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Protein

Probable N-acetyltransferase 16

Gene

NAT16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable N-acetyltransferase. Shows only trace activity toward L-His and no N-acetyltransferase activity toward other amino acids. The physiological substrate of this enzyme is unknown.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable N-acetyltransferase 16 (EC:2.3.1.-)
Gene namesi
Name:NAT16
Synonyms:C7orf52
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:22030. NAT16.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162380580.

Polymorphism and mutation databases

BioMutaiNAT16.
DMDMi269849548.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 369369Probable N-acetyltransferase 16PRO_0000309189Add
BLAST

Proteomic databases

PaxDbiQ8N8M0.
PRIDEiQ8N8M0.

PTM databases

PhosphoSiteiQ8N8M0.

Expressioni

Gene expression databases

BgeeiQ8N8M0.
CleanExiHS_C7orf52.
ExpressionAtlasiQ8N8M0. baseline.
GenevisibleiQ8N8M0. HS.

Organism-specific databases

HPAiHPA021918.

Interactioni

Protein-protein interaction databases

BioGridi131987. 2 interactions.
STRINGi9606.ENSP00000300303.

Structurei

3D structure databases

ProteinModelPortaliQ8N8M0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini53 – 188136N-acetyltransferasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG40779.
GeneTreeiENSGT00390000016398.
HOGENOMiHOG000170303.
HOVERGENiHBG100954.
InParanoidiQ8N8M0.
OMAiSQLADFC.
OrthoDBiEOG7FFMRP.
PhylomeDBiQ8N8M0.
TreeFamiTF331490.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N8M0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKLEASCGTA TSEVPKPEKK TARDAEPSSE TRPQEVEAEP RSGSGPEAEA
60 70 80 90 100
EPLDFVVATE REFEEVLAIS GGIYGGLDYL PSRYHSWLRD PDRTVVLAKR
110 120 130 140 150
NGGVIALESV NVIDAGETVL VEGLRVAPWE RGKGVAGLLQ RFCSQLVKRQ
160 170 180 190 200
HPGVKVARLT RDDQLGPREL KKYRLITKQG ILLVRFNASA LLAGLGARLA
210 220 230 240 250
ALRTSGTFSP LPTEAVSEAG GDVARLLLSP SVQRDVLPGG TIIQDWQPYR
260 270 280 290 300
PSESNLRLLA AKGLEWRVDS RARPRVLTLC TRPFPIPHGG DGTWRYLNID
310 320 330 340 350
AFGSDGAQVQ SQLLWHLQRQ APRLVGLNVM CQLFLEPQLW SQLADFCQVG
360
LGLELVKGYT EQYLLEADI
Length:369
Mass (Da):40,521
Last modified:November 24, 2009 - v2
Checksum:iDC3AD7F15AAF807C
GO
Isoform 2 (identifier: Q8N8M0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     105-112: IALESVNV → VSPGARPR
     113-369: Missing.

Note: No experimental confirmation available.
Show »
Length:112
Mass (Da):12,125
Checksum:i84EBC1F5FD1B9953
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti63 – 631F → S.2 Publications
Corresponds to variant rs34985488 [ dbSNP | Ensembl ].
VAR_036903

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei105 – 1128IALESVNV → VSPGARPR in isoform 2. 1 PublicationVSP_055771
Alternative sequencei113 – 369257Missing in isoform 2. 1 PublicationVSP_055772Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK092119 mRNA. Translation: BAG52484.1.
AK096556 mRNA. Translation: BAC04815.1.
AC004876 Genomic DNA. No translation available.
BC104841 mRNA. Translation: AAI04842.1.
AL831911 mRNA. Translation: CAD38574.3.
CCDSiCCDS5713.1. [Q8N8M0-1]
RefSeqiNP_940973.2. NM_198571.2. [Q8N8M0-1]
XP_005250382.1. XM_005250325.1. [Q8N8M0-1]
UniGeneiHs.213044.

Genome annotation databases

EnsembliENST00000300303; ENSP00000300303; ENSG00000167011. [Q8N8M0-1]
ENST00000443096; ENSP00000394435; ENSG00000167011. [Q8N8M0-2]
ENST00000455377; ENSP00000395125; ENSG00000167011. [Q8N8M0-1]
GeneIDi375607.
KEGGihsa:375607.
UCSCiuc003uxy.2. human. [Q8N8M0-1]
uc003uya.1. human.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK092119 mRNA. Translation: BAG52484.1.
AK096556 mRNA. Translation: BAC04815.1.
AC004876 Genomic DNA. No translation available.
BC104841 mRNA. Translation: AAI04842.1.
AL831911 mRNA. Translation: CAD38574.3.
CCDSiCCDS5713.1. [Q8N8M0-1]
RefSeqiNP_940973.2. NM_198571.2. [Q8N8M0-1]
XP_005250382.1. XM_005250325.1. [Q8N8M0-1]
UniGeneiHs.213044.

3D structure databases

ProteinModelPortaliQ8N8M0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131987. 2 interactions.
STRINGi9606.ENSP00000300303.

PTM databases

PhosphoSiteiQ8N8M0.

Polymorphism and mutation databases

BioMutaiNAT16.
DMDMi269849548.

Proteomic databases

PaxDbiQ8N8M0.
PRIDEiQ8N8M0.

Protocols and materials databases

DNASUi375607.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300303; ENSP00000300303; ENSG00000167011. [Q8N8M0-1]
ENST00000443096; ENSP00000394435; ENSG00000167011. [Q8N8M0-2]
ENST00000455377; ENSP00000395125; ENSG00000167011. [Q8N8M0-1]
GeneIDi375607.
KEGGihsa:375607.
UCSCiuc003uxy.2. human. [Q8N8M0-1]
uc003uya.1. human.

Organism-specific databases

CTDi375607.
GeneCardsiGC07M100814.
HGNCiHGNC:22030. NAT16.
HPAiHPA021918.
MIMi615783. gene.
neXtProtiNX_Q8N8M0.
PharmGKBiPA162380580.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG40779.
GeneTreeiENSGT00390000016398.
HOGENOMiHOG000170303.
HOVERGENiHBG100954.
InParanoidiQ8N8M0.
OMAiSQLADFC.
OrthoDBiEOG7FFMRP.
PhylomeDBiQ8N8M0.
TreeFamiTF331490.

Miscellaneous databases

GenomeRNAii375607.
NextBioi100541.
PROiQ8N8M0.
SOURCEiSearch...

Gene expression databases

BgeeiQ8N8M0.
CleanExiHS_C7orf52.
ExpressionAtlasiQ8N8M0. baseline.
GenevisibleiQ8N8M0. HS.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT SER-63.
    Tissue: Brain.
  2. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT SER-63.
    Tissue: Brain.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 165-369 (ISOFORM 1).
    Tissue: Brain.
  5. "An ectotherm homologue of human predicted gene NAT16 encodes histidine N-acetyltransferase responsible for Nalpha-acetylhistidine synthesis."
    Yamada S., Arikawa S.
    Biochim. Biophys. Acta 1840:434-442(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiNAT16_HUMAN
AccessioniPrimary (citable) accession number: Q8N8M0
Secondary accession number(s): B3KRS2, Q8NDR1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 24, 2009
Last modified: June 24, 2015
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

NAT16 is the ortholog of the ectothermic vertebrates enzyme HISAT (AC I3J7Q8) responsible for the synthesis of N-acetyl-histidine (NAH). NAT16 protein, unlike fish HISAT, has only trace enzyme activity for NAH synthesis.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.