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Protein

G patch domain-containing protein 11

Gene

GPATCH11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

It is uncertain whether Met-1 or Met-27 is the initiator.Curated

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
G patch domain-containing protein 11
Alternative name(s):
Coiled-coil domain-containing protein 75
Gene namesi
Name:GPATCH11
Synonyms:CCDC75, CENP-Y1 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000152133.14
HGNCiHGNC:26768 GPATCH11
neXtProtiNX_Q8N954

Subcellular locationi

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000152133
PharmGKBiPA143485427

Polymorphism and mutation databases

DMDMi294862520

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002797511 – 285G patch domain-containing protein 11Add BLAST285

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei141PhosphoserineCombined sources1
Modified residuei149N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8N954
MaxQBiQ8N954
PaxDbiQ8N954
PeptideAtlasiQ8N954
PRIDEiQ8N954

PTM databases

iPTMnetiQ8N954
PhosphoSitePlusiQ8N954

Expressioni

Gene expression databases

BgeeiENSG00000152133
CleanExiHS_CCDC75
ExpressionAtlasiQ8N954 baseline and differential
GenevisibleiQ8N954 HS

Organism-specific databases

HPAiHPA038231
HPA038232

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi128977, 20 interactors
IntActiQ8N954, 7 interactors
MINTiQ8N954
STRINGi9606.ENSP00000386772

Structurei

3D structure databases

ProteinModelPortaliQ8N954
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini95 – 141G-patchPROSITE-ProRule annotationAdd BLAST47

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili51 – 87Sequence analysisAdd BLAST37

Sequence similaritiesi

Belongs to the GPATCH11 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1994 Eukaryota
ENOG4110RFF LUCA
GeneTreeiENSGT00440000039029
HOGENOMiHOG000007475
HOVERGENiHBG081047
InParanoidiQ8N954
OMAiHFYCIWC
OrthoDBiEOG091G0ELN
PhylomeDBiQ8N954
TreeFamiTF313583

Family and domain databases

InterProiView protein in InterPro
IPR025239 DUF4187
IPR000467 G_patch_dom
PfamiView protein in Pfam
PF13821 DUF4187, 1 hit
PF01585 G-patch, 1 hit
SMARTiView protein in SMART
SM01173 DUF4187, 1 hit
SM00443 G_patch, 1 hit
PROSITEiView protein in PROSITE
PS50174 G_PATCH, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N954-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRSARSTALN RGEQRAVRYY SHMKLNMAEE EDYMSDSFIN VQEDIRPGLP
60 70 80 90 100
MLRQIREARR KEEKQQEANL KNRQKSLKEE EQERRDIGLK NALGCENKGF
110 120 130 140 150
ALLQKMGYKS GQALGKSGGG IVEPIPLNIK TGKSGIGHEA SLKRKAEEKL
160 170 180 190 200
ESYRKKIHMK NQAEEKAAEQ FRMRLKNKQD EMKLEGDLRR SQRACQQLDV
210 220 230 240 250
QKNIQVPREA WYWLRLEEET EEDEEEKEQD EDEYKSEDLS VLEKLQILTS
260 270 280
YLREEHLYCI WCGTAYEDKE DLSSNCPGPT SADHD
Note: No experimental confirmation available.Curated
Length:285
Mass (Da):33,277
Last modified:March 28, 2018 - v4
Checksum:iBB24AFAA10A97F49
GO
Isoform 2 (identifier: Q8N954-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-129: Missing.
     130-132: KTG → MSR

Show »
Length:156
Mass (Da):18,587
Checksum:i84D579B06CAE14B6
GO

Sequence cautioni

The sequence BAH11850 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0235051 – 129Missing in isoform 2. 2 PublicationsAdd BLAST129
Alternative sequenceiVSP_023506130 – 132KTG → MSR in isoform 2. 2 Publications3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095667 mRNA Translation: BAC04602.1
AK289504 mRNA Translation: BAF82193.1
AK294697 mRNA Translation: BAH11850.1 Different initiation.
AC007899 Genomic DNA Translation: AAY24316.1
CH471053 Genomic DNA Translation: EAX00410.1
BC071798 mRNA No translation available.
CCDSiCCDS1785.3 [Q8N954-1]
CCDS62891.1 [Q8N954-2]
RefSeqiNP_001265434.1, NM_001278505.1 [Q8N954-2]
NP_001309178.1, NM_001322249.1
NP_777591.3, NM_174931.3 [Q8N954-1]
XP_016859237.1, XM_017003748.1
UniGeneiHs.595250

Genome annotation databases

EnsembliENST00000281932; ENSP00000281932; ENSG00000152133 [Q8N954-2]
ENST00000409774; ENSP00000386772; ENSG00000152133 [Q8N954-1]
GeneIDi253635
KEGGihsa:253635
UCSCiuc002rpr.6 human [Q8N954-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiGPT11_HUMAN
AccessioniPrimary (citable) accession number: Q8N954
Secondary accession number(s): A0A0A0MSF9
, A8K0D9, B7Z2G4, B8ZZ44
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: March 28, 2018
Last modified: May 23, 2018
This is version 121 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

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