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Q8N8M0

- NAT16_HUMAN

UniProt

Q8N8M0 - NAT16_HUMAN

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Protein

Putative N-acetyltransferase 16

Gene

NAT16

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. N-acetyltransferase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Putative N-acetyltransferase 16 (EC:2.3.1.-)
Gene namesi
Name:NAT16
Synonyms:C7orf52
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:22030. NAT16.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162380580.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 369369Putative N-acetyltransferase 16PRO_0000309189Add
BLAST

Proteomic databases

PaxDbiQ8N8M0.
PRIDEiQ8N8M0.

PTM databases

PhosphoSiteiQ8N8M0.

Expressioni

Gene expression databases

BgeeiQ8N8M0.
CleanExiHS_C7orf52.
ExpressionAtlasiQ8N8M0. baseline.
GenevestigatoriQ8N8M0.

Organism-specific databases

HPAiHPA021918.

Interactioni

Protein-protein interaction databases

BioGridi131987. 2 interactions.
STRINGi9606.ENSP00000300303.

Structurei

3D structure databases

ProteinModelPortaliQ8N8M0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini53 – 188136N-acetyltransferasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG40779.
GeneTreeiENSGT00390000016398.
HOGENOMiHOG000170303.
HOVERGENiHBG100954.
InParanoidiQ8N8M0.
OMAiITKQGIL.
OrthoDBiEOG7FFMRP.
PhylomeDBiQ8N8M0.
TreeFamiTF331490.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8N8M0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKLEASCGTA TSEVPKPEKK TARDAEPSSE TRPQEVEAEP RSGSGPEAEA
60 70 80 90 100
EPLDFVVATE REFEEVLAIS GGIYGGLDYL PSRYHSWLRD PDRTVVLAKR
110 120 130 140 150
NGGVIALESV NVIDAGETVL VEGLRVAPWE RGKGVAGLLQ RFCSQLVKRQ
160 170 180 190 200
HPGVKVARLT RDDQLGPREL KKYRLITKQG ILLVRFNASA LLAGLGARLA
210 220 230 240 250
ALRTSGTFSP LPTEAVSEAG GDVARLLLSP SVQRDVLPGG TIIQDWQPYR
260 270 280 290 300
PSESNLRLLA AKGLEWRVDS RARPRVLTLC TRPFPIPHGG DGTWRYLNID
310 320 330 340 350
AFGSDGAQVQ SQLLWHLQRQ APRLVGLNVM CQLFLEPQLW SQLADFCQVG
360
LGLELVKGYT EQYLLEADI
Length:369
Mass (Da):40,521
Last modified:November 24, 2009 - v2
Checksum:iDC3AD7F15AAF807C
GO
Isoform 2 (identifier: Q8N8M0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     105-112: IALESVNV → VSPGARPR
     113-369: Missing.

Note: No experimental confirmation available.

Show »
Length:112
Mass (Da):12,125
Checksum:i84EBC1F5FD1B9953
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti63 – 631F → S.2 Publications
Corresponds to variant rs34985488 [ dbSNP | Ensembl ].
VAR_036903

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei105 – 1128IALESVNV → VSPGARPR in isoform 2. 1 PublicationVSP_055771
Alternative sequencei113 – 369257Missing in isoform 2. 1 PublicationVSP_055772Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK092119 mRNA. Translation: BAG52484.1.
AK096556 mRNA. Translation: BAC04815.1.
AC004876 Genomic DNA. No translation available.
BC104841 mRNA. Translation: AAI04842.1.
AL831911 mRNA. Translation: CAD38574.3.
CCDSiCCDS5713.1. [Q8N8M0-1]
RefSeqiNP_940973.2. NM_198571.2. [Q8N8M0-1]
XP_005250382.1. XM_005250325.1. [Q8N8M0-1]
UniGeneiHs.213044.

Genome annotation databases

EnsembliENST00000300303; ENSP00000300303; ENSG00000167011. [Q8N8M0-1]
ENST00000443096; ENSP00000394435; ENSG00000167011. [Q8N8M0-2]
ENST00000455377; ENSP00000395125; ENSG00000167011. [Q8N8M0-1]
GeneIDi375607.
KEGGihsa:375607.
UCSCiuc003uxy.2. human. [Q8N8M0-1]

Polymorphism databases

DMDMi269849548.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK092119 mRNA. Translation: BAG52484.1 .
AK096556 mRNA. Translation: BAC04815.1 .
AC004876 Genomic DNA. No translation available.
BC104841 mRNA. Translation: AAI04842.1 .
AL831911 mRNA. Translation: CAD38574.3 .
CCDSi CCDS5713.1. [Q8N8M0-1 ]
RefSeqi NP_940973.2. NM_198571.2. [Q8N8M0-1 ]
XP_005250382.1. XM_005250325.1. [Q8N8M0-1 ]
UniGenei Hs.213044.

3D structure databases

ProteinModelPortali Q8N8M0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 131987. 2 interactions.
STRINGi 9606.ENSP00000300303.

PTM databases

PhosphoSitei Q8N8M0.

Polymorphism databases

DMDMi 269849548.

Proteomic databases

PaxDbi Q8N8M0.
PRIDEi Q8N8M0.

Protocols and materials databases

DNASUi 375607.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000300303 ; ENSP00000300303 ; ENSG00000167011 . [Q8N8M0-1 ]
ENST00000443096 ; ENSP00000394435 ; ENSG00000167011 . [Q8N8M0-2 ]
ENST00000455377 ; ENSP00000395125 ; ENSG00000167011 . [Q8N8M0-1 ]
GeneIDi 375607.
KEGGi hsa:375607.
UCSCi uc003uxy.2. human. [Q8N8M0-1 ]

Organism-specific databases

CTDi 375607.
GeneCardsi GC07M100814.
HGNCi HGNC:22030. NAT16.
HPAi HPA021918.
neXtProti NX_Q8N8M0.
PharmGKBi PA162380580.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG40779.
GeneTreei ENSGT00390000016398.
HOGENOMi HOG000170303.
HOVERGENi HBG100954.
InParanoidi Q8N8M0.
OMAi ITKQGIL.
OrthoDBi EOG7FFMRP.
PhylomeDBi Q8N8M0.
TreeFami TF331490.

Miscellaneous databases

GenomeRNAii 375607.
NextBioi 100541.
PROi Q8N8M0.

Gene expression databases

Bgeei Q8N8M0.
CleanExi HS_C7orf52.
ExpressionAtlasi Q8N8M0. baseline.
Genevestigatori Q8N8M0.

Family and domain databases

Gene3Di 3.40.630.30. 1 hit.
InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view ]
SUPFAMi SSF55729. SSF55729. 1 hit.
PROSITEi PS51186. GNAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT SER-63.
    Tissue: Brain.
  2. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT SER-63.
    Tissue: Brain.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 165-369 (ISOFORM 1).
    Tissue: Brain.

Entry informationi

Entry nameiNAT16_HUMAN
AccessioniPrimary (citable) accession number: Q8N8M0
Secondary accession number(s): B3KRS2, Q8NDR1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 24, 2009
Last modified: October 29, 2014
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3