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Protein

Ankyrin repeat and fibronectin type-III domain-containing protein 1

Gene

ANKFN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and fibronectin type-III domain-containing protein 1
Gene namesi
Name:ANKFN1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:26766. ANKFN1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672624.

Polymorphism and mutation databases

BioMutaiANKFN1.
DMDMi269849542.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 763763Ankyrin repeat and fibronectin type-III domain-containing protein 1PRO_0000247138Add
BLAST

Proteomic databases

PaxDbiQ8N957.
PRIDEiQ8N957.

PTM databases

PhosphoSiteiQ8N957.

Expressioni

Gene expression databases

BgeeiQ8N957.
CleanExiHS_ANKFN1.
ExpressionAtlasiQ8N957. baseline and differential.
GenevestigatoriQ8N957.

Organism-specific databases

HPAiHPA021566.
HPA022538.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000321627.

Structurei

3D structure databases

ProteinModelPortaliQ8N957.
SMRiQ8N957. Positions 136-201, 269-359.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati136 – 16530ANK 1Add
BLAST
Repeati173 – 20230ANK 2Add
BLAST
Domaini273 – 36997Fibronectin type-IIIPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili205 – 23632Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 2 ANK repeats.PROSITE-ProRule annotation
Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiNOG325963.
GeneTreeiENSGT00390000009384.
HOGENOMiHOG000169356.
HOVERGENiHBG080841.
InParanoidiQ8N957.
OrthoDBiEOG77126G.
PhylomeDBiQ8N957.
TreeFamiTF314968.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
2.60.40.10. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 2 hits.
SM00060. FN3. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF49265. SSF49265. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
PS50853. FN3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N957-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEASLTRRLL FKDRHFTCSK IIGRRFACFA QRLSHRRKQS QCDLLNESTG
60 70 80 90 100
QLPTTCSSAA SNSINWNCRV KMTQQMQNLH LCQSKKHSAP SSPNAAKRLY
110 120 130 140 150
RNLSEKLKGS HSSFDEAYFR TRTDRLSLRK TSVNFQGNEA MFEAVEQQDM
160 170 180 190 200
DAVQILLYQY TPEELDLNTP NSEGLTPLDI AIMTNNVPIA RILLRTGARE
210 220 230 240 250
SPHFVSLESR AMHLNTLVQE AQERVSELSA QVENEGFTLD NTEKEKQLKA
260 270 280 290 300
WEWRYRLYRR MKTGFEHARA PEMPTNVCLM VTSSTSLTVS FQEPLSVNAA
310 320 330 340 350
VVTRYKVEWS MSEDFSPLAG EIIMDNLQTL RCTITGLTMG QQYFVQVSAY
360 370 380 390 400
NMKGWGPAQT TTPACASPSN WKDYDDREPR HKGQSEVLEG LLQQVRALHQ
410 420 430 440 450
HYSCRESTKL QTTGRKQSVS RSLKHLFHSS NKFVKTLKRG LYIAVIFYYK
460 470 480 490 500
DNILVTNEDQ VPIVEIDDSH TSSITQDFLW FTKLSCMWED IRWLRQSIPI
510 520 530 540 550
SSSSSTVLQT RQKMLAATAQ LQNLLGTHNL GRVYYEPIKD RHGNILIVTI
560 570 580 590 600
REVEMLYSFF NGKWMQISKL QSQRKSLSTP EEPTALDILL ITIQDILSYH
610 620 630 640 650
KRSHQRLFPG LYLGYLKLCS SVDQIKVLVT QKLPNILCHV KIRENNNISR
660 670 680 690 700
EEWEWIQKLS GSESMESVDH TSDCPMQLFF YELQMAVKAL LQQINIPLHQ
710 720 730 740 750
ARNFRLYTQE VLEMGHNVSF LLLLPASDDV CTAPGQNNPY TPHSGFLNLP
760
LQMFELGIVA CFT
Length:763
Mass (Da):87,604
Last modified:November 24, 2009 - v2
Checksum:i49174DE8572FC994
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti445 – 4451V → I.1 Publication
Corresponds to variant rs10852985 [ dbSNP | Ensembl ].
VAR_060725

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095654 mRNA. Translation: BAC04599.1.
AC006600 Genomic DNA. No translation available.
AC006925 Genomic DNA. No translation available.
AC015724 Genomic DNA. No translation available.
CCDSiCCDS32686.1.
RefSeqiNP_694960.2. NM_153228.2.
UniGeneiHs.673040.

Genome annotation databases

EnsembliENST00000318698; ENSP00000321627; ENSG00000153930.
GeneIDi162282.
KEGGihsa:162282.
UCSCiuc002iun.1. human.

Polymorphism and mutation databases

BioMutaiANKFN1.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095654 mRNA. Translation: BAC04599.1.
AC006600 Genomic DNA. No translation available.
AC006925 Genomic DNA. No translation available.
AC015724 Genomic DNA. No translation available.
CCDSiCCDS32686.1.
RefSeqiNP_694960.2. NM_153228.2.
UniGeneiHs.673040.

3D structure databases

ProteinModelPortaliQ8N957.
SMRiQ8N957. Positions 136-201, 269-359.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000321627.

PTM databases

PhosphoSiteiQ8N957.

Polymorphism and mutation databases

BioMutaiANKFN1.
DMDMi269849542.

Proteomic databases

PaxDbiQ8N957.
PRIDEiQ8N957.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000318698; ENSP00000321627; ENSG00000153930.
GeneIDi162282.
KEGGihsa:162282.
UCSCiuc002iun.1. human.

Organism-specific databases

CTDi162282.
GeneCardsiGC17P054230.
HGNCiHGNC:26766. ANKFN1.
HPAiHPA021566.
HPA022538.
neXtProtiNX_Q8N957.
PharmGKBiPA142672624.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG325963.
GeneTreeiENSGT00390000009384.
HOGENOMiHOG000169356.
HOVERGENiHBG080841.
InParanoidiQ8N957.
OrthoDBiEOG77126G.
PhylomeDBiQ8N957.
TreeFamiTF314968.

Miscellaneous databases

ChiTaRSiANKFN1. human.
GenomeRNAii162282.
NextBioi88148.
PROiQ8N957.

Gene expression databases

BgeeiQ8N957.
CleanExiHS_ANKFN1.
ExpressionAtlasiQ8N957. baseline and differential.
GenevestigatoriQ8N957.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
2.60.40.10. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 2 hits.
SM00060. FN3. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF49265. SSF49265. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
PS50853. FN3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ILE-445.
    Tissue: Brain.
  2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiANKF1_HUMAN
AccessioniPrimary (citable) accession number: Q8N957
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: November 24, 2009
Last modified: April 29, 2015
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.