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Q8N8Z8 (ZN441_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 441
Gene names
Name:ZNF441
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length693 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in transcriptional regulation.

Subcellular location

Nucleus Potential.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 19 C2H2-type zinc fingers.

Contains 1 KRAB domain.

Sequence caution

The sequence BAC04661.1 differs from that shown. Reason: Frameshift at position 2.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8N8Z8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8N8Z8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-44: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 693693Zinc finger protein 441
PRO_0000047590

Regions

Domain4 – 7976KRAB
Zinc finger169 – 19022C2H2-type 1
Zinc finger196 – 21823C2H2-type 2; degenerate
Zinc finger224 – 24623C2H2-type 3; degenerate
Zinc finger252 – 27423C2H2-type 4; degenerate
Zinc finger280 – 30223C2H2-type 5
Zinc finger308 – 33023C2H2-type 6
Zinc finger336 – 35823C2H2-type 7
Zinc finger364 – 38623C2H2-type 8
Zinc finger392 – 41322C2H2-type 9
Zinc finger419 – 44123C2H2-type 10
Zinc finger447 – 46923C2H2-type 11
Zinc finger475 – 49723C2H2-type 12
Zinc finger503 – 52523C2H2-type 13
Zinc finger531 – 55323C2H2-type 14
Zinc finger559 – 58123C2H2-type 15
Zinc finger587 – 60923C2H2-type 16
Zinc finger615 – 63723C2H2-type 17
Zinc finger643 – 66523C2H2-type 18
Zinc finger671 – 69323C2H2-type 19

Natural variations

Alternative sequence1 – 4444Missing in isoform 2.
VSP_039877

Experimental info

Sequence conflict1221V → I in BAC04661. Ref.1
Sequence conflict1221V → I in BC144217. Ref.3
Sequence conflict1311C → Y in BAC04661. Ref.1
Sequence conflict3851T → A in BAC04661. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 5, 2010. Version 2.
Checksum: BDB7F45CDFF7C217

FASTA69380,136
        10         20         30         40         50         60 
MDSVAFEDVA INFTCEEWAL LGPSQKSLYR DVMQETIRNL DCIGMIWQNH DIEEDQYKDL 

        70         80         90        100        110        120 
RRNLRCHMVE RACEIKDNSQ CGGPFTQTQD SIVNEKIPGV DPWESSECTD VLMGRSSLNC 

       130        140        150        160        170        180 
YVRVDSEHKP CEYQEYGEKP YTHTQCGTAF SYQPCFQIHE RPQHGKKLYD CKECASFSSL 

       190        200        210        220        230        240 
ENLQRHMAAH HGDGPRICKL CGNAFIWPSL FHMLRRTHTE EKPYEYEQCS TAFPAYSSTL 

       250        260        270        280        290        300 
RHERTHSGEK PYQCKQCGKA FSCSCYTQLY ERTHTGEQSY ECKQCGKAFY HLGSFQRHMI 

       310        320        330        340        350        360 
VHTGDGPHKC KICGKGFLSP SSVRRHKRTH TGEKPYECKY CGKAFSDCTG FRRHMITHTG 

       370        380        390        400        410        420 
DGPHKCKVCG KAFDSPSLCR RHETTHTGEK PYKCECGKAF SDFYYFRNHE TTHTGEKPYK 

       430        440        450        460        470        480 
CKQCGKAFIC CTYLQIHERI HTGERPYKCK QCGKAFRSSN YIRVHEKTHT GEKPYECKQC 

       490        500        510        520        530        540 
GKALSHLKSF QRHMIMHTGD GPHKCKICGK SFDSPSSFRR HERIHTGERP YKCKLCGKGF 

       550        560        570        580        590        600 
RSSSYIQLHE RTHTGEKPYG CQQCGKALSD LSSFRRHMIT HTGNGPHKCK ICGKGFDYPS 

       610        620        630        640        650        660 
SVQRHERTHT GEKPYECKEC GKAFSHSSYL RIHERVHTGE KPYKCKECGK PFHCPSAFHK 

       670        680        690 
HERTHSMEKP YKCKECGEAF HCISSFHKHE MTH 

« Hide

Isoform 2 [UniParc].

Checksum: 5CB16087CFC074AE
Show »

FASTA64975,144

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[2]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 5-693 (ISOFORM 1).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK095956 mRNA. Translation: BAC04661.1. Frameshift.
AC008543 Genomic DNA. No translation available.
BC144217 mRNA. No translation available.
RefSeqNP_689568.2. NM_152355.2.
UniGeneHs.675132.

3D structure databases

ProteinModelPortalQ8N8Z8.
SMRQ8N8Z8. Positions 4-54, 80-666.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid125951. 1 interaction.
STRING9606.ENSP00000350576.

PTM databases

PhosphoSiteQ8N8Z8.

Polymorphism databases

DMDM308153532.

Proteomic databases

PaxDbQ8N8Z8.
PRIDEQ8N8Z8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000357901; ENSP00000350576; ENSG00000197044. [Q8N8Z8-1]
GeneID126068.
KEGGhsa:126068.
UCSCuc002msn.4. human. [Q8N8Z8-1]

Organism-specific databases

CTD126068.
GeneCardsGC19P011878.
HGNCHGNC:20875. ZNF441.
neXtProtNX_Q8N8Z8.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000234617.
HOVERGENHBG018163.
InParanoidQ8N8Z8.
OMAYIRVHEK.
PhylomeDBQ8N8Z8.
TreeFamTF343410.

Enzyme and pathway databases

ReactomeREACT_71. Gene Expression.

Gene expression databases

ArrayExpressQ8N8Z8.
BgeeQ8N8Z8.
CleanExHS_ZNF441.
GenevestigatorQ8N8Z8.

Family and domain databases

Gene3D3.30.160.60. 18 hits.
InterProIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF01352. KRAB. 1 hit.
[Graphical view]
SMARTSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 18 hits.
[Graphical view]
SUPFAMSSF109640. SSF109640. 1 hit.
PROSITEPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 19 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi126068.
NextBio81653.
PROQ8N8Z8.

Entry information

Entry nameZN441_HUMAN
AccessionPrimary (citable) accession number: Q8N8Z8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: October 5, 2010
Last modified: April 16, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM