ID NAT16_HUMAN Reviewed; 369 AA. AC Q8N8M0; B3KRS2; Q8NDR1; DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot. DT 24-NOV-2009, sequence version 2. DT 24-JAN-2024, entry version 131. DE RecName: Full=Probable N-acetyltransferase 16; DE EC=2.3.1.-; GN Name=NAT16; Synonyms=C7orf52; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT RP SER-63. RC TISSUE=Brain; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=12853948; DOI=10.1038/nature01782; RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H., RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., RA Wilson R.K.; RT "The DNA sequence of human chromosome 7."; RL Nature 424:157-164(2003). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT SER-63. RC TISSUE=Brain; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 165-369 (ISOFORM 1). RC TISSUE=Brain; RX PubMed=17974005; DOI=10.1186/1471-2164-8-399; RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., RA Wiemann S., Schupp I.; RT "The full-ORF clone resource of the German cDNA consortium."; RL BMC Genomics 8:399-399(2007). RN [5] RP FUNCTION. RX PubMed=24121108; DOI=10.1016/j.bbagen.2013.10.004; RA Yamada S., Arikawa S.; RT "An ectotherm homologue of human predicted gene NAT16 encodes histidine N- RT acetyltransferase responsible for Nalpha-acetylhistidine synthesis."; RL Biochim. Biophys. Acta 1840:434-442(2014). CC -!- FUNCTION: Probable N-acetyltransferase. Shows only trace activity CC toward L-His and no N-acetyltransferase activity toward other amino CC acids. The physiological substrate of this enzyme is unknown. CC {ECO:0000269|PubMed:24121108}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=Q8N8M0-1; Sequence=Displayed; CC Name=2; CC IsoId=Q8N8M0-2; Sequence=VSP_055771, VSP_055772; CC -!- MISCELLANEOUS: NAT16 is the ortholog of the ectothermic vertebrates CC enzyme HISAT (AC I3J7Q8) responsible for the synthesis of N-acetyl- CC histidine (NAH). NAT16 protein, unlike fish HISAT, has only trace CC enzyme activity for NAH synthesis. {ECO:0000305|PubMed:24121108}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK092119; BAG52484.1; -; mRNA. DR EMBL; AK096556; BAC04815.1; -; mRNA. DR EMBL; AC004876; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC104841; AAI04842.1; -; mRNA. DR EMBL; AL831911; CAD38574.3; -; mRNA. DR CCDS; CCDS5713.1; -. [Q8N8M0-1] DR RefSeq; NP_940973.2; NM_198571.2. [Q8N8M0-1] DR RefSeq; XP_005250382.1; XM_005250325.1. DR RefSeq; XP_011514470.1; XM_011516168.1. DR AlphaFoldDB; Q8N8M0; -. DR SMR; Q8N8M0; -. DR BioGRID; 131987; 74. DR IntAct; Q8N8M0; 6. DR STRING; 9606.ENSP00000300303; -. DR iPTMnet; Q8N8M0; -. DR PhosphoSitePlus; Q8N8M0; -. DR BioMuta; NAT16; -. DR DMDM; 269849548; -. DR MassIVE; Q8N8M0; -. DR PaxDb; 9606-ENSP00000300303; -. DR PeptideAtlas; Q8N8M0; -. DR ProteomicsDB; 3613; -. DR ProteomicsDB; 72436; -. [Q8N8M0-1] DR Antibodypedia; 16722; 19 antibodies from 13 providers. DR DNASU; 375607; -. DR Ensembl; ENST00000300303.7; ENSP00000300303.2; ENSG00000167011.9. [Q8N8M0-1] DR Ensembl; ENST00000443096.1; ENSP00000394435.1; ENSG00000167011.9. [Q8N8M0-2] DR Ensembl; ENST00000455377.5; ENSP00000395125.1; ENSG00000167011.9. [Q8N8M0-1] DR GeneID; 375607; -. DR KEGG; hsa:375607; -. DR MANE-Select; ENST00000300303.7; ENSP00000300303.2; NM_198571.3; NP_940973.2. DR UCSC; uc003uxy.2; human. [Q8N8M0-1] DR AGR; HGNC:22030; -. DR CTD; 375607; -. DR GeneCards; NAT16; -. DR HGNC; HGNC:22030; NAT16. DR HPA; ENSG00000167011; Group enriched (brain, pancreas, pituitary gland, retina, thyroid gland). DR MIM; 615783; gene. DR neXtProt; NX_Q8N8M0; -. DR OpenTargets; ENSG00000167011; -. DR PharmGKB; PA162380580; -. DR VEuPathDB; HostDB:ENSG00000167011; -. DR eggNOG; ENOG502QW73; Eukaryota. DR GeneTree; ENSGT00390000016398; -. DR HOGENOM; CLU_074598_0_0_1; -. DR InParanoid; Q8N8M0; -. DR OMA; TSWLQET; -. DR OrthoDB; 2907909at2759; -. DR PhylomeDB; Q8N8M0; -. DR TreeFam; TF331490; -. DR BRENDA; 2.3.1.33; 2681. DR PathwayCommons; Q8N8M0; -. DR SignaLink; Q8N8M0; -. DR BioGRID-ORCS; 375607; 10 hits in 1140 CRISPR screens. DR GenomeRNAi; 375607; -. DR Pharos; Q8N8M0; Tdark. DR PRO; PR:Q8N8M0; -. DR Proteomes; UP000005640; Chromosome 7. DR RNAct; Q8N8M0; Protein. DR Bgee; ENSG00000167011; Expressed in cortical plate and 49 other cell types or tissues. DR ExpressionAtlas; Q8N8M0; baseline and differential. DR Genevisible; Q8N8M0; HS. DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro. DR Gene3D; 3.40.630.30; -; 1. DR InterPro; IPR016181; Acyl_CoA_acyltransferase. DR InterPro; IPR000182; GNAT_dom. DR PANTHER; PTHR47403; LOC100145250 PROTEIN; 1. DR PANTHER; PTHR47403:SF3; N-ACETYLTRANSFERASE 16-RELATED; 1. DR Pfam; PF00583; Acetyltransf_1; 1. DR SUPFAM; SSF55729; Acyl-CoA N-acyltransferases (Nat); 1. DR PROSITE; PS51186; GNAT; 1. PE 2: Evidence at transcript level; KW Acyltransferase; Alternative splicing; Reference proteome; Transferase. FT CHAIN 1..369 FT /note="Probable N-acetyltransferase 16" FT /id="PRO_0000309189" FT DOMAIN 53..188 FT /note="N-acetyltransferase" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00532" FT REGION 1..49 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 16..37 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT VAR_SEQ 105..112 FT /note="IALESVNV -> VSPGARPR (in isoform 2)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_055771" FT VAR_SEQ 113..369 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_055772" FT VARIANT 63 FT /note="F -> S (in dbSNP:rs34985488)" FT /evidence="ECO:0000269|PubMed:14702039, FT ECO:0000269|PubMed:15489334" FT /id="VAR_036903" SQ SEQUENCE 369 AA; 40521 MW; DC3AD7F15AAF807C CRC64; MKLEASCGTA TSEVPKPEKK TARDAEPSSE TRPQEVEAEP RSGSGPEAEA EPLDFVVATE REFEEVLAIS GGIYGGLDYL PSRYHSWLRD PDRTVVLAKR NGGVIALESV NVIDAGETVL VEGLRVAPWE RGKGVAGLLQ RFCSQLVKRQ HPGVKVARLT RDDQLGPREL KKYRLITKQG ILLVRFNASA LLAGLGARLA ALRTSGTFSP LPTEAVSEAG GDVARLLLSP SVQRDVLPGG TIIQDWQPYR PSESNLRLLA AKGLEWRVDS RARPRVLTLC TRPFPIPHGG DGTWRYLNID AFGSDGAQVQ SQLLWHLQRQ APRLVGLNVM CQLFLEPQLW SQLADFCQVG LGLELVKGYT EQYLLEADI //