Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Chromodomain Y-like protein 2

Gene

CDYL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Chromodomain Y-like protein 2
Short name:
CDY-like 2
Gene namesi
Name:CDYL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000166446.14.
HGNCiHGNC:23030. CDYL2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi124359.
OpenTargetsiENSG00000166446.
PharmGKBiPA134903387.

Polymorphism and mutation databases

BioMutaiCDYL2.
DMDMi229462825.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000802231 – 506Chromodomain Y-like protein 2Add BLAST506

Proteomic databases

EPDiQ8N8U2.
MaxQBiQ8N8U2.
PaxDbiQ8N8U2.
PeptideAtlasiQ8N8U2.
PRIDEiQ8N8U2.

PTM databases

iPTMnetiQ8N8U2.
PhosphoSitePlusiQ8N8U2.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSG00000166446.
CleanExiHS_CDYL2.
ExpressionAtlasiQ8N8U2. baseline and differential.
GenevisibleiQ8N8U2. HS.

Organism-specific databases

HPAiHPA041016.

Interactioni

Subunit structurei

Interacts (via chromo domain) with histone H3K9me3.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
PRMT5O147442EBI-8467076,EBI-351098

GO - Molecular functioni

Protein-protein interaction databases

BioGridi125860. 11 interactors.
IntActiQ8N8U2. 15 interactors.
MINTiMINT-8417653.
STRINGi9606.ENSP00000299564.

Structurei

Secondary structure

1506
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 17Combined sources12
Beta strandi23 – 29Combined sources7
Turni30 – 32Combined sources3
Helixi34 – 36Combined sources3
Beta strandi38 – 41Combined sources4
Helixi42 – 44Combined sources3
Beta strandi45 – 47Combined sources3
Helixi50 – 58Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MJ8NMR-A2-64[»]
4HAEX-ray2.00A2-64[»]
5JJZX-ray2.00A2-66[»]
ProteinModelPortaliQ8N8U2.
SMRiQ8N8U2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 67ChromoAdd BLAST61

Phylogenomic databases

eggNOGiKOG0016. Eukaryota.
KOG1911. Eukaryota.
COG1024. LUCA.
GeneTreeiENSGT00890000139344.
HOGENOMiHOG000111507.
HOVERGENiHBG006723.
InParanoidiQ8N8U2.
KOiK00653.
PhylomeDBiQ8N8U2.
TreeFamiTF313375.

Family and domain databases

CDDicd00024. CHROMO. 1 hit.
Gene3Di1.10.12.10. 1 hit.
InterProiView protein in InterPro
IPR016197. Chromo-like_dom_sf.
IPR000953. Chromo/chromo_shadow_dom.
IPR023780. Chromo_domain.
IPR023779. Chromodomain_CS.
IPR029045. ClpP/crotonase-like_dom_sf.
IPR014748. Crontonase_C.
IPR001753. Crotonase_core_superfam.
PfamiView protein in Pfam
PF00385. Chromo. 1 hit.
PF00378. ECH_1. 1 hit.
SMARTiView protein in SMART
SM00298. CHROMO. 1 hit.
SUPFAMiSSF52096. SSF52096. 1 hit.
SSF54160. SSF54160. 1 hit.
PROSITEiView protein in PROSITE
PS00598. CHROMO_1. 1 hit.
PS50013. CHROMO_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8N8U2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASGDLYEVE RIVDKRKNKK GKWEYLIRWK GYGSTEDTWE PEHHLLHCEE
60 70 80 90 100
FIDEFNGLHM SKDKRIKSGK QSSTSKLLRD SRGPSVEKLS HRPSDPGKSK
110 120 130 140 150
GTSHKRKRIN PPLAKPKKGY SGKPSSGGDR ATKTVSYRTT PSGLQIMPLK
160 170 180 190 200
KSQNGMENGD AGSEKDERHF GNGSHQPGLD LNDHVGEQDM GECDVNHATL
210 220 230 240 250
AENGLGSALT NGGLNLHSPV KRKLEAEKDY VFDKRLRYSV RQNESNCRFR
260 270 280 290 300
DIVVRKEEGF THILLSSQTS DNNALTPEIM KEVRRALCNA ATDDSKLLLL
310 320 330 340 350
SAVGSVFCSG LDYSYLIGRL SSDRRKESTR IAEAIRDFVK AFIQFKKPIV
360 370 380 390 400
VAINGPALGL GASILPLCDI VWASEKAWFQ TPYATIRLTP AGCSSYTFPQ
410 420 430 440 450
ILGVALANEM LFCGRKLTAQ EACSRGLVSQ VFWPTTFSQE VMLRVKEMAS
460 470 480 490 500
CSAVVLEESK CLVRSFLKSV LEDVNEKECL MLKQLWSSSK GLDSLFSYLQ

DKIYEV
Length:506
Mass (Da):56,500
Last modified:May 5, 2009 - v2
Checksum:iC5093B57FDF6AEBE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti196N → D in BAC04720 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY273798 mRNA. Translation: AAP83842.1.
AK096185 mRNA. Translation: BAC04720.1.
AC092332 Genomic DNA. No translation available.
BC069440 mRNA. Translation: AAH69440.1.
BC100803 mRNA. Translation: AAI00804.1.
BC100804 mRNA. Translation: AAI00805.1.
BC100805 mRNA. Translation: AAI00806.1.
BC100806 mRNA. Translation: AAI00807.1.
CCDSiCCDS32493.1.
RefSeqiNP_689555.2. NM_152342.3.
UniGeneiHs.373908.
Hs.60257.

Genome annotation databases

EnsembliENST00000570137; ENSP00000476295; ENSG00000166446.
GeneIDi124359.
KEGGihsa:124359.
UCSCiuc002ffs.4. human.

Similar proteinsi

Entry informationi

Entry nameiCDYL2_HUMAN
AccessioniPrimary (citable) accession number: Q8N8U2
Secondary accession number(s): Q7Z5I8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: May 5, 2009
Last modified: November 22, 2017
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references