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Protein

Zinc finger protein 41 homolog

Gene

ZFP41

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

A putative DNA-binding regulatory protein associated with meiosis in spermatogenesis.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri87 – 109C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri115 – 137C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri143 – 165C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri171 – 193C2H2-type 4PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Spermatogenesis, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 41 homolog
Short name:
Zfp-41
Gene namesi
Name:ZFP41
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:26786. ZFP41.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670529.

Polymorphism and mutation databases

DMDMi74760014.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002961861 – 198Zinc finger protein 41 homologAdd BLAST198

Proteomic databases

PaxDbiQ8N8Y5.
PeptideAtlasiQ8N8Y5.
PRIDEiQ8N8Y5.

PTM databases

iPTMnetiQ8N8Y5.
PhosphoSitePlusiQ8N8Y5.

Expressioni

Gene expression databases

CleanExiHS_ZFP41.
GenevisibleiQ8N8Y5. HS.

Organism-specific databases

HPAiHPA047232.
HPA056268.

Interactioni

Protein-protein interaction databases

BioGridi130307. 46 interactors.
IntActiQ8N8Y5. 3 interactors.
STRINGi9606.ENSP00000428966.

Structurei

3D structure databases

ProteinModelPortaliQ8N8Y5.
SMRiQ8N8Y5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri87 – 109C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri115 – 137C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri143 – 165C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri171 – 193C2H2-type 4PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOGENOMiHOG000234617.
HOVERGENiHBG098192.
InParanoidiQ8N8Y5.
OMAiRHPRKKH.
PhylomeDBiQ8N8Y5.
TreeFamiTF337091.

Family and domain databases

InterProiView protein in InterPro
IPR036236. Znf_C2H2_sf.
IPR013087. Znf_C2H2_type.
SMARTiView protein in SMART
SM00355. ZnF_C2H2. 4 hits.
SUPFAMiSSF57667. SSF57667. 2 hits.
PROSITEiView protein in PROSITE
PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.

Sequencei

Sequence statusi: Complete.

Q8N8Y5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKPAGRKKK TPTPREEADV QKSALREEKV SGDRKPPERP TVPRKPRTEP
60 70 80 90 100
CLSPEDEEHV FDAFDASFKD DFEGVPVFIP FQRKKPYECS ECGRIFKHKT
110 120 130 140 150
DHIRHQRVHT GEKPFKCAQC GKAFRHSSDV TKHQRTHTGE KPFKCGECGK
160 170 180 190
AFNCGSNLLK HQKTHTGEKP YECTHCGKAF AYSSCLIRHQ KRHPRKKP
Length:198
Mass (Da):22,806
Last modified:October 1, 2002 - v1
Checksum:iA41841AA44CCBDE1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096024 mRNA. Translation: BAC04676.1.
CH471162 Genomic DNA. Translation: EAW82273.1.
CH471162 Genomic DNA. Translation: EAW82274.1.
CH471162 Genomic DNA. Translation: EAW82275.1.
BC034608 mRNA. Translation: AAH34608.1.
RefSeqiNP_001258085.2. NM_001271156.2.
NP_776193.2. NM_173832.5.
UniGeneiHs.668016.

Genome annotation databases

EnsembliENST00000626353; ENSP00000486248; ENSG00000181638.
ENST00000627729; ENSP00000486020; ENSG00000181638.
GeneIDi286128.
KEGGihsa:286128.
UCSCiuc003yxw.5. human.

Similar proteinsi

Entry informationi

Entry nameiZFP41_HUMAN
AccessioniPrimary (citable) accession number: Q8N8Y5
Secondary accession number(s): D3DWJ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: October 1, 2002
Last modified: November 22, 2017
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families