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Q8N8U2

- CDYL2_HUMAN

UniProt

Q8N8U2 - CDYL2_HUMAN

Protein

Chromodomain Y-like protein 2

Gene

CDYL2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 2 (05 May 2009)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. catalytic activity Source: InterPro
    2. protein binding Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chromodomain Y-like protein 2
    Short name:
    CDY-like 2
    Gene namesi
    Name:CDYL2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:23030. CDYL2.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134903387.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 506506Chromodomain Y-like protein 2PRO_0000080223Add
    BLAST

    Proteomic databases

    MaxQBiQ8N8U2.
    PaxDbiQ8N8U2.
    PRIDEiQ8N8U2.

    PTM databases

    PhosphoSiteiQ8N8U2.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed.1 Publication

    Gene expression databases

    ArrayExpressiQ8N8U2.
    BgeeiQ8N8U2.
    CleanExiHS_CDYL2.
    GenevestigatoriQ8N8U2.

    Organism-specific databases

    HPAiHPA041016.

    Interactioni

    Subunit structurei

    Interacts (via chromo domain) with histone H3K9me3.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PRMT5O147442EBI-8467076,EBI-351098

    Protein-protein interaction databases

    BioGridi125860. 2 interactions.
    IntActiQ8N8U2. 1 interaction.
    MINTiMINT-8417653.
    STRINGi9606.ENSP00000299564.

    Structurei

    Secondary structure

    1
    506
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi6 – 1712
    Beta strandi23 – 297
    Turni30 – 323
    Helixi34 – 363
    Beta strandi38 – 414
    Helixi42 – 443
    Beta strandi45 – 473
    Helixi50 – 589

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2MJ8NMR-A2-64[»]
    4HAEX-ray2.00A2-64[»]
    ProteinModelPortaliQ8N8U2.
    SMRiQ8N8U2. Positions 2-60, 248-505.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini7 – 6761ChromoPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 chromo domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG1024.
    HOGENOMiHOG000111507.
    HOVERGENiHBG006723.
    InParanoidiQ8N8U2.
    OrthoDBiEOG72RN06.
    PhylomeDBiQ8N8U2.
    TreeFamiTF313375.

    Family and domain databases

    Gene3Di3.90.226.10. 1 hit.
    InterProiIPR023780. Chromo_domain.
    IPR000953. Chromo_domain/shadow.
    IPR016197. Chromodomain-like.
    IPR023779. Chromodomain_CS.
    IPR029045. ClpP/crotonase-like_dom.
    IPR001753. Crotonase_core_superfam.
    [Graphical view]
    PfamiPF00385. Chromo. 1 hit.
    PF00378. ECH. 1 hit.
    [Graphical view]
    SMARTiSM00298. CHROMO. 1 hit.
    [Graphical view]
    SUPFAMiSSF52096. SSF52096. 1 hit.
    SSF54160. SSF54160. 1 hit.
    PROSITEiPS00598. CHROMO_1. 1 hit.
    PS50013. CHROMO_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8N8U2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASGDLYEVE RIVDKRKNKK GKWEYLIRWK GYGSTEDTWE PEHHLLHCEE    50
    FIDEFNGLHM SKDKRIKSGK QSSTSKLLRD SRGPSVEKLS HRPSDPGKSK 100
    GTSHKRKRIN PPLAKPKKGY SGKPSSGGDR ATKTVSYRTT PSGLQIMPLK 150
    KSQNGMENGD AGSEKDERHF GNGSHQPGLD LNDHVGEQDM GECDVNHATL 200
    AENGLGSALT NGGLNLHSPV KRKLEAEKDY VFDKRLRYSV RQNESNCRFR 250
    DIVVRKEEGF THILLSSQTS DNNALTPEIM KEVRRALCNA ATDDSKLLLL 300
    SAVGSVFCSG LDYSYLIGRL SSDRRKESTR IAEAIRDFVK AFIQFKKPIV 350
    VAINGPALGL GASILPLCDI VWASEKAWFQ TPYATIRLTP AGCSSYTFPQ 400
    ILGVALANEM LFCGRKLTAQ EACSRGLVSQ VFWPTTFSQE VMLRVKEMAS 450
    CSAVVLEESK CLVRSFLKSV LEDVNEKECL MLKQLWSSSK GLDSLFSYLQ 500
    DKIYEV 506
    Length:506
    Mass (Da):56,500
    Last modified:May 5, 2009 - v2
    Checksum:iC5093B57FDF6AEBE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti196 – 1961N → D in BAC04720. (PubMed:14702039)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY273798 mRNA. Translation: AAP83842.1.
    AK096185 mRNA. Translation: BAC04720.1.
    AC092332 Genomic DNA. No translation available.
    BC069440 mRNA. Translation: AAH69440.1.
    BC100803 mRNA. Translation: AAI00804.1.
    BC100804 mRNA. Translation: AAI00805.1.
    BC100805 mRNA. Translation: AAI00806.1.
    BC100806 mRNA. Translation: AAI00807.1.
    CCDSiCCDS32493.1.
    RefSeqiNP_689555.2. NM_152342.2.
    UniGeneiHs.373908.

    Genome annotation databases

    EnsembliENST00000570137; ENSP00000476295; ENSG00000166446.
    GeneIDi124359.
    KEGGihsa:124359.
    UCSCiuc002ffs.3. human.

    Polymorphism databases

    DMDMi229462825.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY273798 mRNA. Translation: AAP83842.1 .
    AK096185 mRNA. Translation: BAC04720.1 .
    AC092332 Genomic DNA. No translation available.
    BC069440 mRNA. Translation: AAH69440.1 .
    BC100803 mRNA. Translation: AAI00804.1 .
    BC100804 mRNA. Translation: AAI00805.1 .
    BC100805 mRNA. Translation: AAI00806.1 .
    BC100806 mRNA. Translation: AAI00807.1 .
    CCDSi CCDS32493.1.
    RefSeqi NP_689555.2. NM_152342.2.
    UniGenei Hs.373908.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2MJ8 NMR - A 2-64 [» ]
    4HAE X-ray 2.00 A 2-64 [» ]
    ProteinModelPortali Q8N8U2.
    SMRi Q8N8U2. Positions 2-60, 248-505.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125860. 2 interactions.
    IntActi Q8N8U2. 1 interaction.
    MINTi MINT-8417653.
    STRINGi 9606.ENSP00000299564.

    PTM databases

    PhosphoSitei Q8N8U2.

    Polymorphism databases

    DMDMi 229462825.

    Proteomic databases

    MaxQBi Q8N8U2.
    PaxDbi Q8N8U2.
    PRIDEi Q8N8U2.

    Protocols and materials databases

    DNASUi 124359.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000570137 ; ENSP00000476295 ; ENSG00000166446 .
    GeneIDi 124359.
    KEGGi hsa:124359.
    UCSCi uc002ffs.3. human.

    Organism-specific databases

    CTDi 124359.
    GeneCardsi GC16M080637.
    H-InvDB HIX0013264.
    HGNCi HGNC:23030. CDYL2.
    HPAi HPA041016.
    neXtProti NX_Q8N8U2.
    PharmGKBi PA134903387.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1024.
    HOGENOMi HOG000111507.
    HOVERGENi HBG006723.
    InParanoidi Q8N8U2.
    OrthoDBi EOG72RN06.
    PhylomeDBi Q8N8U2.
    TreeFami TF313375.

    Miscellaneous databases

    ChiTaRSi CDYL2. human.
    GenomeRNAii 124359.
    NextBioi 81257.
    PROi Q8N8U2.

    Gene expression databases

    ArrayExpressi Q8N8U2.
    Bgeei Q8N8U2.
    CleanExi HS_CDYL2.
    Genevestigatori Q8N8U2.

    Family and domain databases

    Gene3Di 3.90.226.10. 1 hit.
    InterProi IPR023780. Chromo_domain.
    IPR000953. Chromo_domain/shadow.
    IPR016197. Chromodomain-like.
    IPR023779. Chromodomain_CS.
    IPR029045. ClpP/crotonase-like_dom.
    IPR001753. Crotonase_core_superfam.
    [Graphical view ]
    Pfami PF00385. Chromo. 1 hit.
    PF00378. ECH. 1 hit.
    [Graphical view ]
    SMARTi SM00298. CHROMO. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52096. SSF52096. 1 hit.
    SSF54160. SSF54160. 1 hit.
    PROSITEi PS00598. CHROMO_1. 1 hit.
    PS50013. CHROMO_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The CDY-related gene family: coordinated evolution in copy number, expression profile and protein sequence."
      Dorus S., Gilbert S.L., Forster M.L., Barndt R.J., Lahn B.T.
      Hum. Mol. Genet. 12:1643-1650(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
      , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
      Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiCDYL2_HUMAN
    AccessioniPrimary (citable) accession number: Q8N8U2
    Secondary accession number(s): Q7Z5I8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2003
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 96 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3