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Protein

Retrotransposon Gag-like protein 3

Gene

RTL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May function as a transcriptional regulator. Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal.By similarity

Miscellaneous

RTL3 is one of at least 11 genes called Mar or Mart related to long terminal repeat retrotransposons. They do not correspond to functional retrotransposons, but rather to neofunctionalized retrotransposons genes.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri443 – 462CCHC-typePROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Retrotransposon Gag-like protein 3Imported
Alternative name(s):
Zinc finger CCHC domain-containing protein 5Curated
Gene namesi
Name:RTL3Imported
Synonyms:MAR31 Publication, MART31 Publication, ZCCHC5Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000179300.3.
HGNCiHGNC:22997. RTL3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi203430.
OpenTargetsiENSG00000179300.
PharmGKBiPA134958360.

Polymorphism and mutation databases

BioMutaiZCCHC5.
DMDMi34223121.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001509561 – 475Retrotransposon Gag-like protein 3Add BLAST475

Proteomic databases

PaxDbiQ8N8U3.
PRIDEiQ8N8U3.

PTM databases

PhosphoSitePlusiQ8N8U3.

Expressioni

Gene expression databases

BgeeiENSG00000179300.
CleanExiHS_ZCCHC5.
GenevisibleiQ8N8U3. HS.

Organism-specific databases

HPAiHPA051991.
HPA053174.
HPA075136.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000316794.

Structurei

3D structure databases

ProteinModelPortaliQ8N8U3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi61 – 194Pro-richAdd BLAST134

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri443 – 462CCHC-typePROSITE-ProRule annotationAdd BLAST20

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410JFQX. Eukaryota.
ENOG4111E4H. LUCA.
GeneTreeiENSGT00880000138019.
HOGENOMiHOG000143388.
HOVERGENiHBG056204.
InParanoidiQ8N8U3.
OMAiYMRVRGH.
OrthoDBiEOG091G02TH.
PhylomeDBiQ8N8U3.
TreeFamiTF335133.

Family and domain databases

Gene3Di4.10.60.10. 1 hit.
InterProiView protein in InterPro
IPR032549. DUF4939.
IPR032567. LDOC1-rel.
IPR001878. Znf_CCHC.
PANTHERiPTHR15503. PTHR15503. 1 hit.
PfamiView protein in Pfam
PF16297. DUF4939. 1 hit.
PF00098. zf-CCHC. 1 hit.
SMARTiView protein in SMART
SM00343. ZnF_C2HC. 1 hit.
SUPFAMiSSF57756. SSF57756. 1 hit.
PROSITEiView protein in PROSITE
PS50158. ZF_CCHC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8N8U3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVEDLAASYI VLKLENEIRQ AQVQWLMEEN AALQAQIPEL QKSQAAKEYD
60 70 80 90 100
LLRKSSEAKE PQKLPEHMNP PAAWEAQKTP EFKEPQKPPE PQDLLPWEPP
110 120 130 140 150
AAWELQEAPA APESLAPPAT RESQKPPMAH EIPTVLEGQG PANTQDATIA
160 170 180 190 200
QEPKNSEPQD PPNIEKPQEA PEYQETAAQL EFLELPPPQE PLEPSNAQEF
210 220 230 240 250
LELSAAQESL EGLIVVETSA ASEFPQAPIG LEATDFPLQY TLTFSGDSQK
260 270 280 290 300
LPEFLVQLYS YMRVRGHLYP TEAALVSFVG NCFSGRAGWW FQLLLDIQSP
310 320 330 340 350
LLEQCESFIP VLQDTFDNPE NMKDANQCIH QLCQGEGHVA THFHLIAQEL
360 370 380 390 400
NWDESTLWIQ FQEGLASSIQ DELSHTSPAT NLSDLITQCI SLEEKPDPNP
410 420 430 440 450
LGKSSSAEGD GPESPPAENQ PMQAAINCPH ISEAEWVRWH KGRLCLYCGY
460 470
PGHFARDCPV KPHQALQAGN IQACQ
Length:475
Mass (Da):52,817
Last modified:October 1, 2002 - v1
Checksum:i0A56ABB62220F56D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053752117P → S1 PublicationCorresponds to variant dbSNP:rs4077512Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096184 mRNA. Translation: BAC04719.1.
AL662885 Genomic DNA. No translation available.
BC136548 mRNA. Translation: AAI36549.1.
BC136549 mRNA. Translation: AAI36550.1.
CCDSiCCDS14440.1.
RefSeqiNP_689907.1. NM_152694.2.
UniGeneiHs.134873.

Genome annotation databases

EnsembliENST00000321110; ENSP00000316794; ENSG00000179300.
GeneIDi203430.
KEGGihsa:203430.
UCSCiuc004edc.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRTL3_HUMAN
AccessioniPrimary (citable) accession number: Q8N8U3
Secondary accession number(s): B2RMZ0, Q5JQE9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: October 1, 2002
Last modified: September 27, 2017
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations