Q8N8U2 (CDYL2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chromodomain Y-like protein 2
Short name=CDY-like 2

Gene names

Name:

CDYL2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	506 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Nucleus By similarity.
Tissue specificity	Ubiquitously expressed. Ref.1
Sequence similarities	Contains 1 chromo domain.

Ontologies

Keywords
Cellular component	Nucleus
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	catalytic activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 506

506

Chromodomain Y-like protein 2

PRO_0000080223

Regions

Domain

7 – 67

61

Chromo

Experimental info

Sequence conflict

196

1

N → D in BAC04720. Ref.2

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

506

Helix Strand Turn

Details...

Beta strand

6 – 17

12

Beta strand

23 – 29

7

Helix

34 – 36

3

Beta strand

38 – 41

4

Helix

42 – 44

3

Beta strand

45 – 47

3

Sequences

	Sequence		Length	Mass (Da)
	Q8N8U2 [UniParc]. Last modified May 5, 2009. Version 2. Checksum: C5093B57FDF6AEBE	FASTA	506	56,500
	10 20 30 40 50 60 MASGDLYEVE RIVDKRKNKK GKWEYLIRWK GYGSTEDTWE PEHHLLHCEE FIDEFNGLHM 70 80 90 100 110 120 SKDKRIKSGK QSSTSKLLRD SRGPSVEKLS HRPSDPGKSK GTSHKRKRIN PPLAKPKKGY 130 140 150 160 170 180 SGKPSSGGDR ATKTVSYRTT PSGLQIMPLK KSQNGMENGD AGSEKDERHF GNGSHQPGLD 190 200 210 220 230 240 LNDHVGEQDM GECDVNHATL AENGLGSALT NGGLNLHSPV KRKLEAEKDY VFDKRLRYSV 250 260 270 280 290 300 RQNESNCRFR DIVVRKEEGF THILLSSQTS DNNALTPEIM KEVRRALCNA ATDDSKLLLL 310 320 330 340 350 360 SAVGSVFCSG LDYSYLIGRL SSDRRKESTR IAEAIRDFVK AFIQFKKPIV VAINGPALGL 370 380 390 400 410 420 GASILPLCDI VWASEKAWFQ TPYATIRLTP AGCSSYTFPQ ILGVALANEM LFCGRKLTAQ 430 440 450 460 470 480 EACSRGLVSQ VFWPTTFSQE VMLRVKEMAS CSAVVLEESK CLVRSFLKSV LEDVNEKECL 490 500 MLKQLWSSSK GLDSLFSYLQ DKIYEV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The CDY-related gene family: coordinated evolution in copy number, expression profile and protein sequence." Dorus S., Gilbert S.L., Forster M.L., Barndt R.J., Lahn B.T. Hum. Mol. Genet. 12:1643-1650(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A. Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AY273798 mRNA. Translation: AAP83842.1.
AK096185 mRNA. Translation: BAC04720.1.
AC092332 Genomic DNA. No translation available.
BC069440 mRNA. Translation: AAH69440.1.
BC100803 mRNA. Translation: AAI00804.1.
BC100804 mRNA. Translation: AAI00805.1.
BC100805 mRNA. Translation: AAI00806.1.
BC100806 mRNA. Translation: AAI00807.1.

IPI

IPI00178475.

RefSeq

NP_689555.2. NM_152342.2.

UniGene

Hs.373908.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
4HAE	X-ray	2.00	A	2-64	[»]

ProteinModelPortal

Q8N8U2.

ModBase

Search...

Protein-protein interaction databases

STRING

9606.ENSP00000299564.

PTM databases

PhosphoSite

Q8N8U2.

Polymorphism databases

DMDM

229462825.

Proteomic databases

PaxDb

Q8N8U2.

PRIDE

Q8N8U2.

Protocols and materials databases

DNASU

124359.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000299564; ENSP00000299564; ENSG00000166446.

GeneID

124359.

KEGG

hsa:124359.

UCSC

uc002ffs.3. human.

Organism-specific databases

CTD

124359.

GeneCards

GC16M080637.

H-InvDB

HIX0013264.

HGNC

HGNC:23030. CDYL2.

HPA

HPA041016.

neXtProt

NX_Q8N8U2.

PharmGKB

PA134903387.

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG1024.

HOGENOM

HOG000111507.

HOVERGEN

HBG006723.

InParanoid

Q8N8U2.

OMA

KRINPPL.

OrthoDB

EOG437RDT.

PhylomeDB

Q8N8U2.

Gene expression databases

ArrayExpress

Q8N8U2.

Bgee

Q8N8U2.

CleanEx

HS_CDYL2.

Genevestigator

Q8N8U2.

GermOnline

ENSG00000166446. Homo sapiens.

Family and domain databases

InterPro

IPR023780. Chromo_domain.
IPR000953. Chromo_domain/shadow.
IPR016197. Chromodomain-like.
IPR023779. Chromodomain_CS.
IPR001753. Crotonase_core_superfam.
[Graphical view]

Pfam

PF00385. Chromo. 1 hit.
PF00378. ECH. 1 hit.
[Graphical view]

SMART

SM00298. CHROMO. 1 hit.
[Graphical view]

SUPFAM

SSF54160. Chromodomain-like. 1 hit.

PROSITE

PS00598. CHROMO_1. 1 hit.
PS50013. CHROMO_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

CDYL2. human.

GenomeRNAi

124359.

NextBio

81257.

Entry information

Entry name

CDYL2_HUMAN

Accession

Primary (citable) accession number: Q8N8U2
Secondary accession number(s): Q7Z5I8

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2003
Last sequence update:	May 5, 2009
Last modified:	May 1, 2013
This is version 85 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.