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Q8N907

- DAND5_HUMAN

UniProt

Q8N907 - DAND5_HUMAN

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Protein

DAN domain family member 5

Gene
DAND5, CER2, CKTSF1B3, GREM3, SP1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Seems to play a role in the correct specification of the left-right axis. May antagonize NODAL and BMP4 signaling. Cystine knot-containing proteins play important roles during development, organogenesis, tissue growth and differentiation By similarity.

GO - Molecular functioni

  1. morphogen activity Source: BHF-UCL

GO - Biological processi

  1. atrial septum development Source: BHF-UCL
  2. determination of heart left/right asymmetry Source: BHF-UCL
  3. determination of left/right asymmetry in lateral mesoderm Source: BHF-UCL
  4. negative regulation of BMP signaling pathway Source: BHF-UCL
  5. negative regulation of nodal signaling pathway Source: BHF-UCL
  6. negative regulation of transforming growth factor beta receptor signaling pathway Source: BHF-UCL
  7. sequestering of nodal from receptor via nodal binding Source: BHF-UCL
  8. ventricular septum development Source: BHF-UCL
Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ8N907.

Names & Taxonomyi

Protein namesi
Recommended name:
DAN domain family member 5
Alternative name(s):
Cerberus-like protein 2
Short name:
Cerl-2
Cysteine knot superfamily 1, BMP antagonist 3
Gremlin-3
Gene namesi
Name:DAND5
Synonyms:CER2, CKTSF1B3, GREM3, SP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:26780. DAND5.

Subcellular locationi

Secreted Inferred

GO - Cellular componenti

  1. extracellular region Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134875268.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 Reviewed predictionAdd
BLAST
Chaini23 – 189167DAN domain family member 5PRO_0000311804Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi38 – 381N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi101 ↔ 148 By similarity
Disulfide bondi115 ↔ 162 By similarity
Disulfide bondi125 ↔ 183 By similarity
Disulfide bondi129 ↔ 185 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8N907.
PRIDEiQ8N907.

Expressioni

Gene expression databases

ArrayExpressiQ8N907.
BgeeiQ8N907.
CleanExiHS_DAND5.
HS_SP1.
GenevestigatoriQ8N907.

Organism-specific databases

HPAiHPA049472.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000323155.

Structurei

3D structure databases

ProteinModelPortaliQ8N907.
SMRiQ8N907. Positions 98-189.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini101 – 18686CTCKAdd
BLAST

Sequence similaritiesi

Belongs to the DAN family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG38827.
HOGENOMiHOG000112140.
HOVERGENiHBG094958.
InParanoidiQ8N907.
OMAiAPVVLWC.
PhylomeDBiQ8N907.
TreeFamiTF106445.

Family and domain databases

InterProiIPR016860. Cerberus.
IPR004133. DAN.
[Graphical view]
PfamiPF03045. DAN. 1 hit.
[Graphical view]
PIRSFiPIRSF027807. Cerberus. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8N907-1 [UniParc]FASTAAdd to Basket

« Hide

MLLGQLSTLL CLLSGALPTG SGRPEPQSPR PQSWAAANQT WALGPGALPP    50
LVPASALGSW KAFLGLQKAR QLGMGRLQRG QDEVAAVTLP LNPQEVIQGM 100
CKAVPFVQVF SRPGCSAIRL RNHLCFGHCS SLYIPGSDPT PLVLCNSCMP 150
ARKRWAPVVL WCLTGSSASR RRVKISTMLI EGCHCSPKA 189
Length:189
Mass (Da):20,180
Last modified:October 1, 2002 - v1
Checksum:iDE97689CBE2F65A7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB070695 mRNA. Translation: BAC82440.1.
AK095926 mRNA. Translation: BAC04651.1.
BC101800 mRNA. Translation: AAI01801.1.
BC113476 mRNA. Translation: AAI13477.1.
CCDSiCCDS12291.1.
RefSeqiNP_689867.1. NM_152654.2.
UniGeneiHs.331981.

Genome annotation databases

EnsembliENST00000317060; ENSP00000323155; ENSG00000179284.
GeneIDi199699.
KEGGihsa:199699.
UCSCiuc002mwc.1. human.

Polymorphism databases

DMDMi74729571.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB070695 mRNA. Translation: BAC82440.1 .
AK095926 mRNA. Translation: BAC04651.1 .
BC101800 mRNA. Translation: AAI01801.1 .
BC113476 mRNA. Translation: AAI13477.1 .
CCDSi CCDS12291.1.
RefSeqi NP_689867.1. NM_152654.2.
UniGenei Hs.331981.

3D structure databases

ProteinModelPortali Q8N907.
SMRi Q8N907. Positions 98-189.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000323155.

Polymorphism databases

DMDMi 74729571.

Proteomic databases

PaxDbi Q8N907.
PRIDEi Q8N907.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000317060 ; ENSP00000323155 ; ENSG00000179284 .
GeneIDi 199699.
KEGGi hsa:199699.
UCSCi uc002mwc.1. human.

Organism-specific databases

CTDi 199699.
GeneCardsi GC19P013081.
HGNCi HGNC:26780. DAND5.
HPAi HPA049472.
MIMi 609068. gene.
neXtProti NX_Q8N907.
PharmGKBi PA134875268.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG38827.
HOGENOMi HOG000112140.
HOVERGENi HBG094958.
InParanoidi Q8N907.
OMAi APVVLWC.
PhylomeDBi Q8N907.
TreeFami TF106445.

Enzyme and pathway databases

SignaLinki Q8N907.

Miscellaneous databases

GenomeRNAii 199699.
NextBioi 89693.
PROi Q8N907.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8N907.
Bgeei Q8N907.
CleanExi HS_DAND5.
HS_SP1.
Genevestigatori Q8N907.

Family and domain databases

InterProi IPR016860. Cerberus.
IPR004133. DAN.
[Graphical view ]
Pfami PF03045. DAN. 1 hit.
[Graphical view ]
PIRSFi PIRSF027807. Cerberus. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cysteine knot protein (SP1)."
    Itoh N.
    Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "Identification and characterization of human CKTSF1B2 and CKTSF1B3 genes in silico."
    Katoh M., Katoh M.
    Oncol. Rep. 12:423-427(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiDAND5_HUMAN
AccessioniPrimary (citable) accession number: Q8N907
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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