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Q8N957

- ANKF1_HUMAN

UniProt

Q8N957 - ANKF1_HUMAN

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Protein

Ankyrin repeat and fibronectin type-III domain-containing protein 1

Gene

ANKFN1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and fibronectin type-III domain-containing protein 1
Gene namesi
Name:ANKFN1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:26766. ANKFN1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672624.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 763763Ankyrin repeat and fibronectin type-III domain-containing protein 1PRO_0000247138Add
BLAST

Proteomic databases

PaxDbiQ8N957.
PRIDEiQ8N957.

PTM databases

PhosphoSiteiQ8N957.

Expressioni

Gene expression databases

BgeeiQ8N957.
CleanExiHS_ANKFN1.
ExpressionAtlasiQ8N957. baseline and differential.
GenevestigatoriQ8N957.

Organism-specific databases

HPAiHPA021566.
HPA022538.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000321627.

Structurei

3D structure databases

ProteinModelPortaliQ8N957.
SMRiQ8N957. Positions 137-199, 268-359.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati136 – 16530ANK 1Add
BLAST
Repeati173 – 20230ANK 2Add
BLAST
Domaini273 – 36997Fibronectin type-IIIPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili205 – 23632Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 2 ANK repeats.PROSITE-ProRule annotation
Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiNOG325963.
GeneTreeiENSGT00390000009384.
HOGENOMiHOG000169356.
HOVERGENiHBG080841.
InParanoidiQ8N957.
OrthoDBiEOG77126G.
PhylomeDBiQ8N957.
TreeFamiTF314968.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
2.60.40.10. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 2 hits.
SM00060. FN3. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF49265. SSF49265. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
PS50853. FN3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N957-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEASLTRRLL FKDRHFTCSK IIGRRFACFA QRLSHRRKQS QCDLLNESTG
60 70 80 90 100
QLPTTCSSAA SNSINWNCRV KMTQQMQNLH LCQSKKHSAP SSPNAAKRLY
110 120 130 140 150
RNLSEKLKGS HSSFDEAYFR TRTDRLSLRK TSVNFQGNEA MFEAVEQQDM
160 170 180 190 200
DAVQILLYQY TPEELDLNTP NSEGLTPLDI AIMTNNVPIA RILLRTGARE
210 220 230 240 250
SPHFVSLESR AMHLNTLVQE AQERVSELSA QVENEGFTLD NTEKEKQLKA
260 270 280 290 300
WEWRYRLYRR MKTGFEHARA PEMPTNVCLM VTSSTSLTVS FQEPLSVNAA
310 320 330 340 350
VVTRYKVEWS MSEDFSPLAG EIIMDNLQTL RCTITGLTMG QQYFVQVSAY
360 370 380 390 400
NMKGWGPAQT TTPACASPSN WKDYDDREPR HKGQSEVLEG LLQQVRALHQ
410 420 430 440 450
HYSCRESTKL QTTGRKQSVS RSLKHLFHSS NKFVKTLKRG LYIAVIFYYK
460 470 480 490 500
DNILVTNEDQ VPIVEIDDSH TSSITQDFLW FTKLSCMWED IRWLRQSIPI
510 520 530 540 550
SSSSSTVLQT RQKMLAATAQ LQNLLGTHNL GRVYYEPIKD RHGNILIVTI
560 570 580 590 600
REVEMLYSFF NGKWMQISKL QSQRKSLSTP EEPTALDILL ITIQDILSYH
610 620 630 640 650
KRSHQRLFPG LYLGYLKLCS SVDQIKVLVT QKLPNILCHV KIRENNNISR
660 670 680 690 700
EEWEWIQKLS GSESMESVDH TSDCPMQLFF YELQMAVKAL LQQINIPLHQ
710 720 730 740 750
ARNFRLYTQE VLEMGHNVSF LLLLPASDDV CTAPGQNNPY TPHSGFLNLP
760
LQMFELGIVA CFT
Length:763
Mass (Da):87,604
Last modified:November 24, 2009 - v2
Checksum:i49174DE8572FC994
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti445 – 4451V → I.1 Publication
Corresponds to variant rs10852985 [ dbSNP | Ensembl ].
VAR_060725

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK095654 mRNA. Translation: BAC04599.1.
AC006600 Genomic DNA. No translation available.
AC006925 Genomic DNA. No translation available.
AC015724 Genomic DNA. No translation available.
CCDSiCCDS32686.1.
RefSeqiNP_694960.2. NM_153228.2.
UniGeneiHs.673040.

Genome annotation databases

EnsembliENST00000318698; ENSP00000321627; ENSG00000153930.
GeneIDi162282.
KEGGihsa:162282.
UCSCiuc002iun.1. human.

Polymorphism databases

DMDMi269849542.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK095654 mRNA. Translation: BAC04599.1 .
AC006600 Genomic DNA. No translation available.
AC006925 Genomic DNA. No translation available.
AC015724 Genomic DNA. No translation available.
CCDSi CCDS32686.1.
RefSeqi NP_694960.2. NM_153228.2.
UniGenei Hs.673040.

3D structure databases

ProteinModelPortali Q8N957.
SMRi Q8N957. Positions 137-199, 268-359.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000321627.

PTM databases

PhosphoSitei Q8N957.

Polymorphism databases

DMDMi 269849542.

Proteomic databases

PaxDbi Q8N957.
PRIDEi Q8N957.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000318698 ; ENSP00000321627 ; ENSG00000153930 .
GeneIDi 162282.
KEGGi hsa:162282.
UCSCi uc002iun.1. human.

Organism-specific databases

CTDi 162282.
GeneCardsi GC17P054230.
HGNCi HGNC:26766. ANKFN1.
HPAi HPA021566.
HPA022538.
neXtProti NX_Q8N957.
PharmGKBi PA142672624.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG325963.
GeneTreei ENSGT00390000009384.
HOGENOMi HOG000169356.
HOVERGENi HBG080841.
InParanoidi Q8N957.
OrthoDBi EOG77126G.
PhylomeDBi Q8N957.
TreeFami TF314968.

Miscellaneous databases

GenomeRNAii 162282.
NextBioi 88148.
PROi Q8N957.

Gene expression databases

Bgeei Q8N957.
CleanExi HS_ANKFN1.
ExpressionAtlasi Q8N957. baseline and differential.
Genevestigatori Q8N957.

Family and domain databases

Gene3Di 1.25.40.20. 2 hits.
2.60.40.10. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
[Graphical view ]
Pfami PF00041. fn3. 1 hit.
[Graphical view ]
SMARTi SM00248. ANK. 2 hits.
SM00060. FN3. 1 hit.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
SSF49265. SSF49265. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
PS50853. FN3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ILE-445.
    Tissue: Brain.
  2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiANKF1_HUMAN
AccessioniPrimary (citable) accession number: Q8N957
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: November 24, 2009
Last modified: October 29, 2014
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3