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Q8N8Q9

- NIPA2_HUMAN

UniProt

Q8N8Q9 - NIPA2_HUMAN

Protein

Magnesium transporter NIPA2

Gene

NIPA2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Acts as a selective Mg2+ transporter.By similarity

    GO - Molecular functioni

    1. magnesium ion transmembrane transporter activity Source: InterPro

    Keywords - Biological processi

    Ion transport, Transport

    Keywords - Ligandi

    Magnesium

    Protein family/group databases

    TCDBi2.A.7.25.2. the drug/metabolite transporter (dmt) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Magnesium transporter NIPA2
    Alternative name(s):
    Non-imprinted in Prader-Willi/Angelman syndrome region protein 2
    Gene namesi
    Name:NIPA2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:17044. NIPA2.

    Subcellular locationi

    Cell membrane Curated; Multi-pass membrane protein Curated. Early endosome By similarity
    Note: Recruited to the cell membrane in response to low extracellular magnesium.By similarity

    GO - Cellular componenti

    1. early endosome Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Endosome, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134911294.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 360360Magnesium transporter NIPA2PRO_0000191743Add
    BLAST

    Proteomic databases

    MaxQBiQ8N8Q9.
    PaxDbiQ8N8Q9.
    PRIDEiQ8N8Q9.

    PTM databases

    PhosphoSiteiQ8N8Q9.

    Expressioni

    Tissue specificityi

    Widely expressed.1 Publication

    Gene expression databases

    ArrayExpressiQ8N8Q9.
    BgeeiQ8N8Q9.
    CleanExiHS_NIPA2.
    GenevestigatoriQ8N8Q9.

    Interactioni

    Protein-protein interaction databases

    BioGridi123549. 2 interactions.
    STRINGi9606.ENSP00000337618.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N8Q9.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 99ExtracellularSequence Analysis
    Topological domaini31 – 5626CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini78 – 781ExtracellularSequence Analysis
    Topological domaini100 – 1078CytoplasmicSequence Analysis
    Topological domaini129 – 14921ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini171 – 1755CytoplasmicSequence Analysis
    Topological domaini197 – 21519ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini237 – 24610CytoplasmicSequence Analysis
    Topological domaini268 – 27811ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini300 – 36061CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei10 – 3021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei57 – 7721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei79 – 9921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei108 – 12821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei150 – 17021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei176 – 19621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei216 – 23621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei247 – 26721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei279 – 29921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NIPA family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG298616.
    HOGENOMiHOG000203962.
    HOVERGENiHBG055032.
    InParanoidiQ8N8Q9.
    OMAiKEWQHMA.
    OrthoDBiEOG73BVD7.
    PhylomeDBiQ8N8Q9.
    TreeFamiTF313214.

    Family and domain databases

    InterProiIPR008521. Mg_trans_NIPA.
    [Graphical view]
    PANTHERiPTHR12570. PTHR12570. 1 hit.
    PfamiPF05653. Mg_trans_NIPA. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8N8Q9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSQGRGKYDF YIGLGLAMSS SIFIGGSFIL KKKGLLRLAR KGSMRAGQGG    50
    HAYLKEWLWW AGLLSMGAGE VANFAAYAFA PATLVTPLGA LSVLVSAILS 100
    SYFLNERLNL HGKIGCLLSI LGSTVMVIHA PKEEEIETLN EMSHKLGDPG 150
    FVVFATLVVI VALILIFVVG PRHGQTNILV YITICSVIGA FSVSCVKGLG 200
    IAIKELFAGK PVLRHPLAWI LLLSLIVCVS TQINYLNRAL DIFNTSIVTP 250
    IYYVFFTTSV LTCSAILFKE WQDMPVDDVI GTLSGFFTII VGIFLLHAFK 300
    DVSFSLASLP VSFRKDEKAM NGNLSNMYEV LNNNEESLTC GIEQHTGENV 350
    SRRNGNLTAF 360
    Length:360
    Mass (Da):39,185
    Last modified:October 1, 2002 - v1
    Checksum:iA8ED640DA7AF7F4B
    GO
    Isoform 2 (identifier: Q8N8Q9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         47-66: GQGGHAYLKEWLWWAGLLSM → V

    Note: Not experimental evidence available.

    Show »
    Length:341
    Mass (Da):36,999
    Checksum:i893B0E54C8CEA4E3
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti303 – 3031S → G in AAU34000. 1 PublicationCurated
    Sequence conflicti303 – 3031S → G in AAH11775. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei47 – 6620GQGGH…GLLSM → V in isoform 2. 1 PublicationVSP_044587Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BK001120 mRNA. Translation: DAA01509.1.
    AY732242 mRNA. Translation: AAU34000.1.
    AK096305 mRNA. Translation: BAC04757.1.
    AK300843 mRNA. Translation: BAG62494.1.
    CR606982 mRNA. No translation available.
    AC011767 Genomic DNA. No translation available.
    BC000957 mRNA. Translation: AAH00957.3.
    BC011775 mRNA. Translation: AAH11775.1.
    CCDSiCCDS10010.1. [Q8N8Q9-1]
    CCDS32174.1. [Q8N8Q9-2]
    RefSeqiNP_001008860.1. NM_001008860.2. [Q8N8Q9-1]
    NP_001008892.1. NM_001008892.2. [Q8N8Q9-1]
    NP_001008894.1. NM_001008894.2. [Q8N8Q9-2]
    NP_001171817.1. NM_001184888.1. [Q8N8Q9-2]
    NP_001171818.1. NM_001184889.1. [Q8N8Q9-1]
    NP_112184.4. NM_030922.6. [Q8N8Q9-1]
    XP_005272603.1. XM_005272546.2. [Q8N8Q9-1]
    XP_005272604.1. XM_005272547.2. [Q8N8Q9-1]
    XP_005272605.1. XM_005272548.2. [Q8N8Q9-1]
    XP_005272606.1. XM_005272549.2. [Q8N8Q9-1]
    XP_005272607.1. XM_005272550.2. [Q8N8Q9-1]
    XP_005272609.1. XM_005272552.2. [Q8N8Q9-1]
    XP_005272610.1. XM_005272553.2. [Q8N8Q9-1]
    XP_006720427.1. XM_006720364.1. [Q8N8Q9-1]
    XP_006720428.1. XM_006720365.1. [Q8N8Q9-1]
    XP_006720429.1. XM_006720366.1. [Q8N8Q9-1]
    XP_006720430.1. XM_006720367.1. [Q8N8Q9-2]
    UniGeneiHs.591003.

    Genome annotation databases

    EnsembliENST00000337451; ENSP00000337618; ENSG00000140157. [Q8N8Q9-1]
    ENST00000359727; ENSP00000352762; ENSG00000140157. [Q8N8Q9-2]
    ENST00000398013; ENSP00000381095; ENSG00000140157. [Q8N8Q9-1]
    ENST00000398014; ENSP00000381096; ENSG00000140157. [Q8N8Q9-1]
    ENST00000539711; ENSP00000437746; ENSG00000140157. [Q8N8Q9-2]
    GeneIDi81614.
    KEGGihsa:81614.
    UCSCiuc001yux.3. human. [Q8N8Q9-1]
    uc001yva.3. human.

    Polymorphism databases

    DMDMi73921217.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BK001120 mRNA. Translation: DAA01509.1 .
    AY732242 mRNA. Translation: AAU34000.1 .
    AK096305 mRNA. Translation: BAC04757.1 .
    AK300843 mRNA. Translation: BAG62494.1 .
    CR606982 mRNA. No translation available.
    AC011767 Genomic DNA. No translation available.
    BC000957 mRNA. Translation: AAH00957.3 .
    BC011775 mRNA. Translation: AAH11775.1 .
    CCDSi CCDS10010.1. [Q8N8Q9-1 ]
    CCDS32174.1. [Q8N8Q9-2 ]
    RefSeqi NP_001008860.1. NM_001008860.2. [Q8N8Q9-1 ]
    NP_001008892.1. NM_001008892.2. [Q8N8Q9-1 ]
    NP_001008894.1. NM_001008894.2. [Q8N8Q9-2 ]
    NP_001171817.1. NM_001184888.1. [Q8N8Q9-2 ]
    NP_001171818.1. NM_001184889.1. [Q8N8Q9-1 ]
    NP_112184.4. NM_030922.6. [Q8N8Q9-1 ]
    XP_005272603.1. XM_005272546.2. [Q8N8Q9-1 ]
    XP_005272604.1. XM_005272547.2. [Q8N8Q9-1 ]
    XP_005272605.1. XM_005272548.2. [Q8N8Q9-1 ]
    XP_005272606.1. XM_005272549.2. [Q8N8Q9-1 ]
    XP_005272607.1. XM_005272550.2. [Q8N8Q9-1 ]
    XP_005272609.1. XM_005272552.2. [Q8N8Q9-1 ]
    XP_005272610.1. XM_005272553.2. [Q8N8Q9-1 ]
    XP_006720427.1. XM_006720364.1. [Q8N8Q9-1 ]
    XP_006720428.1. XM_006720365.1. [Q8N8Q9-1 ]
    XP_006720429.1. XM_006720366.1. [Q8N8Q9-1 ]
    XP_006720430.1. XM_006720367.1. [Q8N8Q9-2 ]
    UniGenei Hs.591003.

    3D structure databases

    ProteinModelPortali Q8N8Q9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123549. 2 interactions.
    STRINGi 9606.ENSP00000337618.

    Protein family/group databases

    TCDBi 2.A.7.25.2. the drug/metabolite transporter (dmt) superfamily.

    PTM databases

    PhosphoSitei Q8N8Q9.

    Polymorphism databases

    DMDMi 73921217.

    Proteomic databases

    MaxQBi Q8N8Q9.
    PaxDbi Q8N8Q9.
    PRIDEi Q8N8Q9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000337451 ; ENSP00000337618 ; ENSG00000140157 . [Q8N8Q9-1 ]
    ENST00000359727 ; ENSP00000352762 ; ENSG00000140157 . [Q8N8Q9-2 ]
    ENST00000398013 ; ENSP00000381095 ; ENSG00000140157 . [Q8N8Q9-1 ]
    ENST00000398014 ; ENSP00000381096 ; ENSG00000140157 . [Q8N8Q9-1 ]
    ENST00000539711 ; ENSP00000437746 ; ENSG00000140157 . [Q8N8Q9-2 ]
    GeneIDi 81614.
    KEGGi hsa:81614.
    UCSCi uc001yux.3. human. [Q8N8Q9-1 ]
    uc001yva.3. human.

    Organism-specific databases

    CTDi 81614.
    GeneCardsi GC15M023004.
    HGNCi HGNC:17044. NIPA2.
    MIMi 608146. gene.
    neXtProti NX_Q8N8Q9.
    PharmGKBi PA134911294.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG298616.
    HOGENOMi HOG000203962.
    HOVERGENi HBG055032.
    InParanoidi Q8N8Q9.
    OMAi KEWQHMA.
    OrthoDBi EOG73BVD7.
    PhylomeDBi Q8N8Q9.
    TreeFami TF313214.

    Miscellaneous databases

    GeneWikii NIPA2.
    GenomeRNAii 81614.
    NextBioi 71944.
    PROi Q8N8Q9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8N8Q9.
    Bgeei Q8N8Q9.
    CleanExi HS_NIPA2.
    Genevestigatori Q8N8Q9.

    Family and domain databases

    InterProi IPR008521. Mg_trans_NIPA.
    [Graphical view ]
    PANTHERi PTHR12570. PTHR12570. 1 hit.
    Pfami PF05653. Mg_trans_NIPA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of four highly conserved genes between breakpoint hotspots BP1 and BP2 of the Prader-Willi/Angelman syndromes deletion region that have undergone evolutionary transposition mediated by flanking duplicons."
      Chai J.-H., Locke D.P., Greally J.M., Knoll J.H.M., Ohta T., Dunai J., Yavor A., Eichler E.E., Nicholls R.D.
      Am. J. Hum. Genet. 73:898-925(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    2. "Non-imprinted transcript from the Prader-Willi syndrome region."
      Jiang Y.-H., Beaudet A.L.
      Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Small intestine.
    4. "Full-length cDNA libraries and normalization."
      Li W.B., Gruber C., Jessee J., Polayes D.
      Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: B-cell.
    5. "Analysis of the DNA sequence and duplication history of human chromosome 15."
      Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
      , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
      Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Pancreas and Placenta.

    Entry informationi

    Entry nameiNIPA2_HUMAN
    AccessioniPrimary (citable) accession number: Q8N8Q9
    Secondary accession number(s): F8W7Y8, Q96F03, Q9BVS2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 30, 2005
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3