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Protein

Mitochondrial basic amino acids transporter

Gene

SLC25A29

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transports arginine, lysine, homoarginine, methylarginine and, to a much lesser extent, ornithine and histidine (PubMed:24652292). Can restore ornithine transport in cells lacking the primary mitochondrial ornithine transporter SLC25A15 (PubMed:19287344). Does not transport carnitine nor acylcarnitines (PubMed:24652292). Functions by both counter-exchange and uniport mechanisms (PubMed:24652292).2 Publications

GO - Molecular functioni

  • acyl carnitine transmembrane transporter activity Source: GO_Central
  • amino acid transmembrane transporter activity Source: GO_Central
  • basic amino acid transmembrane transporter activity Source: UniProtKB
  • high-affinity arginine transmembrane transporter activity Source: UniProtKB
  • high-affinity lysine transmembrane transporter activity Source: UniProtKB

GO - Biological processi

  • amino acid transport Source: GO_Central
  • L-arginine transmembrane transport Source: UniProtKB
  • L-histidine transmembrane transport Source: UniProtKB
  • L-lysine transmembrane transport Source: UniProtKB
  • mitochondrial L-ornithine transmembrane transport Source: UniProtKB
  • mitochondrial transport Source: GO_Central
  • ornithine transport Source: UniProtKB

Keywordsi

Biological processAmino-acid transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-352230. Amino acid transport across the plasma membrane.

Protein family/group databases

TCDBi2.A.29.8.9. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial basic amino acids transporter
Alternative name(s):
Carnitine/acylcarnitine translocase-like
Short name:
CACT-like
Mitochondrial carnitine/acylcarnitine carrier protein CACL
Mitochondrial ornithine transporter 3
Solute carrier family 25 member 29
Gene namesi
Name:SLC25A29
Synonyms:C14orf69, ORNT3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000197119.12.
HGNCiHGNC:20116. SLC25A29.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei2 – 22Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei61 – 81Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei96 – 116Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei153 – 172Helical; Name=4Sequence analysisAdd BLAST20
Transmembranei187 – 207Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei255 – 275Helical; Name=6Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi123096.
OpenTargetsiENSG00000197119.
PharmGKBiPA134980581.

Chemistry databases

DrugBankiDB00583. L-Carnitine.

Polymorphism and mutation databases

BioMutaiSLC25A29.
DMDMi31340019.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000906321 – 303Mitochondrial basic amino acids transporterAdd BLAST303

Proteomic databases

EPDiQ8N8R3.
MaxQBiQ8N8R3.
PaxDbiQ8N8R3.
PeptideAtlasiQ8N8R3.
PRIDEiQ8N8R3.

PTM databases

iPTMnetiQ8N8R3.
PhosphoSitePlusiQ8N8R3.

Expressioni

Gene expression databases

BgeeiENSG00000197119.
CleanExiHS_SLC25A29.
ExpressionAtlasiQ8N8R3. baseline and differential.
GenevisibleiQ8N8R3. HS.

Organism-specific databases

HPAiHPA030781.

Interactioni

Protein-protein interaction databases

BioGridi125814. 4 interactors.
STRINGi9606.ENSP00000352167.

Structurei

3D structure databases

ProteinModelPortaliQ8N8R3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati2 – 86Solcar 1Add BLAST85
Repeati90 – 178Solcar 2Add BLAST89
Repeati185 – 275Solcar 3Add BLAST91

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0758. Eukaryota.
ENOG410XS86. LUCA.
GeneTreeiENSGT00700000104295.
HOGENOMiHOG000168307.
HOVERGENiHBG003500.
InParanoidiQ8N8R3.
KOiK15109.
OMAiGVCVSIQ.
OrthoDBiEOG091G0HVE.
PhylomeDBiQ8N8R3.
TreeFamiTF351739.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiView protein in InterPro
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom_sf.
PfamiView protein in Pfam
PF00153. Mito_carr. 3 hits.
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiView protein in PROSITE
PS50920. SOLCAR. 3 hits.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N8R3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALDFLAGCA GGVAGVLVGH PFDTVKVRLQ VQSVEKPQYR GTLHCFKSII
60 70 80 90 100
KQESVLGLYK GLGSPLMGLT FINALVFGVQ GNTLRALGHD SPLNQFLAGA
110 120 130 140 150
AAGAIQCVIC CPMELAKTRL QLQDAGPART YKGSLDCLAQ IYGHEGLRGV
160 170 180 190 200
NRGMVSTLLR ETPSFGVYFL TYDALTRALG CEPGDRLLVP KLLLAGGTSG
210 220 230 240 250
IVSWLSTYPV DVVKSRLQAD GLRGAPRYRG ILDCVHQSYR AEGWRVFTRG
260 270 280 290 300
LASTLLRAFP VNAATFATVT VVLTYARGEE AGPEGEAVPA APAGPALAQP

SSL
Length:303
Mass (Da):32,062
Last modified:May 30, 2003 - v2
Checksum:i34C2D596781EE58A
GO
Isoform 2 (identifier: Q8N8R3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     13-145: VAGVLVGHPF...DCLAQIYGHE → TASGPERGEA...QPGHGVHVAA
     146-303: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:145
Mass (Da):14,504
Checksum:i351A973379EAF6EA
GO
Isoform 3 (identifier: Q8N8R3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-66: Missing.

Note: No experimental confirmation available.
Show »
Length:237
Mass (Da):25,051
Checksum:iAB0E43F7F7052DD5
GO

Sequence cautioni

The sequence CAD62317 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0553351 – 66Missing in isoform 3. 2 PublicationsAdd BLAST66
Alternative sequenceiVSP_04628613 – 145VAGVL…IYGHE → TASGPERGEASVPRDVALLQ VHHQARERAGPVQGPGLAAH GAHLHQRAGVRGAGQHPPGP GPRLAPQPVPGRCGGGRHPV RHLLPHGAGQDAAAAAGRGP SAHLQGLAGLPRADLRARGS AWRQPGHGVHVAA in isoform 2. 1 PublicationAdd BLAST133
Alternative sequenceiVSP_046287146 – 303Missing in isoform 2. 1 PublicationAdd BLAST158

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX247983 mRNA. Translation: CAD62317.1. Different initiation.
AK095532 mRNA. Translation: BAG53079.1.
AK096294 mRNA. Translation: BAC04751.1.
AK123821 mRNA. Translation: BAG53964.1.
AK172788 mRNA. Translation: BAD18767.1.
AK289627 mRNA. Translation: BAF82316.1.
AL157871 Genomic DNA. No translation available.
CH471061 Genomic DNA. Translation: EAW81692.1.
CH471061 Genomic DNA. Translation: EAW81695.1.
BC132964 mRNA. Translation: AAI32965.1.
BC132966 mRNA. Translation: AAI32967.1.
CCDSiCCDS32156.1. [Q8N8R3-1]
RefSeqiNP_001034444.1. NM_001039355.2. [Q8N8R3-1]
NP_001278742.1. NM_001291813.1. [Q8N8R3-3]
NP_001278743.1. NM_001291814.1. [Q8N8R3-3]
NP_689546.1. NM_152333.3. [Q8N8R3-3]
XP_011534748.1. XM_011536446.1. [Q8N8R3-3]
XP_011534749.1. XM_011536447.1. [Q8N8R3-3]
XP_011534750.1. XM_011536448.1. [Q8N8R3-3]
XP_016876469.1. XM_017020980.1. [Q8N8R3-3]
XP_016876470.1. XM_017020981.1. [Q8N8R3-3]
XP_016876471.1. XM_017020982.1. [Q8N8R3-3]
XP_016876472.1. XM_017020983.1. [Q8N8R3-3]
XP_016876473.1. XM_017020984.1. [Q8N8R3-3]
XP_016876474.1. XM_017020985.1. [Q8N8R3-3]
XP_016876475.1. XM_017020986.1. [Q8N8R3-3]
XP_016876476.1. XM_017020987.1. [Q8N8R3-3]
UniGeneiHs.578109.

Genome annotation databases

EnsembliENST00000359232; ENSP00000352167; ENSG00000197119. [Q8N8R3-1]
ENST00000392908; ENSP00000376640; ENSG00000197119. [Q8N8R3-2]
ENST00000554912; ENSP00000450913; ENSG00000197119. [Q8N8R3-3]
ENST00000555927; ENSP00000452078; ENSG00000197119. [Q8N8R3-3]
ENST00000556505; ENSP00000452446; ENSG00000197119. [Q8N8R3-3]
GeneIDi123096.
KEGGihsa:123096.
UCSCiuc001yha.4. human. [Q8N8R3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMCATL_HUMAN
AccessioniPrimary (citable) accession number: Q8N8R3
Secondary accession number(s): A3KMR5, Q541V0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2003
Last sequence update: May 30, 2003
Last modified: November 22, 2017
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families