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Protein

Zinc finger protein 441

Gene

ZNF441

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri169 – 19022C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri196 – 21823C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri224 – 24623C2H2-type 3; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri252 – 27423C2H2-type 4; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri280 – 30223C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri308 – 33023C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri336 – 35823C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri364 – 38623C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri392 – 41322C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri419 – 44123C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri447 – 46923C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri475 – 49723C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri503 – 52523C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri531 – 55323C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri559 – 58123C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri587 – 60923C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri615 – 63723C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri643 – 66523C2H2-type 18PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri671 – 69323C2H2-type 19PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 441
Gene namesi
Name:ZNF441
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:20875. ZNF441.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 693693Zinc finger protein 441PRO_0000047590Add
BLAST

Proteomic databases

PaxDbiQ8N8Z8.
PRIDEiQ8N8Z8.

PTM databases

PhosphoSiteiQ8N8Z8.

Expressioni

Gene expression databases

BgeeiQ8N8Z8.
CleanExiHS_ZNF441.
ExpressionAtlasiQ8N8Z8. baseline and differential.
GenevestigatoriQ8N8Z8.

Interactioni

Protein-protein interaction databases

BioGridi125951. 1 interaction.
STRINGi9606.ENSP00000350576.

Structurei

3D structure databases

ProteinModelPortaliQ8N8Z8.
SMRiQ8N8Z8. Positions 4-54, 80-666.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 7976KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 19 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri169 – 19022C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri196 – 21823C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri224 – 24623C2H2-type 3; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri252 – 27423C2H2-type 4; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri280 – 30223C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri308 – 33023C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri336 – 35823C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri364 – 38623C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri392 – 41322C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri419 – 44123C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri447 – 46923C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri475 – 49723C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri503 – 52523C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri531 – 55323C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri559 – 58123C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri587 – 60923C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri615 – 63723C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri643 – 66523C2H2-type 18PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri671 – 69323C2H2-type 19PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000119089.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8N8Z8.
OMAiYIRVHEK.
PhylomeDBiQ8N8Z8.
TreeFamiTF343410.

Family and domain databases

Gene3Di3.30.160.60. 18 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 18 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 19 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8N8Z8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSVAFEDVA INFTCEEWAL LGPSQKSLYR DVMQETIRNL DCIGMIWQNH
60 70 80 90 100
DIEEDQYKDL RRNLRCHMVE RACEIKDNSQ CGGPFTQTQD SIVNEKIPGV
110 120 130 140 150
DPWESSECTD VLMGRSSLNC YVRVDSEHKP CEYQEYGEKP YTHTQCGTAF
160 170 180 190 200
SYQPCFQIHE RPQHGKKLYD CKECASFSSL ENLQRHMAAH HGDGPRICKL
210 220 230 240 250
CGNAFIWPSL FHMLRRTHTE EKPYEYEQCS TAFPAYSSTL RHERTHSGEK
260 270 280 290 300
PYQCKQCGKA FSCSCYTQLY ERTHTGEQSY ECKQCGKAFY HLGSFQRHMI
310 320 330 340 350
VHTGDGPHKC KICGKGFLSP SSVRRHKRTH TGEKPYECKY CGKAFSDCTG
360 370 380 390 400
FRRHMITHTG DGPHKCKVCG KAFDSPSLCR RHETTHTGEK PYKCECGKAF
410 420 430 440 450
SDFYYFRNHE TTHTGEKPYK CKQCGKAFIC CTYLQIHERI HTGERPYKCK
460 470 480 490 500
QCGKAFRSSN YIRVHEKTHT GEKPYECKQC GKALSHLKSF QRHMIMHTGD
510 520 530 540 550
GPHKCKICGK SFDSPSSFRR HERIHTGERP YKCKLCGKGF RSSSYIQLHE
560 570 580 590 600
RTHTGEKPYG CQQCGKALSD LSSFRRHMIT HTGNGPHKCK ICGKGFDYPS
610 620 630 640 650
SVQRHERTHT GEKPYECKEC GKAFSHSSYL RIHERVHTGE KPYKCKECGK
660 670 680 690
PFHCPSAFHK HERTHSMEKP YKCKECGEAF HCISSFHKHE MTH
Length:693
Mass (Da):80,136
Last modified:October 5, 2010 - v2
Checksum:iBDB7F45CDFF7C217
GO
Isoform 2 (identifier: Q8N8Z8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-44: Missing.

Show »
Length:649
Mass (Da):75,144
Checksum:i5CB16087CFC074AE
GO

Sequence cautioni

The sequence BAC04661.1 differs from that shown. Reason: Frameshift at position 2. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti122 – 1221V → I in BAC04661. (PubMed:14702039)Curated
Sequence conflicti122 – 1221V → I in BC144217. (PubMed:15489334)Curated
Sequence conflicti131 – 1311C → Y in BAC04661. (PubMed:14702039)Curated
Sequence conflicti385 – 3851T → A in BAC04661. (PubMed:14702039)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4444Missing in isoform 2. 1 PublicationVSP_039877Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095956 mRNA. Translation: BAC04661.1. Frameshift.
AC008543 Genomic DNA. No translation available.
BC144217 mRNA. No translation available.
CCDSiCCDS12266.2. [Q8N8Z8-1]
RefSeqiNP_689568.2. NM_152355.2. [Q8N8Z8-1]
UniGeneiHs.675132.

Genome annotation databases

EnsembliENST00000357901; ENSP00000350576; ENSG00000197044. [Q8N8Z8-1]
GeneIDi126068.
KEGGihsa:126068.
UCSCiuc002msn.4. human. [Q8N8Z8-1]

Polymorphism databases

DMDMi308153532.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095956 mRNA. Translation: BAC04661.1. Frameshift.
AC008543 Genomic DNA. No translation available.
BC144217 mRNA. No translation available.
CCDSiCCDS12266.2. [Q8N8Z8-1]
RefSeqiNP_689568.2. NM_152355.2. [Q8N8Z8-1]
UniGeneiHs.675132.

3D structure databases

ProteinModelPortaliQ8N8Z8.
SMRiQ8N8Z8. Positions 4-54, 80-666.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125951. 1 interaction.
STRINGi9606.ENSP00000350576.

PTM databases

PhosphoSiteiQ8N8Z8.

Polymorphism databases

DMDMi308153532.

Proteomic databases

PaxDbiQ8N8Z8.
PRIDEiQ8N8Z8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357901; ENSP00000350576; ENSG00000197044. [Q8N8Z8-1]
GeneIDi126068.
KEGGihsa:126068.
UCSCiuc002msn.4. human. [Q8N8Z8-1]

Organism-specific databases

CTDi126068.
GeneCardsiGC19P011878.
HGNCiHGNC:20875. ZNF441.
neXtProtiNX_Q8N8Z8.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000119089.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8N8Z8.
OMAiYIRVHEK.
PhylomeDBiQ8N8Z8.
TreeFamiTF343410.

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii126068.
NextBioi81653.
PROiQ8N8Z8.

Gene expression databases

BgeeiQ8N8Z8.
CleanExiHS_ZNF441.
ExpressionAtlasiQ8N8Z8. baseline and differential.
GenevestigatoriQ8N8Z8.

Family and domain databases

Gene3Di3.30.160.60. 18 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 18 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 19 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 5-693 (ISOFORM 1).

Entry informationi

Entry nameiZN441_HUMAN
AccessioniPrimary (citable) accession number: Q8N8Z8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: October 5, 2010
Last modified: January 7, 2015
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.