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Q8N957

- ANKF1_HUMAN

UniProt

Q8N957 - ANKF1_HUMAN

Protein

Ankyrin repeat and fibronectin type-III domain-containing protein 1

Gene

ANKFN1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 2 (24 Nov 2009)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ankyrin repeat and fibronectin type-III domain-containing protein 1
    Gene namesi
    Name:ANKFN1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:26766. ANKFN1.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142672624.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 763763Ankyrin repeat and fibronectin type-III domain-containing protein 1PRO_0000247138Add
    BLAST

    Proteomic databases

    PaxDbiQ8N957.
    PRIDEiQ8N957.

    PTM databases

    PhosphoSiteiQ8N957.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8N957.
    BgeeiQ8N957.
    CleanExiHS_ANKFN1.
    GenevestigatoriQ8N957.

    Organism-specific databases

    HPAiHPA021566.
    HPA022538.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000321627.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N957.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati136 – 16530ANK 1Add
    BLAST
    Repeati173 – 20230ANK 2Add
    BLAST
    Domaini273 – 36997Fibronectin type-IIIPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili205 – 23632Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 2 ANK repeats.PROSITE-ProRule annotation
    Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation

    Keywords - Domaini

    ANK repeat, Coiled coil, Repeat

    Phylogenomic databases

    eggNOGiNOG325963.
    HOGENOMiHOG000169356.
    HOVERGENiHBG080841.
    InParanoidiQ8N957.
    OrthoDBiEOG77126G.
    PhylomeDBiQ8N957.
    TreeFamiTF314968.

    Family and domain databases

    Gene3Di1.25.40.20. 2 hits.
    2.60.40.10. 1 hit.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    [Graphical view]
    PfamiPF00041. fn3. 1 hit.
    [Graphical view]
    SMARTiSM00248. ANK. 2 hits.
    SM00060. FN3. 1 hit.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    SSF49265. SSF49265. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 1 hit.
    PS50853. FN3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8N957-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEASLTRRLL FKDRHFTCSK IIGRRFACFA QRLSHRRKQS QCDLLNESTG    50
    QLPTTCSSAA SNSINWNCRV KMTQQMQNLH LCQSKKHSAP SSPNAAKRLY 100
    RNLSEKLKGS HSSFDEAYFR TRTDRLSLRK TSVNFQGNEA MFEAVEQQDM 150
    DAVQILLYQY TPEELDLNTP NSEGLTPLDI AIMTNNVPIA RILLRTGARE 200
    SPHFVSLESR AMHLNTLVQE AQERVSELSA QVENEGFTLD NTEKEKQLKA 250
    WEWRYRLYRR MKTGFEHARA PEMPTNVCLM VTSSTSLTVS FQEPLSVNAA 300
    VVTRYKVEWS MSEDFSPLAG EIIMDNLQTL RCTITGLTMG QQYFVQVSAY 350
    NMKGWGPAQT TTPACASPSN WKDYDDREPR HKGQSEVLEG LLQQVRALHQ 400
    HYSCRESTKL QTTGRKQSVS RSLKHLFHSS NKFVKTLKRG LYIAVIFYYK 450
    DNILVTNEDQ VPIVEIDDSH TSSITQDFLW FTKLSCMWED IRWLRQSIPI 500
    SSSSSTVLQT RQKMLAATAQ LQNLLGTHNL GRVYYEPIKD RHGNILIVTI 550
    REVEMLYSFF NGKWMQISKL QSQRKSLSTP EEPTALDILL ITIQDILSYH 600
    KRSHQRLFPG LYLGYLKLCS SVDQIKVLVT QKLPNILCHV KIRENNNISR 650
    EEWEWIQKLS GSESMESVDH TSDCPMQLFF YELQMAVKAL LQQINIPLHQ 700
    ARNFRLYTQE VLEMGHNVSF LLLLPASDDV CTAPGQNNPY TPHSGFLNLP 750
    LQMFELGIVA CFT 763
    Length:763
    Mass (Da):87,604
    Last modified:November 24, 2009 - v2
    Checksum:i49174DE8572FC994
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti445 – 4451V → I.1 Publication
    Corresponds to variant rs10852985 [ dbSNP | Ensembl ].
    VAR_060725

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK095654 mRNA. Translation: BAC04599.1.
    AC006600 Genomic DNA. No translation available.
    AC006925 Genomic DNA. No translation available.
    AC015724 Genomic DNA. No translation available.
    CCDSiCCDS32686.1.
    RefSeqiNP_694960.2. NM_153228.2.
    UniGeneiHs.673040.

    Genome annotation databases

    EnsembliENST00000318698; ENSP00000321627; ENSG00000153930.
    GeneIDi162282.
    KEGGihsa:162282.
    UCSCiuc002iun.1. human.

    Polymorphism databases

    DMDMi269849542.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK095654 mRNA. Translation: BAC04599.1 .
    AC006600 Genomic DNA. No translation available.
    AC006925 Genomic DNA. No translation available.
    AC015724 Genomic DNA. No translation available.
    CCDSi CCDS32686.1.
    RefSeqi NP_694960.2. NM_153228.2.
    UniGenei Hs.673040.

    3D structure databases

    ProteinModelPortali Q8N957.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000321627.

    PTM databases

    PhosphoSitei Q8N957.

    Polymorphism databases

    DMDMi 269849542.

    Proteomic databases

    PaxDbi Q8N957.
    PRIDEi Q8N957.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000318698 ; ENSP00000321627 ; ENSG00000153930 .
    GeneIDi 162282.
    KEGGi hsa:162282.
    UCSCi uc002iun.1. human.

    Organism-specific databases

    CTDi 162282.
    GeneCardsi GC17P054230.
    HGNCi HGNC:26766. ANKFN1.
    HPAi HPA021566.
    HPA022538.
    neXtProti NX_Q8N957.
    PharmGKBi PA142672624.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG325963.
    HOGENOMi HOG000169356.
    HOVERGENi HBG080841.
    InParanoidi Q8N957.
    OrthoDBi EOG77126G.
    PhylomeDBi Q8N957.
    TreeFami TF314968.

    Miscellaneous databases

    GenomeRNAii 162282.
    NextBioi 88148.
    PROi Q8N957.

    Gene expression databases

    ArrayExpressi Q8N957.
    Bgeei Q8N957.
    CleanExi HS_ANKFN1.
    Genevestigatori Q8N957.

    Family and domain databases

    Gene3Di 1.25.40.20. 2 hits.
    2.60.40.10. 1 hit.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    [Graphical view ]
    Pfami PF00041. fn3. 1 hit.
    [Graphical view ]
    SMARTi SM00248. ANK. 2 hits.
    SM00060. FN3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    SSF49265. SSF49265. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 1 hit.
    PS50853. FN3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ILE-445.
      Tissue: Brain.
    2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiANKF1_HUMAN
    AccessioniPrimary (citable) accession number: Q8N957
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2006
    Last sequence update: November 24, 2009
    Last modified: October 1, 2014
    This is version 86 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3