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Q8N907 (DAND5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DAN domain family member 5
Alternative name(s):
Cerberus-like protein 2
Short name=Cerl-2
Cysteine knot superfamily 1, BMP antagonist 3
Gremlin-3
Gene names
Name:DAND5
Synonyms:CER2, CKTSF1B3, GREM3, SP1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length189 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Seems to play a role in the correct specification of the left-right axis. May antagonize NODAL and BMP4 signaling. Cystine knot-containing proteins play important roles during development, organogenesis, tissue growth and differentiation By similarity.

Subcellular location

Secreted Probable.

Sequence similarities

Belongs to the DAN family.

Contains 1 CTCK (C-terminal cystine knot-like) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 189167DAN domain family member 5
PRO_0000311804

Regions

Domain101 – 18686CTCK

Amino acid modifications

Glycosylation381N-linked (GlcNAc...) Potential
Disulfide bond101 ↔ 148 By similarity
Disulfide bond115 ↔ 162 By similarity
Disulfide bond125 ↔ 183 By similarity
Disulfide bond129 ↔ 185 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8N907 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: DE97689CBE2F65A7

FASTA18920,180
        10         20         30         40         50         60 
MLLGQLSTLL CLLSGALPTG SGRPEPQSPR PQSWAAANQT WALGPGALPP LVPASALGSW 

        70         80         90        100        110        120 
KAFLGLQKAR QLGMGRLQRG QDEVAAVTLP LNPQEVIQGM CKAVPFVQVF SRPGCSAIRL 

       130        140        150        160        170        180 
RNHLCFGHCS SLYIPGSDPT PLVLCNSCMP ARKRWAPVVL WCLTGSSASR RRVKISTMLI 


EGCHCSPKA 

« Hide

References

« Hide 'large scale' references
[1]"Cysteine knot protein (SP1)."
Itoh N.
Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Heart.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[4]"Identification and characterization of human CKTSF1B2 and CKTSF1B3 genes in silico."
Katoh M., Katoh M.
Oncol. Rep. 12:423-427(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB070695 mRNA. Translation: BAC82440.1.
AK095926 mRNA. Translation: BAC04651.1.
BC101800 mRNA. Translation: AAI01801.1.
BC113476 mRNA. Translation: AAI13477.1.
RefSeqNP_689867.1. NM_152654.2.
UniGeneHs.331981.

3D structure databases

ProteinModelPortalQ8N907.
SMRQ8N907. Positions 92-187.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000323155.

Polymorphism databases

DMDM74729571.

Proteomic databases

PaxDbQ8N907.
PRIDEQ8N907.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000317060; ENSP00000323155; ENSG00000179284.
GeneID199699.
KEGGhsa:199699.
UCSCuc002mwc.1. human.

Organism-specific databases

CTD199699.
GeneCardsGC19P013081.
HGNCHGNC:26780. DAND5.
HPAHPA049472.
MIM609068. gene.
neXtProtNX_Q8N907.
PharmGKBPA134875268.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG38827.
HOGENOMHOG000112140.
HOVERGENHBG094958.
InParanoidQ8N907.
OMARNHLCFG.
PhylomeDBQ8N907.
TreeFamTF106445.

Enzyme and pathway databases

SignaLinkQ8N907.

Gene expression databases

ArrayExpressQ8N907.
BgeeQ8N907.
CleanExHS_DAND5.
HS_SP1.
GenevestigatorQ8N907.

Family and domain databases

InterProIPR016860. Cerberus.
IPR004133. DAN.
[Graphical view]
PfamPF03045. DAN. 1 hit.
[Graphical view]
PIRSFPIRSF027807. Cerberus. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi199699.
NextBio89693.
PROQ8N907.
SOURCESearch...

Entry information

Entry nameDAND5_HUMAN
AccessionPrimary (citable) accession number: Q8N907
Entry history
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM