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Protein

G patch domain-containing protein 11

Gene

GPATCH11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
G patch domain-containing protein 11
Alternative name(s):
Coiled-coil domain-containing protein 75
Gene namesi
Name:GPATCH11
Synonyms:CCDC75
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:26768. GPATCH11.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485427.

Polymorphism and mutation databases

DMDMi294862520.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 259259G patch domain-containing protein 11PRO_0000279751Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei123 – 1231N6-acetyllysineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8N954.
MaxQBiQ8N954.
PaxDbiQ8N954.
PRIDEiQ8N954.

PTM databases

iPTMnetiQ8N954.
PhosphoSiteiQ8N954.

Expressioni

Gene expression databases

BgeeiQ8N954.
CleanExiHS_CCDC75.
ExpressionAtlasiQ8N954. baseline and differential.
GenevisibleiQ8N954. HS.

Organism-specific databases

HPAiHPA038231.
HPA038232.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ADGRB3O602423EBI-2555378,EBI-2682765
SDCBPO005603EBI-2555378,EBI-727004

Protein-protein interaction databases

BioGridi128977. 15 interactions.
IntActiQ8N954. 5 interactions.
STRINGi9606.ENSP00000386772.

Structurei

3D structure databases

ProteinModelPortaliQ8N954.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini69 – 11547G-patchPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili25 – 6137Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the GPATCH11 family.Curated
Contains 1 G-patch domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1994. Eukaryota.
ENOG4110RFF. LUCA.
GeneTreeiENSGT00440000039029.
HOGENOMiHOG000007475.
HOVERGENiHBG081047.
InParanoidiQ8N954.
OrthoDBiEOG7TTQ8K.
PhylomeDBiQ8N954.
TreeFamiTF313583.

Family and domain databases

InterProiIPR025239. DUF4187.
IPR000467. G_patch_dom.
[Graphical view]
PfamiPF13821. DUF4187. 1 hit.
PF01585. G-patch. 1 hit.
[Graphical view]
SMARTiSM01173. DUF4187. 1 hit.
SM00443. G_patch. 1 hit.
[Graphical view]
PROSITEiPS50174. G_PATCH. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N954-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEEEDYMSD SFINVQEDIR PGLPMLRQIR EARRKEEKQQ EANLKNRQKS
60 70 80 90 100
LKEEEQERRD IGLKNALGCE NKGFALLQKM GYKSGQALGK SGGGIVEPIP
110 120 130 140 150
LNIKTGKSGI GHEASLKRKA EEKLESYRKK IHMKNQAEEK AAEQFRMRLK
160 170 180 190 200
NKQDEMKLEG DLRRSQRACQ QLDVQKNIQV PREAWYWLRL EEETEEDEEE
210 220 230 240 250
KEQDEDEYKS EDLSVLEKLQ ILTSYLREEH LYCIWCGTAY EDKEDLSSNC

PGPTSADHD
Length:259
Mass (Da):30,199
Last modified:April 20, 2010 - v3
Checksum:i9A55614CEF21E152
GO
Isoform 2 (identifier: Q8N954-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-103: Missing.
     104-106: KTG → MSR

Show »
Length:156
Mass (Da):18,587
Checksum:i84D579B06CAE14B6
GO

Sequence cautioni

The sequence BAH11850.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 103103Missing in isoform 2. 2 PublicationsVSP_023505Add
BLAST
Alternative sequencei104 – 1063KTG → MSR in isoform 2. 2 PublicationsVSP_023506

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095667 mRNA. Translation: BAC04602.1.
AK289504 mRNA. Translation: BAF82193.1.
AK294697 mRNA. Translation: BAH11850.1. Different initiation.
AC007899 Genomic DNA. Translation: AAY24316.1.
CH471053 Genomic DNA. Translation: EAX00410.1.
BC071798 mRNA. No translation available.
CCDSiCCDS62891.1. [Q8N954-2]
RefSeqiNP_001265434.1. NM_001278505.1. [Q8N954-2]
NP_777591.3. NM_174931.3.
UniGeneiHs.595250.

Genome annotation databases

EnsembliENST00000281932; ENSP00000281932; ENSG00000152133. [Q8N954-2]
GeneIDi253635.
KEGGihsa:253635.
UCSCiuc002rpr.6. human. [Q8N954-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095667 mRNA. Translation: BAC04602.1.
AK289504 mRNA. Translation: BAF82193.1.
AK294697 mRNA. Translation: BAH11850.1. Different initiation.
AC007899 Genomic DNA. Translation: AAY24316.1.
CH471053 Genomic DNA. Translation: EAX00410.1.
BC071798 mRNA. No translation available.
CCDSiCCDS62891.1. [Q8N954-2]
RefSeqiNP_001265434.1. NM_001278505.1. [Q8N954-2]
NP_777591.3. NM_174931.3.
UniGeneiHs.595250.

3D structure databases

ProteinModelPortaliQ8N954.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128977. 15 interactions.
IntActiQ8N954. 5 interactions.
STRINGi9606.ENSP00000386772.

PTM databases

iPTMnetiQ8N954.
PhosphoSiteiQ8N954.

Polymorphism and mutation databases

DMDMi294862520.

Proteomic databases

EPDiQ8N954.
MaxQBiQ8N954.
PaxDbiQ8N954.
PRIDEiQ8N954.

Protocols and materials databases

DNASUi253635.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000281932; ENSP00000281932; ENSG00000152133. [Q8N954-2]
GeneIDi253635.
KEGGihsa:253635.
UCSCiuc002rpr.6. human. [Q8N954-1]

Organism-specific databases

CTDi253635.
GeneCardsiGPATCH11.
H-InvDBHIX0001971.
HGNCiHGNC:26768. GPATCH11.
HPAiHPA038231.
HPA038232.
neXtProtiNX_Q8N954.
PharmGKBiPA143485427.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1994. Eukaryota.
ENOG4110RFF. LUCA.
GeneTreeiENSGT00440000039029.
HOGENOMiHOG000007475.
HOVERGENiHBG081047.
InParanoidiQ8N954.
OrthoDBiEOG7TTQ8K.
PhylomeDBiQ8N954.
TreeFamiTF313583.

Miscellaneous databases

GenomeRNAii253635.
PROiQ8N954.

Gene expression databases

BgeeiQ8N954.
CleanExiHS_CCDC75.
ExpressionAtlasiQ8N954. baseline and differential.
GenevisibleiQ8N954. HS.

Family and domain databases

InterProiIPR025239. DUF4187.
IPR000467. G_patch_dom.
[Graphical view]
PfamiPF13821. DUF4187. 1 hit.
PF01585. G-patch. 1 hit.
[Graphical view]
SMARTiSM01173. DUF4187. 1 hit.
SM00443. G_patch. 1 hit.
[Graphical view]
PROSITEiPS50174. G_PATCH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain and Cerebellum.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  5. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-123, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiGPT11_HUMAN
AccessioniPrimary (citable) accession number: Q8N954
Secondary accession number(s): A8K0D9, B7Z2G4, B8ZZ44
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: April 20, 2010
Last modified: June 8, 2016
This is version 109 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.