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Q8N8U2

- CDYL2_HUMAN

UniProt

Q8N8U2 - CDYL2_HUMAN

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Protein

Chromodomain Y-like protein 2

Gene

CDYL2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. catalytic activity Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Chromodomain Y-like protein 2
Short name:
CDY-like 2
Gene namesi
Name:CDYL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:23030. CDYL2.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134903387.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 506506Chromodomain Y-like protein 2PRO_0000080223Add
BLAST

Proteomic databases

MaxQBiQ8N8U2.
PaxDbiQ8N8U2.
PRIDEiQ8N8U2.

PTM databases

PhosphoSiteiQ8N8U2.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiQ8N8U2.
CleanExiHS_CDYL2.
ExpressionAtlasiQ8N8U2. baseline and differential.
GenevestigatoriQ8N8U2.

Organism-specific databases

HPAiHPA041016.

Interactioni

Subunit structurei

Interacts (via chromo domain) with histone H3K9me3.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
PRMT5O147442EBI-8467076,EBI-351098

Protein-protein interaction databases

BioGridi125860. 2 interactions.
IntActiQ8N8U2. 1 interaction.
MINTiMINT-8417653.
STRINGi9606.ENSP00000299564.

Structurei

Secondary structure

1
506
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi6 – 1712Combined sources
Beta strandi23 – 297Combined sources
Turni30 – 323Combined sources
Helixi34 – 363Combined sources
Beta strandi38 – 414Combined sources
Helixi42 – 443Combined sources
Beta strandi45 – 473Combined sources
Helixi50 – 589Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2MJ8NMR-A2-64[»]
4HAEX-ray2.00A2-64[»]
ProteinModelPortaliQ8N8U2.
SMRiQ8N8U2. Positions 2-64, 248-505.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 6761ChromoPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 chromo domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG1024.
GeneTreeiENSGT00760000119100.
HOGENOMiHOG000111507.
HOVERGENiHBG006723.
InParanoidiQ8N8U2.
OrthoDBiEOG72RN06.
PhylomeDBiQ8N8U2.
TreeFamiTF313375.

Family and domain databases

Gene3Di3.90.226.10. 1 hit.
InterProiIPR023780. Chromo_domain.
IPR000953. Chromo_domain/shadow.
IPR016197. Chromodomain-like.
IPR023779. Chromodomain_CS.
IPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
[Graphical view]
PfamiPF00385. Chromo. 1 hit.
PF00378. ECH. 1 hit.
[Graphical view]
SMARTiSM00298. CHROMO. 1 hit.
[Graphical view]
SUPFAMiSSF52096. SSF52096. 1 hit.
SSF54160. SSF54160. 1 hit.
PROSITEiPS00598. CHROMO_1. 1 hit.
PS50013. CHROMO_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N8U2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASGDLYEVE RIVDKRKNKK GKWEYLIRWK GYGSTEDTWE PEHHLLHCEE
60 70 80 90 100
FIDEFNGLHM SKDKRIKSGK QSSTSKLLRD SRGPSVEKLS HRPSDPGKSK
110 120 130 140 150
GTSHKRKRIN PPLAKPKKGY SGKPSSGGDR ATKTVSYRTT PSGLQIMPLK
160 170 180 190 200
KSQNGMENGD AGSEKDERHF GNGSHQPGLD LNDHVGEQDM GECDVNHATL
210 220 230 240 250
AENGLGSALT NGGLNLHSPV KRKLEAEKDY VFDKRLRYSV RQNESNCRFR
260 270 280 290 300
DIVVRKEEGF THILLSSQTS DNNALTPEIM KEVRRALCNA ATDDSKLLLL
310 320 330 340 350
SAVGSVFCSG LDYSYLIGRL SSDRRKESTR IAEAIRDFVK AFIQFKKPIV
360 370 380 390 400
VAINGPALGL GASILPLCDI VWASEKAWFQ TPYATIRLTP AGCSSYTFPQ
410 420 430 440 450
ILGVALANEM LFCGRKLTAQ EACSRGLVSQ VFWPTTFSQE VMLRVKEMAS
460 470 480 490 500
CSAVVLEESK CLVRSFLKSV LEDVNEKECL MLKQLWSSSK GLDSLFSYLQ

DKIYEV
Length:506
Mass (Da):56,500
Last modified:May 5, 2009 - v2
Checksum:iC5093B57FDF6AEBE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti196 – 1961N → D in BAC04720. (PubMed:14702039)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY273798 mRNA. Translation: AAP83842.1.
AK096185 mRNA. Translation: BAC04720.1.
AC092332 Genomic DNA. No translation available.
BC069440 mRNA. Translation: AAH69440.1.
BC100803 mRNA. Translation: AAI00804.1.
BC100804 mRNA. Translation: AAI00805.1.
BC100805 mRNA. Translation: AAI00806.1.
BC100806 mRNA. Translation: AAI00807.1.
CCDSiCCDS32493.1.
RefSeqiNP_689555.2. NM_152342.2.
UniGeneiHs.373908.

Genome annotation databases

EnsembliENST00000570137; ENSP00000476295; ENSG00000166446.
GeneIDi124359.
KEGGihsa:124359.
UCSCiuc002ffs.3. human.

Polymorphism databases

DMDMi229462825.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY273798 mRNA. Translation: AAP83842.1 .
AK096185 mRNA. Translation: BAC04720.1 .
AC092332 Genomic DNA. No translation available.
BC069440 mRNA. Translation: AAH69440.1 .
BC100803 mRNA. Translation: AAI00804.1 .
BC100804 mRNA. Translation: AAI00805.1 .
BC100805 mRNA. Translation: AAI00806.1 .
BC100806 mRNA. Translation: AAI00807.1 .
CCDSi CCDS32493.1.
RefSeqi NP_689555.2. NM_152342.2.
UniGenei Hs.373908.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2MJ8 NMR - A 2-64 [» ]
4HAE X-ray 2.00 A 2-64 [» ]
ProteinModelPortali Q8N8U2.
SMRi Q8N8U2. Positions 2-64, 248-505.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 125860. 2 interactions.
IntActi Q8N8U2. 1 interaction.
MINTi MINT-8417653.
STRINGi 9606.ENSP00000299564.

PTM databases

PhosphoSitei Q8N8U2.

Polymorphism databases

DMDMi 229462825.

Proteomic databases

MaxQBi Q8N8U2.
PaxDbi Q8N8U2.
PRIDEi Q8N8U2.

Protocols and materials databases

DNASUi 124359.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000570137 ; ENSP00000476295 ; ENSG00000166446 .
GeneIDi 124359.
KEGGi hsa:124359.
UCSCi uc002ffs.3. human.

Organism-specific databases

CTDi 124359.
GeneCardsi GC16M080637.
H-InvDB HIX0013264.
HGNCi HGNC:23030. CDYL2.
HPAi HPA041016.
neXtProti NX_Q8N8U2.
PharmGKBi PA134903387.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1024.
GeneTreei ENSGT00760000119100.
HOGENOMi HOG000111507.
HOVERGENi HBG006723.
InParanoidi Q8N8U2.
OrthoDBi EOG72RN06.
PhylomeDBi Q8N8U2.
TreeFami TF313375.

Miscellaneous databases

ChiTaRSi CDYL2. human.
GenomeRNAii 124359.
NextBioi 81257.
PROi Q8N8U2.

Gene expression databases

Bgeei Q8N8U2.
CleanExi HS_CDYL2.
ExpressionAtlasi Q8N8U2. baseline and differential.
Genevestigatori Q8N8U2.

Family and domain databases

Gene3Di 3.90.226.10. 1 hit.
InterProi IPR023780. Chromo_domain.
IPR000953. Chromo_domain/shadow.
IPR016197. Chromodomain-like.
IPR023779. Chromodomain_CS.
IPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
[Graphical view ]
Pfami PF00385. Chromo. 1 hit.
PF00378. ECH. 1 hit.
[Graphical view ]
SMARTi SM00298. CHROMO. 1 hit.
[Graphical view ]
SUPFAMi SSF52096. SSF52096. 1 hit.
SSF54160. SSF54160. 1 hit.
PROSITEi PS00598. CHROMO_1. 1 hit.
PS50013. CHROMO_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The CDY-related gene family: coordinated evolution in copy number, expression profile and protein sequence."
    Dorus S., Gilbert S.L., Forster M.L., Barndt R.J., Lahn B.T.
    Hum. Mol. Genet. 12:1643-1650(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiCDYL2_HUMAN
AccessioniPrimary (citable) accession number: Q8N8U2
Secondary accession number(s): Q7Z5I8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: May 5, 2009
Last modified: November 26, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3