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Protein

Magnesium transporter NIPA2

Gene

NIPA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a selective Mg2+ transporter.By similarity

GO - Molecular functioni

  1. magnesium ion transmembrane transporter activity Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Magnesium

Protein family/group databases

TCDBi2.A.7.25.2. the drug/metabolite transporter (dmt) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Magnesium transporter NIPA2
Alternative name(s):
Non-imprinted in Prader-Willi/Angelman syndrome region protein 2
Gene namesi
Name:NIPA2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:17044. NIPA2.

Subcellular locationi

Cell membrane Curated; Multi-pass membrane protein Curated. Early endosome By similarity
Note: Recruited to the cell membrane in response to low extracellular magnesium.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 99ExtracellularSequence Analysis
Transmembranei10 – 3021HelicalSequence AnalysisAdd
BLAST
Topological domaini31 – 5626CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei57 – 7721HelicalSequence AnalysisAdd
BLAST
Topological domaini78 – 781ExtracellularSequence Analysis
Transmembranei79 – 9921HelicalSequence AnalysisAdd
BLAST
Topological domaini100 – 1078CytoplasmicSequence Analysis
Transmembranei108 – 12821HelicalSequence AnalysisAdd
BLAST
Topological domaini129 – 14921ExtracellularSequence AnalysisAdd
BLAST
Transmembranei150 – 17021HelicalSequence AnalysisAdd
BLAST
Topological domaini171 – 1755CytoplasmicSequence Analysis
Transmembranei176 – 19621HelicalSequence AnalysisAdd
BLAST
Topological domaini197 – 21519ExtracellularSequence AnalysisAdd
BLAST
Transmembranei216 – 23621HelicalSequence AnalysisAdd
BLAST
Topological domaini237 – 24610CytoplasmicSequence Analysis
Transmembranei247 – 26721HelicalSequence AnalysisAdd
BLAST
Topological domaini268 – 27811ExtracellularSequence AnalysisAdd
BLAST
Transmembranei279 – 29921HelicalSequence AnalysisAdd
BLAST
Topological domaini300 – 36061CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. early endosome Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134911294.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 360360Magnesium transporter NIPA2PRO_0000191743Add
BLAST

Proteomic databases

MaxQBiQ8N8Q9.
PaxDbiQ8N8Q9.
PRIDEiQ8N8Q9.

PTM databases

PhosphoSiteiQ8N8Q9.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiQ8N8Q9.
CleanExiHS_NIPA2.
ExpressionAtlasiQ8N8Q9. baseline and differential.
GenevestigatoriQ8N8Q9.

Interactioni

Protein-protein interaction databases

BioGridi123549. 1 interaction.
STRINGi9606.ENSP00000337618.

Structurei

3D structure databases

ProteinModelPortaliQ8N8Q9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NIPA family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG298616.
GeneTreeiENSGT00550000074395.
HOGENOMiHOG000203962.
HOVERGENiHBG055032.
InParanoidiQ8N8Q9.
OMAiKEWQHMA.
OrthoDBiEOG73BVD7.
PhylomeDBiQ8N8Q9.
TreeFamiTF313214.

Family and domain databases

InterProiIPR008521. Mg_trans_NIPA.
[Graphical view]
PANTHERiPTHR12570. PTHR12570. 1 hit.
PfamiPF05653. Mg_trans_NIPA. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N8Q9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSQGRGKYDF YIGLGLAMSS SIFIGGSFIL KKKGLLRLAR KGSMRAGQGG
60 70 80 90 100
HAYLKEWLWW AGLLSMGAGE VANFAAYAFA PATLVTPLGA LSVLVSAILS
110 120 130 140 150
SYFLNERLNL HGKIGCLLSI LGSTVMVIHA PKEEEIETLN EMSHKLGDPG
160 170 180 190 200
FVVFATLVVI VALILIFVVG PRHGQTNILV YITICSVIGA FSVSCVKGLG
210 220 230 240 250
IAIKELFAGK PVLRHPLAWI LLLSLIVCVS TQINYLNRAL DIFNTSIVTP
260 270 280 290 300
IYYVFFTTSV LTCSAILFKE WQDMPVDDVI GTLSGFFTII VGIFLLHAFK
310 320 330 340 350
DVSFSLASLP VSFRKDEKAM NGNLSNMYEV LNNNEESLTC GIEQHTGENV
360
SRRNGNLTAF
Length:360
Mass (Da):39,185
Last modified:September 30, 2002 - v1
Checksum:iA8ED640DA7AF7F4B
GO
Isoform 2 (identifier: Q8N8Q9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     47-66: GQGGHAYLKEWLWWAGLLSM → V

Note: Not experimental evidence available.

Show »
Length:341
Mass (Da):36,999
Checksum:i893B0E54C8CEA4E3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti303 – 3031S → G in AAU34000 (Ref. 2) Curated
Sequence conflicti303 – 3031S → G in AAH11775 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei47 – 6620GQGGH…GLLSM → V in isoform 2. 1 PublicationVSP_044587Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BK001120 mRNA. Translation: DAA01509.1.
AY732242 mRNA. Translation: AAU34000.1.
AK096305 mRNA. Translation: BAC04757.1.
AK300843 mRNA. Translation: BAG62494.1.
CR606982 mRNA. No translation available.
AC011767 Genomic DNA. No translation available.
BC000957 mRNA. Translation: AAH00957.3.
BC011775 mRNA. Translation: AAH11775.1.
CCDSiCCDS73693.1. [Q8N8Q9-1]
CCDS73694.1. [Q8N8Q9-2]
RefSeqiNP_001008860.1. NM_001008860.2. [Q8N8Q9-1]
NP_001008892.1. NM_001008892.2. [Q8N8Q9-1]
NP_001008894.1. NM_001008894.2. [Q8N8Q9-2]
NP_001171817.1. NM_001184888.1. [Q8N8Q9-2]
NP_001171818.1. NM_001184889.1. [Q8N8Q9-1]
NP_112184.4. NM_030922.6. [Q8N8Q9-1]
XP_005272603.1. XM_005272546.2. [Q8N8Q9-1]
XP_005272604.1. XM_005272547.2. [Q8N8Q9-1]
XP_005272605.1. XM_005272548.2. [Q8N8Q9-1]
XP_005272606.1. XM_005272549.2. [Q8N8Q9-1]
XP_005272607.1. XM_005272550.2. [Q8N8Q9-1]
XP_005272609.1. XM_005272552.2. [Q8N8Q9-1]
XP_005272610.1. XM_005272553.2. [Q8N8Q9-1]
XP_006720427.1. XM_006720364.1. [Q8N8Q9-1]
XP_006720428.1. XM_006720365.1. [Q8N8Q9-1]
XP_006720429.1. XM_006720366.1. [Q8N8Q9-1]
XP_006720430.1. XM_006720367.1. [Q8N8Q9-2]
UniGeneiHs.591003.

Genome annotation databases

EnsembliENST00000337451; ENSP00000337618; ENSG00000140157. [Q8N8Q9-1]
ENST00000359727; ENSP00000352762; ENSG00000140157. [Q8N8Q9-2]
ENST00000398013; ENSP00000381095; ENSG00000140157. [Q8N8Q9-1]
ENST00000398014; ENSP00000381096; ENSG00000140157. [Q8N8Q9-1]
ENST00000539711; ENSP00000437746; ENSG00000140157. [Q8N8Q9-2]
GeneIDi81614.
KEGGihsa:81614.
UCSCiuc001yux.3. human. [Q8N8Q9-1]
uc001yva.3. human.

Polymorphism databases

DMDMi73921217.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BK001120 mRNA. Translation: DAA01509.1.
AY732242 mRNA. Translation: AAU34000.1.
AK096305 mRNA. Translation: BAC04757.1.
AK300843 mRNA. Translation: BAG62494.1.
CR606982 mRNA. No translation available.
AC011767 Genomic DNA. No translation available.
BC000957 mRNA. Translation: AAH00957.3.
BC011775 mRNA. Translation: AAH11775.1.
CCDSiCCDS73693.1. [Q8N8Q9-1]
CCDS73694.1. [Q8N8Q9-2]
RefSeqiNP_001008860.1. NM_001008860.2. [Q8N8Q9-1]
NP_001008892.1. NM_001008892.2. [Q8N8Q9-1]
NP_001008894.1. NM_001008894.2. [Q8N8Q9-2]
NP_001171817.1. NM_001184888.1. [Q8N8Q9-2]
NP_001171818.1. NM_001184889.1. [Q8N8Q9-1]
NP_112184.4. NM_030922.6. [Q8N8Q9-1]
XP_005272603.1. XM_005272546.2. [Q8N8Q9-1]
XP_005272604.1. XM_005272547.2. [Q8N8Q9-1]
XP_005272605.1. XM_005272548.2. [Q8N8Q9-1]
XP_005272606.1. XM_005272549.2. [Q8N8Q9-1]
XP_005272607.1. XM_005272550.2. [Q8N8Q9-1]
XP_005272609.1. XM_005272552.2. [Q8N8Q9-1]
XP_005272610.1. XM_005272553.2. [Q8N8Q9-1]
XP_006720427.1. XM_006720364.1. [Q8N8Q9-1]
XP_006720428.1. XM_006720365.1. [Q8N8Q9-1]
XP_006720429.1. XM_006720366.1. [Q8N8Q9-1]
XP_006720430.1. XM_006720367.1. [Q8N8Q9-2]
UniGeneiHs.591003.

3D structure databases

ProteinModelPortaliQ8N8Q9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123549. 1 interaction.
STRINGi9606.ENSP00000337618.

Protein family/group databases

TCDBi2.A.7.25.2. the drug/metabolite transporter (dmt) superfamily.

PTM databases

PhosphoSiteiQ8N8Q9.

Polymorphism databases

DMDMi73921217.

Proteomic databases

MaxQBiQ8N8Q9.
PaxDbiQ8N8Q9.
PRIDEiQ8N8Q9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000337451; ENSP00000337618; ENSG00000140157. [Q8N8Q9-1]
ENST00000359727; ENSP00000352762; ENSG00000140157. [Q8N8Q9-2]
ENST00000398013; ENSP00000381095; ENSG00000140157. [Q8N8Q9-1]
ENST00000398014; ENSP00000381096; ENSG00000140157. [Q8N8Q9-1]
ENST00000539711; ENSP00000437746; ENSG00000140157. [Q8N8Q9-2]
GeneIDi81614.
KEGGihsa:81614.
UCSCiuc001yux.3. human. [Q8N8Q9-1]
uc001yva.3. human.

Organism-specific databases

CTDi81614.
GeneCardsiGC15M023004.
HGNCiHGNC:17044. NIPA2.
MIMi608146. gene.
neXtProtiNX_Q8N8Q9.
PharmGKBiPA134911294.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG298616.
GeneTreeiENSGT00550000074395.
HOGENOMiHOG000203962.
HOVERGENiHBG055032.
InParanoidiQ8N8Q9.
OMAiKEWQHMA.
OrthoDBiEOG73BVD7.
PhylomeDBiQ8N8Q9.
TreeFamiTF313214.

Miscellaneous databases

GeneWikiiNIPA2.
GenomeRNAii81614.
NextBioi71944.
PROiQ8N8Q9.
SOURCEiSearch...

Gene expression databases

BgeeiQ8N8Q9.
CleanExiHS_NIPA2.
ExpressionAtlasiQ8N8Q9. baseline and differential.
GenevestigatoriQ8N8Q9.

Family and domain databases

InterProiIPR008521. Mg_trans_NIPA.
[Graphical view]
PANTHERiPTHR12570. PTHR12570. 1 hit.
PfamiPF05653. Mg_trans_NIPA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of four highly conserved genes between breakpoint hotspots BP1 and BP2 of the Prader-Willi/Angelman syndromes deletion region that have undergone evolutionary transposition mediated by flanking duplicons."
    Chai J.-H., Locke D.P., Greally J.M., Knoll J.H.M., Ohta T., Dunai J., Yavor A., Eichler E.E., Nicholls R.D.
    Am. J. Hum. Genet. 73:898-925(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  2. "Non-imprinted transcript from the Prader-Willi syndrome region."
    Jiang Y.-H., Beaudet A.L.
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Small intestine.
  4. "Full-length cDNA libraries and normalization."
    Li W.B., Gruber C., Jessee J., Polayes D.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: B-cell.
  5. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Pancreas and Placenta.

Entry informationi

Entry nameiNIPA2_HUMAN
AccessioniPrimary (citable) accession number: Q8N8Q9
Secondary accession number(s): F8W7Y8, Q96F03, Q9BVS2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2005
Last sequence update: September 30, 2002
Last modified: January 6, 2015
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.