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Q8N907

- DAND5_HUMAN

UniProt

Q8N907 - DAND5_HUMAN

Protein

DAN domain family member 5

Gene

DAND5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Seems to play a role in the correct specification of the left-right axis. May antagonize NODAL and BMP4 signaling. Cystine knot-containing proteins play important roles during development, organogenesis, tissue growth and differentiation By similarity.By similarity

    GO - Molecular functioni

    1. morphogen activity Source: BHF-UCL

    GO - Biological processi

    1. atrial septum development Source: BHF-UCL
    2. determination of heart left/right asymmetry Source: BHF-UCL
    3. determination of left/right asymmetry in lateral mesoderm Source: BHF-UCL
    4. negative regulation of BMP signaling pathway Source: BHF-UCL
    5. negative regulation of nodal signaling pathway Source: BHF-UCL
    6. negative regulation of transforming growth factor beta receptor signaling pathway Source: BHF-UCL
    7. sequestering of nodal from receptor via nodal binding Source: BHF-UCL
    8. ventricular septum development Source: BHF-UCL

    Enzyme and pathway databases

    SignaLinkiQ8N907.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DAN domain family member 5
    Alternative name(s):
    Cerberus-like protein 2
    Short name:
    Cerl-2
    Cysteine knot superfamily 1, BMP antagonist 3
    Gremlin-3
    Gene namesi
    Name:DAND5
    Synonyms:CER2, CKTSF1B3, GREM3, SP1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:26780. DAND5.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: BHF-UCL

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134875268.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 189167DAN domain family member 5PRO_0000311804Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi38 – 381N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi101 ↔ 148By similarity
    Disulfide bondi115 ↔ 162By similarity
    Disulfide bondi125 ↔ 183By similarity
    Disulfide bondi129 ↔ 185By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8N907.
    PRIDEiQ8N907.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8N907.
    BgeeiQ8N907.
    CleanExiHS_DAND5.
    HS_SP1.
    GenevestigatoriQ8N907.

    Organism-specific databases

    HPAiHPA049472.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000323155.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N907.
    SMRiQ8N907. Positions 98-189.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini101 – 18686CTCKAdd
    BLAST

    Sequence similaritiesi

    Belongs to the DAN family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG38827.
    HOGENOMiHOG000112140.
    HOVERGENiHBG094958.
    InParanoidiQ8N907.
    OMAiAPVVLWC.
    PhylomeDBiQ8N907.
    TreeFamiTF106445.

    Family and domain databases

    InterProiIPR016860. Cerberus.
    IPR004133. DAN.
    [Graphical view]
    PfamiPF03045. DAN. 1 hit.
    [Graphical view]
    PIRSFiPIRSF027807. Cerberus. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8N907-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLLGQLSTLL CLLSGALPTG SGRPEPQSPR PQSWAAANQT WALGPGALPP    50
    LVPASALGSW KAFLGLQKAR QLGMGRLQRG QDEVAAVTLP LNPQEVIQGM 100
    CKAVPFVQVF SRPGCSAIRL RNHLCFGHCS SLYIPGSDPT PLVLCNSCMP 150
    ARKRWAPVVL WCLTGSSASR RRVKISTMLI EGCHCSPKA 189
    Length:189
    Mass (Da):20,180
    Last modified:October 1, 2002 - v1
    Checksum:iDE97689CBE2F65A7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB070695 mRNA. Translation: BAC82440.1.
    AK095926 mRNA. Translation: BAC04651.1.
    BC101800 mRNA. Translation: AAI01801.1.
    BC113476 mRNA. Translation: AAI13477.1.
    CCDSiCCDS12291.1.
    RefSeqiNP_689867.1. NM_152654.2.
    UniGeneiHs.331981.

    Genome annotation databases

    EnsembliENST00000317060; ENSP00000323155; ENSG00000179284.
    GeneIDi199699.
    KEGGihsa:199699.
    UCSCiuc002mwc.1. human.

    Polymorphism databases

    DMDMi74729571.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB070695 mRNA. Translation: BAC82440.1 .
    AK095926 mRNA. Translation: BAC04651.1 .
    BC101800 mRNA. Translation: AAI01801.1 .
    BC113476 mRNA. Translation: AAI13477.1 .
    CCDSi CCDS12291.1.
    RefSeqi NP_689867.1. NM_152654.2.
    UniGenei Hs.331981.

    3D structure databases

    ProteinModelPortali Q8N907.
    SMRi Q8N907. Positions 98-189.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000323155.

    Polymorphism databases

    DMDMi 74729571.

    Proteomic databases

    PaxDbi Q8N907.
    PRIDEi Q8N907.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000317060 ; ENSP00000323155 ; ENSG00000179284 .
    GeneIDi 199699.
    KEGGi hsa:199699.
    UCSCi uc002mwc.1. human.

    Organism-specific databases

    CTDi 199699.
    GeneCardsi GC19P013081.
    HGNCi HGNC:26780. DAND5.
    HPAi HPA049472.
    MIMi 609068. gene.
    neXtProti NX_Q8N907.
    PharmGKBi PA134875268.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG38827.
    HOGENOMi HOG000112140.
    HOVERGENi HBG094958.
    InParanoidi Q8N907.
    OMAi APVVLWC.
    PhylomeDBi Q8N907.
    TreeFami TF106445.

    Enzyme and pathway databases

    SignaLinki Q8N907.

    Miscellaneous databases

    GenomeRNAii 199699.
    NextBioi 89693.
    PROi Q8N907.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8N907.
    Bgeei Q8N907.
    CleanExi HS_DAND5.
    HS_SP1.
    Genevestigatori Q8N907.

    Family and domain databases

    InterProi IPR016860. Cerberus.
    IPR004133. DAN.
    [Graphical view ]
    Pfami PF03045. DAN. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF027807. Cerberus. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cysteine knot protein (SP1)."
      Itoh N.
      Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Heart.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    4. "Identification and characterization of human CKTSF1B2 and CKTSF1B3 genes in silico."
      Katoh M., Katoh M.
      Oncol. Rep. 12:423-427(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiDAND5_HUMAN
    AccessioniPrimary (citable) accession number: Q8N907
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 4, 2007
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3