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Q8N8Z8

- ZN441_HUMAN

UniProt

Q8N8Z8 - ZN441_HUMAN

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Protein
Zinc finger protein 441
Gene
ZNF441
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri169 – 19022C2H2-type 1
Add
BLAST
Zinc fingeri196 – 21823C2H2-type 2; degenerate
Add
BLAST
Zinc fingeri224 – 24623C2H2-type 3; degenerate
Add
BLAST
Zinc fingeri252 – 27423C2H2-type 4; degenerate
Add
BLAST
Zinc fingeri280 – 30223C2H2-type 5
Add
BLAST
Zinc fingeri308 – 33023C2H2-type 6
Add
BLAST
Zinc fingeri336 – 35823C2H2-type 7
Add
BLAST
Zinc fingeri364 – 38623C2H2-type 8
Add
BLAST
Zinc fingeri392 – 41322C2H2-type 9
Add
BLAST
Zinc fingeri419 – 44123C2H2-type 10
Add
BLAST
Zinc fingeri447 – 46923C2H2-type 11
Add
BLAST
Zinc fingeri475 – 49723C2H2-type 12
Add
BLAST
Zinc fingeri503 – 52523C2H2-type 13
Add
BLAST
Zinc fingeri531 – 55323C2H2-type 14
Add
BLAST
Zinc fingeri559 – 58123C2H2-type 15
Add
BLAST
Zinc fingeri587 – 60923C2H2-type 16
Add
BLAST
Zinc fingeri615 – 63723C2H2-type 17
Add
BLAST
Zinc fingeri643 – 66523C2H2-type 18
Add
BLAST
Zinc fingeri671 – 69323C2H2-type 19
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 441
Gene namesi
Name:ZNF441
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:20875. ZNF441.

Subcellular locationi

Nucleus Reviewed prediction

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 693693Zinc finger protein 441
PRO_0000047590Add
BLAST

Proteomic databases

PaxDbiQ8N8Z8.
PRIDEiQ8N8Z8.

PTM databases

PhosphoSiteiQ8N8Z8.

Expressioni

Gene expression databases

ArrayExpressiQ8N8Z8.
BgeeiQ8N8Z8.
CleanExiHS_ZNF441.
GenevestigatoriQ8N8Z8.

Interactioni

Protein-protein interaction databases

BioGridi125951. 1 interaction.
STRINGi9606.ENSP00000350576.

Structurei

3D structure databases

ProteinModelPortaliQ8N8Z8.
SMRiQ8N8Z8. Positions 4-54, 80-666.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 7976KRAB
Add
BLAST

Sequence similaritiesi

Contains 19 C2H2-type zinc fingers.
Contains 1 KRAB domain.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8N8Z8.
OMAiYIRVHEK.
PhylomeDBiQ8N8Z8.
TreeFamiTF343410.

Family and domain databases

Gene3Di3.30.160.60. 18 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 18 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 19 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8N8Z8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDSVAFEDVA INFTCEEWAL LGPSQKSLYR DVMQETIRNL DCIGMIWQNH    50
DIEEDQYKDL RRNLRCHMVE RACEIKDNSQ CGGPFTQTQD SIVNEKIPGV 100
DPWESSECTD VLMGRSSLNC YVRVDSEHKP CEYQEYGEKP YTHTQCGTAF 150
SYQPCFQIHE RPQHGKKLYD CKECASFSSL ENLQRHMAAH HGDGPRICKL 200
CGNAFIWPSL FHMLRRTHTE EKPYEYEQCS TAFPAYSSTL RHERTHSGEK 250
PYQCKQCGKA FSCSCYTQLY ERTHTGEQSY ECKQCGKAFY HLGSFQRHMI 300
VHTGDGPHKC KICGKGFLSP SSVRRHKRTH TGEKPYECKY CGKAFSDCTG 350
FRRHMITHTG DGPHKCKVCG KAFDSPSLCR RHETTHTGEK PYKCECGKAF 400
SDFYYFRNHE TTHTGEKPYK CKQCGKAFIC CTYLQIHERI HTGERPYKCK 450
QCGKAFRSSN YIRVHEKTHT GEKPYECKQC GKALSHLKSF QRHMIMHTGD 500
GPHKCKICGK SFDSPSSFRR HERIHTGERP YKCKLCGKGF RSSSYIQLHE 550
RTHTGEKPYG CQQCGKALSD LSSFRRHMIT HTGNGPHKCK ICGKGFDYPS 600
SVQRHERTHT GEKPYECKEC GKAFSHSSYL RIHERVHTGE KPYKCKECGK 650
PFHCPSAFHK HERTHSMEKP YKCKECGEAF HCISSFHKHE MTH 693
Length:693
Mass (Da):80,136
Last modified:October 5, 2010 - v2
Checksum:iBDB7F45CDFF7C217
GO
Isoform 2 (identifier: Q8N8Z8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-44: Missing.

Show »
Length:649
Mass (Da):75,144
Checksum:i5CB16087CFC074AE
GO

Sequence cautioni

The sequence BAC04661.1 differs from that shown. Reason: Frameshift at position 2.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4444Missing in isoform 2.
VSP_039877Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti122 – 1221V → I in BAC04661. 1 Publication
Sequence conflicti122 – 1221V → I in BC144217. 1 Publication
Sequence conflicti131 – 1311C → Y in BAC04661. 1 Publication
Sequence conflicti385 – 3851T → A in BAC04661. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK095956 mRNA. Translation: BAC04661.1. Frameshift.
AC008543 Genomic DNA. No translation available.
BC144217 mRNA. No translation available.
CCDSiCCDS12266.2. [Q8N8Z8-1]
RefSeqiNP_689568.2. NM_152355.2. [Q8N8Z8-1]
UniGeneiHs.675132.

Genome annotation databases

EnsembliENST00000357901; ENSP00000350576; ENSG00000197044. [Q8N8Z8-1]
GeneIDi126068.
KEGGihsa:126068.
UCSCiuc002msn.4. human. [Q8N8Z8-1]

Polymorphism databases

DMDMi308153532.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK095956 mRNA. Translation: BAC04661.1 . Frameshift.
AC008543 Genomic DNA. No translation available.
BC144217 mRNA. No translation available.
CCDSi CCDS12266.2. [Q8N8Z8-1 ]
RefSeqi NP_689568.2. NM_152355.2. [Q8N8Z8-1 ]
UniGenei Hs.675132.

3D structure databases

ProteinModelPortali Q8N8Z8.
SMRi Q8N8Z8. Positions 4-54, 80-666.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 125951. 1 interaction.
STRINGi 9606.ENSP00000350576.

PTM databases

PhosphoSitei Q8N8Z8.

Polymorphism databases

DMDMi 308153532.

Proteomic databases

PaxDbi Q8N8Z8.
PRIDEi Q8N8Z8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000357901 ; ENSP00000350576 ; ENSG00000197044 . [Q8N8Z8-1 ]
GeneIDi 126068.
KEGGi hsa:126068.
UCSCi uc002msn.4. human. [Q8N8Z8-1 ]

Organism-specific databases

CTDi 126068.
GeneCardsi GC19P011878.
HGNCi HGNC:20875. ZNF441.
neXtProti NX_Q8N8Z8.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
HOGENOMi HOG000234617.
HOVERGENi HBG018163.
InParanoidi Q8N8Z8.
OMAi YIRVHEK.
PhylomeDBi Q8N8Z8.
TreeFami TF343410.

Enzyme and pathway databases

Reactomei REACT_12627. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii 126068.
NextBioi 81653.
PROi Q8N8Z8.

Gene expression databases

ArrayExpressi Q8N8Z8.
Bgeei Q8N8Z8.
CleanExi HS_ZNF441.
Genevestigatori Q8N8Z8.

Family and domain databases

Gene3Di 3.30.160.60. 18 hits.
InterProi IPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF01352. KRAB. 1 hit.
[Graphical view ]
SMARTi SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 18 hits.
[Graphical view ]
SUPFAMi SSF109640. SSF109640. 1 hit.
PROSITEi PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 19 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 5-693 (ISOFORM 1).

Entry informationi

Entry nameiZN441_HUMAN
AccessioniPrimary (citable) accession number: Q8N8Z8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: October 5, 2010
Last modified: September 3, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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