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Q8N961 (ABTB2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ankyrin repeat and BTB/POZ domain-containing protein 2
Gene names
Name:ABTB2
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length839 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in the initiation of hepatocyte growth By similarity.

Sequence similarities

Contains 4 ANK repeats.

Contains 1 BTB (POZ) domain.

Sequence caution

The sequence BAC03697.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   DomainANK repeat
Repeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processregulation of cell growth

Non-traceable author statement. Source: UniProtKB

   Molecular functionDNA binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 839839Ankyrin repeat and BTB/POZ domain-containing protein 2
PRO_0000066887

Regions

Repeat335 – 36430ANK 1
Repeat381 – 41030ANK 2
Repeat420 – 44930ANK 3
Repeat463 – 49230ANK 4
Domain659 – 72870BTB

Natural variations

Natural variant641H → Q.
Corresponds to variant rs1925368 [ dbSNP | Ensembl ].
VAR_022087
Natural variant7321T → A.
Corresponds to variant rs2473928 [ dbSNP | Ensembl ].
VAR_024171

Sequences

Sequence LengthMass (Da)Tools
Q8N961 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 0E48EE96F0C85DB2

FASTA83993,290
        10         20         30         40         50         60 
MSAGDGLRRG KSARCGLTFS VGRFFRWMVD TRISVRIHEY AAISLTACME NLVEEIRARV 

        70         80         90        100        110        120 
MASHSPDGGG AGGGEVSAEA LEMVINNDAE LWGVLQPYEH LICGKNANGV LSLPAYFSPY 

       130        140        150        160        170        180 
NGGSLGHDER ADAYAQLELR TLEQSLLATC VGSISELSDL VSRAMHHMQG RHPLCPGASP 

       190        200        210        220        230        240 
ARQARQPPQP ITWSPDALHT LYYFLRCPQM ESMENPNLDP PRMTLNNERP FMLLPPLMEW 

       250        260        270        280        290        300 
MRVAITYAEH RRSLTVDSGD IRQAARLLLP GLDCEPRQLK PEHCFSSFRR LDARAATEKF 

       310        320        330        340        350        360 
NQDLGFRMLN CGRTDLINQA IEALGPDGVN TMDDQGMTPL MYACAAGDEA MVQMLIDAGA 

       370        380        390        400        410        420 
NLDIQVPSNS PRHPSIHPDS RHWTSLTFAV LHGHISVVQL LLDAGAHVEG SAVNGGEDSY 

       430        440        450        460        470        480 
AETPLQLASA AGNYELVSLL LSRGADPLLS MLEAHGMGSS LHEDMNCFSH SAAHGHRNVL 

       490        500        510        520        530        540 
RKLLTQPQQA KADVLSLEEI LAEGVEESDA SSQGSGSEGP VRLSRTRTKA LQEAMYYSAE 

       550        560        570        580        590        600 
HGYVDITMEL RALGVPWKLH IWIESLRTSF SQSRYSVVQS LLRDFSSIRE EEYNEELVTE 

       610        620        630        640        650        660 
GLQLMFDILK TSKNDSVIQQ LATIFTHCYG SSPIPSIPEI RKTLPARLDP HFLNNKEMSD 

       670        680        690        700        710        720 
VTFLVEGKLF YAHKVLLVTA SNRFKTLMTN KSEQDGDSSK TIEISDMKYH IFQMMMQYLY 

       730        740        750        760        770        780 
YGGTESMEIP TTDILELLSA ASLFQLDALQ RHCEILCSQT LSMESAVNTY KYAKIHNAPE 

       790        800        810        820        830 
LALFCEGFFL KHMKALLEQD AFRQLIYGRS SKVQGLDPLQ DLQNTLAERV HSVYITSRV

« Hide

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Fetal brain.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[3]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 440-839.
Tissue: Rectum tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK091560 mRNA. Translation: BAC03697.1. Different initiation.
AK095632 mRNA. Translation: BAC04595.1.
BC093968 mRNA. Translation: AAH93968.1.
BX640841 mRNA. Translation: CAE45913.3.
IPIIPI00974022.
UniGeneHs.23361.

3D structure databases

ProteinModelPortalQ8N961.
SMRQ8N961. Positions 8-111, 310-582, 649-792.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ8N961.

Polymorphism databases

DMDM61218305.

Proteomic databases

PRIDEQ8N961.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000298992; ENSP00000298992; ENSG00000166016.
UCSCuc001mvl.1. human.

Organism-specific databases

GeneCardsGC11M034129.
H-InvDBHIX0009548.
HGNCHGNC:23842. ABTB2.
HPAHPA020065.
neXtProtNX_Q8N961.
PharmGKBPA134937734.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG14146.
GeneTreeENSGT00550000074669.
HOGENOMHBG444734.
HOVERGENHBG050447.
InParanoidQ8N961.
OMARQLIYGR.
OrthoDBEOG4H729T.
PhylomeDBQ8N961.

Gene expression databases

ArrayExpressQ8N961.
BgeeQ8N961.
CleanExHS_ABTB2.
GenevestigatorQ8N961.
GermOnlineENSG00000166016. Homo sapiens.

Family and domain databases

InterProIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR009072. Histone-fold.
[Graphical view]
Gene3DG3DSA:1.25.40.20. ANK. 2 hits.
G3DSA:3.30.710.10. BTB/POZ_fold. 1 hit.
G3DSA:1.10.20.10. Histone-fold. 1 hit.
PfamPF00023. Ank. 1 hit.
PF12796. Ank_2. 1 hit.
PF00651. BTB. 1 hit.
[Graphical view]
SMARTSM00248. ANK. 5 hits.
SM00225. BTB. 1 hit.
[Graphical view]
SUPFAMSSF48403. ANK. 1 hit.
SSF54695. BTB/POZ_fold. 1 hit.
SSF47113. Histone-fold. 1 hit.
PROSITEPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
PS50097. BTB. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio47159.

Entry information

Entry nameABTB2_HUMAN
AccessionPrimary (citable) accession number: Q8N961
Secondary accession number(s): Q52LD6, Q6MZW4, Q8NB44
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: October 1, 2002
Last modified: January 25, 2012
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents