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Protein

APC membrane recruitment protein 3

Gene

AMER3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Wnt signaling pathway

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
APC membrane recruitment protein 3
Short name:
Amer3
Alternative name(s):
Protein FAM123C
Gene namesi
Name:AMER3
Synonyms:FAM123C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:26771. AMER3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162385791.

Polymorphism and mutation databases

BioMutaiAMER3.
DMDMi311033381.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 861861APC membrane recruitment protein 3PRO_0000320594Add
BLAST

Proteomic databases

EPDiQ8N944.
PaxDbiQ8N944.
PeptideAtlasiQ8N944.
PRIDEiQ8N944.

PTM databases

iPTMnetiQ8N944.
PhosphoSiteiQ8N944.

Expressioni

Gene expression databases

BgeeiENSG00000178171.
CleanExiHS_FAM123C.
ExpressionAtlasiQ8N944. baseline and differential.
GenevisibleiQ8N944. HS.

Organism-specific databases

HPAiHPA045593.
HPA054230.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
AMER1Q5JTC64EBI-8869590,EBI-6169747
APCP250548EBI-8869590,EBI-727707
AXIN2Q9Y2T12EBI-8869590,EBI-4400025
Axin2O885662EBI-8869590,EBI-7690990From a different organism.

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ8N944. 4 interactions.
STRINGi9606.ENSP00000314914.

Structurei

3D structure databases

ProteinModelPortaliQ8N944.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Amer family.Curated

Phylogenomic databases

eggNOGiENOG410IGBM. Eukaryota.
ENOG41116WM. LUCA.
GeneTreeiENSGT00530000063529.
HOGENOMiHOG000112433.
HOVERGENiHBG098193.
InParanoidiQ8N944.
OMAiNLFHIRR.
OrthoDBiEOG091G039L.
PhylomeDBiQ8N944.
TreeFamiTF333006.

Family and domain databases

InterProiIPR019003. Uncharacterised_FAM123.
[Graphical view]
PfamiPF09422. WTX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N944-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELKRGKTFI KSSLQVSHEK PPDPAAVAAA REGTGPWSVL PGGQQRPHSE
60 70 80 90 100
KGPQASPSAQ EYDRCPNKGA QLDPKGGPAA LCGATFKPVR KCKTHDSMSG
110 120 130 140 150
AGRATAATGQ LVGSASFPGS PGSRRMIDYR HFVPQMPFVP AVAKSIPRKR
160 170 180 190 200
ISLKRPKKCF RNLFHIRRNK TEDLASLAAE GKSLPSPGDP SDPGGRRSKA
210 220 230 240 250
FLPPGEGPGL DGLCQDLLDS ELLADASFGL CRALCEDVAS LQSFDSLTGC
260 270 280 290 300
GEVFADESSV PSLELNEGPE SPTQAAQGLE SKVPRGPLQG SVEQLASPAQ
310 320 330 340 350
NEASDFTRFW DSVNRSVRQQ QRALLGPWLS GPQGTDRDQS RLDTAGLAEL
360 370 380 390 400
PLCPCRDPRS GSKASSIDTG TPKSEQPESV STSDEGYYDS FSPGLEEDKK
410 420 430 440 450
EAESPGTPAA TFPRDSYSGD ALYELFHDPS EGPLGPSPDD DLCVSESLSG
460 470 480 490 500
PALGTPLSIC SFRVGAEENL APAPGPDLLS QGFLQSSWKG KECLLKLCDT
510 520 530 540 550
ELAITMGIVS WLRRGPTPRA PPTPGQPAAP PGSQGAPRAP TEKLGGREGL
560 570 580 590 600
ASDAGGATVC SAPSRQELWA HPGTTGLLAG ESKALGGATQ GTGTLSRDAS
610 620 630 640 650
REEETRGHSE GLFSSMESAA TSTTDTSGKN KAPVPSTWPC SQKEPGPPGV
660 670 680 690 700
LGCFRGPWRP GHGGDTLDAE PMLAGCVARV AALKISSNEQ PPAAWPPRQD
710 720 730 740 750
MGSGLFGQRW ARGPDMLEQK QSSSSPSMTT IHGLPYSAST QDQRCRDRVQ
760 770 780 790 800
DLSWLRVEPT GLGVQAWASV EDQPLQLSTE AVEQVAHGSQ LDSEPRSAPA
810 820 830 840 850
ARWSSQGHHP ESLGLTLNSQ QEGGVSASAP ECRCSLLARE GLLCGQPEVG
860
ASGPAMAEPH L
Length:861
Mass (Da):90,445
Last modified:November 2, 2010 - v2
Checksum:iA98BF11AB57E1E12
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti340 – 3401S → P.3 Publications
Corresponds to variant rs1905235 [ dbSNP | Ensembl ].
VAR_039218

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095696 mRNA. Translation: BAC04612.1.
AK289525 mRNA. Translation: BAF82214.1.
AK291424 mRNA. Translation: BAF84113.1.
AC010984 Genomic DNA. Translation: AAY24355.1.
AC140481 Genomic DNA. No translation available.
CH471250 Genomic DNA. Translation: EAW51273.1.
BC113445 mRNA. Translation: AAI13446.1.
BC113447 mRNA. Translation: AAI13448.1.
BC143806 mRNA. Translation: AAI43807.1.
CCDSiCCDS2164.1.
RefSeqiNP_001098663.1. NM_001105193.1.
NP_001098664.1. NM_001105194.1.
NP_001098665.1. NM_001105195.1.
NP_689911.2. NM_152698.2.
XP_011509095.1. XM_011510793.2.
UniGeneiHs.369289.

Genome annotation databases

EnsembliENST00000321420; ENSP00000314914; ENSG00000178171.
ENST00000423981; ENSP00000392700; ENSG00000178171.
GeneIDi205147.
KEGGihsa:205147.
UCSCiuc002trw.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095696 mRNA. Translation: BAC04612.1.
AK289525 mRNA. Translation: BAF82214.1.
AK291424 mRNA. Translation: BAF84113.1.
AC010984 Genomic DNA. Translation: AAY24355.1.
AC140481 Genomic DNA. No translation available.
CH471250 Genomic DNA. Translation: EAW51273.1.
BC113445 mRNA. Translation: AAI13446.1.
BC113447 mRNA. Translation: AAI13448.1.
BC143806 mRNA. Translation: AAI43807.1.
CCDSiCCDS2164.1.
RefSeqiNP_001098663.1. NM_001105193.1.
NP_001098664.1. NM_001105194.1.
NP_001098665.1. NM_001105195.1.
NP_689911.2. NM_152698.2.
XP_011509095.1. XM_011510793.2.
UniGeneiHs.369289.

3D structure databases

ProteinModelPortaliQ8N944.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8N944. 4 interactions.
STRINGi9606.ENSP00000314914.

PTM databases

iPTMnetiQ8N944.
PhosphoSiteiQ8N944.

Polymorphism and mutation databases

BioMutaiAMER3.
DMDMi311033381.

Proteomic databases

EPDiQ8N944.
PaxDbiQ8N944.
PeptideAtlasiQ8N944.
PRIDEiQ8N944.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000321420; ENSP00000314914; ENSG00000178171.
ENST00000423981; ENSP00000392700; ENSG00000178171.
GeneIDi205147.
KEGGihsa:205147.
UCSCiuc002trw.3. human.

Organism-specific databases

CTDi205147.
GeneCardsiAMER3.
HGNCiHGNC:26771. AMER3.
HPAiHPA045593.
HPA054230.
neXtProtiNX_Q8N944.
PharmGKBiPA162385791.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGBM. Eukaryota.
ENOG41116WM. LUCA.
GeneTreeiENSGT00530000063529.
HOGENOMiHOG000112433.
HOVERGENiHBG098193.
InParanoidiQ8N944.
OMAiNLFHIRR.
OrthoDBiEOG091G039L.
PhylomeDBiQ8N944.
TreeFamiTF333006.

Miscellaneous databases

GenomeRNAii205147.
PROiQ8N944.

Gene expression databases

BgeeiENSG00000178171.
CleanExiHS_FAM123C.
ExpressionAtlasiQ8N944. baseline and differential.
GenevisibleiQ8N944. HS.

Family and domain databases

InterProiIPR019003. Uncharacterised_FAM123.
[Graphical view]
PfamiPF09422. WTX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAMER3_HUMAN
AccessioniPrimary (citable) accession number: Q8N944
Secondary accession number(s): B7ZLH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: November 2, 2010
Last modified: September 7, 2016
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.