Q8N957 (ANKF1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ankyrin repeat and fibronectin type-III domain-containing protein 1

Gene names

Name:

ANKFN1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	763 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 2 ANK repeats. Contains 1 fibronectin type-III domain.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	ANK repeat Coiled coil Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 763	763	Ankyrin repeat and fibronectin type-III domain-containing protein 1		PRO_0000247138
Regions
	Repeat	136 – 165	30	ANK 1
	Repeat	173 – 202	30	ANK 2
	Domain	271 – 364	94	Fibronectin type-III
	Coiled coil	205 – 236	32	Potential
Natural variations
	Natural variant	445	1	V → I. Ref.1 Corresponds to variant rs10852985 [ dbSNP | Ensembl ].		VAR_060725

Sequences

	Sequence		Length	Mass (Da)
	Q8N957 [UniParc]. Last modified November 24, 2009. Version 2. Checksum: 49174DE8572FC994	FASTA	763	87,604
	10 20 30 40 50 60 MEASLTRRLL FKDRHFTCSK IIGRRFACFA QRLSHRRKQS QCDLLNESTG QLPTTCSSAA 70 80 90 100 110 120 SNSINWNCRV KMTQQMQNLH LCQSKKHSAP SSPNAAKRLY RNLSEKLKGS HSSFDEAYFR 130 140 150 160 170 180 TRTDRLSLRK TSVNFQGNEA MFEAVEQQDM DAVQILLYQY TPEELDLNTP NSEGLTPLDI 190 200 210 220 230 240 AIMTNNVPIA RILLRTGARE SPHFVSLESR AMHLNTLVQE AQERVSELSA QVENEGFTLD 250 260 270 280 290 300 NTEKEKQLKA WEWRYRLYRR MKTGFEHARA PEMPTNVCLM VTSSTSLTVS FQEPLSVNAA 310 320 330 340 350 360 VVTRYKVEWS MSEDFSPLAG EIIMDNLQTL RCTITGLTMG QQYFVQVSAY NMKGWGPAQT 370 380 390 400 410 420 TTPACASPSN WKDYDDREPR HKGQSEVLEG LLQQVRALHQ HYSCRESTKL QTTGRKQSVS 430 440 450 460 470 480 RSLKHLFHSS NKFVKTLKRG LYIAVIFYYK DNILVTNEDQ VPIVEIDDSH TSSITQDFLW 490 500 510 520 530 540 FTKLSCMWED IRWLRQSIPI SSSSSTVLQT RQKMLAATAQ LQNLLGTHNL GRVYYEPIKD 550 560 570 580 590 600 RHGNILIVTI REVEMLYSFF NGKWMQISKL QSQRKSLSTP EEPTALDILL ITIQDILSYH 610 620 630 640 650 660 KRSHQRLFPG LYLGYLKLCS SVDQIKVLVT QKLPNILCHV KIRENNNISR EEWEWIQKLS 670 680 690 700 710 720 GSESMESVDH TSDCPMQLFF YELQMAVKAL LQQINIPLHQ ARNFRLYTQE VLEMGHNVSF 730 740 750 760 LLLLPASDDV CTAPGQNNPY TPHSGFLNLP LQMFELGIVA CFT

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ILE-445. Tissue: Brain.
[2]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK095654 mRNA. Translation: BAC04599.1. AC006600 Genomic DNA. No translation available. AC006925 Genomic DNA. No translation available. AC015724 Genomic DNA. No translation available.
IPI	IPI00167602.
RefSeq	NP_694960.2. NM_153228.2.
UniGene	Hs.673040.
3D structure databases
ProteinModelPortal	Q8N957.
SMR	Q8N957. Positions 134-201, 268-359.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000321627.
PTM databases
PhosphoSite	Q8N957.
Polymorphism databases
DMDM	269849542.
Proteomic databases
PaxDb	Q8N957.
PRIDE	Q8N957.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000318698; ENSP00000321627; ENSG00000153930.
GeneID	162282.
KEGG	hsa:162282.
UCSC	uc002iun.1. human.
Organism-specific databases
CTD	162282.
GeneCards	GC17P054230.
HGNC	HGNC:26766. ANKFN1.
HPA	HPA021566. HPA022538.
neXtProt	NX_Q8N957.
PharmGKB	PA142672624.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG325963.
HOGENOM	HOG000169356.
HOVERGEN	HBG080841.
InParanoid	Q8N957.
OMA	VKMTQQM.
OrthoDB	EOG4DZ1TX.
PhylomeDB	Q8N957.
Gene expression databases
ArrayExpress	Q8N957.
Bgee	Q8N957.
CleanEx	HS_ANKFN1.
Genevestigator	Q8N957.
GermOnline	ENSG00000153930. Homo sapiens.
Family and domain databases
Gene3D	1.25.40.20. 2 hits. 2.60.40.10. 1 hit.
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR003961. Fibronectin_type3. IPR013783. Ig-like_fold. [Graphical view]
Pfam	PF00041. fn3. 1 hit. [Graphical view]
SMART	SM00248. ANK. 2 hits. SM00060. FN3. 1 hit. [Graphical view]
SUPFAM	SSF48403. ANK. 1 hit. SSF49265. FN_III-like. 1 hit.
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 1 hit. PS50853. FN3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	162282.
NextBio	88148.

Entry information

Entry name

ANKF1_HUMAN

Accession

Primary (citable) accession number: Q8N957

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 25, 2006
Last sequence update:	November 24, 2009
Last modified:	May 1, 2013
This is version 75 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.