Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Magnesium transporter NIPA2

Gene

NIPA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a selective Mg2+ transporter.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

BioCyciZFISH:ENSG00000140157-MONOMER.
ReactomeiR-HSA-5223345. Miscellaneous transport and binding events.

Protein family/group databases

TCDBi2.A.7.25.2. the drug/metabolite transporter (dmt) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Magnesium transporter NIPA2
Alternative name(s):
Non-imprinted in Prader-Willi/Angelman syndrome region protein 2
Gene namesi
Name:NIPA2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:17044. NIPA2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9ExtracellularSequence analysis9
Transmembranei10 – 30HelicalSequence analysisAdd BLAST21
Topological domaini31 – 56CytoplasmicSequence analysisAdd BLAST26
Transmembranei57 – 77HelicalSequence analysisAdd BLAST21
Topological domaini78ExtracellularSequence analysis1
Transmembranei79 – 99HelicalSequence analysisAdd BLAST21
Topological domaini100 – 107CytoplasmicSequence analysis8
Transmembranei108 – 128HelicalSequence analysisAdd BLAST21
Topological domaini129 – 149ExtracellularSequence analysisAdd BLAST21
Transmembranei150 – 170HelicalSequence analysisAdd BLAST21
Topological domaini171 – 175CytoplasmicSequence analysis5
Transmembranei176 – 196HelicalSequence analysisAdd BLAST21
Topological domaini197 – 215ExtracellularSequence analysisAdd BLAST19
Transmembranei216 – 236HelicalSequence analysisAdd BLAST21
Topological domaini237 – 246CytoplasmicSequence analysis10
Transmembranei247 – 267HelicalSequence analysisAdd BLAST21
Topological domaini268 – 278ExtracellularSequence analysisAdd BLAST11
Transmembranei279 – 299HelicalSequence analysisAdd BLAST21
Topological domaini300 – 360CytoplasmicSequence analysisAdd BLAST61

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi81614.
OpenTargetsiENSG00000140157.
PharmGKBiPA134911294.

Polymorphism and mutation databases

BioMutaiNIPA2.
DMDMi73921217.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001917431 – 360Magnesium transporter NIPA2Add BLAST360

Proteomic databases

MaxQBiQ8N8Q9.
PaxDbiQ8N8Q9.
PeptideAtlasiQ8N8Q9.
PRIDEiQ8N8Q9.

PTM databases

iPTMnetiQ8N8Q9.
PhosphoSitePlusiQ8N8Q9.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSG00000140157.
CleanExiHS_NIPA2.
ExpressionAtlasiQ8N8Q9. baseline and differential.
GenevisibleiQ8N8Q9. HS.

Organism-specific databases

HPAiHPA067160.
HPA071342.

Interactioni

Protein-protein interaction databases

BioGridi123549. 2 interactors.
STRINGi9606.ENSP00000337618.

Structurei

3D structure databases

ProteinModelPortaliQ8N8Q9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NIPA family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2922. Eukaryota.
ENOG410XNR8. LUCA.
GeneTreeiENSGT00550000074395.
HOGENOMiHOG000203962.
HOVERGENiHBG055032.
InParanoidiQ8N8Q9.
OMAiEWEHMGA.
OrthoDBiEOG091G0M8A.
PhylomeDBiQ8N8Q9.
TreeFamiTF313214.

Family and domain databases

InterProiIPR008521. Mg_trans_NIPA.
[Graphical view]
PANTHERiPTHR12570. PTHR12570. 1 hit.
PfamiPF05653. Mg_trans_NIPA. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N8Q9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSQGRGKYDF YIGLGLAMSS SIFIGGSFIL KKKGLLRLAR KGSMRAGQGG
60 70 80 90 100
HAYLKEWLWW AGLLSMGAGE VANFAAYAFA PATLVTPLGA LSVLVSAILS
110 120 130 140 150
SYFLNERLNL HGKIGCLLSI LGSTVMVIHA PKEEEIETLN EMSHKLGDPG
160 170 180 190 200
FVVFATLVVI VALILIFVVG PRHGQTNILV YITICSVIGA FSVSCVKGLG
210 220 230 240 250
IAIKELFAGK PVLRHPLAWI LLLSLIVCVS TQINYLNRAL DIFNTSIVTP
260 270 280 290 300
IYYVFFTTSV LTCSAILFKE WQDMPVDDVI GTLSGFFTII VGIFLLHAFK
310 320 330 340 350
DVSFSLASLP VSFRKDEKAM NGNLSNMYEV LNNNEESLTC GIEQHTGENV
360
SRRNGNLTAF
Length:360
Mass (Da):39,185
Last modified:October 1, 2002 - v1
Checksum:iA8ED640DA7AF7F4B
GO
Isoform 2 (identifier: Q8N8Q9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     47-66: GQGGHAYLKEWLWWAGLLSM → V

Note: Not experimental evidence available.
Show »
Length:341
Mass (Da):36,999
Checksum:i893B0E54C8CEA4E3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti303S → G in AAU34000 (Ref. 2) Curated1
Sequence conflicti303S → G in AAH11775 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04458747 – 66GQGGH…GLLSM → V in isoform 2. 1 PublicationAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BK001120 mRNA. Translation: DAA01509.1.
AY732242 mRNA. Translation: AAU34000.1.
AK096305 mRNA. Translation: BAC04757.1.
AK300843 mRNA. Translation: BAG62494.1.
CR606982 mRNA. No translation available.
AC011767 Genomic DNA. No translation available.
BC000957 mRNA. Translation: AAH00957.3.
BC011775 mRNA. Translation: AAH11775.1.
CCDSiCCDS73693.1. [Q8N8Q9-1]
CCDS73694.1. [Q8N8Q9-2]
RefSeqiNP_001008860.1. NM_001008860.2. [Q8N8Q9-1]
NP_001008892.1. NM_001008892.2. [Q8N8Q9-1]
NP_001008894.1. NM_001008894.2. [Q8N8Q9-2]
NP_001171817.1. NM_001184888.1. [Q8N8Q9-2]
NP_001171818.1. NM_001184889.1. [Q8N8Q9-1]
NP_112184.4. NM_030922.6. [Q8N8Q9-1]
XP_005272603.1. XM_005272546.3. [Q8N8Q9-1]
XP_005272604.1. XM_005272547.4. [Q8N8Q9-1]
XP_005272605.1. XM_005272548.3. [Q8N8Q9-1]
XP_005272607.1. XM_005272550.3. [Q8N8Q9-1]
XP_005272609.1. XM_005272552.3. [Q8N8Q9-1]
XP_005272610.1. XM_005272553.4. [Q8N8Q9-1]
XP_006720427.1. XM_006720364.2. [Q8N8Q9-1]
XP_006720428.1. XM_006720365.2. [Q8N8Q9-1]
XP_006720429.1. XM_006720366.3. [Q8N8Q9-1]
XP_006720430.1. XM_006720367.1. [Q8N8Q9-2]
XP_011542179.1. XM_011543877.2. [Q8N8Q9-1]
XP_011542180.1. XM_011543878.2. [Q8N8Q9-1]
XP_011542181.1. XM_011543879.2. [Q8N8Q9-1]
XP_011542182.1. XM_011543880.2. [Q8N8Q9-1]
XP_016878134.1. XM_017022645.1. [Q8N8Q9-1]
XP_016878135.1. XM_017022646.1. [Q8N8Q9-1]
XP_016878136.1. XM_017022647.1. [Q8N8Q9-1]
XP_016878137.1. XM_017022648.1. [Q8N8Q9-1]
XP_016878138.1. XM_017022649.1. [Q8N8Q9-1]
XP_016878139.1. XM_017022650.1. [Q8N8Q9-1]
XP_016878140.1. XM_017022651.1. [Q8N8Q9-1]
XP_016878141.1. XM_017022652.1. [Q8N8Q9-1]
XP_016878142.1. XM_017022653.1. [Q8N8Q9-1]
XP_016878143.1. XM_017022654.1. [Q8N8Q9-1]
XP_016878144.1. XM_017022655.1. [Q8N8Q9-2]
XP_016878145.1. XM_017022656.1. [Q8N8Q9-2]
XP_016878146.1. XM_017022657.1. [Q8N8Q9-2]
XP_016878147.1. XM_017022658.1. [Q8N8Q9-2]
XP_016878148.1. XM_017022659.1. [Q8N8Q9-2]
XP_016878149.1. XM_017022660.1. [Q8N8Q9-2]
XP_016878150.1. XM_017022661.1. [Q8N8Q9-2]
XP_016878151.1. XM_017022662.1. [Q8N8Q9-2]
XP_016878152.1. XM_017022663.1. [Q8N8Q9-2]
UniGeneiHs.591003.

Genome annotation databases

EnsembliENST00000337451; ENSP00000337618; ENSG00000140157. [Q8N8Q9-1]
ENST00000359727; ENSP00000352762; ENSG00000140157. [Q8N8Q9-2]
ENST00000398013; ENSP00000381095; ENSG00000140157. [Q8N8Q9-1]
ENST00000398014; ENSP00000381096; ENSG00000140157. [Q8N8Q9-1]
ENST00000539711; ENSP00000437746; ENSG00000140157. [Q8N8Q9-2]
GeneIDi81614.
KEGGihsa:81614.
UCSCiuc001yux.4. human. [Q8N8Q9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BK001120 mRNA. Translation: DAA01509.1.
AY732242 mRNA. Translation: AAU34000.1.
AK096305 mRNA. Translation: BAC04757.1.
AK300843 mRNA. Translation: BAG62494.1.
CR606982 mRNA. No translation available.
AC011767 Genomic DNA. No translation available.
BC000957 mRNA. Translation: AAH00957.3.
BC011775 mRNA. Translation: AAH11775.1.
CCDSiCCDS73693.1. [Q8N8Q9-1]
CCDS73694.1. [Q8N8Q9-2]
RefSeqiNP_001008860.1. NM_001008860.2. [Q8N8Q9-1]
NP_001008892.1. NM_001008892.2. [Q8N8Q9-1]
NP_001008894.1. NM_001008894.2. [Q8N8Q9-2]
NP_001171817.1. NM_001184888.1. [Q8N8Q9-2]
NP_001171818.1. NM_001184889.1. [Q8N8Q9-1]
NP_112184.4. NM_030922.6. [Q8N8Q9-1]
XP_005272603.1. XM_005272546.3. [Q8N8Q9-1]
XP_005272604.1. XM_005272547.4. [Q8N8Q9-1]
XP_005272605.1. XM_005272548.3. [Q8N8Q9-1]
XP_005272607.1. XM_005272550.3. [Q8N8Q9-1]
XP_005272609.1. XM_005272552.3. [Q8N8Q9-1]
XP_005272610.1. XM_005272553.4. [Q8N8Q9-1]
XP_006720427.1. XM_006720364.2. [Q8N8Q9-1]
XP_006720428.1. XM_006720365.2. [Q8N8Q9-1]
XP_006720429.1. XM_006720366.3. [Q8N8Q9-1]
XP_006720430.1. XM_006720367.1. [Q8N8Q9-2]
XP_011542179.1. XM_011543877.2. [Q8N8Q9-1]
XP_011542180.1. XM_011543878.2. [Q8N8Q9-1]
XP_011542181.1. XM_011543879.2. [Q8N8Q9-1]
XP_011542182.1. XM_011543880.2. [Q8N8Q9-1]
XP_016878134.1. XM_017022645.1. [Q8N8Q9-1]
XP_016878135.1. XM_017022646.1. [Q8N8Q9-1]
XP_016878136.1. XM_017022647.1. [Q8N8Q9-1]
XP_016878137.1. XM_017022648.1. [Q8N8Q9-1]
XP_016878138.1. XM_017022649.1. [Q8N8Q9-1]
XP_016878139.1. XM_017022650.1. [Q8N8Q9-1]
XP_016878140.1. XM_017022651.1. [Q8N8Q9-1]
XP_016878141.1. XM_017022652.1. [Q8N8Q9-1]
XP_016878142.1. XM_017022653.1. [Q8N8Q9-1]
XP_016878143.1. XM_017022654.1. [Q8N8Q9-1]
XP_016878144.1. XM_017022655.1. [Q8N8Q9-2]
XP_016878145.1. XM_017022656.1. [Q8N8Q9-2]
XP_016878146.1. XM_017022657.1. [Q8N8Q9-2]
XP_016878147.1. XM_017022658.1. [Q8N8Q9-2]
XP_016878148.1. XM_017022659.1. [Q8N8Q9-2]
XP_016878149.1. XM_017022660.1. [Q8N8Q9-2]
XP_016878150.1. XM_017022661.1. [Q8N8Q9-2]
XP_016878151.1. XM_017022662.1. [Q8N8Q9-2]
XP_016878152.1. XM_017022663.1. [Q8N8Q9-2]
UniGeneiHs.591003.

3D structure databases

ProteinModelPortaliQ8N8Q9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123549. 2 interactors.
STRINGi9606.ENSP00000337618.

Protein family/group databases

TCDBi2.A.7.25.2. the drug/metabolite transporter (dmt) superfamily.

PTM databases

iPTMnetiQ8N8Q9.
PhosphoSitePlusiQ8N8Q9.

Polymorphism and mutation databases

BioMutaiNIPA2.
DMDMi73921217.

Proteomic databases

MaxQBiQ8N8Q9.
PaxDbiQ8N8Q9.
PeptideAtlasiQ8N8Q9.
PRIDEiQ8N8Q9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000337451; ENSP00000337618; ENSG00000140157. [Q8N8Q9-1]
ENST00000359727; ENSP00000352762; ENSG00000140157. [Q8N8Q9-2]
ENST00000398013; ENSP00000381095; ENSG00000140157. [Q8N8Q9-1]
ENST00000398014; ENSP00000381096; ENSG00000140157. [Q8N8Q9-1]
ENST00000539711; ENSP00000437746; ENSG00000140157. [Q8N8Q9-2]
GeneIDi81614.
KEGGihsa:81614.
UCSCiuc001yux.4. human. [Q8N8Q9-1]

Organism-specific databases

CTDi81614.
DisGeNETi81614.
GeneCardsiNIPA2.
HGNCiHGNC:17044. NIPA2.
HPAiHPA067160.
HPA071342.
MIMi608146. gene.
neXtProtiNX_Q8N8Q9.
OpenTargetsiENSG00000140157.
PharmGKBiPA134911294.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2922. Eukaryota.
ENOG410XNR8. LUCA.
GeneTreeiENSGT00550000074395.
HOGENOMiHOG000203962.
HOVERGENiHBG055032.
InParanoidiQ8N8Q9.
OMAiEWEHMGA.
OrthoDBiEOG091G0M8A.
PhylomeDBiQ8N8Q9.
TreeFamiTF313214.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000140157-MONOMER.
ReactomeiR-HSA-5223345. Miscellaneous transport and binding events.

Miscellaneous databases

GeneWikiiNIPA2.
GenomeRNAii81614.
PROiQ8N8Q9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000140157.
CleanExiHS_NIPA2.
ExpressionAtlasiQ8N8Q9. baseline and differential.
GenevisibleiQ8N8Q9. HS.

Family and domain databases

InterProiIPR008521. Mg_trans_NIPA.
[Graphical view]
PANTHERiPTHR12570. PTHR12570. 1 hit.
PfamiPF05653. Mg_trans_NIPA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNIPA2_HUMAN
AccessioniPrimary (citable) accession number: Q8N8Q9
Secondary accession number(s): F8W7Y8, Q96F03, Q9BVS2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.