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Protein

PRELI domain-containing protein 2

Gene

PRELID2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
PRELI domain-containing protein 2
Gene namesi
Name:PRELID2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:28306. PRELID2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162400041.

Polymorphism and mutation databases

DMDMi74729598.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 189189PRELI domain-containing protein 2PRO_0000307773Add
BLAST

Proteomic databases

PaxDbiQ8N945.
PRIDEiQ8N945.

PTM databases

iPTMnetiQ8N945.
PhosphoSiteiQ8N945.

Expressioni

Gene expression databases

BgeeiQ8N945.
CleanExiHS_PRELID2.
ExpressionAtlasiQ8N945. baseline and differential.
GenevisibleiQ8N945. HS.

Organism-specific databases

HPAiHPA042486.

Structurei

3D structure databases

ProteinModelPortaliQ8N945.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 187187PRELI/MSF1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 PRELI/MSF1 domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IIHT. Eukaryota.
ENOG4111WVY. LUCA.
GeneTreeiENSGT00550000074707.
HOGENOMiHOG000115699.
HOVERGENiHBG106647.
InParanoidiQ8N945.
OMAiVCQNVVP.
OrthoDBiEOG7060S7.
PhylomeDBiQ8N945.
TreeFamiTF337953.

Family and domain databases

InterProiIPR006797. PRELI/MSF1_dom.
[Graphical view]
PfamiPF04707. PRELI. 1 hit.
[Graphical view]
PROSITEiPS50904. PRELI_MSF1. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N945-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGVSVDVHQV YKYPFEQVVA SFLRKYPNPM DKNVISVKIM EEKRDESTGV
60 70 80 90 100
IYRKRIAICQ NVVPEILRKS LSTLVILCWK KVSILKVPNI QLEEESWLNP
110 120 130 140 150
RERNMAIRSH CLTWTQYASM KEESVFRESM ENPNWTEFIQ RGRISITGVG
160 170 180
FLNCVLETFA STFLRQGAQK GIRIMEMLLK EQCGAPLAE
Length:189
Mass (Da):21,905
Last modified:October 1, 2002 - v1
Checksum:iAE39CE8FE26C7851
GO
Isoform 2 (identifier: Q8N945-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: Missing.
     70-81: Missing.

Note: No experimental confirmation available.
Show »
Length:148
Mass (Da):17,151
Checksum:iC360E57E8F6CCCD4
GO
Isoform 3 (identifier: Q8N945-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     69-80: Missing.

Note: No experimental confirmation available.
Show »
Length:177
Mass (Da):20,532
Checksum:iBF6077444FAEB749
GO

Sequence cautioni

The sequence BQ425760 differs from that shown. Reason: Frameshift at positions 143 and 169. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti99 – 991N → S.
Corresponds to variant rs9324996 [ dbSNP | Ensembl ].
VAR_053910

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2929Missing in isoform 2. 1 PublicationVSP_028824Add
BLAST
Alternative sequencei69 – 8012Missing in isoform 3. 1 PublicationVSP_044841Add
BLAST
Alternative sequencei70 – 8112Missing in isoform 2. 1 PublicationVSP_028825Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095695 mRNA. Translation: BAC04611.1.
AC008631 Genomic DNA. No translation available.
AC008700 Genomic DNA. No translation available.
AC011355 Genomic DNA. No translation available.
AC011359 Genomic DNA. No translation available.
AC011411 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW61857.1.
CH471062 Genomic DNA. Translation: EAW61858.1.
BC012033 mRNA. Translation: AAH12033.1.
BQ425760 mRNA. No translation available.
CCDSiCCDS34261.1. [Q8N945-3]
CCDS34262.1. [Q8N945-1]
CCDS43377.1. [Q8N945-2]
RefSeqiNP_612501.3. NM_138492.5. [Q8N945-2]
NP_892005.1. NM_182960.3. [Q8N945-1]
NP_995318.1. NM_205846.2. [Q8N945-3]
XP_011535864.1. XM_011537562.1. [Q8N945-3]
XP_011535865.1. XM_011537563.1. [Q8N945-3]
XP_011535866.1. XM_011537564.1. [Q8N945-3]
UniGeneiHs.314261.

Genome annotation databases

EnsembliENST00000334744; ENSP00000335675; ENSG00000186314. [Q8N945-1]
ENST00000394450; ENSP00000377965; ENSG00000186314. [Q8N945-2]
ENST00000505416; ENSP00000424730; ENSG00000186314. [Q8N945-3]
GeneIDi153768.
KEGGihsa:153768.
UCSCiuc003lno.3. human. [Q8N945-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095695 mRNA. Translation: BAC04611.1.
AC008631 Genomic DNA. No translation available.
AC008700 Genomic DNA. No translation available.
AC011355 Genomic DNA. No translation available.
AC011359 Genomic DNA. No translation available.
AC011411 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW61857.1.
CH471062 Genomic DNA. Translation: EAW61858.1.
BC012033 mRNA. Translation: AAH12033.1.
BQ425760 mRNA. No translation available.
CCDSiCCDS34261.1. [Q8N945-3]
CCDS34262.1. [Q8N945-1]
CCDS43377.1. [Q8N945-2]
RefSeqiNP_612501.3. NM_138492.5. [Q8N945-2]
NP_892005.1. NM_182960.3. [Q8N945-1]
NP_995318.1. NM_205846.2. [Q8N945-3]
XP_011535864.1. XM_011537562.1. [Q8N945-3]
XP_011535865.1. XM_011537563.1. [Q8N945-3]
XP_011535866.1. XM_011537564.1. [Q8N945-3]
UniGeneiHs.314261.

3D structure databases

ProteinModelPortaliQ8N945.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ8N945.
PhosphoSiteiQ8N945.

Polymorphism and mutation databases

DMDMi74729598.

Proteomic databases

PaxDbiQ8N945.
PRIDEiQ8N945.

Protocols and materials databases

DNASUi153768.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334744; ENSP00000335675; ENSG00000186314. [Q8N945-1]
ENST00000394450; ENSP00000377965; ENSG00000186314. [Q8N945-2]
ENST00000505416; ENSP00000424730; ENSG00000186314. [Q8N945-3]
GeneIDi153768.
KEGGihsa:153768.
UCSCiuc003lno.3. human. [Q8N945-1]

Organism-specific databases

CTDi153768.
GeneCardsiPRELID2.
HGNCiHGNC:28306. PRELID2.
HPAiHPA042486.
neXtProtiNX_Q8N945.
PharmGKBiPA162400041.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIHT. Eukaryota.
ENOG4111WVY. LUCA.
GeneTreeiENSGT00550000074707.
HOGENOMiHOG000115699.
HOVERGENiHBG106647.
InParanoidiQ8N945.
OMAiVCQNVVP.
OrthoDBiEOG7060S7.
PhylomeDBiQ8N945.
TreeFamiTF337953.

Miscellaneous databases

GenomeRNAii153768.
NextBioi87179.
PROiQ8N945.

Gene expression databases

BgeeiQ8N945.
CleanExiHS_PRELID2.
ExpressionAtlasiQ8N945. baseline and differential.
GenevisibleiQ8N945. HS.

Family and domain databases

InterProiIPR006797. PRELI/MSF1_dom.
[Graphical view]
PfamiPF04707. PRELI. 1 hit.
[Graphical view]
PROSITEiPS50904. PRELI_MSF1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Melanoma and Prostate.

Entry informationi

Entry nameiPRLD2_HUMAN
AccessioniPrimary (citable) accession number: Q8N945
Secondary accession number(s): G5EA01, Q96EQ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 1, 2002
Last modified: May 11, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.