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Protein

Discoidin, CUB and LCCL domain-containing protein 1

Gene

DCBLD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Discoidin, CUB and LCCL domain-containing protein 1
Gene namesi
Name:DCBLD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21479. DCBLD1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini35 – 459425ExtracellularSequence analysisAdd
BLAST
Transmembranei460 – 48021HelicalSequence analysisAdd
BLAST
Topological domaini481 – 715235CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134903108.

Polymorphism and mutation databases

BioMutaiDCBLD1.
DMDMi50400555.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434Sequence analysisAdd
BLAST
Chaini35 – 715681Discoidin, CUB and LCCL domain-containing protein 1PRO_0000021076Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi41 ↔ 68By similarity
Glycosylationi64 – 641N-linked (GlcNAc...)Sequence analysis
Disulfide bondi94 ↔ 112By similarity
Glycosylationi124 – 1241N-linked (GlcNAc...)Sequence analysis
Disulfide bondi158 ↔ 174By similarity
Disulfide bondi178 ↔ 200By similarity
Glycosylationi277 – 2771N-linked (GlcNAc...)Sequence analysis
Glycosylationi351 – 3511N-linked (GlcNAc...)Sequence analysis
Glycosylationi418 – 4181N-linked (GlcNAc...)Sequence analysis
Glycosylationi455 – 4551N-linked (GlcNAc...)Sequence analysis
Modified residuei513 – 5131PhosphoserineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ8N8Z6.
MaxQBiQ8N8Z6.
PaxDbiQ8N8Z6.
PRIDEiQ8N8Z6.

PTM databases

iPTMnetiQ8N8Z6.
PhosphoSiteiQ8N8Z6.
SwissPalmiQ8N8Z6.

Expressioni

Gene expression databases

BgeeiQ8N8Z6.
CleanExiHS_DCBLD1.
ExpressionAtlasiQ8N8Z6. baseline and differential.
GenevisibleiQ8N8Z6. HS.

Organism-specific databases

HPAiHPA059667.

Interactioni

Protein-protein interaction databases

BioGridi130203. 4 interactions.
IntActiQ8N8Z6. 1 interaction.
MINTiMINT-4053610.
STRINGi9606.ENSP00000296955.

Structurei

3D structure databases

ProteinModelPortaliQ8N8Z6.
SMRiQ8N8Z6. Positions 41-415.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini41 – 150110CUBPROSITE-ProRule annotationAdd
BLAST
Domaini152 – 24897LCCLPROSITE-ProRule annotationAdd
BLAST
Domaini248 – 412165F5/8 type CPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi482 – 4865Poly-Lys

Sequence similaritiesi

Contains 1 CUB domain.PROSITE-ProRule annotation
Contains 1 F5/8 type C domain.PROSITE-ProRule annotation
Contains 1 LCCL domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II5Z. Eukaryota.
ENOG4110JCT. LUCA.
GeneTreeiENSGT00760000119073.
HOGENOMiHOG000000681.
HOVERGENiHBG051317.
InParanoidiQ8N8Z6.
OMAiGPQPGHK.
OrthoDBiEOG7J446F.
PhylomeDBiQ8N8Z6.

Family and domain databases

Gene3Di2.170.130.20. 1 hit.
2.60.120.260. 1 hit.
2.60.120.290. 1 hit.
InterProiIPR000859. CUB_dom.
IPR000421. FA58C.
IPR008979. Galactose-bd-like.
IPR004043. LCCL.
[Graphical view]
PfamiPF00431. CUB. 1 hit.
PF00754. F5_F8_type_C. 1 hit.
PF03815. LCCL. 1 hit.
[Graphical view]
SMARTiSM00042. CUB. 1 hit.
SM00231. FA58C. 1 hit.
SM00603. LCCL. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF49854. SSF49854. 1 hit.
SSF69848. SSF69848. 1 hit.
PROSITEiPS01180. CUB. 1 hit.
PS01285. FA58C_1. 1 hit.
PS50022. FA58C_3. 1 hit.
PS50820. LCCL. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N8Z6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVPGARGGGA LARAAGRGLL ALLLAVSAPL RLQAEELGDG CGHLVTYQDS
60 70 80 90 100
GTMTSKNYPG TYPNHTVCEK TITVPKGKRL ILRLGDLDIE SQTCASDYLL
110 120 130 140 150
FTSSSDQYGP YCGSMTVPKE LLLNTSEVTV RFESGSHISG RGFLLTYASS
160 170 180 190 200
DHPDLITCLE RASHYLKTEY SKFCPAGCRD VAGDISGNMV DGYRDTSLLC
210 220 230 240 250
KAAIHAGIIA DELGGQISVL QRKGISRYEG ILANGVLSRD GSLSDKRFLF
260 270 280 290 300
TSNGCSRSLS FEPDGQIRAS SSWQSVNESG DQVHWSPGQA RLQDQGPSWA
310 320 330 340 350
SGDSSNNHKP REWLEIDLGE KKKITGIRTT GSTQSNFNFY VKSFVMNFKN
360 370 380 390 400
NNSKWKTYKG IVNNEEKVFQ GNSNFRDPVQ NNFIPPIVAR YVRVVPQTWH
410 420 430 440 450
QRIALKVELI GCQITQGNDS LVWRKTSQST SVSTKKEDET ITRPIPSEET
460 470 480 490 500
STGINITTVA IPLVLLVVLV FAGMGIFAAF RKKKKKGSPY GSAEAQKTDC
510 520 530 540 550
WKQIKYPFAR HQSAEFTISY DNEKEMTQKL DLITSDMADY QQPLMIGTGT
560 570 580 590 600
VTRKGSTFRP MDTDAEEAGV STDAGGHYDC PQRAGRHEYA LPLAPPEPEY
610 620 630 640 650
ATPIVERHVL RAHTFSAQSG YRVPGPQPGH KHSLSSGGFS PVAGVGAQDG
660 670 680 690 700
DYQRPHSAQP ADRGYDRPKA VSALATESGH PDSQKPPTHP GTSDSYSAPR
710
DCLTPLNQTA MTALL
Length:715
Mass (Da):77,920
Last modified:July 19, 2004 - v2
Checksum:iF8724D094F66EF2E
GO
Isoform 2 (identifier: Q8N8Z6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     539-539: D → G
     540-715: Missing.

Show »
Length:539
Mass (Da):59,196
Checksum:i929D4B1AC1AAAA4C
GO

Sequence cautioni

The sequence BAC04663.1 differs from that shown. Reason: Frameshift at position 483. Curated
The sequence BAC05258.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti57 – 571N → D in BAC04663 (PubMed:14702039).Curated
Sequence conflicti369 – 3691F → L in BAC05258 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei539 – 5391D → G in isoform 2. 1 PublicationVSP_040221
Alternative sequencei540 – 715176Missing in isoform 2. 1 PublicationVSP_040222Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK098194 mRNA. Translation: BAC05258.1. Different initiation.
AK095973 mRNA. Translation: BAC04663.1. Frameshift.
AL132671, Z85999 Genomic DNA. Translation: CAI43159.1.
Z85999, AL132671 Genomic DNA. Translation: CAI43171.1.
BC035671 mRNA. Translation: AAH35671.1.
CCDSiCCDS34522.1. [Q8N8Z6-2]
RefSeqiNP_775945.1. NM_173674.2. [Q8N8Z6-2]
UniGeneiHs.658304.

Genome annotation databases

EnsembliENST00000296955; ENSP00000296955; ENSG00000164465. [Q8N8Z6-2]
ENST00000338728; ENSP00000342422; ENSG00000164465. [Q8N8Z6-1]
GeneIDi285761.
KEGGihsa:285761.
UCSCiuc003pxs.4. human. [Q8N8Z6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK098194 mRNA. Translation: BAC05258.1. Different initiation.
AK095973 mRNA. Translation: BAC04663.1. Frameshift.
AL132671, Z85999 Genomic DNA. Translation: CAI43159.1.
Z85999, AL132671 Genomic DNA. Translation: CAI43171.1.
BC035671 mRNA. Translation: AAH35671.1.
CCDSiCCDS34522.1. [Q8N8Z6-2]
RefSeqiNP_775945.1. NM_173674.2. [Q8N8Z6-2]
UniGeneiHs.658304.

3D structure databases

ProteinModelPortaliQ8N8Z6.
SMRiQ8N8Z6. Positions 41-415.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130203. 4 interactions.
IntActiQ8N8Z6. 1 interaction.
MINTiMINT-4053610.
STRINGi9606.ENSP00000296955.

PTM databases

iPTMnetiQ8N8Z6.
PhosphoSiteiQ8N8Z6.
SwissPalmiQ8N8Z6.

Polymorphism and mutation databases

BioMutaiDCBLD1.
DMDMi50400555.

Proteomic databases

EPDiQ8N8Z6.
MaxQBiQ8N8Z6.
PaxDbiQ8N8Z6.
PRIDEiQ8N8Z6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296955; ENSP00000296955; ENSG00000164465. [Q8N8Z6-2]
ENST00000338728; ENSP00000342422; ENSG00000164465. [Q8N8Z6-1]
GeneIDi285761.
KEGGihsa:285761.
UCSCiuc003pxs.4. human. [Q8N8Z6-1]

Organism-specific databases

CTDi285761.
GeneCardsiDCBLD1.
HGNCiHGNC:21479. DCBLD1.
HPAiHPA059667.
neXtProtiNX_Q8N8Z6.
PharmGKBiPA134903108.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II5Z. Eukaryota.
ENOG4110JCT. LUCA.
GeneTreeiENSGT00760000119073.
HOGENOMiHOG000000681.
HOVERGENiHBG051317.
InParanoidiQ8N8Z6.
OMAiGPQPGHK.
OrthoDBiEOG7J446F.
PhylomeDBiQ8N8Z6.

Miscellaneous databases

GenomeRNAii285761.
NextBioi95761.
PROiQ8N8Z6.

Gene expression databases

BgeeiQ8N8Z6.
CleanExiHS_DCBLD1.
ExpressionAtlasiQ8N8Z6. baseline and differential.
GenevisibleiQ8N8Z6. HS.

Family and domain databases

Gene3Di2.170.130.20. 1 hit.
2.60.120.260. 1 hit.
2.60.120.290. 1 hit.
InterProiIPR000859. CUB_dom.
IPR000421. FA58C.
IPR008979. Galactose-bd-like.
IPR004043. LCCL.
[Graphical view]
PfamiPF00431. CUB. 1 hit.
PF00754. F5_F8_type_C. 1 hit.
PF03815. LCCL. 1 hit.
[Graphical view]
SMARTiSM00042. CUB. 1 hit.
SM00231. FA58C. 1 hit.
SM00603. LCCL. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF49854. SSF49854. 1 hit.
SSF69848. SSF69848. 1 hit.
PROSITEiPS01180. CUB. 1 hit.
PS01285. FA58C_1. 1 hit.
PS50022. FA58C_3. 1 hit.
PS50820. LCCL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  4. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiDCBD1_HUMAN
AccessioniPrimary (citable) accession number: Q8N8Z6
Secondary accession number(s): Q5H992
, Q8IYK5, Q8N7L9, Q96NH2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: May 11, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.