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Q8N8Z8

- ZN441_HUMAN

UniProt

Q8N8Z8 - ZN441_HUMAN

Protein

Zinc finger protein 441

Gene

ZNF441

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 2 (05 Oct 2010)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri169 – 19022C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri196 – 21823C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri224 – 24623C2H2-type 3; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri252 – 27423C2H2-type 4; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri280 – 30223C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri308 – 33023C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri336 – 35823C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri364 – 38623C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri392 – 41322C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri419 – 44123C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri447 – 46923C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri475 – 49723C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri503 – 52523C2H2-type 13PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri531 – 55323C2H2-type 14PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri559 – 58123C2H2-type 15PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri587 – 60923C2H2-type 16PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri615 – 63723C2H2-type 17PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri643 – 66523C2H2-type 18PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri671 – 69323C2H2-type 19PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_12627. Generic Transcription Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 441
    Gene namesi
    Name:ZNF441
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:20875. ZNF441.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 693693Zinc finger protein 441PRO_0000047590Add
    BLAST

    Proteomic databases

    PaxDbiQ8N8Z8.
    PRIDEiQ8N8Z8.

    PTM databases

    PhosphoSiteiQ8N8Z8.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8N8Z8.
    BgeeiQ8N8Z8.
    CleanExiHS_ZNF441.
    GenevestigatoriQ8N8Z8.

    Interactioni

    Protein-protein interaction databases

    BioGridi125951. 1 interaction.
    STRINGi9606.ENSP00000350576.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N8Z8.
    SMRiQ8N8Z8. Positions 4-54, 80-666.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 7976KRABPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 19 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 KRAB domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri169 – 19022C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri196 – 21823C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri224 – 24623C2H2-type 3; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri252 – 27423C2H2-type 4; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri280 – 30223C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri308 – 33023C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri336 – 35823C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri364 – 38623C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri392 – 41322C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri419 – 44123C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri447 – 46923C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri475 – 49723C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri503 – 52523C2H2-type 13PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri531 – 55323C2H2-type 14PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri559 – 58123C2H2-type 15PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri587 – 60923C2H2-type 16PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri615 – 63723C2H2-type 17PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri643 – 66523C2H2-type 18PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri671 – 69323C2H2-type 19PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000234617.
    HOVERGENiHBG018163.
    InParanoidiQ8N8Z8.
    OMAiYIRVHEK.
    PhylomeDBiQ8N8Z8.
    TreeFamiTF343410.

    Family and domain databases

    Gene3Di3.30.160.60. 18 hits.
    InterProiIPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF01352. KRAB. 1 hit.
    [Graphical view]
    SMARTiSM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 18 hits.
    [Graphical view]
    SUPFAMiSSF109640. SSF109640. 1 hit.
    PROSITEiPS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 14 hits.
    PS50157. ZINC_FINGER_C2H2_2. 19 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8N8Z8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDSVAFEDVA INFTCEEWAL LGPSQKSLYR DVMQETIRNL DCIGMIWQNH    50
    DIEEDQYKDL RRNLRCHMVE RACEIKDNSQ CGGPFTQTQD SIVNEKIPGV 100
    DPWESSECTD VLMGRSSLNC YVRVDSEHKP CEYQEYGEKP YTHTQCGTAF 150
    SYQPCFQIHE RPQHGKKLYD CKECASFSSL ENLQRHMAAH HGDGPRICKL 200
    CGNAFIWPSL FHMLRRTHTE EKPYEYEQCS TAFPAYSSTL RHERTHSGEK 250
    PYQCKQCGKA FSCSCYTQLY ERTHTGEQSY ECKQCGKAFY HLGSFQRHMI 300
    VHTGDGPHKC KICGKGFLSP SSVRRHKRTH TGEKPYECKY CGKAFSDCTG 350
    FRRHMITHTG DGPHKCKVCG KAFDSPSLCR RHETTHTGEK PYKCECGKAF 400
    SDFYYFRNHE TTHTGEKPYK CKQCGKAFIC CTYLQIHERI HTGERPYKCK 450
    QCGKAFRSSN YIRVHEKTHT GEKPYECKQC GKALSHLKSF QRHMIMHTGD 500
    GPHKCKICGK SFDSPSSFRR HERIHTGERP YKCKLCGKGF RSSSYIQLHE 550
    RTHTGEKPYG CQQCGKALSD LSSFRRHMIT HTGNGPHKCK ICGKGFDYPS 600
    SVQRHERTHT GEKPYECKEC GKAFSHSSYL RIHERVHTGE KPYKCKECGK 650
    PFHCPSAFHK HERTHSMEKP YKCKECGEAF HCISSFHKHE MTH 693
    Length:693
    Mass (Da):80,136
    Last modified:October 5, 2010 - v2
    Checksum:iBDB7F45CDFF7C217
    GO
    Isoform 2 (identifier: Q8N8Z8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-44: Missing.

    Show »
    Length:649
    Mass (Da):75,144
    Checksum:i5CB16087CFC074AE
    GO

    Sequence cautioni

    The sequence BAC04661.1 differs from that shown. Reason: Frameshift at position 2.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti122 – 1221V → I in BAC04661. (PubMed:14702039)Curated
    Sequence conflicti122 – 1221V → I in BC144217. (PubMed:15489334)Curated
    Sequence conflicti131 – 1311C → Y in BAC04661. (PubMed:14702039)Curated
    Sequence conflicti385 – 3851T → A in BAC04661. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 4444Missing in isoform 2. 1 PublicationVSP_039877Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK095956 mRNA. Translation: BAC04661.1. Frameshift.
    AC008543 Genomic DNA. No translation available.
    BC144217 mRNA. No translation available.
    CCDSiCCDS12266.2. [Q8N8Z8-1]
    RefSeqiNP_689568.2. NM_152355.2. [Q8N8Z8-1]
    UniGeneiHs.675132.

    Genome annotation databases

    EnsembliENST00000357901; ENSP00000350576; ENSG00000197044. [Q8N8Z8-1]
    GeneIDi126068.
    KEGGihsa:126068.
    UCSCiuc002msn.4. human. [Q8N8Z8-1]

    Polymorphism databases

    DMDMi308153532.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK095956 mRNA. Translation: BAC04661.1 . Frameshift.
    AC008543 Genomic DNA. No translation available.
    BC144217 mRNA. No translation available.
    CCDSi CCDS12266.2. [Q8N8Z8-1 ]
    RefSeqi NP_689568.2. NM_152355.2. [Q8N8Z8-1 ]
    UniGenei Hs.675132.

    3D structure databases

    ProteinModelPortali Q8N8Z8.
    SMRi Q8N8Z8. Positions 4-54, 80-666.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125951. 1 interaction.
    STRINGi 9606.ENSP00000350576.

    PTM databases

    PhosphoSitei Q8N8Z8.

    Polymorphism databases

    DMDMi 308153532.

    Proteomic databases

    PaxDbi Q8N8Z8.
    PRIDEi Q8N8Z8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000357901 ; ENSP00000350576 ; ENSG00000197044 . [Q8N8Z8-1 ]
    GeneIDi 126068.
    KEGGi hsa:126068.
    UCSCi uc002msn.4. human. [Q8N8Z8-1 ]

    Organism-specific databases

    CTDi 126068.
    GeneCardsi GC19P011878.
    HGNCi HGNC:20875. ZNF441.
    neXtProti NX_Q8N8Z8.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000234617.
    HOVERGENi HBG018163.
    InParanoidi Q8N8Z8.
    OMAi YIRVHEK.
    PhylomeDBi Q8N8Z8.
    TreeFami TF343410.

    Enzyme and pathway databases

    Reactomei REACT_12627. Generic Transcription Pathway.

    Miscellaneous databases

    GenomeRNAii 126068.
    NextBioi 81653.
    PROi Q8N8Z8.

    Gene expression databases

    ArrayExpressi Q8N8Z8.
    Bgeei Q8N8Z8.
    CleanExi HS_ZNF441.
    Genevestigatori Q8N8Z8.

    Family and domain databases

    Gene3Di 3.30.160.60. 18 hits.
    InterProi IPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF01352. KRAB. 1 hit.
    [Graphical view ]
    SMARTi SM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 18 hits.
    [Graphical view ]
    SUPFAMi SSF109640. SSF109640. 1 hit.
    PROSITEi PS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 14 hits.
    PS50157. ZINC_FINGER_C2H2_2. 19 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    2. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 5-693 (ISOFORM 1).

    Entry informationi

    Entry nameiZN441_HUMAN
    AccessioniPrimary (citable) accession number: Q8N8Z8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 9, 2003
    Last sequence update: October 5, 2010
    Last modified: October 1, 2014
    This is version 104 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3