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Protein

Zinc finger protein 491

Gene

ZNF491

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri35 – 5925C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri103 – 12523C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri131 – 15323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri159 – 18123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri187 – 20923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri215 – 23723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri243 – 26523C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri271 – 29323C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri299 – 32123C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri327 – 34923C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri355 – 37723C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri383 – 40523C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri411 – 43323C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 491
Gene namesi
Name:ZNF491
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:23706. ZNF491.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134982286.

Polymorphism and mutation databases

BioMutaiZNF491.
DMDMi51316965.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 437437Zinc finger protein 491PRO_0000047614Add
BLAST

Proteomic databases

PaxDbiQ8N8L2.
PRIDEiQ8N8L2.

PTM databases

iPTMnetiQ8N8L2.
PhosphoSiteiQ8N8L2.

Expressioni

Gene expression databases

BgeeiQ8N8L2.
CleanExiHS_ZNF491.
ExpressionAtlasiQ8N8L2. baseline and differential.
GenevisibleiQ8N8L2. HS.

Interactioni

Protein-protein interaction databases

BioGridi125952. 11 interactions.
STRINGi9606.ENSP00000313443.

Structurei

3D structure databases

ProteinModelPortaliQ8N8L2.
SMRiQ8N8L2. Positions 13-434.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 13 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri35 – 5925C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri103 – 12523C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri131 – 15323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri159 – 18123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri187 – 20923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri215 – 23723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri243 – 26523C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri271 – 29323C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri299 – 32123C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri327 – 34923C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri355 – 37723C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri383 – 40523C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri411 – 43323C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119089.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8N8L2.
OMAiCFRTHER.
PhylomeDBiQ8N8L2.
TreeFamiTF338854.

Family and domain databases

Gene3Di3.30.160.60. 13 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 12 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N8L2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGERLFESAE GSQCGETFTQ VPEDMLNKKT LPGVKSCESG TCGEIFMGYS
60 70 80 90 100
SFNRNIRTDT GHQPHKCQKF LEKPYKHKQR RKALSHSHCF RTHERPHTRE
110 120 130 140 150
KPFDCKECEK SFISPASIRR YMVTHSGDGP YKCKFCGKAL DCLSLYLTHE
160 170 180 190 200
RTHTGEKRYE CKQCGKAFSW HSSVRIHERT HTGEKPYECK ECGKSFNFSS
210 220 230 240 250
SFRRHERTHT GEKPYKCKEC GKAFNCPSSF HRHERTHTGE KPYECKLYGK
260 270 280 290 300
ALSRLISFRR HMRMHTGERP HKCKICGKAF YSPSSFQRHE RSHTGEKPYK
310 320 330 340 350
CKQCGKAFTC STSFQYHERT HTGEKPDGCK QCGKAFRSAK YIRIHGRTHT
360 370 380 390 400
GEKPYECKQC GKAFHCVSSF HRHERTHAGE KPYECKHCGK AFTCSIYIRI
410 420 430
HERIHTGEKP YQCKECGKAF IRSSYCRKHE RTHTINI
Length:437
Mass (Da):50,950
Last modified:October 1, 2002 - v1
Checksum:i1F4BC6E07A031634
GO

Sequence cautioni

The sequence BAC03809.1 differs from that shown. Reason: Erroneous termination at position 408. Translated as Glu.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK092110 mRNA. Translation: BAC03809.1. Sequence problems.
AK096593 mRNA. Translation: BAC04824.1.
BC101590 mRNA. Translation: AAI01591.1.
BC101592 mRNA. Translation: AAI01593.1.
CCDSiCCDS12267.1.
RefSeqiNP_689569.2. NM_152356.3.
XP_005259787.1. XM_005259730.2.
XP_011525979.1. XM_011527677.1.
UniGeneiHs.631634.

Genome annotation databases

EnsembliENST00000323169; ENSP00000313443; ENSG00000177599.
GeneIDi126069.
KEGGihsa:126069.
UCSCiuc002mso.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK092110 mRNA. Translation: BAC03809.1. Sequence problems.
AK096593 mRNA. Translation: BAC04824.1.
BC101590 mRNA. Translation: AAI01591.1.
BC101592 mRNA. Translation: AAI01593.1.
CCDSiCCDS12267.1.
RefSeqiNP_689569.2. NM_152356.3.
XP_005259787.1. XM_005259730.2.
XP_011525979.1. XM_011527677.1.
UniGeneiHs.631634.

3D structure databases

ProteinModelPortaliQ8N8L2.
SMRiQ8N8L2. Positions 13-434.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125952. 11 interactions.
STRINGi9606.ENSP00000313443.

PTM databases

iPTMnetiQ8N8L2.
PhosphoSiteiQ8N8L2.

Polymorphism and mutation databases

BioMutaiZNF491.
DMDMi51316965.

Proteomic databases

PaxDbiQ8N8L2.
PRIDEiQ8N8L2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000323169; ENSP00000313443; ENSG00000177599.
GeneIDi126069.
KEGGihsa:126069.
UCSCiuc002mso.2. human.

Organism-specific databases

CTDi126069.
GeneCardsiZNF491.
HGNCiHGNC:23706. ZNF491.
neXtProtiNX_Q8N8L2.
PharmGKBiPA134982286.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119089.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8N8L2.
OMAiCFRTHER.
PhylomeDBiQ8N8L2.
TreeFamiTF338854.

Miscellaneous databases

GenomeRNAii126069.
NextBioi81657.
PROiQ8N8L2.

Gene expression databases

BgeeiQ8N8L2.
CleanExiHS_ZNF491.
ExpressionAtlasiQ8N8L2. baseline and differential.
GenevisibleiQ8N8L2. HS.

Family and domain databases

Gene3Di3.30.160.60. 13 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 12 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiZN491_HUMAN
AccessioniPrimary (citable) accession number: Q8N8L2
Secondary accession number(s): Q3MJ35, Q8NAT8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: October 1, 2002
Last modified: March 16, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.