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Protein

ADP-ribosylation factor-like protein 10

Gene

ARL10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi84 – 91GTPBy similarity8
Nucleotide bindingi128 – 132GTPBy similarity5
Nucleotide bindingi185 – 188GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor-like protein 10
Gene namesi
Name:ARL10
Synonyms:ARL10A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000175414.6.
HGNCiHGNC:22042. ARL10.

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000175414.
PharmGKBiPA134871031.

Polymorphism and mutation databases

BioMutaiARL10.
DMDMi74751109.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002074761 – 244ADP-ribosylation factor-like protein 10Add BLAST244

Proteomic databases

EPDiQ8N8L6.
PaxDbiQ8N8L6.
PeptideAtlasiQ8N8L6.
PRIDEiQ8N8L6.

PTM databases

iPTMnetiQ8N8L6.
PhosphoSitePlusiQ8N8L6.

Expressioni

Gene expression databases

BgeeiENSG00000175414.
CleanExiHS_ARL10.
ExpressionAtlasiQ8N8L6. baseline and differential.
GenevisibleiQ8N8L6. HS.

Organism-specific databases

HPAiHPA047044.

Interactioni

Protein-protein interaction databases

BioGridi130153. 30 interactors.
IntActiQ8N8L6. 1 interactor.
STRINGi9606.ENSP00000308496.

Structurei

3D structure databases

ProteinModelPortaliQ8N8L6.
SMRiQ8N8L6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

eggNOGiENOG410IVQ0. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00890000139352.
HOGENOMiHOG000163691.
HOVERGENiHBG002073.
InParanoidiQ8N8L6.
KOiK07958.
OMAiWDRGEAW.
OrthoDBiEOG091G0NKZ.
PhylomeDBiQ8N8L6.
TreeFamiTF105469.

Family and domain databases

InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
PfamiView protein in Pfam
PF00025. Arf. 1 hit.
PRINTSiPR00328. SAR1GTPBP.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS51417. ARF. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8N8L6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPRPLGPLV LALGGAAAVL GSVLFILWKT YFGRGRERRW DRGEAWWGAE
60 70 80 90 100
AARLPEWDEW DPEDEEDEEP ALEELEQREV LVLGLDGAGK STFLRVLSGK
110 120 130 140 150
PPLEGHIPTW GFNSVRLPTK DFEVDLLEIG GSQNLRFYWK EFVSEVDVLV
160 170 180 190 200
FVVDSADRLR LPWARQELHK LLDKDPDLPV VVVANKQDLS EAMSMGELQR
210 220 230 240
ELGLQAIDNQ REVFLLAASI APAGPTFEEP GTVHIWKLLL ELLS
Length:244
Mass (Da):27,459
Last modified:October 1, 2002 - v1
Checksum:i56F2DFEA9AA51C9D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096568 mRNA. Translation: BAC04820.1.
BK001673 mRNA. Translation: DAA02136.1.
CCDSiCCDS4400.1.
RefSeqiNP_775935.1. NM_173664.5.
UniGeneiHs.424552.

Genome annotation databases

EnsembliENST00000310389; ENSP00000308496; ENSG00000175414.
GeneIDi285598.
KEGGihsa:285598.
UCSCiuc003mec.2. human.

Similar proteinsi

Entry informationi

Entry nameiARL10_HUMAN
AccessioniPrimary (citable) accession number: Q8N8L6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: October 1, 2002
Last modified: September 27, 2017
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families