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Q8N957 (ANKF1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ankyrin repeat and fibronectin type-III domain-containing protein 1
Gene names
Name:ANKFN1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length763 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 2 ANK repeats.

Contains 1 fibronectin type-III domain.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   DomainANK repeat
Coiled coil
Repeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 763763Ankyrin repeat and fibronectin type-III domain-containing protein 1
PRO_0000247138

Regions

Repeat136 – 16530ANK 1
Repeat173 – 20230ANK 2
Domain273 – 36997Fibronectin type-III
Coiled coil205 – 23632 Potential

Natural variations

Natural variant4451V → I. Ref.1
Corresponds to variant rs10852985 [ dbSNP | Ensembl ].
VAR_060725

Sequences

Sequence LengthMass (Da)Tools
Q8N957 [UniParc].

Last modified November 24, 2009. Version 2.
Checksum: 49174DE8572FC994

FASTA76387,604
        10         20         30         40         50         60 
MEASLTRRLL FKDRHFTCSK IIGRRFACFA QRLSHRRKQS QCDLLNESTG QLPTTCSSAA 

        70         80         90        100        110        120 
SNSINWNCRV KMTQQMQNLH LCQSKKHSAP SSPNAAKRLY RNLSEKLKGS HSSFDEAYFR 

       130        140        150        160        170        180 
TRTDRLSLRK TSVNFQGNEA MFEAVEQQDM DAVQILLYQY TPEELDLNTP NSEGLTPLDI 

       190        200        210        220        230        240 
AIMTNNVPIA RILLRTGARE SPHFVSLESR AMHLNTLVQE AQERVSELSA QVENEGFTLD 

       250        260        270        280        290        300 
NTEKEKQLKA WEWRYRLYRR MKTGFEHARA PEMPTNVCLM VTSSTSLTVS FQEPLSVNAA 

       310        320        330        340        350        360 
VVTRYKVEWS MSEDFSPLAG EIIMDNLQTL RCTITGLTMG QQYFVQVSAY NMKGWGPAQT 

       370        380        390        400        410        420 
TTPACASPSN WKDYDDREPR HKGQSEVLEG LLQQVRALHQ HYSCRESTKL QTTGRKQSVS 

       430        440        450        460        470        480 
RSLKHLFHSS NKFVKTLKRG LYIAVIFYYK DNILVTNEDQ VPIVEIDDSH TSSITQDFLW 

       490        500        510        520        530        540 
FTKLSCMWED IRWLRQSIPI SSSSSTVLQT RQKMLAATAQ LQNLLGTHNL GRVYYEPIKD 

       550        560        570        580        590        600 
RHGNILIVTI REVEMLYSFF NGKWMQISKL QSQRKSLSTP EEPTALDILL ITIQDILSYH 

       610        620        630        640        650        660 
KRSHQRLFPG LYLGYLKLCS SVDQIKVLVT QKLPNILCHV KIRENNNISR EEWEWIQKLS 

       670        680        690        700        710        720 
GSESMESVDH TSDCPMQLFF YELQMAVKAL LQQINIPLHQ ARNFRLYTQE VLEMGHNVSF 

       730        740        750        760 
LLLLPASDDV CTAPGQNNPY TPHSGFLNLP LQMFELGIVA CFT 

« Hide

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ILE-445.
Tissue: Brain.
[2]"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. expand/collapse author list , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK095654 mRNA. Translation: BAC04599.1.
AC006600 Genomic DNA. No translation available.
AC006925 Genomic DNA. No translation available.
AC015724 Genomic DNA. No translation available.
CCDSCCDS32686.1.
RefSeqNP_694960.2. NM_153228.2.
UniGeneHs.673040.

3D structure databases

ProteinModelPortalQ8N957.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000321627.

PTM databases

PhosphoSiteQ8N957.

Polymorphism databases

DMDM269849542.

Proteomic databases

PaxDbQ8N957.
PRIDEQ8N957.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000318698; ENSP00000321627; ENSG00000153930.
GeneID162282.
KEGGhsa:162282.
UCSCuc002iun.1. human.

Organism-specific databases

CTD162282.
GeneCardsGC17P054230.
HGNCHGNC:26766. ANKFN1.
HPAHPA021566.
HPA022538.
neXtProtNX_Q8N957.
PharmGKBPA142672624.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG325963.
HOGENOMHOG000169356.
HOVERGENHBG080841.
InParanoidQ8N957.
OrthoDBEOG77126G.
PhylomeDBQ8N957.
TreeFamTF314968.

Gene expression databases

ArrayExpressQ8N957.
BgeeQ8N957.
CleanExHS_ANKFN1.
GenevestigatorQ8N957.

Family and domain databases

Gene3D1.25.40.20. 2 hits.
2.60.40.10. 1 hit.
InterProIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
[Graphical view]
PfamPF00041. fn3. 1 hit.
[Graphical view]
SMARTSM00248. ANK. 2 hits.
SM00060. FN3. 1 hit.
[Graphical view]
SUPFAMSSF48403. SSF48403. 1 hit.
SSF49265. SSF49265. 1 hit.
PROSITEPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
PS50853. FN3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi162282.
NextBio88148.
PROQ8N957.

Entry information

Entry nameANKF1_HUMAN
AccessionPrimary (citable) accession number: Q8N957
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: November 24, 2009
Last modified: July 9, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM