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Protein

Zinc finger CCHC domain-containing protein 5

Gene

ZCCHC5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri443 – 46220CCHC-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger CCHC domain-containing protein 5
Gene namesi
Name:ZCCHC5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:22997. ZCCHC5.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134958360.

Polymorphism and mutation databases

BioMutaiZCCHC5.
DMDMi34223121.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 475475Zinc finger CCHC domain-containing protein 5PRO_0000150956Add
BLAST

Proteomic databases

PaxDbiQ8N8U3.
PRIDEiQ8N8U3.

PTM databases

PhosphoSiteiQ8N8U3.

Expressioni

Gene expression databases

BgeeiQ8N8U3.
CleanExiHS_ZCCHC5.
GenevisibleiQ8N8U3. HS.

Organism-specific databases

HPAiHPA051991.
HPA053174.

Structurei

3D structure databases

ProteinModelPortaliQ8N8U3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi61 – 194134Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 CCHC-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri443 – 46220CCHC-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410JFQX. Eukaryota.
ENOG4111E4H. LUCA.
GeneTreeiENSGT00840000129902.
HOGENOMiHOG000143388.
HOVERGENiHBG056204.
InParanoidiQ8N8U3.
OMAiQDTFDNP.
OrthoDBiEOG70KGNZ.
PhylomeDBiQ8N8U3.
TreeFamiTF335133.

Family and domain databases

Gene3Di4.10.60.10. 1 hit.
InterProiIPR032549. DUF4939.
IPR032567. LDOC1-rel.
IPR001878. Znf_CCHC.
[Graphical view]
PANTHERiPTHR15503. PTHR15503. 1 hit.
PfamiPF16297. DUF4939. 1 hit.
PF00098. zf-CCHC. 1 hit.
[Graphical view]
SMARTiSM00343. ZnF_C2HC. 1 hit.
[Graphical view]
SUPFAMiSSF57756. SSF57756. 1 hit.
PROSITEiPS50158. ZF_CCHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N8U3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVEDLAASYI VLKLENEIRQ AQVQWLMEEN AALQAQIPEL QKSQAAKEYD
60 70 80 90 100
LLRKSSEAKE PQKLPEHMNP PAAWEAQKTP EFKEPQKPPE PQDLLPWEPP
110 120 130 140 150
AAWELQEAPA APESLAPPAT RESQKPPMAH EIPTVLEGQG PANTQDATIA
160 170 180 190 200
QEPKNSEPQD PPNIEKPQEA PEYQETAAQL EFLELPPPQE PLEPSNAQEF
210 220 230 240 250
LELSAAQESL EGLIVVETSA ASEFPQAPIG LEATDFPLQY TLTFSGDSQK
260 270 280 290 300
LPEFLVQLYS YMRVRGHLYP TEAALVSFVG NCFSGRAGWW FQLLLDIQSP
310 320 330 340 350
LLEQCESFIP VLQDTFDNPE NMKDANQCIH QLCQGEGHVA THFHLIAQEL
360 370 380 390 400
NWDESTLWIQ FQEGLASSIQ DELSHTSPAT NLSDLITQCI SLEEKPDPNP
410 420 430 440 450
LGKSSSAEGD GPESPPAENQ PMQAAINCPH ISEAEWVRWH KGRLCLYCGY
460 470
PGHFARDCPV KPHQALQAGN IQACQ
Length:475
Mass (Da):52,817
Last modified:October 1, 2002 - v1
Checksum:i0A56ABB62220F56D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti117 – 1171P → S.1 Publication
Corresponds to variant rs4077512 [ dbSNP | Ensembl ].
VAR_053752

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096184 mRNA. Translation: BAC04719.1.
AL662885 Genomic DNA. Translation: CAI41449.1.
BC136548 mRNA. Translation: AAI36549.1.
BC136549 mRNA. Translation: AAI36550.1.
CCDSiCCDS14440.1.
RefSeqiNP_689907.1. NM_152694.2.
XP_011529188.1. XM_011530886.1.
UniGeneiHs.134873.

Genome annotation databases

EnsembliENST00000321110; ENSP00000316794; ENSG00000179300.
GeneIDi203430.
KEGGihsa:203430.
UCSCiuc004edc.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096184 mRNA. Translation: BAC04719.1.
AL662885 Genomic DNA. Translation: CAI41449.1.
BC136548 mRNA. Translation: AAI36549.1.
BC136549 mRNA. Translation: AAI36550.1.
CCDSiCCDS14440.1.
RefSeqiNP_689907.1. NM_152694.2.
XP_011529188.1. XM_011530886.1.
UniGeneiHs.134873.

3D structure databases

ProteinModelPortaliQ8N8U3.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ8N8U3.

Polymorphism and mutation databases

BioMutaiZCCHC5.
DMDMi34223121.

Proteomic databases

PaxDbiQ8N8U3.
PRIDEiQ8N8U3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000321110; ENSP00000316794; ENSG00000179300.
GeneIDi203430.
KEGGihsa:203430.
UCSCiuc004edc.1. human.

Organism-specific databases

CTDi203430.
GeneCardsiZCCHC5.
HGNCiHGNC:22997. ZCCHC5.
HPAiHPA051991.
HPA053174.
neXtProtiNX_Q8N8U3.
PharmGKBiPA134958360.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JFQX. Eukaryota.
ENOG4111E4H. LUCA.
GeneTreeiENSGT00840000129902.
HOGENOMiHOG000143388.
HOVERGENiHBG056204.
InParanoidiQ8N8U3.
OMAiQDTFDNP.
OrthoDBiEOG70KGNZ.
PhylomeDBiQ8N8U3.
TreeFamiTF335133.

Miscellaneous databases

GenomeRNAii203430.
NextBioi90428.
PROiQ8N8U3.

Gene expression databases

BgeeiQ8N8U3.
CleanExiHS_ZCCHC5.
GenevisibleiQ8N8U3. HS.

Family and domain databases

Gene3Di4.10.60.10. 1 hit.
InterProiIPR032549. DUF4939.
IPR032567. LDOC1-rel.
IPR001878. Znf_CCHC.
[Graphical view]
PANTHERiPTHR15503. PTHR15503. 1 hit.
PfamiPF16297. DUF4939. 1 hit.
PF00098. zf-CCHC. 1 hit.
[Graphical view]
SMARTiSM00343. ZnF_C2HC. 1 hit.
[Graphical view]
SUPFAMiSSF57756. SSF57756. 1 hit.
PROSITEiPS50158. ZF_CCHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-117.

Entry informationi

Entry nameiZCHC5_HUMAN
AccessioniPrimary (citable) accession number: Q8N8U3
Secondary accession number(s): B2RMZ0, Q5JQE9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: October 1, 2002
Last modified: May 11, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.