Q8N907 (DAND5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DAN domain family member 5

Alternative name(s):
Cerberus-like protein 2
Short name=Cerl-2
Cysteine knot superfamily 1, BMP antagonist 3
Gremlin-3

Gene names

Name:	DAND5
Synonyms:	CER2, CKTSF1B3, GREM3, SP1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	189 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Seems to play a role in the correct specification of the left-right axis. May antagonize NODAL and BMP4 signaling. Cystine knot-containing proteins play important roles during development, organogenesis, tissue growth and differentiation By similarity.
Subcellular location	Secreted Probable.
Sequence similarities	Belongs to the DAN family. Contains 1 CTCK (C-terminal cystine knot-like) domain.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	atrial septum development Inferred from sequence or structural similarity. Source: BHF-UCL determination of heart left/right asymmetry Inferred from sequence or structural similarity. Source: BHF-UCL determination of left/right asymmetry in lateral mesoderm Inferred from sequence or structural similarity. Source: BHF-UCL negative regulation of BMP signaling pathway Inferred from sequence or structural similarity. Source: BHF-UCL negative regulation of transforming growth factor beta receptor signaling pathway Inferred from sequence or structural similarity. Source: BHF-UCL sequestering of nodal from receptor via nodal binding Inferred from sequence or structural similarity. Source: BHF-UCL ventricular septum development Inferred from sequence or structural similarity. Source: BHF-UCL
Cellular_component	extracellular region Non-traceable author statement PubMed 15466485. Source: BHF-UCL
Molecular_function	morphogen activity Inferred from sequence or structural similarity. Source: BHF-UCL
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Chain	23 – 189	167	DAN domain family member 5		PRO_0000311804
Regions
	Domain	101 – 186	86	CTCK
Amino acid modifications
	Glycosylation	38	1	N-linked (GlcNAc...) Potential
	Disulfide bond	101 ↔ 148		By similarity
	Disulfide bond	115 ↔ 162		By similarity
	Disulfide bond	125 ↔ 183		By similarity
	Disulfide bond	129 ↔ 185		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8N907 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: DE97689CBE2F65A7	FASTA	189	20,180
	10 20 30 40 50 60 MLLGQLSTLL CLLSGALPTG SGRPEPQSPR PQSWAAANQT WALGPGALPP LVPASALGSW 70 80 90 100 110 120 KAFLGLQKAR QLGMGRLQRG QDEVAAVTLP LNPQEVIQGM CKAVPFVQVF SRPGCSAIRL 130 140 150 160 170 180 RNHLCFGHCS SLYIPGSDPT PLVLCNSCMP ARKRWAPVVL WCLTGSSASR RRVKISTMLI EGCHCSPKA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cysteine knot protein (SP1)." Itoh N. Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Heart.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[4]	"Identification and characterization of human CKTSF1B2 and CKTSF1B3 genes in silico." Katoh M., Katoh M. Oncol. Rep. 12:423-427(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB070695 mRNA. Translation: BAC82440.1. AK095926 mRNA. Translation: BAC04651.1. BC101800 mRNA. Translation: AAI01801.1. BC113476 mRNA. Translation: AAI13477.1.
IPI	IPI00167536.
RefSeq	NP_689867.1. NM_152654.2.
UniGene	Hs.331981.
3D structure databases
ProteinModelPortal	Q8N907.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000323155.
Polymorphism databases
DMDM	74729571.
Proteomic databases
PaxDb	Q8N907.
PRIDE	Q8N907.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000317060; ENSP00000323155; ENSG00000179284.
GeneID	199699.
KEGG	hsa:199699.
UCSC	uc002mwc.1. human.
Organism-specific databases
CTD	199699.
GeneCards	GC19P013081.
HGNC	HGNC:26780. DAND5.
HPA	HPA049472.
MIM	609068. gene.
neXtProt	NX_Q8N907.
PharmGKB	PA134875268.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG38827.
HOGENOM	HOG000112140.
HOVERGEN	HBG094958.
InParanoid	Q8N907.
OMA	RNHLCFG.
OrthoDB	EOG4Z62Q2.
PhylomeDB	Q8N907.
Gene expression databases
Bgee	Q8N907.
CleanEx	HS_DAND5. HS_SP1.
Genevestigator	Q8N907.
Family and domain databases
InterPro	IPR016860. Cerberus. IPR004133. DAN. [Graphical view]
Pfam	PF03045. DAN. 1 hit. [Graphical view]
PIRSF	PIRSF027807. Cerberus. 1 hit.
PROSITE	PS01225. CTCK_2. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	199699.
NextBio	89693.
SOURCE	Search...

Entry information

Entry name

DAND5_HUMAN

Accession

Primary (citable) accession number: Q8N907

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 4, 2007
Last sequence update:	October 1, 2002
Last modified:	April 3, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.