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Q8N8M0

- NAT16_HUMAN

UniProt

Q8N8M0 - NAT16_HUMAN

Protein

Putative N-acetyltransferase 16

Gene

NAT16

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 2 (24 Nov 2009)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. N-acetyltransferase activity Source: InterPro

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative N-acetyltransferase 16 (EC:2.3.1.-)
    Gene namesi
    Name:NAT16
    Synonyms:C7orf52
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:22030. NAT16.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162380580.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 369369Putative N-acetyltransferase 16PRO_0000309189Add
    BLAST

    Proteomic databases

    PaxDbiQ8N8M0.
    PRIDEiQ8N8M0.

    PTM databases

    PhosphoSiteiQ8N8M0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8N8M0.
    BgeeiQ8N8M0.
    CleanExiHS_C7orf52.
    GenevestigatoriQ8N8M0.

    Organism-specific databases

    HPAiHPA021918.

    Interactioni

    Protein-protein interaction databases

    BioGridi131987. 2 interactions.
    STRINGi9606.ENSP00000300303.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N8M0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini53 – 188136N-acetyltransferasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG40779.
    HOGENOMiHOG000170303.
    HOVERGENiHBG100954.
    InParanoidiQ8N8M0.
    OMAiITKQGIL.
    OrthoDBiEOG7FFMRP.
    PhylomeDBiQ8N8M0.
    TreeFamiTF331490.

    Family and domain databases

    Gene3Di3.40.630.30. 1 hit.
    InterProiIPR016181. Acyl_CoA_acyltransferase.
    IPR000182. GNAT_dom.
    [Graphical view]
    SUPFAMiSSF55729. SSF55729. 1 hit.
    PROSITEiPS51186. GNAT. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8N8M0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKLEASCGTA TSEVPKPEKK TARDAEPSSE TRPQEVEAEP RSGSGPEAEA    50
    EPLDFVVATE REFEEVLAIS GGIYGGLDYL PSRYHSWLRD PDRTVVLAKR 100
    NGGVIALESV NVIDAGETVL VEGLRVAPWE RGKGVAGLLQ RFCSQLVKRQ 150
    HPGVKVARLT RDDQLGPREL KKYRLITKQG ILLVRFNASA LLAGLGARLA 200
    ALRTSGTFSP LPTEAVSEAG GDVARLLLSP SVQRDVLPGG TIIQDWQPYR 250
    PSESNLRLLA AKGLEWRVDS RARPRVLTLC TRPFPIPHGG DGTWRYLNID 300
    AFGSDGAQVQ SQLLWHLQRQ APRLVGLNVM CQLFLEPQLW SQLADFCQVG 350
    LGLELVKGYT EQYLLEADI 369
    Length:369
    Mass (Da):40,521
    Last modified:November 24, 2009 - v2
    Checksum:iDC3AD7F15AAF807C
    GO
    Isoform 2 (identifier: Q8N8M0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         105-112: IALESVNV → VSPGARPR
         113-369: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:112
    Mass (Da):12,125
    Checksum:i84EBC1F5FD1B9953
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti63 – 631F → S.2 Publications
    Corresponds to variant rs34985488 [ dbSNP | Ensembl ].
    VAR_036903

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei105 – 1128IALESVNV → VSPGARPR in isoform 2. 1 PublicationVSP_055771
    Alternative sequencei113 – 369257Missing in isoform 2. 1 PublicationVSP_055772Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK092119 mRNA. Translation: BAG52484.1.
    AK096556 mRNA. Translation: BAC04815.1.
    AC004876 Genomic DNA. No translation available.
    BC104841 mRNA. Translation: AAI04842.1.
    AL831911 mRNA. Translation: CAD38574.3.
    CCDSiCCDS5713.1.
    RefSeqiNP_940973.2. NM_198571.2.
    XP_005250382.1. XM_005250325.1.
    UniGeneiHs.213044.

    Genome annotation databases

    EnsembliENST00000300303; ENSP00000300303; ENSG00000167011. [Q8N8M0-1]
    ENST00000443096; ENSP00000394435; ENSG00000167011. [Q8N8M0-2]
    ENST00000455377; ENSP00000395125; ENSG00000167011. [Q8N8M0-1]
    GeneIDi375607.
    KEGGihsa:375607.
    UCSCiuc003uxy.2. human.

    Polymorphism databases

    DMDMi269849548.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK092119 mRNA. Translation: BAG52484.1 .
    AK096556 mRNA. Translation: BAC04815.1 .
    AC004876 Genomic DNA. No translation available.
    BC104841 mRNA. Translation: AAI04842.1 .
    AL831911 mRNA. Translation: CAD38574.3 .
    CCDSi CCDS5713.1.
    RefSeqi NP_940973.2. NM_198571.2.
    XP_005250382.1. XM_005250325.1.
    UniGenei Hs.213044.

    3D structure databases

    ProteinModelPortali Q8N8M0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 131987. 2 interactions.
    STRINGi 9606.ENSP00000300303.

    PTM databases

    PhosphoSitei Q8N8M0.

    Polymorphism databases

    DMDMi 269849548.

    Proteomic databases

    PaxDbi Q8N8M0.
    PRIDEi Q8N8M0.

    Protocols and materials databases

    DNASUi 375607.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000300303 ; ENSP00000300303 ; ENSG00000167011 . [Q8N8M0-1 ]
    ENST00000443096 ; ENSP00000394435 ; ENSG00000167011 . [Q8N8M0-2 ]
    ENST00000455377 ; ENSP00000395125 ; ENSG00000167011 . [Q8N8M0-1 ]
    GeneIDi 375607.
    KEGGi hsa:375607.
    UCSCi uc003uxy.2. human.

    Organism-specific databases

    CTDi 375607.
    GeneCardsi GC07M100814.
    HGNCi HGNC:22030. NAT16.
    HPAi HPA021918.
    neXtProti NX_Q8N8M0.
    PharmGKBi PA162380580.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG40779.
    HOGENOMi HOG000170303.
    HOVERGENi HBG100954.
    InParanoidi Q8N8M0.
    OMAi ITKQGIL.
    OrthoDBi EOG7FFMRP.
    PhylomeDBi Q8N8M0.
    TreeFami TF331490.

    Miscellaneous databases

    GenomeRNAii 375607.
    NextBioi 100541.
    PROi Q8N8M0.

    Gene expression databases

    ArrayExpressi Q8N8M0.
    Bgeei Q8N8M0.
    CleanExi HS_C7orf52.
    Genevestigatori Q8N8M0.

    Family and domain databases

    Gene3Di 3.40.630.30. 1 hit.
    InterProi IPR016181. Acyl_CoA_acyltransferase.
    IPR000182. GNAT_dom.
    [Graphical view ]
    SUPFAMi SSF55729. SSF55729. 1 hit.
    PROSITEi PS51186. GNAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT SER-63.
      Tissue: Brain.
    2. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT SER-63.
      Tissue: Brain.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 165-369 (ISOFORM 1).
      Tissue: Brain.

    Entry informationi

    Entry nameiNAT16_HUMAN
    AccessioniPrimary (citable) accession number: Q8N8M0
    Secondary accession number(s): B3KRS2, Q8NDR1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 13, 2007
    Last sequence update: November 24, 2009
    Last modified: October 1, 2014
    This is version 78 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3