Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Uncharacterized protein KIAA1958

Gene

KIAA1958

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein KIAA1958
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000165185.14.
HGNCiHGNC:23427. KIAA1958.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi158405.
OpenTargetsiENSG00000165185.
PharmGKBiPA134937806.

Polymorphism and mutation databases

BioMutaiKIAA1958.
DMDMi73621119.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000508111 – 716Uncharacterized protein KIAA1958Add BLAST716

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei97PhosphoserineCombined sources1
Cross-linki201Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki204Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki237Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki283Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki626Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ8N8K9.
PaxDbiQ8N8K9.
PeptideAtlasiQ8N8K9.
PRIDEiQ8N8K9.

PTM databases

iPTMnetiQ8N8K9.
PhosphoSitePlusiQ8N8K9.

Expressioni

Gene expression databases

BgeeiENSG00000165185.
CleanExiHS_KIAA1958.
GenevisibleiQ8N8K9. HS.

Organism-specific databases

HPAiHPA020625.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi127680. 13 interactors.
IntActiQ8N8K9. 15 interactors.
STRINGi9606.ENSP00000336940.

Structurei

3D structure databases

ProteinModelPortaliQ8N8K9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IHMV. Eukaryota.
ENOG410XWKQ. LUCA.
GeneTreeiENSGT00440000039527.
HOGENOMiHOG000049241.
HOVERGENiHBG080373.
InParanoidiQ8N8K9.
OMAiYWCMTKG.
OrthoDBiEOG091G070E.
PhylomeDBiQ8N8K9.
TreeFamiTF332895.

Family and domain databases

InterProiView protein in InterPro
IPR021893. DUF3504.
PfamiView protein in Pfam
PF12012. DUF3504. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N8K9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEDCLHTSSE NLSKLVSWAH SHGTICSLIP NLKHLLSEGS HGNLTAMWGC
60 70 80 90 100
SAGHAYHWPL TATCRAGSQE RVCFQDNRSF NSDSPSIIGV PSETQTSPVE
110 120 130 140 150
RYPGRPVKAK LDCNRTRDSC DFSYCSEPSE LDETVEEYED ENTLFDMVCE
160 170 180 190 200
SSVTDEDSDF EPQTQRPQSI ARKRPGVVPS SLHSSSQTQM VDECSNDVII
210 220 230 240 250
KKIKQEIPED YYIVANAELT GGVDGPALSL TQMAKPKPQT HAGPSCVGSA
260 270 280 290 300
KLIPHVTSAI STELDPHGMS ASPSVISRPI VQKTARVSLA SPNRGPPGTH
310 320 330 340 350
GTNQQVAMQM PVSTSHPNKQ ISIPLSALQL PGQDEQVASE EFLSHLPSQV
360 370 380 390 400
SSCEVALSPS VNTEPEVSSS QQQPPVAPAI TTEATAQCIP AYSTKLNKFP
410 420 430 440 450
VFNINDDLND LCTSAVSPNT TKATRYALNV WRYWCMTNGL KDHTDITKIP
460 470 480 490 500
AVKLNELLEN FYVTVKKSDG SDFLATSLHA IRRGLDRILK NAGVGFSITS
510 520 530 540 550
STFSSSTKKL KEKLWVLSKA GMSGARSRNI VYFSLSDEEE MWQAGCLGDD
560 570 580 590 600
SPITLLSTVV KYNSQYLNMR TLQEHADLMY GDIELLKDPQ NQPYFARTDS
610 620 630 640 650
VKRESRSGST RVCHGKIYHE HSRGHKQCPY CLLYKYMYIH RPPTQMEAKS
660 670 680 690 700
PFYLTARKEA TDMGSVWYEE QRMGLRSLRG IVPNLAKKVK LENCENFTFV
710
SFTQVSRRLG SHSCCQ
Length:716
Mass (Da):79,212
Last modified:October 1, 2002 - v1
Checksum:iAA5FD94A98446863
GO
Isoform 2 (identifier: Q8N8K9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     391-716: AYSTKLNKFP...RRLGSHSCCQ → DQDERAAELS...ASYDSSSDTA

Note: Gene prediction confirmed by EST data.
Show »
Length:738
Mass (Da):81,630
Checksum:i4834D17BE93A66BE
GO
Isoform 3 (identifier: Q8N8K9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     390-391: PA → PDQDERAAELSREQNEKTIRSTQTALRNFP

Note: No experimental confirmation available.
Show »
Length:744
Mass (Da):82,528
Checksum:iFE3D9E9A48F05497
GO

Sequence cautioni

The sequence BAB71114 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti541M → V in BAB71114 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_054654390 – 391PA → PDQDERAAELSREQNEKTIR STQTALRNFP in isoform 3. 1 Publication2
Alternative sequenceiVSP_015146391 – 716AYSTK…HSCCQ → DQDERAAELSREQNEKTIRS TQTALRNFREFLISKYPSET REIYVIPCKELDAYLASFFV DARQKDGSEYEPNSLANYQC GLERYLKEHRYGYSITRDKE FKRSQEALKQKQIELRCKGK GNKPHKSMKLTFADELILRK RGLLSRYNPEGLLNLVWLNN TKAFGHCTGFHGSTLKWGDI RLRVTETGLEYLEWMGQDTG DLNAKTKRGGTDSRVYATQH APQTCPVQDYKEYAQRRPPA MRYEDAPFYLSIKPVVNLAA LHWYNCQALGKNKLAKMVKT MCEKGNIPGRKTNFSVYQSC STLSEAQSNQLVLICNNLSQ QAAQSVAGHSNNGNFIVSAS YDSSSDTA in isoform 2. CuratedAdd BLAST326

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096613 mRNA. Translation: BAC04827.1.
AK056181 mRNA. Translation: BAB71114.1. Different initiation.
AL162732 Genomic DNA. No translation available.
AL390067 Genomic DNA. No translation available.
AL445187 Genomic DNA. No translation available.
BC105048 mRNA. Translation: AAI05049.1.
BC113515 mRNA. Translation: AAI13516.1.
BC143424 mRNA. Translation: AAI43425.1.
AB075838 mRNA. Translation: BAB85544.1.
CCDSiCCDS35108.1. [Q8N8K9-1]
CCDS69642.1. [Q8N8K9-3]
RefSeqiNP_001273965.1. NM_001287036.1. [Q8N8K9-3]
NP_001273967.1. NM_001287038.1.
NP_597722.1. NM_133465.3. [Q8N8K9-1]
XP_011516613.1. XM_011518311.2. [Q8N8K9-2]
UniGeneiHs.656619.
Hs.660744.

Genome annotation databases

EnsembliENST00000337530; ENSP00000336940; ENSG00000165185. [Q8N8K9-1]
ENST00000374244; ENSP00000363362; ENSG00000165185. [Q8N8K9-2]
ENST00000536272; ENSP00000440504; ENSG00000165185. [Q8N8K9-3]
GeneIDi158405.
KEGGihsa:158405.
UCSCiuc004bgf.3. human. [Q8N8K9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiK1958_HUMAN
AccessioniPrimary (citable) accession number: Q8N8K9
Secondary accession number(s): B7ZKW6
, Q2M336, Q5T252, Q8TF43, Q96N02
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: October 1, 2002
Last modified: November 22, 2017
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot