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Protein

ARL14 effector protein

Gene

ARL14EP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Through its interaction with ARL14 and MYO1E, may connect MHC class II-containing cytoplasmic vesicles to the actin network and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
ARL14 effector protein
Alternative name(s):
ARF7 effector protein
Gene namesi
Name:ARL14EP
Synonyms:ARF7EP, C11orf46
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:26798. ARL14EP.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672291.

Polymorphism and mutation databases

BioMutaiARL14EP.
DMDMi74729511.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 260260ARL14 effector proteinPRO_0000251892Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8N8R7.
MaxQBiQ8N8R7.
PaxDbiQ8N8R7.
PRIDEiQ8N8R7.

PTM databases

iPTMnetiQ8N8R7.
PhosphoSiteiQ8N8R7.

Expressioni

Tissue specificityi

Expressed in the immune system.1 Publication

Gene expression databases

BgeeiQ8N8R7.
CleanExiHS_C11orf46.
ExpressionAtlasiQ8N8R7. baseline and differential.
GenevisibleiQ8N8R7. HS.

Organism-specific databases

HPAiHPA039634.
HPA048127.

Interactioni

Subunit structurei

Interacts with ARL14 and MYO1E.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ARL14Q8N4G23EBI-2807994,EBI-3921493
MYO1EQ129652EBI-2807994,EBI-4279548
SETDB2Q96T683EBI-2807994,EBI-1222089

Protein-protein interaction databases

BioGridi125690. 8 interactions.
IntActiQ8N8R7. 7 interactions.
STRINGi9606.ENSP00000282032.

Structurei

3D structure databases

ProteinModelPortaliQ8N8R7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi209 – 23729Cys-richAdd
BLAST

Phylogenomic databases

eggNOGiKOG4850. Eukaryota.
ENOG4111QTN. LUCA.
GeneTreeiENSGT00510000047210.
HOGENOMiHOG000232178.
HOVERGENiHBG055275.
InParanoidiQ8N8R7.
OMAiFANPGRQ.
OrthoDBiEOG7S4X8Z.
PhylomeDBiQ8N8R7.
TreeFamiTF333216.

Family and domain databases

InterProiIPR026515. ARF14EP.
IPR029264. ARF7EP_C.
[Graphical view]
PANTHERiPTHR23080:SF72. PTHR23080:SF72. 1 hit.
PfamiPF14949. ARF7EP_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N8R7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMDPCSVGVQ LRTTNECHKT YYTRHTGFKT LQELSSNDML LLQLRTGMTL
60 70 80 90 100
SGNNTICFHH VKIYIDRFED LQKSCCDPFN IHKKLAKKNL HVIDLDDATF
110 120 130 140 150
LSAKFGRQLV PGWKLCPKCT QIINGSVDVD TEDRQKRKPE SDGRTAKALR
160 170 180 190 200
SLQFTNPGRQ TEFAPETGKR EKRRLTKNAT AGSDRQVIPA KSKVYDSQGL
210 220 230 240 250
LIFSGMDLCD CLDEDCLGCF YACPACGSTK CGAECRCDRK WLYEQIEIEG
260
GEIIHNKHAG
Length:260
Mass (Da):29,338
Last modified:October 1, 2002 - v1
Checksum:i18B70E7DB57B3252
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti88 – 881K → KK in CAI46092 (PubMed:17974005).Curated
Sequence conflicti245 – 2451Q → QK in CAI46092 (PubMed:17974005).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti180 – 1801T → P.
Corresponds to variant rs7940297 [ dbSNP | Ensembl ].
VAR_033740

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096287 mRNA. Translation: BAC04747.1.
BX647617 mRNA. Translation: CAI46092.1.
BC047775 mRNA. Translation: AAH47775.1.
CCDSiCCDS7869.1.
RefSeqiNP_689529.1. NM_152316.2.
UniGeneiHs.502208.

Genome annotation databases

EnsembliENST00000282032; ENSP00000282032; ENSG00000152219.
GeneIDi120534.
KEGGihsa:120534.
UCSCiuc001mso.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096287 mRNA. Translation: BAC04747.1.
BX647617 mRNA. Translation: CAI46092.1.
BC047775 mRNA. Translation: AAH47775.1.
CCDSiCCDS7869.1.
RefSeqiNP_689529.1. NM_152316.2.
UniGeneiHs.502208.

3D structure databases

ProteinModelPortaliQ8N8R7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125690. 8 interactions.
IntActiQ8N8R7. 7 interactions.
STRINGi9606.ENSP00000282032.

PTM databases

iPTMnetiQ8N8R7.
PhosphoSiteiQ8N8R7.

Polymorphism and mutation databases

BioMutaiARL14EP.
DMDMi74729511.

Proteomic databases

EPDiQ8N8R7.
MaxQBiQ8N8R7.
PaxDbiQ8N8R7.
PRIDEiQ8N8R7.

Protocols and materials databases

DNASUi120534.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000282032; ENSP00000282032; ENSG00000152219.
GeneIDi120534.
KEGGihsa:120534.
UCSCiuc001mso.2. human.

Organism-specific databases

CTDi120534.
GeneCardsiARL14EP.
H-InvDBHIX0017336.
HGNCiHGNC:26798. ARL14EP.
HPAiHPA039634.
HPA048127.
MIMi612295. gene.
neXtProtiNX_Q8N8R7.
PharmGKBiPA142672291.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4850. Eukaryota.
ENOG4111QTN. LUCA.
GeneTreeiENSGT00510000047210.
HOGENOMiHOG000232178.
HOVERGENiHBG055275.
InParanoidiQ8N8R7.
OMAiFANPGRQ.
OrthoDBiEOG7S4X8Z.
PhylomeDBiQ8N8R7.
TreeFamiTF333216.

Miscellaneous databases

GenomeRNAii120534.
NextBioi80603.
PROiQ8N8R7.
SOURCEiSearch...

Gene expression databases

BgeeiQ8N8R7.
CleanExiHS_C11orf46.
ExpressionAtlasiQ8N8R7. baseline and differential.
GenevisibleiQ8N8R7. HS.

Family and domain databases

InterProiIPR026515. ARF14EP.
IPR029264. ARF7EP_C.
[Graphical view]
PANTHERiPTHR23080:SF72. PTHR23080:SF72. 1 hit.
PfamiPF14949. ARF7EP_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Teratocarcinoma.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.
  4. "A Genome-wide multidimensional RNAi screen reveals pathways controlling MHC class II antigen presentation."
    Paul P., van den Hoorn T., Jongsma M.L., Bakker M.J., Hengeveld R., Janssen L., Cresswell P., Egan D.A., van Ham M., Ten Brinke A., Ovaa H., Beijersbergen R.L., Kuijl C., Neefjes J.
    Cell 145:268-283(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH ARL14 AND MYO1E, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  5. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiAL14E_HUMAN
AccessioniPrimary (citable) accession number: Q8N8R7
Secondary accession number(s): Q5HYH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 1, 2002
Last modified: May 11, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.