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Protein

DAN domain family member 5

Gene

DAND5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Seems to play a role in the correct specification of the left-right axis. May antagonize NODAL and BMP4 signaling. Cystine knot-containing proteins play important roles during development, organogenesis, tissue growth and differentiation (By similarity).By similarity

GO - Molecular functioni

  1. morphogen activity Source: BHF-UCL

GO - Biological processi

  1. atrial septum development Source: BHF-UCL
  2. determination of heart left/right asymmetry Source: BHF-UCL
  3. determination of left/right asymmetry in lateral mesoderm Source: BHF-UCL
  4. negative regulation of BMP signaling pathway Source: BHF-UCL
  5. negative regulation of nodal signaling pathway Source: BHF-UCL
  6. negative regulation of transforming growth factor beta receptor signaling pathway Source: BHF-UCL
  7. sequestering of nodal from receptor via nodal binding Source: BHF-UCL
  8. ventricular septum development Source: BHF-UCL
Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ8N907.

Names & Taxonomyi

Protein namesi
Recommended name:
DAN domain family member 5
Alternative name(s):
Cerberus-like protein 2
Short name:
Cerl-2
Cysteine knot superfamily 1, BMP antagonist 3
Gremlin-3
Gene namesi
Name:DAND5
Synonyms:CER2, CKTSF1B3, GREM3, SP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:26780. DAND5.

Subcellular locationi

  1. Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134875268.

Polymorphism and mutation databases

BioMutaiDAND5.
DMDMi74729571.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 189167DAN domain family member 5PRO_0000311804Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi38 – 381N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi101 ↔ 148By similarity
Disulfide bondi115 ↔ 162By similarity
Disulfide bondi125 ↔ 183By similarity
Disulfide bondi129 ↔ 185By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8N907.
PaxDbiQ8N907.
PRIDEiQ8N907.

Expressioni

Gene expression databases

BgeeiQ8N907.
CleanExiHS_DAND5.
HS_SP1.
ExpressionAtlasiQ8N907. baseline and differential.
GenevestigatoriQ8N907.

Organism-specific databases

HPAiHPA049472.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000323155.

Structurei

3D structure databases

ProteinModelPortaliQ8N907.
SMRiQ8N907. Positions 98-189.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini101 – 18686CTCKAdd
BLAST

Sequence similaritiesi

Belongs to the DAN family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG38827.
GeneTreeiENSGT00530000063926.
HOGENOMiHOG000112140.
HOVERGENiHBG094958.
InParanoidiQ8N907.
OMAiRNHLCFG.
PhylomeDBiQ8N907.
TreeFamiTF106445.

Family and domain databases

InterProiIPR016860. Cerberus.
IPR004133. DAN.
[Graphical view]
PfamiPF03045. DAN. 1 hit.
[Graphical view]
PIRSFiPIRSF027807. Cerberus. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8N907-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLGQLSTLL CLLSGALPTG SGRPEPQSPR PQSWAAANQT WALGPGALPP
60 70 80 90 100
LVPASALGSW KAFLGLQKAR QLGMGRLQRG QDEVAAVTLP LNPQEVIQGM
110 120 130 140 150
CKAVPFVQVF SRPGCSAIRL RNHLCFGHCS SLYIPGSDPT PLVLCNSCMP
160 170 180
ARKRWAPVVL WCLTGSSASR RRVKISTMLI EGCHCSPKA
Length:189
Mass (Da):20,180
Last modified:October 1, 2002 - v1
Checksum:iDE97689CBE2F65A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB070695 mRNA. Translation: BAC82440.1.
AK095926 mRNA. Translation: BAC04651.1.
BC101800 mRNA. Translation: AAI01801.1.
BC113476 mRNA. Translation: AAI13477.1.
CCDSiCCDS12291.1.
RefSeqiNP_689867.1. NM_152654.2.
UniGeneiHs.331981.

Genome annotation databases

EnsembliENST00000317060; ENSP00000323155; ENSG00000179284.
GeneIDi199699.
KEGGihsa:199699.
UCSCiuc002mwc.1. human.

Polymorphism and mutation databases

BioMutaiDAND5.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB070695 mRNA. Translation: BAC82440.1.
AK095926 mRNA. Translation: BAC04651.1.
BC101800 mRNA. Translation: AAI01801.1.
BC113476 mRNA. Translation: AAI13477.1.
CCDSiCCDS12291.1.
RefSeqiNP_689867.1. NM_152654.2.
UniGeneiHs.331981.

3D structure databases

ProteinModelPortaliQ8N907.
SMRiQ8N907. Positions 98-189.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000323155.

Polymorphism and mutation databases

BioMutaiDAND5.
DMDMi74729571.

Proteomic databases

MaxQBiQ8N907.
PaxDbiQ8N907.
PRIDEiQ8N907.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317060; ENSP00000323155; ENSG00000179284.
GeneIDi199699.
KEGGihsa:199699.
UCSCiuc002mwc.1. human.

Organism-specific databases

CTDi199699.
GeneCardsiGC19P013081.
HGNCiHGNC:26780. DAND5.
HPAiHPA049472.
MIMi609068. gene.
neXtProtiNX_Q8N907.
PharmGKBiPA134875268.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG38827.
GeneTreeiENSGT00530000063926.
HOGENOMiHOG000112140.
HOVERGENiHBG094958.
InParanoidiQ8N907.
OMAiRNHLCFG.
PhylomeDBiQ8N907.
TreeFamiTF106445.

Enzyme and pathway databases

SignaLinkiQ8N907.

Miscellaneous databases

GenomeRNAii199699.
NextBioi89693.
PROiQ8N907.
SOURCEiSearch...

Gene expression databases

BgeeiQ8N907.
CleanExiHS_DAND5.
HS_SP1.
ExpressionAtlasiQ8N907. baseline and differential.
GenevestigatoriQ8N907.

Family and domain databases

InterProiIPR016860. Cerberus.
IPR004133. DAN.
[Graphical view]
PfamiPF03045. DAN. 1 hit.
[Graphical view]
PIRSFiPIRSF027807. Cerberus. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cysteine knot protein (SP1)."
    Itoh N.
    Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "Identification and characterization of human CKTSF1B2 and CKTSF1B3 genes in silico."
    Katoh M., Katoh M.
    Oncol. Rep. 12:423-427(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiDAND5_HUMAN
AccessioniPrimary (citable) accession number: Q8N907
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: October 1, 2002
Last modified: April 29, 2015
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.