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Q8N8Y5

- ZFP41_HUMAN

UniProt

Q8N8Y5 - ZFP41_HUMAN

Protein

Zinc finger protein 41 homolog

Gene

ZFP41

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    A putative DNA-binding regulatory protein associated with meiosis in spermatogenesis.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri87 – 10923C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri115 – 13723C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri143 – 16523C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri171 – 19323C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. multicellular organismal development Source: UniProtKB-KW
    3. regulation of transcription, DNA-templated Source: UniProtKB-KW
    4. spermatogenesis Source: UniProtKB-KW
    5. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Spermatogenesis, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 41 homolog
    Short name:
    Zfp-41
    Gene namesi
    Name:ZFP41
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:26786. ZFP41.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142670529.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 198198Zinc finger protein 41 homologPRO_0000296186Add
    BLAST

    Proteomic databases

    PRIDEiQ8N8Y5.

    Expressioni

    Gene expression databases

    BgeeiQ8N8Y5.
    CleanExiHS_ZFP41.
    GenevestigatoriQ8N8Y5.

    Organism-specific databases

    HPAiHPA056268.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N8Y5.
    SMRiQ8N8Y5. Positions 58-198.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 4 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri87 – 10923C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri115 – 13723C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri143 – 16523C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri171 – 19323C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    HOGENOMiHOG000234617.
    HOVERGENiHBG098192.
    InParanoidiQ8N8Y5.
    OMAiFTPFQRK.
    PhylomeDBiQ8N8Y5.
    TreeFamiTF337091.

    Family and domain databases

    Gene3Di3.30.160.60. 4 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 4 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
    PS50157. ZINC_FINGER_C2H2_2. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8N8Y5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEKPAGRKKK TPTPREEADV QKSALREEKV SGDRKPPERP TVPRKPRTEP    50
    CLSPEDEEHV FDAFDASFKD DFEGVPVFIP FQRKKPYECS ECGRIFKHKT 100
    DHIRHQRVHT GEKPFKCAQC GKAFRHSSDV TKHQRTHTGE KPFKCGECGK 150
    AFNCGSNLLK HQKTHTGEKP YECTHCGKAF AYSSCLIRHQ KRHPRKKP 198
    Length:198
    Mass (Da):22,806
    Last modified:October 1, 2002 - v1
    Checksum:iA41841AA44CCBDE1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK096024 mRNA. Translation: BAC04676.1.
    CH471162 Genomic DNA. Translation: EAW82273.1.
    CH471162 Genomic DNA. Translation: EAW82274.1.
    CH471162 Genomic DNA. Translation: EAW82275.1.
    BC034608 mRNA. Translation: AAH34608.1.
    RefSeqiNP_001258085.2. NM_001271156.2.
    NP_776193.2. NM_173832.5.
    UniGeneiHs.668016.

    Genome annotation databases

    EnsembliENST00000330701; ENSP00000327427; ENSG00000181638.
    ENST00000520584; ENSP00000430465; ENSG00000181638.
    GeneIDi286128.
    KEGGihsa:286128.
    UCSCiuc003yxw.4. human.

    Polymorphism databases

    DMDMi74760014.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK096024 mRNA. Translation: BAC04676.1 .
    CH471162 Genomic DNA. Translation: EAW82273.1 .
    CH471162 Genomic DNA. Translation: EAW82274.1 .
    CH471162 Genomic DNA. Translation: EAW82275.1 .
    BC034608 mRNA. Translation: AAH34608.1 .
    RefSeqi NP_001258085.2. NM_001271156.2.
    NP_776193.2. NM_173832.5.
    UniGenei Hs.668016.

    3D structure databases

    ProteinModelPortali Q8N8Y5.
    SMRi Q8N8Y5. Positions 58-198.
    ModBasei Search...
    MobiDBi Search...

    Polymorphism databases

    DMDMi 74760014.

    Proteomic databases

    PRIDEi Q8N8Y5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000330701 ; ENSP00000327427 ; ENSG00000181638 .
    ENST00000520584 ; ENSP00000430465 ; ENSG00000181638 .
    GeneIDi 286128.
    KEGGi hsa:286128.
    UCSCi uc003yxw.4. human.

    Organism-specific databases

    CTDi 286128.
    GeneCardsi GC08P144331.
    HGNCi HGNC:26786. ZFP41.
    HPAi HPA056268.
    neXtProti NX_Q8N8Y5.
    PharmGKBi PA142670529.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000234617.
    HOVERGENi HBG098192.
    InParanoidi Q8N8Y5.
    OMAi FTPFQRK.
    PhylomeDBi Q8N8Y5.
    TreeFami TF337091.

    Miscellaneous databases

    GenomeRNAii 286128.
    NextBioi 96001.
    PROi Q8N8Y5.

    Gene expression databases

    Bgeei Q8N8Y5.
    CleanExi HS_ZFP41.
    Genevestigatori Q8N8Y5.

    Family and domain databases

    Gene3Di 3.30.160.60. 4 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 4 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 4 hits.
    PS50157. ZINC_FINGER_C2H2_2. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiZFP41_HUMAN
    AccessioniPrimary (citable) accession number: Q8N8Y5
    Secondary accession number(s): D3DWJ5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 24, 2007
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3