Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

ADP-ribosylation factor-like protein 10

Gene

ARL10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi84 – 918GTPBy similarity
Nucleotide bindingi128 – 1325GTPBy similarity
Nucleotide bindingi185 – 1884GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor-like protein 10
Gene namesi
Name:ARL10
Synonyms:ARL10A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:22042. ARL10.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134871031.

Polymorphism and mutation databases

BioMutaiARL10.
DMDMi74751109.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 244244ADP-ribosylation factor-like protein 10PRO_0000207476Add
BLAST

Proteomic databases

PaxDbiQ8N8L6.
PRIDEiQ8N8L6.

PTM databases

iPTMnetiQ8N8L6.
PhosphoSiteiQ8N8L6.

Expressioni

Gene expression databases

BgeeiQ8N8L6.
CleanExiHS_ARL10.
ExpressionAtlasiQ8N8L6. baseline and differential.
GenevisibleiQ8N8L6. HS.

Organism-specific databases

HPAiHPA047044.

Interactioni

Protein-protein interaction databases

BioGridi130153. 23 interactions.
STRINGi9606.ENSP00000308496.

Structurei

3D structure databases

ProteinModelPortaliQ8N8L6.
SMRiQ8N8L6. Positions 36-229.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

eggNOGiENOG410IVQ0. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00840000129731.
HOGENOMiHOG000163691.
HOVERGENiHBG002073.
InParanoidiQ8N8L6.
KOiK07958.
OMAiWDRGEAW.
OrthoDBiEOG7KM5VD.
PhylomeDBiQ8N8L6.
TreeFamiTF105469.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
[Graphical view]
PRINTSiPR00328. SAR1GTPBP.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51417. ARF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N8L6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPRPLGPLV LALGGAAAVL GSVLFILWKT YFGRGRERRW DRGEAWWGAE
60 70 80 90 100
AARLPEWDEW DPEDEEDEEP ALEELEQREV LVLGLDGAGK STFLRVLSGK
110 120 130 140 150
PPLEGHIPTW GFNSVRLPTK DFEVDLLEIG GSQNLRFYWK EFVSEVDVLV
160 170 180 190 200
FVVDSADRLR LPWARQELHK LLDKDPDLPV VVVANKQDLS EAMSMGELQR
210 220 230 240
ELGLQAIDNQ REVFLLAASI APAGPTFEEP GTVHIWKLLL ELLS
Length:244
Mass (Da):27,459
Last modified:October 1, 2002 - v1
Checksum:i56F2DFEA9AA51C9D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096568 mRNA. Translation: BAC04820.1.
BK001673 mRNA. Translation: DAA02136.1.
CCDSiCCDS4400.1.
RefSeqiNP_775935.1. NM_173664.5.
UniGeneiHs.424552.

Genome annotation databases

EnsembliENST00000310389; ENSP00000308496; ENSG00000175414.
GeneIDi285598.
KEGGihsa:285598.
UCSCiuc003mec.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096568 mRNA. Translation: BAC04820.1.
BK001673 mRNA. Translation: DAA02136.1.
CCDSiCCDS4400.1.
RefSeqiNP_775935.1. NM_173664.5.
UniGeneiHs.424552.

3D structure databases

ProteinModelPortaliQ8N8L6.
SMRiQ8N8L6. Positions 36-229.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130153. 23 interactions.
STRINGi9606.ENSP00000308496.

PTM databases

iPTMnetiQ8N8L6.
PhosphoSiteiQ8N8L6.

Polymorphism and mutation databases

BioMutaiARL10.
DMDMi74751109.

Proteomic databases

PaxDbiQ8N8L6.
PRIDEiQ8N8L6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310389; ENSP00000308496; ENSG00000175414.
GeneIDi285598.
KEGGihsa:285598.
UCSCiuc003mec.2. human.

Organism-specific databases

CTDi285598.
GeneCardsiARL10.
H-InvDBHIX0032072.
HGNCiHGNC:22042. ARL10.
HPAiHPA047044.
neXtProtiNX_Q8N8L6.
PharmGKBiPA134871031.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVQ0. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00840000129731.
HOGENOMiHOG000163691.
HOVERGENiHBG002073.
InParanoidiQ8N8L6.
KOiK07958.
OMAiWDRGEAW.
OrthoDBiEOG7KM5VD.
PhylomeDBiQ8N8L6.
TreeFamiTF105469.

Miscellaneous databases

ChiTaRSiARL10. human.
GenomeRNAii285598.
PROiQ8N8L6.

Gene expression databases

BgeeiQ8N8L6.
CleanExiHS_ARL10.
ExpressionAtlasiQ8N8L6. baseline and differential.
GenevisibleiQ8N8L6. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
[Graphical view]
PRINTSiPR00328. SAR1GTPBP.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51417. ARF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "Rasl11a, member of a novel small monomeric GTPase gene family, is differentially expressed in prostate tumors."
    Louro R., Nakaya H.I., Paquola A.C.M., Martins E.A.L., da Silva A.M., Verjovski-Almeida S., Reis E.M.
    Biochem. Biophys. Res. Commun. 316:618-627(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiARL10_HUMAN
AccessioniPrimary (citable) accession number: Q8N8L6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: October 1, 2002
Last modified: June 8, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.