Q8N8L6 (ARL10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ADP-ribosylation factor-like protein 10

Gene names

Name:	ARL10
Synonyms:	ARL10A

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	244 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the small GTPase superfamily. Arf family.

Ontologies

Keywords
Ligand	GTP-binding Nucleotide-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 244	244	ADP-ribosylation factor-like protein 10		PRO_0000207476
Regions
	Nucleotide binding	84 – 91	8	GTP By similarity
	Nucleotide binding	128 – 132	5	GTP By similarity
	Nucleotide binding	185 – 188	4	GTP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8N8L6 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 56F2DFEA9AA51C9D	FASTA	244	27,459
	10 20 30 40 50 60 MAPRPLGPLV LALGGAAAVL GSVLFILWKT YFGRGRERRW DRGEAWWGAE AARLPEWDEW 70 80 90 100 110 120 DPEDEEDEEP ALEELEQREV LVLGLDGAGK STFLRVLSGK PPLEGHIPTW GFNSVRLPTK 130 140 150 160 170 180 DFEVDLLEIG GSQNLRFYWK EFVSEVDVLV FVVDSADRLR LPWARQELHK LLDKDPDLPV 190 200 210 220 230 240 VVVANKQDLS EAMSMGELQR ELGLQAIDNQ REVFLLAASI APAGPTFEEP GTVHIWKLLL ELLS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[2]	"Rasl11a, member of a novel small monomeric GTPase gene family, is differentially expressed in prostate tumors." Louro R., Nakaya H.I., Paquola A.C.M., Martins E.A.L., da Silva A.M., Verjovski-Almeida S., Reis E.M. Biochem. Biophys. Res. Commun. 316:618-627(2004) [PubMed: 15033445] [Abstract] Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK096568 mRNA. Translation: BAC04820.1. BK001673 mRNA. Translation: DAA02136.1.
IPI	IPI00167501.
RefSeq	NP_775935.1. NM_173664.4.
UniGene	Hs.424552.
3D structure databases
ProteinModelPortal	Q8N8L6.
SMR	Q8N8L6. Positions 72-230.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8N8L6.
Polymorphism databases
DMDM	74751109.
Proteomic databases
PRIDE	Q8N8L6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000310389; ENSP00000308496; ENSG00000175414.
GeneID	285598.
KEGG	hsa:285598.
UCSC	uc003mec.1. human.
Organism-specific databases
CTD	285598.
GeneCards	GC05P175792.
H-InvDB	HIX0032072.
HGNC	HGNC:22042. ARL10.
neXtProt	NX_Q8N8L6.
PharmGKB	PA134871031.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00600000084447.
HOGENOM	HBG745225.
HOVERGEN	HBG002073.
InParanoid	Q8N8L6.
OMA	NQREVFL.
OrthoDB	EOG46DM40.
PhylomeDB	Q8N8L6.
Gene expression databases
ArrayExpress	Q8N8L6.
Bgee	Q8N8L6.
CleanEx	HS_ARL10.
Genevestigator	Q8N8L6.
GermOnline	ENSG00000175414. Homo sapiens.
Family and domain databases
InterPro	IPR024156. Small_GTPase_ARF. IPR006689. Small_GTPase_ARF/SAR. [Graphical view]
KO	K07958.
PANTHER	PTHR11711. ARF/SAR. 1 hit.
Pfam	PF00025. Arf. 1 hit. [Graphical view]
PRINTS	PR00328. SAR1GTPBP.
PROSITE	PS51417. ARF. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	95636.

Entry information

Entry name

ARL10_HUMAN

Accession

Primary (citable) accession number: Q8N8L6

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	October 1, 2002
Last modified:	January 25, 2012
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.