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Protein

Uncharacterized protein KIAA1958

Gene

KIAA1958

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein KIAA1958
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:23427. KIAA1958.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134937806.

Polymorphism and mutation databases

BioMutaiKIAA1958.
DMDMi73621119.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 716716Uncharacterized protein KIAA1958PRO_0000050811Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei97 – 971PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8N8K9.
PaxDbiQ8N8K9.
PeptideAtlasiQ8N8K9.
PRIDEiQ8N8K9.

PTM databases

iPTMnetiQ8N8K9.
PhosphoSiteiQ8N8K9.

Expressioni

Gene expression databases

BgeeiQ8N8K9.
CleanExiHS_KIAA1958.
GenevisibleiQ8N8K9. HS.

Organism-specific databases

HPAiHPA020625.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
AQP1P299723EBI-10181113,EBI-745213
CEP19Q96LK03EBI-10181113,EBI-741885
COASYQ13057-23EBI-10181113,EBI-10227704
FAM124BQ9H5Z63EBI-10181113,EBI-741626
GABARAPL2P605203EBI-10181113,EBI-720116
LMO4P619683EBI-10181113,EBI-2798728
MCRS1Q96EZ83EBI-10181113,EBI-348259
RWDD2BP570603EBI-10181113,EBI-724442
SOCS3O145433EBI-10181113,EBI-714146
STACQ8WUK83EBI-10181113,EBI-10276615
TCEA2Q155603EBI-10181113,EBI-710310

Protein-protein interaction databases

BioGridi127680. 13 interactions.
IntActiQ8N8K9. 12 interactions.
STRINGi9606.ENSP00000336940.

Structurei

3D structure databases

ProteinModelPortaliQ8N8K9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IHMV. Eukaryota.
ENOG410XWKQ. LUCA.
GeneTreeiENSGT00440000039527.
HOGENOMiHOG000049241.
HOVERGENiHBG080373.
InParanoidiQ8N8K9.
OMAiYWCMTKG.
OrthoDBiEOG75B84M.
PhylomeDBiQ8N8K9.
TreeFamiTF332895.

Family and domain databases

InterProiIPR021893. DUF3504.
[Graphical view]
PfamiPF12012. DUF3504. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N8K9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEDCLHTSSE NLSKLVSWAH SHGTICSLIP NLKHLLSEGS HGNLTAMWGC
60 70 80 90 100
SAGHAYHWPL TATCRAGSQE RVCFQDNRSF NSDSPSIIGV PSETQTSPVE
110 120 130 140 150
RYPGRPVKAK LDCNRTRDSC DFSYCSEPSE LDETVEEYED ENTLFDMVCE
160 170 180 190 200
SSVTDEDSDF EPQTQRPQSI ARKRPGVVPS SLHSSSQTQM VDECSNDVII
210 220 230 240 250
KKIKQEIPED YYIVANAELT GGVDGPALSL TQMAKPKPQT HAGPSCVGSA
260 270 280 290 300
KLIPHVTSAI STELDPHGMS ASPSVISRPI VQKTARVSLA SPNRGPPGTH
310 320 330 340 350
GTNQQVAMQM PVSTSHPNKQ ISIPLSALQL PGQDEQVASE EFLSHLPSQV
360 370 380 390 400
SSCEVALSPS VNTEPEVSSS QQQPPVAPAI TTEATAQCIP AYSTKLNKFP
410 420 430 440 450
VFNINDDLND LCTSAVSPNT TKATRYALNV WRYWCMTNGL KDHTDITKIP
460 470 480 490 500
AVKLNELLEN FYVTVKKSDG SDFLATSLHA IRRGLDRILK NAGVGFSITS
510 520 530 540 550
STFSSSTKKL KEKLWVLSKA GMSGARSRNI VYFSLSDEEE MWQAGCLGDD
560 570 580 590 600
SPITLLSTVV KYNSQYLNMR TLQEHADLMY GDIELLKDPQ NQPYFARTDS
610 620 630 640 650
VKRESRSGST RVCHGKIYHE HSRGHKQCPY CLLYKYMYIH RPPTQMEAKS
660 670 680 690 700
PFYLTARKEA TDMGSVWYEE QRMGLRSLRG IVPNLAKKVK LENCENFTFV
710
SFTQVSRRLG SHSCCQ
Length:716
Mass (Da):79,212
Last modified:October 1, 2002 - v1
Checksum:iAA5FD94A98446863
GO
Isoform 2 (identifier: Q8N8K9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     391-716: AYSTKLNKFP...RRLGSHSCCQ → DQDERAAELS...ASYDSSSDTA

Note: Gene prediction confirmed by EST data.
Show »
Length:738
Mass (Da):81,630
Checksum:i4834D17BE93A66BE
GO
Isoform 3 (identifier: Q8N8K9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     390-391: PA → PDQDERAAELSREQNEKTIRSTQTALRNFP

Note: No experimental confirmation available.
Show »
Length:744
Mass (Da):82,528
Checksum:iFE3D9E9A48F05497
GO

Sequence cautioni

The sequence BAB71114.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti541 – 5411M → V in BAB71114 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei390 – 3912PA → PDQDERAAELSREQNEKTIR STQTALRNFP in isoform 3. 1 PublicationVSP_054654
Alternative sequencei391 – 716326AYSTK…HSCCQ → DQDERAAELSREQNEKTIRS TQTALRNFREFLISKYPSET REIYVIPCKELDAYLASFFV DARQKDGSEYEPNSLANYQC GLERYLKEHRYGYSITRDKE FKRSQEALKQKQIELRCKGK GNKPHKSMKLTFADELILRK RGLLSRYNPEGLLNLVWLNN TKAFGHCTGFHGSTLKWGDI RLRVTETGLEYLEWMGQDTG DLNAKTKRGGTDSRVYATQH APQTCPVQDYKEYAQRRPPA MRYEDAPFYLSIKPVVNLAA LHWYNCQALGKNKLAKMVKT MCEKGNIPGRKTNFSVYQSC STLSEAQSNQLVLICNNLSQ QAAQSVAGHSNNGNFIVSAS YDSSSDTA in isoform 2. CuratedVSP_015146Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096613 mRNA. Translation: BAC04827.1.
AK056181 mRNA. Translation: BAB71114.1. Different initiation.
AL162732 Genomic DNA. No translation available.
AL390067, AL445187 Genomic DNA. Translation: CAH71933.1.
AL445187, AL390067 Genomic DNA. Translation: CAI16023.1.
AL445187 Genomic DNA. Translation: CAI16024.1.
BC105048 mRNA. Translation: AAI05049.1.
BC113515 mRNA. Translation: AAI13516.1.
BC143424 mRNA. Translation: AAI43425.1.
AB075838 mRNA. Translation: BAB85544.1.
CCDSiCCDS35108.1. [Q8N8K9-1]
CCDS69642.1. [Q8N8K9-3]
RefSeqiNP_001273965.1. NM_001287036.1. [Q8N8K9-3]
NP_001273967.1. NM_001287038.1.
NP_597722.1. NM_133465.3. [Q8N8K9-1]
XP_006717041.1. XM_006716978.2. [Q8N8K9-2]
XP_011516612.1. XM_011518310.1. [Q8N8K9-2]
XP_011516613.1. XM_011518311.1. [Q8N8K9-2]
UniGeneiHs.656619.
Hs.660744.

Genome annotation databases

EnsembliENST00000337530; ENSP00000336940; ENSG00000165185. [Q8N8K9-1]
ENST00000374244; ENSP00000363362; ENSG00000165185. [Q8N8K9-2]
ENST00000536272; ENSP00000440504; ENSG00000165185. [Q8N8K9-3]
GeneIDi158405.
KEGGihsa:158405.
UCSCiuc004bgf.3. human. [Q8N8K9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096613 mRNA. Translation: BAC04827.1.
AK056181 mRNA. Translation: BAB71114.1. Different initiation.
AL162732 Genomic DNA. No translation available.
AL390067, AL445187 Genomic DNA. Translation: CAH71933.1.
AL445187, AL390067 Genomic DNA. Translation: CAI16023.1.
AL445187 Genomic DNA. Translation: CAI16024.1.
BC105048 mRNA. Translation: AAI05049.1.
BC113515 mRNA. Translation: AAI13516.1.
BC143424 mRNA. Translation: AAI43425.1.
AB075838 mRNA. Translation: BAB85544.1.
CCDSiCCDS35108.1. [Q8N8K9-1]
CCDS69642.1. [Q8N8K9-3]
RefSeqiNP_001273965.1. NM_001287036.1. [Q8N8K9-3]
NP_001273967.1. NM_001287038.1.
NP_597722.1. NM_133465.3. [Q8N8K9-1]
XP_006717041.1. XM_006716978.2. [Q8N8K9-2]
XP_011516612.1. XM_011518310.1. [Q8N8K9-2]
XP_011516613.1. XM_011518311.1. [Q8N8K9-2]
UniGeneiHs.656619.
Hs.660744.

3D structure databases

ProteinModelPortaliQ8N8K9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127680. 13 interactions.
IntActiQ8N8K9. 12 interactions.
STRINGi9606.ENSP00000336940.

PTM databases

iPTMnetiQ8N8K9.
PhosphoSiteiQ8N8K9.

Polymorphism and mutation databases

BioMutaiKIAA1958.
DMDMi73621119.

Proteomic databases

MaxQBiQ8N8K9.
PaxDbiQ8N8K9.
PeptideAtlasiQ8N8K9.
PRIDEiQ8N8K9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000337530; ENSP00000336940; ENSG00000165185. [Q8N8K9-1]
ENST00000374244; ENSP00000363362; ENSG00000165185. [Q8N8K9-2]
ENST00000536272; ENSP00000440504; ENSG00000165185. [Q8N8K9-3]
GeneIDi158405.
KEGGihsa:158405.
UCSCiuc004bgf.3. human. [Q8N8K9-1]

Organism-specific databases

CTDi158405.
GeneCardsiKIAA1958.
HGNCiHGNC:23427. KIAA1958.
HPAiHPA020625.
neXtProtiNX_Q8N8K9.
PharmGKBiPA134937806.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHMV. Eukaryota.
ENOG410XWKQ. LUCA.
GeneTreeiENSGT00440000039527.
HOGENOMiHOG000049241.
HOVERGENiHBG080373.
InParanoidiQ8N8K9.
OMAiYWCMTKG.
OrthoDBiEOG75B84M.
PhylomeDBiQ8N8K9.
TreeFamiTF332895.

Miscellaneous databases

ChiTaRSiKIAA1958. human.
GeneWikiiKIAA1958.
GenomeRNAii158405.
PROiQ8N8K9.

Gene expression databases

BgeeiQ8N8K9.
CleanExiHS_KIAA1958.
GenevisibleiQ8N8K9. HS.

Family and domain databases

InterProiIPR021893. DUF3504.
[Graphical view]
PfamiPF12012. DUF3504. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain and Teratocarcinoma.
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Brain.
  4. "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins."
    Nagase T., Kikuno R., Ohara O.
    DNA Res. 8:319-327(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 110-716 (ISOFORM 1).
  5. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-97, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.

Entry informationi

Entry nameiK1958_HUMAN
AccessioniPrimary (citable) accession number: Q8N8K9
Secondary accession number(s): B7ZKW6
, Q2M336, Q5T252, Q8TF43, Q96N02
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: October 1, 2002
Last modified: June 8, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.