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Q8N961 (ABTB2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ankyrin repeat and BTB/POZ domain-containing protein 2
Gene names
Name:ABTB2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1025 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in the initiation of hepatocyte growth By similarity.

Sequence similarities

Contains 4 ANK repeats.

Contains 1 BTB (POZ) domain.

Sequence caution

The sequence AAH93968.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence BAC03697.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence BAF84433.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence BAF84433.1 differs from that shown. Reason: Erroneous termination at position 101. Translated as Glu.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainANK repeat
Repeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentnucleus

Inferred from direct assay. Source: HPA

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8N961-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8N961-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-186: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10251025Ankyrin repeat and BTB/POZ domain-containing protein 2
PRO_0000066887

Regions

Repeat521 – 55030ANK 1
Repeat567 – 59630ANK 2
Repeat606 – 63530ANK 3
Repeat649 – 67830ANK 4
Domain845 – 91470BTB

Natural variations

Alternative sequence1 – 186186Missing in isoform 2.
VSP_046439
Natural variant2501H → Q. Ref.1
Corresponds to variant rs1925368 [ dbSNP | Ensembl ].
VAR_022087
Natural variant9181T → A.
Corresponds to variant rs2473928 [ dbSNP | Ensembl ].
VAR_024171

Experimental info

Sequence conflict1891A → D in BAF84433. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 1, 2013. Version 2.
Checksum: E0DBA1B9BC0AFB82

FASTA1,025113,656
        10         20         30         40         50         60 
MAGTYSSTLK TLEDLTLDSG YGAGDSCRSL SLSSSKSNSQ ALNSSAQQHR GAAWWCYSGS 

        70         80         90        100        110        120 
MNSRHNSWDT VNTVLPEDPE VADLFSRCPR LPELEEFPWT EGDVARVLRK GAGGRRLPQF 

       130        140        150        160        170        180 
SAEAVRRLAG LLRRALIRVA REAQRLSVLH AKCTRFEVQS AVRLVHSWAL AESCALAAVK 

       190        200        210        220        230        240 
ALSLYSMSAG DGLRRGKSAR CGLTFSVGRF FRWMVDTRIS VRIHEYAAIS LTACMENLVE 

       250        260        270        280        290        300 
EIRARVMASH SPDGGGAGGG EVSAEALEMV INNDAELWGV LQPYEHLICG KNANGVLSLP 

       310        320        330        340        350        360 
AYFSPYNGGS LGHDERADAY AQLELRTLEQ SLLATCVGSI SELSDLVSRA MHHMQGRHPL 

       370        380        390        400        410        420 
CPGASPARQA RQPPQPITWS PDALHTLYYF LRCPQMESME NPNLDPPRMT LNNERPFMLL 

       430        440        450        460        470        480 
PPLMEWMRVA ITYAEHRRSL TVDSGDIRQA ARLLLPGLDC EPRQLKPEHC FSSFRRLDAR 

       490        500        510        520        530        540 
AATEKFNQDL GFRMLNCGRT DLINQAIEAL GPDGVNTMDD QGMTPLMYAC AAGDEAMVQM 

       550        560        570        580        590        600 
LIDAGANLDI QVPSNSPRHP SIHPDSRHWT SLTFAVLHGH ISVVQLLLDA GAHVEGSAVN 

       610        620        630        640        650        660 
GGEDSYAETP LQLASAAGNY ELVSLLLSRG ADPLLSMLEA HGMGSSLHED MNCFSHSAAH 

       670        680        690        700        710        720 
GHRNVLRKLL TQPQQAKADV LSLEEILAEG VEESDASSQG SGSEGPVRLS RTRTKALQEA 

       730        740        750        760        770        780 
MYYSAEHGYV DITMELRALG VPWKLHIWIE SLRTSFSQSR YSVVQSLLRD FSSIREEEYN 

       790        800        810        820        830        840 
EELVTEGLQL MFDILKTSKN DSVIQQLATI FTHCYGSSPI PSIPEIRKTL PARLDPHFLN 

       850        860        870        880        890        900 
NKEMSDVTFL VEGKLFYAHK VLLVTASNRF KTLMTNKSEQ DGDSSKTIEI SDMKYHIFQM 

       910        920        930        940        950        960 
MMQYLYYGGT ESMEIPTTDI LELLSAASLF QLDALQRHCE ILCSQTLSME SAVNTYKYAK 

       970        980        990       1000       1010       1020 
IHNAPELALF CEGFFLKHMK ALLEQDAFRQ LIYGRSSKVQ GLDPLQDLQN TLAERVHSVY 


ITSRV 

« Hide

Isoform 2 [UniParc].

Checksum: 0E48EE96F0C85DB2
Show »

FASTA83993,290

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT GLN-250.
Tissue: Fetal brain and Placenta.
[2]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[4]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 626-1025 (ISOFORM 1/2).
Tissue: Rectum tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK091560 mRNA. Translation: BAC03697.1. Different initiation.
AK095632 mRNA. Translation: BAC04595.1.
AK291744 mRNA. Translation: BAF84433.1. Sequence problems.
AC090469 Genomic DNA. No translation available.
AL035079 Genomic DNA. No translation available.
AL133294 Genomic DNA. No translation available.
AL139174 Genomic DNA. No translation available.
BC093968 mRNA. Translation: AAH93968.1. Different initiation.
BX640841 mRNA. Translation: CAE45913.3.
CCDSCCDS7890.2. [Q8N961-1]
RefSeqNP_665803.2. NM_145804.2. [Q8N961-1]
UniGeneHs.23361.

3D structure databases

ProteinModelPortalQ8N961.
SMRQ8N961. Positions 521-738, 841-944.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000298992.

PTM databases

PhosphoSiteQ8N961.

Polymorphism databases

DMDM485955977.

Proteomic databases

MaxQBQ8N961.
PaxDbQ8N961.
PRIDEQ8N961.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000298992; ENSP00000298992; ENSG00000166016. [Q8N961-2]
ENST00000435224; ENSP00000410157; ENSG00000166016. [Q8N961-1]
GeneID25841.
KEGGhsa:25841.

Organism-specific databases

CTD25841.
GeneCardsGC11M034129.
H-InvDBHIX0009548.
HGNCHGNC:23842. ABTB2.
HPAHPA020065.
HPA030699.
neXtProtNX_Q8N961.
PharmGKBPA134937734.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG81568.
HOGENOMHOG000033776.
HOVERGENHBG050447.
InParanoidQ8N961.
KOK10521.
OMAFPWTEGD.
OrthoDBEOG773XF8.
PhylomeDBQ8N961.
TreeFamTF106437.

Gene expression databases

BgeeQ8N961.
CleanExHS_ABTB2.
GenevestigatorQ8N961.

Family and domain databases

Gene3D1.10.20.10. 2 hits.
1.25.40.20. 3 hits.
3.30.710.10. 1 hit.
InterProIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR009072. Histone-fold.
[Graphical view]
PfamPF00023. Ank. 1 hit.
PF12796. Ank_2. 1 hit.
PF00651. BTB. 1 hit.
[Graphical view]
SMARTSM00248. ANK. 5 hits.
SM00225. BTB. 1 hit.
[Graphical view]
SUPFAMSSF47113. SSF47113. 2 hits.
SSF48403. SSF48403. 1 hit.
SSF54695. SSF54695. 1 hit.
PROSITEPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
PS50097. BTB. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSABTB2. human.
GenomeRNAi25841.
NextBio13640301.
PROQ8N961.

Entry information

Entry nameABTB2_HUMAN
AccessionPrimary (citable) accession number: Q8N961
Secondary accession number(s): A8K6S9 expand/collapse secondary AC list , E9PRW7, Q52LD6, Q6MZW4, Q8NB44
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: May 1, 2013
Last modified: July 9, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM