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Protein

PRELI domain-containing protein 2

Gene

PRELID2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
PRELI domain-containing protein 2
Gene namesi
Name:PRELID2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000186314.11
HGNCiHGNC:28306 PRELID2
neXtProtiNX_Q8N945

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi153768
OpenTargetsiENSG00000186314
PharmGKBiPA162400041

Polymorphism and mutation databases

DMDMi74729598

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003077731 – 189PRELI domain-containing protein 2Add BLAST189

Proteomic databases

PaxDbiQ8N945
PeptideAtlasiQ8N945
PRIDEiQ8N945
ProteomicsDBi72486
72487 [Q8N945-2]

PTM databases

iPTMnetiQ8N945
PhosphoSitePlusiQ8N945

Expressioni

Gene expression databases

BgeeiENSG00000186314
CleanExiHS_PRELID2
ExpressionAtlasiQ8N945 baseline and differential
GenevisibleiQ8N945 HS

Organism-specific databases

HPAiHPA042486

Interactioni

Protein-protein interaction databases

BioGridi127516, 17 interactors
STRINGi9606.ENSP00000335675

Structurei

3D structure databases

ProteinModelPortaliQ8N945
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 187PRELI/MSF1PROSITE-ProRule annotationAdd BLAST187

Phylogenomic databases

eggNOGiENOG410IIHT Eukaryota
ENOG4111WVY LUCA
GeneTreeiENSGT00550000074707
HOGENOMiHOG000115699
HOVERGENiHBG106647
InParanoidiQ8N945
OMAiVCQNVVP
OrthoDBiEOG091G0O53
PhylomeDBiQ8N945
TreeFamiTF337953

Family and domain databases

InterProiView protein in InterPro
IPR006797 PRELI/MSF1_dom
IPR037365 Slowmo/Ups
PANTHERiPTHR11158 PTHR11158, 1 hit
PfamiView protein in Pfam
PF04707 PRELI, 1 hit
PROSITEiView protein in PROSITE
PS50904 PRELI_MSF1, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N945-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGVSVDVHQV YKYPFEQVVA SFLRKYPNPM DKNVISVKIM EEKRDESTGV
60 70 80 90 100
IYRKRIAICQ NVVPEILRKS LSTLVILCWK KVSILKVPNI QLEEESWLNP
110 120 130 140 150
RERNMAIRSH CLTWTQYASM KEESVFRESM ENPNWTEFIQ RGRISITGVG
160 170 180
FLNCVLETFA STFLRQGAQK GIRIMEMLLK EQCGAPLAE
Length:189
Mass (Da):21,905
Last modified:October 1, 2002 - v1
Checksum:iAE39CE8FE26C7851
GO
Isoform 2 (identifier: Q8N945-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: Missing.
     70-81: Missing.

Note: No experimental confirmation available.
Show »
Length:148
Mass (Da):17,151
Checksum:iC360E57E8F6CCCD4
GO
Isoform 3 (identifier: Q8N945-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     69-80: Missing.

Note: No experimental confirmation available.
Show »
Length:177
Mass (Da):20,532
Checksum:iBF6077444FAEB749
GO

Sequence cautioni

The sequence BQ425760 differs from that shown. Reason: Frameshift at positions 143 and 169.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05391099N → S. Corresponds to variant dbSNP:rs9324996Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0288241 – 29Missing in isoform 2. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_04484169 – 80Missing in isoform 3. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_02882570 – 81Missing in isoform 2. 1 PublicationAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095695 mRNA Translation: BAC04611.1
AC008631 Genomic DNA No translation available.
AC008700 Genomic DNA No translation available.
AC011355 Genomic DNA No translation available.
AC011359 Genomic DNA No translation available.
AC011411 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW61857.1
CH471062 Genomic DNA Translation: EAW61858.1
BC012033 mRNA Translation: AAH12033.1
BQ425760 mRNA No translation available.
CCDSiCCDS34261.1 [Q8N945-3]
CCDS34262.1 [Q8N945-1]
CCDS43377.1 [Q8N945-2]
RefSeqiNP_612501.3, NM_138492.5 [Q8N945-2]
NP_892005.1, NM_182960.3 [Q8N945-1]
NP_995318.1, NM_205846.2 [Q8N945-3]
XP_016864618.1, XM_017009129.1 [Q8N945-1]
XP_016864619.1, XM_017009130.1 [Q8N945-1]
XP_016864620.1, XM_017009131.1 [Q8N945-1]
UniGeneiHs.314261

Genome annotation databases

EnsembliENST00000334744; ENSP00000335675; ENSG00000186314 [Q8N945-1]
ENST00000394450; ENSP00000377965; ENSG00000186314 [Q8N945-2]
ENST00000505416; ENSP00000424730; ENSG00000186314 [Q8N945-3]
GeneIDi153768
KEGGihsa:153768
UCSCiuc003lno.3 human [Q8N945-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPRLD2_HUMAN
AccessioniPrimary (citable) accession number: Q8N945
Secondary accession number(s): G5EA01, Q96EQ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 1, 2002
Last modified: June 20, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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