAC03697.1. Different initiation.
AK095632 mRNA. Translation: BAC04595.1.
AK291744 mRNA. Translation: BAF84433.1. Sequence problems.
AC090469 Genomic DNA. No translation available.
AL035079 Genomic DNA. No translation available.
AL133294 Genomic DNA. No translation available.
AL139174 Genomic DNA. No translation available.
BC093968 mRNA. Translation: AAH93968.1. Different initiation.
BX640841 mRNA. Translation: CAE45913.3.
CCDSiCCDS7890.2. [Q8N961-1]
RefSeqiNP_665803.2. NM_145804.2. [Q8N961-1]
UniGeneiHs.23361.

Genome annotation databases

EnsembliENST00000435224; ENSP00000410157; ENSG00000166016. [Q8N961-1]
GeneIDi25841.
KEGGihsa:25841.

Polymorphism databases

DMDMi485955977.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091560 mRNA. Translation: BAC03697.1 . Different initiation.
AK095632 mRNA. Translation: BAC04595.1 .
AK291744 mRNA. Translation: BAF84433.1 . Sequence problems.
AC090469 Genomic DNA. No translation available.
AL035079 Genomic DNA. No translation available.
AL133294 Genomic DNA. No translation available.
AL139174 Genomic DNA. No translation available.
BC093968 mRNA. Translation: AAH93968.1 . Different initiation.
BX640841 mRNA. Translation: CAE45913.3 .
CCDSi CCDS7890.2. [Q8N961-1 ]
RefSeqi NP_665803.2. NM_145804.2. [Q8N961-1 ]
UniGenei Hs.23361.

3D structure databases

ProteinModelPortali Q8N961.
SMRi Q8N961. Positions 521-738, 841-944.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000298992.

PTM databases

PhosphoSitei Q8N961.

Polymorphism databases

DMDMi 485955977.

Proteomic databases

MaxQBi Q8N961.
PaxDbi Q8N961.
PRIDEi Q8N961.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000435224 ; ENSP00000410157 ; ENSG00000166016 . [Q8N961-1 ]
GeneIDi 25841.
KEGGi hsa:25841.

Organism-specific databases

CTDi 25841.
GeneCardsi GC11M034129.
H-InvDB HIX0009548.
HGNCi HGNC:23842. ABTB2.
HPAi HPA020065.
HPA030699.
neXtProti NX_Q8N961.
PharmGKBi PA134937734.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG81568.
GeneTreei ENSGT00550000074669.
HOGENOMi HOG000033776.
HOVERGENi HBG050447.
InParanoidi Q8N961.
KOi K10521.
OMAi FPWTEGD.
OrthoDBi EOG773XF8.
PhylomeDBi Q8N961.
TreeFami TF106437.

Miscellaneous databases

ChiTaRSi ABTB2. human.
GenomeRNAii 25841.
NextBioi 13640301.
PROi Q8N961.

Gene expression databases

Bgeei Q8N961.
CleanExi HS_ABTB2.
Genevestigatori Q8N961.

Family and domain databases

Gene3Di 1.10.20.10. 2 hits.
1.25.40.20. 3 hits.
3.30.710.10. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR009072. Histone-fold.
[Graphical view ]
Pfami PF00023. Ank. 1 hit.
PF12796. Ank_2. 1 hit.
PF00651. BTB. 1 hit.
[Graphical view ]
SMARTi SM00248. ANK. 5 hits.
SM00225. BTB. 1 hit.
[Graphical view ]
SUPFAMi SSF47113. SSF47113. 2 hits.
SSF48403. SSF48403. 1 hit.
SSF54695. SSF54695. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
PS50097. BTB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT GLN-250.
    Tissue: Fetal brain and Placenta.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 626-1025 (ISOFORM 1/2).
    Tissue: Rectum tumor.

Entry informationi

Entry nameiABTB2_HUMAN
AccessioniPrimary (citable) accession number: Q8N961
Secondary accession number(s): A8K6S9
, E9PRW7, Q52LD6, Q6MZW4, Q8NB44
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: May 1, 2013
Last modified: October 29, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3