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Protein

DAN domain family member 5

Gene

DAND5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Seems to play a role in the correct specification of the left-right axis. May antagonize NODAL and BMP4 signaling. Cystine knot-containing proteins play important roles during development, organogenesis, tissue growth and differentiation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-1181150. Signaling by NODAL.
R-HSA-1433617. Regulation of signaling by NODAL.
SignaLinkiQ8N907.

Names & Taxonomyi

Protein namesi
Recommended name:
DAN domain family member 5
Alternative name(s):
Cerberus-like protein 2
Short name:
Cerl-2
Cysteine knot superfamily 1, BMP antagonist 3
Gremlin-3
Gene namesi
Name:DAND5
Synonyms:CER2, CKTSF1B3, GREM3, SP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000179284.5.
HGNCiHGNC:26780. DAND5.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi199699.
OpenTargetsiENSG00000179284.
PharmGKBiPA134875268.

Polymorphism and mutation databases

BioMutaiDAND5.
DMDMi74729571.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000031180423 – 189DAN domain family member 5Add BLAST167

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi38N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi101 ↔ 148By similarity
Disulfide bondi115 ↔ 162By similarity
Disulfide bondi125 ↔ 183By similarity
Disulfide bondi129 ↔ 185By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8N907.
PaxDbiQ8N907.
PRIDEiQ8N907.

PTM databases

iPTMnetiQ8N907.
PhosphoSitePlusiQ8N907.

Expressioni

Gene expression databases

BgeeiENSG00000179284.
CleanExiHS_DAND5.
HS_SP1.
ExpressionAtlasiQ8N907. baseline and differential.
GenevisibleiQ8N907. HS.

Organism-specific databases

HPAiHPA049472.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000323155.

Structurei

3D structure databases

ProteinModelPortaliQ8N907.
SMRiQ8N907.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini101 – 186CTCKAdd BLAST86

Sequence similaritiesi

Belongs to the DAN family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYA9. Eukaryota.
ENOG410Y6UJ. LUCA.
GeneTreeiENSGT00530000063926.
HOGENOMiHOG000112140.
HOVERGENiHBG094958.
InParanoidiQ8N907.
OMAiHLCFGRC.
OrthoDBiEOG091G0PRJ.
PhylomeDBiQ8N907.
TreeFamiTF106445.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiView protein in InterPro
IPR016860. Cerberus.
IPR029034. Cystine-knot_cytokine.
IPR004133. DAN.
PfamiView protein in Pfam
PF03045. DAN. 1 hit.
PIRSFiPIRSF027807. Cerberus. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8N907-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLGQLSTLL CLLSGALPTG SGRPEPQSPR PQSWAAANQT WALGPGALPP
60 70 80 90 100
LVPASALGSW KAFLGLQKAR QLGMGRLQRG QDEVAAVTLP LNPQEVIQGM
110 120 130 140 150
CKAVPFVQVF SRPGCSAIRL RNHLCFGHCS SLYIPGSDPT PLVLCNSCMP
160 170 180
ARKRWAPVVL WCLTGSSASR RRVKISTMLI EGCHCSPKA
Length:189
Mass (Da):20,180
Last modified:October 1, 2002 - v1
Checksum:iDE97689CBE2F65A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB070695 mRNA. Translation: BAC82440.1.
AK095926 mRNA. Translation: BAC04651.1.
BC101800 mRNA. Translation: AAI01801.1.
BC113476 mRNA. Translation: AAI13477.1.
CCDSiCCDS12291.1.
RefSeqiNP_689867.1. NM_152654.2.
UniGeneiHs.331981.

Genome annotation databases

EnsembliENST00000317060; ENSP00000323155; ENSG00000179284.
GeneIDi199699.
KEGGihsa:199699.
UCSCiuc002mwc.2. human.

Similar proteinsi

Entry informationi

Entry nameiDAND5_HUMAN
AccessioniPrimary (citable) accession number: Q8N907
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: October 1, 2002
Last modified: September 27, 2017
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families