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Protein

Zinc finger protein 41 homolog

Gene

ZFP41

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

A putative DNA-binding regulatory protein associated with meiosis in spermatogenesis.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri87 – 10923C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri115 – 13723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri143 – 16523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri171 – 19323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 41 homolog
Short name:
Zfp-41
Gene namesi
Name:ZFP41
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:26786. ZFP41.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670529.

Polymorphism and mutation databases

DMDMi74760014.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 198198Zinc finger protein 41 homologPRO_0000296186Add
BLAST

Proteomic databases

PRIDEiQ8N8Y5.

Expressioni

Gene expression databases

BgeeiQ8N8Y5.
CleanExiHS_ZFP41.
GenevisibleiQ8N8Y5. HS.

Organism-specific databases

HPAiHPA056268.

Interactioni

Protein-protein interaction databases

BioGridi130307. 35 interactions.
STRINGi9606.ENSP00000428966.

Structurei

3D structure databases

ProteinModelPortaliQ8N8Y5.
SMRiQ8N8Y5. Positions 84-198.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 4 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri87 – 10923C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri115 – 13723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri143 – 16523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri171 – 19323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00800000124281.
HOGENOMiHOG000234617.
HOVERGENiHBG098192.
InParanoidiQ8N8Y5.
OMAiRHPRKKH.
PhylomeDBiQ8N8Y5.
TreeFamiTF337091.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 4 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N8Y5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKPAGRKKK TPTPREEADV QKSALREEKV SGDRKPPERP TVPRKPRTEP
60 70 80 90 100
CLSPEDEEHV FDAFDASFKD DFEGVPVFIP FQRKKPYECS ECGRIFKHKT
110 120 130 140 150
DHIRHQRVHT GEKPFKCAQC GKAFRHSSDV TKHQRTHTGE KPFKCGECGK
160 170 180 190
AFNCGSNLLK HQKTHTGEKP YECTHCGKAF AYSSCLIRHQ KRHPRKKP
Length:198
Mass (Da):22,806
Last modified:October 1, 2002 - v1
Checksum:iA41841AA44CCBDE1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096024 mRNA. Translation: BAC04676.1.
CH471162 Genomic DNA. Translation: EAW82273.1.
CH471162 Genomic DNA. Translation: EAW82274.1.
CH471162 Genomic DNA. Translation: EAW82275.1.
BC034608 mRNA. Translation: AAH34608.1.
RefSeqiNP_001258085.2. NM_001271156.2.
NP_776193.2. NM_173832.5.
UniGeneiHs.668016.

Genome annotation databases

EnsembliENST00000626353; ENSP00000486248; ENSG00000181638.
ENST00000627729; ENSP00000486020; ENSG00000181638.
GeneIDi286128.
KEGGihsa:286128.
UCSCiuc003yxw.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096024 mRNA. Translation: BAC04676.1.
CH471162 Genomic DNA. Translation: EAW82273.1.
CH471162 Genomic DNA. Translation: EAW82274.1.
CH471162 Genomic DNA. Translation: EAW82275.1.
BC034608 mRNA. Translation: AAH34608.1.
RefSeqiNP_001258085.2. NM_001271156.2.
NP_776193.2. NM_173832.5.
UniGeneiHs.668016.

3D structure databases

ProteinModelPortaliQ8N8Y5.
SMRiQ8N8Y5. Positions 84-198.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130307. 35 interactions.
STRINGi9606.ENSP00000428966.

Polymorphism and mutation databases

DMDMi74760014.

Proteomic databases

PRIDEiQ8N8Y5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000626353; ENSP00000486248; ENSG00000181638.
ENST00000627729; ENSP00000486020; ENSG00000181638.
GeneIDi286128.
KEGGihsa:286128.
UCSCiuc003yxw.4. human.

Organism-specific databases

CTDi286128.
GeneCardsiGC08P144331.
HGNCiHGNC:26786. ZFP41.
HPAiHPA056268.
neXtProtiNX_Q8N8Y5.
PharmGKBiPA142670529.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00800000124281.
HOGENOMiHOG000234617.
HOVERGENiHBG098192.
InParanoidiQ8N8Y5.
OMAiRHPRKKH.
PhylomeDBiQ8N8Y5.
TreeFamiTF337091.

Miscellaneous databases

GenomeRNAii286128.
NextBioi96001.
PROiQ8N8Y5.

Gene expression databases

BgeeiQ8N8Y5.
CleanExiHS_ZFP41.
GenevisibleiQ8N8Y5. HS.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 4 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiZFP41_HUMAN
AccessioniPrimary (citable) accession number: Q8N8Y5
Secondary accession number(s): D3DWJ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: October 1, 2002
Last modified: July 22, 2015
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.