Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

V-type proton ATPase subunit d 2

Gene

ATP6V0D2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

BioCyciMetaCyc:HS07458-MONOMER
ReactomeiR-HSA-1222556 ROS, RNS production in phagocytes
R-HSA-77387 Insulin receptor recycling
R-HSA-917977 Transferrin endocytosis and recycling
R-HSA-983712 Ion channel transport

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit d 2
Short name:
V-ATPase subunit d 2
Alternative name(s):
Vacuolar proton pump subunit d 2
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000147614.3
HGNCiHGNC:18266 ATP6V0D2
neXtProtiNX_Q8N8Y2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi245972
OpenTargetsiENSG00000147614
PharmGKBiPA38516

Polymorphism and mutation databases

BioMutaiATP6V0D2
DMDMi74729555

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002856571 – 350V-type proton ATPase subunit d 2Add BLAST350

Proteomic databases

EPDiQ8N8Y2
MaxQBiQ8N8Y2
PaxDbiQ8N8Y2
PeptideAtlasiQ8N8Y2
PRIDEiQ8N8Y2
ProteomicsDBi72473

PTM databases

iPTMnetiQ8N8Y2
PhosphoSitePlusiQ8N8Y2

Expressioni

Tissue specificityi

Kidney, osteoclast and lung.1 Publication

Gene expression databases

BgeeiENSG00000147614
CleanExiHS_ATP6V0D2
ExpressionAtlasiQ8N8Y2 baseline and differential
GenevisibleiQ8N8Y2 HS

Organism-specific databases

HPAiHPA055327
HPA058496

Interactioni

Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).

Protein-protein interaction databases

BioGridi128858, 23 interactors
IntActiQ8N8Y2, 17 interactors
STRINGi9606.ENSP00000285393

Structurei

3D structure databases

ProteinModelPortaliQ8N8Y2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the V-ATPase V0D/AC39 subunit family.Curated

Phylogenomic databases

eggNOGiKOG2957 Eukaryota
COG1527 LUCA
GeneTreeiENSGT00390000002200
HOGENOMiHOG000199065
HOVERGENiHBG018065
InParanoidiQ8N8Y2
KOiK02146
OMAiDCMSENT
OrthoDBiEOG091G09L5
PhylomeDBiQ8N8Y2
TreeFamiTF300857

Family and domain databases

Gene3Di1.20.1690.10, 2 hits
InterProiView protein in InterPro
IPR036079 ATPase_su_C-like
IPR002843 ATPase_V0-cplx_csu/dsu
IPR016727 ATPase_V0-cplx_dsu
IPR035067 V-type_ATPase_suC
PANTHERiPTHR11028 PTHR11028, 1 hit
PfamiView protein in Pfam
PF01992 vATP-synt_AC39, 1 hit
PIRSFiPIRSF018497 V-ATP_synth_D, 1 hit
SUPFAMiSSF103486 SSF103486, 1 hit

Sequencei

Sequence statusi: Complete.

Q8N8Y2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLEGAELYFN VDHGYLEGLV RGCKASLLTQ QDYINLVQCE TLEDLKIHLQ
60 70 80 90 100
TTDYGNFLAN HTNPLTVSKI DTEMRKRLCG EFEYFRNHSL EPLSTFLTYM
110 120 130 140 150
TCSYMIDNVI LLMNGALQKK SVKEILGKCH PLGRFTEMEA VNIAETPSDL
160 170 180 190 200
FNAILIETPL APFFQDCMSE NALDELNIEL LRNKLYKSYL EAFYKFCKNH
210 220 230 240 250
GDVTAEVMCP ILEFEADRRA FIITLNSFGT ELSKEDRETL YPTFGKLYPE
260 270 280 290 300
GLRLLAQAED FDQMKNVADH YGVYKPLFEA VGGSGGKTLE DVFYEREVQM
310 320 330 340 350
NVLAFNRQFH YGVFYAYVKL KEQEIRNIVW IAECISQRHR TKINSYIPIL
Length:350
Mass (Da):40,426
Last modified:October 1, 2002 - v1
Checksum:i07658C37F2A10CB7
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032039272G → R. Corresponds to variant dbSNP:rs10094744Ensembl.1
Natural variantiVAR_032040295E → K. Corresponds to variant dbSNP:rs4263741Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY079172 mRNA Translation: AAL87000.1
AK096027 mRNA Translation: BAC04679.1
BC065207 mRNA Translation: AAH65207.1
CCDSiCCDS6241.1
RefSeqiNP_689778.1, NM_152565.1
UniGeneiHs.436360

Genome annotation databases

EnsembliENST00000285393; ENSP00000285393; ENSG00000147614
GeneIDi245972
KEGGihsa:245972
UCSCiuc003ydp.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiVA0D2_HUMAN
AccessioniPrimary (citable) accession number: Q8N8Y2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: October 1, 2002
Last modified: June 20, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health