Q8N961 (ABTB2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ankyrin repeat and BTB/POZ domain-containing protein 2

Gene names

Name:

ABTB2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1025 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in the initiation of hepatocyte growth By similarity.
Sequence similarities	Contains 4 ANK repeats. Contains 1 BTB (POZ) domain.
Sequence caution	The sequence AAH93968.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAC03697.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAF84433.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAF84433.1 differs from that shown. Reason: Erroneous termination at position 101. Translated as Glu.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	ANK repeat Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of cell growth Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8N961-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8N961-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-186: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1025	1025	Ankyrin repeat and BTB/POZ domain-containing protein 2		PRO_0000066887
Regions
	Repeat	521 – 550	30	ANK 1
	Repeat	567 – 596	30	ANK 2
	Repeat	606 – 635	30	ANK 3
	Repeat	649 – 678	30	ANK 4
	Domain	845 – 914	70	BTB
Natural variations
	Alternative sequence	1 – 186	186	Missing in isoform 2.		VSP_046439
	Natural variant	250	1	H → Q. Ref.1 Corresponds to variant rs1925368 [ dbSNP | Ensembl ].		VAR_022087
	Natural variant	918	1	T → A. Corresponds to variant rs2473928 [ dbSNP | Ensembl ].		VAR_024171
Experimental info
	Sequence conflict	189	1	A → D in BAF84433. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 1, 2013. Version 2. Checksum: E0DBA1B9BC0AFB82	FASTA	1,025	113,656
	10 20 30 40 50 60 MAGTYSSTLK TLEDLTLDSG YGAGDSCRSL SLSSSKSNSQ ALNSSAQQHR GAAWWCYSGS 70 80 90 100 110 120 MNSRHNSWDT VNTVLPEDPE VADLFSRCPR LPELEEFPWT EGDVARVLRK GAGGRRLPQF 130 140 150 160 170 180 SAEAVRRLAG LLRRALIRVA REAQRLSVLH AKCTRFEVQS AVRLVHSWAL AESCALAAVK 190 200 210 220 230 240 ALSLYSMSAG DGLRRGKSAR CGLTFSVGRF FRWMVDTRIS VRIHEYAAIS LTACMENLVE 250 260 270 280 290 300 EIRARVMASH SPDGGGAGGG EVSAEALEMV INNDAELWGV LQPYEHLICG KNANGVLSLP 310 320 330 340 350 360 AYFSPYNGGS LGHDERADAY AQLELRTLEQ SLLATCVGSI SELSDLVSRA MHHMQGRHPL 370 380 390 400 410 420 CPGASPARQA RQPPQPITWS PDALHTLYYF LRCPQMESME NPNLDPPRMT LNNERPFMLL 430 440 450 460 470 480 PPLMEWMRVA ITYAEHRRSL TVDSGDIRQA ARLLLPGLDC EPRQLKPEHC FSSFRRLDAR 490 500 510 520 530 540 AATEKFNQDL GFRMLNCGRT DLINQAIEAL GPDGVNTMDD QGMTPLMYAC AAGDEAMVQM 550 560 570 580 590 600 LIDAGANLDI QVPSNSPRHP SIHPDSRHWT SLTFAVLHGH ISVVQLLLDA GAHVEGSAVN 610 620 630 640 650 660 GGEDSYAETP LQLASAAGNY ELVSLLLSRG ADPLLSMLEA HGMGSSLHED MNCFSHSAAH 670 680 690 700 710 720 GHRNVLRKLL TQPQQAKADV LSLEEILAEG VEESDASSQG SGSEGPVRLS RTRTKALQEA 730 740 750 760 770 780 MYYSAEHGYV DITMELRALG VPWKLHIWIE SLRTSFSQSR YSVVQSLLRD FSSIREEEYN 790 800 810 820 830 840 EELVTEGLQL MFDILKTSKN DSVIQQLATI FTHCYGSSPI PSIPEIRKTL PARLDPHFLN 850 860 870 880 890 900 NKEMSDVTFL VEGKLFYAHK VLLVTASNRF KTLMTNKSEQ DGDSSKTIEI SDMKYHIFQM 910 920 930 940 950 960 MMQYLYYGGT ESMEIPTTDI LELLSAASLF QLDALQRHCE ILCSQTLSME SAVNTYKYAK 970 980 990 1000 1010 1020 IHNAPELALF CEGFFLKHMK ALLEQDAFRQ LIYGRSSKVQ GLDPLQDLQN TLAERVHSVY ITSRV
	Isoform 2 [UniParc]. Checksum: 0E48EE96F0C85DB2	FASTA	839	93,290
	10 20 30 40 50 60 MSAGDGLRRG KSARCGLTFS VGRFFRWMVD TRISVRIHEY AAISLTACME NLVEEIRARV 70 80 90 100 110 120 MASHSPDGGG AGGGEVSAEA LEMVINNDAE LWGVLQPYEH LICGKNANGV LSLPAYFSPY 130 140 150 160 170 180 NGGSLGHDER ADAYAQLELR TLEQSLLATC VGSISELSDL VSRAMHHMQG RHPLCPGASP 190 200 210 220 230 240 ARQARQPPQP ITWSPDALHT LYYFLRCPQM ESMENPNLDP PRMTLNNERP FMLLPPLMEW 250 260 270 280 290 300 MRVAITYAEH RRSLTVDSGD IRQAARLLLP GLDCEPRQLK PEHCFSSFRR LDARAATEKF 310 320 330 340 350 360 NQDLGFRMLN CGRTDLINQA IEALGPDGVN TMDDQGMTPL MYACAAGDEA MVQMLIDAGA 370 380 390 400 410 420 NLDIQVPSNS PRHPSIHPDS RHWTSLTFAV LHGHISVVQL LLDAGAHVEG SAVNGGEDSY 430 440 450 460 470 480 AETPLQLASA AGNYELVSLL LSRGADPLLS MLEAHGMGSS LHEDMNCFSH SAAHGHRNVL 490 500 510 520 530 540 RKLLTQPQQA KADVLSLEEI LAEGVEESDA SSQGSGSEGP VRLSRTRTKA LQEAMYYSAE 550 560 570 580 590 600 HGYVDITMEL RALGVPWKLH IWIESLRTSF SQSRYSVVQS LLRDFSSIRE EEYNEELVTE 610 620 630 640 650 660 GLQLMFDILK TSKNDSVIQQ LATIFTHCYG SSPIPSIPEI RKTLPARLDP HFLNNKEMSD 670 680 690 700 710 720 VTFLVEGKLF YAHKVLLVTA SNRFKTLMTN KSEQDGDSSK TIEISDMKYH IFQMMMQYLY 730 740 750 760 770 780 YGGTESMEIP TTDILELLSA ASLFQLDALQ RHCEILCSQT LSMESAVNTY KYAKIHNAPE 790 800 810 820 830 LALFCEGFFL KHMKALLEQD AFRQLIYGRS SKVQGLDPLQ DLQNTLAERV HSVYITSRV

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT GLN-250. Tissue: Fetal brain and Placenta.
[2]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[4]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 626-1025 (ISOFORM 1/2). Tissue: Rectum tumor.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK091560 mRNA. Translation: BAC03697.1. Different initiation. AK095632 mRNA. Translation: BAC04595.1. AK291744 mRNA. Translation: BAF84433.1. Sequence problems. AC090469 Genomic DNA. No translation available. AL035079 Genomic DNA. No translation available. AL133294 Genomic DNA. No translation available. AL139174 Genomic DNA. No translation available. BC093968 mRNA. Translation: AAH93968.1. Different initiation. BX640841 mRNA. Translation: CAE45913.3.
IPI	IPI00974022.
RefSeq	NP_665803.2. NM_145804.2.
UniGene	Hs.23361.
3D structure databases
ProteinModelPortal	Q8N961.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000298992.
PTM databases
PhosphoSite	Q8N961.
Polymorphism databases
DMDM	61218305.
Proteomic databases
PaxDb	Q8N961.
PRIDE	Q8N961.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000298992; ENSP00000298992; ENSG00000166016. ENST00000435224; ENSP00000410157; ENSG00000166016.
GeneID	25841.
KEGG	hsa:25841.
Organism-specific databases
GeneCards	GC11M034129.
H-InvDB	HIX0009548.
HGNC	HGNC:23842. ABTB2.
HPA	HPA020065.
neXtProt	NX_Q8N961.
PharmGKB	PA134937734.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG81568.
HOGENOM	HOG000033776.
HOVERGEN	HBG050447.
InParanoid	Q8N961.
KO	K10521.
OMA	HRGAAWW.
OrthoDB	EOG4H729T.
PhylomeDB	Q8N961.
Gene expression databases
ArrayExpress	Q8N961.
Bgee	Q8N961.
CleanEx	HS_ABTB2.
Genevestigator	Q8N961.
GermOnline	ENSG00000166016. Homo sapiens.
Family and domain databases
Gene3D	1.10.20.10. 1 hit. 1.25.40.20. 2 hits. 3.30.710.10. 1 hit.
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR000210. BTB/POZ-like. IPR011333. BTB/POZ_fold. IPR013069. BTB_POZ. IPR009072. Histone-fold. [Graphical view]
Pfam	PF12796. Ank_2. 1 hit. PF00651. BTB. 1 hit. [Graphical view]
SMART	SM00248. ANK. 5 hits. SM00225. BTB. 1 hit. [Graphical view]
SUPFAM	SSF48403. ANK. 1 hit. SSF54695. BTB/POZ_fold. 1 hit. SSF47113. Histone-fold. 1 hit.
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 3 hits. PS50097. BTB. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	ABTB2. human.
GenomeRNAi	25841.
NextBio	13640301.

Entry information

Entry name

ABTB2_HUMAN

Accession

Primary (citable) accession number: Q8N961
Secondary accession number(s): A8K6S9 , E9PRW7, Q52LD6, Q6MZW4, Q8NB44

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	May 1, 2013
Last modified:	May 1, 2013
This is version 94 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.