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Protein

APC membrane recruitment protein 3

Gene

AMER3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processWnt signaling pathway
LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
APC membrane recruitment protein 3
Short name:
Amer3
Alternative name(s):
Protein FAM123C
Gene namesi
Name:AMER3
Synonyms:FAM123C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000178171.10
HGNCiHGNC:26771 AMER3
neXtProtiNX_Q8N944

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi205147
OpenTargetsiENSG00000178171
PharmGKBiPA162385791

Polymorphism and mutation databases

BioMutaiAMER3
DMDMi311033381

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003205941 – 861APC membrane recruitment protein 3Add BLAST861

Proteomic databases

PaxDbiQ8N944
PeptideAtlasiQ8N944
PRIDEiQ8N944

PTM databases

iPTMnetiQ8N944
PhosphoSitePlusiQ8N944

Expressioni

Gene expression databases

BgeeiENSG00000178171
CleanExiHS_FAM123C
ExpressionAtlasiQ8N944 baseline and differential
GenevisibleiQ8N944 HS

Organism-specific databases

HPAiHPA045593
HPA054230

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ8N944, 4 interactors
MINTiQ8N944
STRINGi9606.ENSP00000314914

Structurei

3D structure databases

ProteinModelPortaliQ8N944
SMRiQ8N944
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Amer family.Curated

Phylogenomic databases

eggNOGiENOG410IGBM Eukaryota
ENOG41116WM LUCA
GeneTreeiENSGT00530000063529
HOGENOMiHOG000112433
HOVERGENiHBG098193
InParanoidiQ8N944
OMAiIDYRHFV
OrthoDBiEOG091G039L
PhylomeDBiQ8N944
TreeFamiTF333006

Family and domain databases

InterProiView protein in InterPro
IPR019003 AMER
PANTHERiPTHR22237 PTHR22237, 1 hit
PfamiView protein in Pfam
PF09422 WTX, 1 hit

Sequencei

Sequence statusi: Complete.

Q8N944-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELKRGKTFI KSSLQVSHEK PPDPAAVAAA REGTGPWSVL PGGQQRPHSE
60 70 80 90 100
KGPQASPSAQ EYDRCPNKGA QLDPKGGPAA LCGATFKPVR KCKTHDSMSG
110 120 130 140 150
AGRATAATGQ LVGSASFPGS PGSRRMIDYR HFVPQMPFVP AVAKSIPRKR
160 170 180 190 200
ISLKRPKKCF RNLFHIRRNK TEDLASLAAE GKSLPSPGDP SDPGGRRSKA
210 220 230 240 250
FLPPGEGPGL DGLCQDLLDS ELLADASFGL CRALCEDVAS LQSFDSLTGC
260 270 280 290 300
GEVFADESSV PSLELNEGPE SPTQAAQGLE SKVPRGPLQG SVEQLASPAQ
310 320 330 340 350
NEASDFTRFW DSVNRSVRQQ QRALLGPWLS GPQGTDRDQS RLDTAGLAEL
360 370 380 390 400
PLCPCRDPRS GSKASSIDTG TPKSEQPESV STSDEGYYDS FSPGLEEDKK
410 420 430 440 450
EAESPGTPAA TFPRDSYSGD ALYELFHDPS EGPLGPSPDD DLCVSESLSG
460 470 480 490 500
PALGTPLSIC SFRVGAEENL APAPGPDLLS QGFLQSSWKG KECLLKLCDT
510 520 530 540 550
ELAITMGIVS WLRRGPTPRA PPTPGQPAAP PGSQGAPRAP TEKLGGREGL
560 570 580 590 600
ASDAGGATVC SAPSRQELWA HPGTTGLLAG ESKALGGATQ GTGTLSRDAS
610 620 630 640 650
REEETRGHSE GLFSSMESAA TSTTDTSGKN KAPVPSTWPC SQKEPGPPGV
660 670 680 690 700
LGCFRGPWRP GHGGDTLDAE PMLAGCVARV AALKISSNEQ PPAAWPPRQD
710 720 730 740 750
MGSGLFGQRW ARGPDMLEQK QSSSSPSMTT IHGLPYSAST QDQRCRDRVQ
760 770 780 790 800
DLSWLRVEPT GLGVQAWASV EDQPLQLSTE AVEQVAHGSQ LDSEPRSAPA
810 820 830 840 850
ARWSSQGHHP ESLGLTLNSQ QEGGVSASAP ECRCSLLARE GLLCGQPEVG
860
ASGPAMAEPH L
Length:861
Mass (Da):90,445
Last modified:November 2, 2010 - v2
Checksum:iA98BF11AB57E1E12
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_039218340S → P3 PublicationsCorresponds to variant dbSNP:rs1905235Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095696 mRNA Translation: BAC04612.1
AK289525 mRNA Translation: BAF82214.1
AK291424 mRNA Translation: BAF84113.1
AC010984 Genomic DNA Translation: AAY24355.1
AC140481 Genomic DNA No translation available.
CH471250 Genomic DNA Translation: EAW51273.1
BC113445 mRNA Translation: AAI13446.1
BC113447 mRNA Translation: AAI13448.1
BC143806 mRNA Translation: AAI43807.1
CCDSiCCDS2164.1
RefSeqiNP_001098663.1, NM_001105193.1
NP_001098664.1, NM_001105194.1
NP_001098665.1, NM_001105195.1
NP_689911.2, NM_152698.2
XP_011509095.1, XM_011510793.2
UniGeneiHs.369289

Genome annotation databases

EnsembliENST00000321420; ENSP00000314914; ENSG00000178171
ENST00000423981; ENSP00000392700; ENSG00000178171
GeneIDi205147
KEGGihsa:205147
UCSCiuc002trw.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiAMER3_HUMAN
AccessioniPrimary (citable) accession number: Q8N944
Secondary accession number(s): B7ZLH6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: November 2, 2010
Last modified: May 23, 2018
This is version 104 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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