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Protein

Zinc finger protein 615

Gene

ZNF615

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri204 – 226C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri232 – 254C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri260 – 282C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri288 – 310C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri316 – 338C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri344 – 366C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri372 – 394C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri400 – 422C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri428 – 450C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri456 – 478C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri484 – 506C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri512 – 534C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri540 – 562C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri568 – 590C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri596 – 618C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri624 – 646C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri652 – 674C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri680 – 702C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri708 – 730C2H2-type 19PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000176089-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 615
Gene namesi
Name:ZNF615
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:24740. ZNF615.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000197619.
PharmGKBiPA134872929.

Polymorphism and mutation databases

BioMutaiZNF615.
DMDMi161784348.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000476901 – 731Zinc finger protein 615Add BLAST731

Proteomic databases

MaxQBiQ8N8J6.
PaxDbiQ8N8J6.
PeptideAtlasiQ8N8J6.
PRIDEiQ8N8J6.

PTM databases

iPTMnetiQ8N8J6.
PhosphoSitePlusiQ8N8J6.

Expressioni

Gene expression databases

BgeeiENSG00000197619.
CleanExiHS_ZNF615.
ExpressionAtlasiQ8N8J6. baseline and differential.
GenevisibleiQ8N8J6. HS.

Organism-specific databases

HPAiHPA052422.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000365906.

Structurei

3D structure databases

ProteinModelPortaliQ8N8J6.
SMRiQ8N8J6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 79KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Contains 19 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri204 – 226C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri232 – 254C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri260 – 282C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri288 – 310C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri316 – 338C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri344 – 366C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri372 – 394C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri400 – 422C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri428 – 450C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri456 – 478C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri484 – 506C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri512 – 534C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri540 – 562C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri568 – 590C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri596 – 618C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri624 – 646C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri652 – 674C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri680 – 702C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri708 – 730C2H2-type 19PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133681.
HOVERGENiHBG018163.
InParanoidiQ8N8J6.
KOiK09228.
OMAiFSLRKND.
OrthoDBiEOG091G02KC.
PhylomeDBiQ8N8J6.
TreeFamiTF350804.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 19 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 19 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 18 hits.
PS50157. ZINC_FINGER_C2H2_2. 19 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N8J6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMQAQESLTL EDVAVDFTWE EWQFLSPAQK DLYRDVMLEN YSNLVAVGYQ
60 70 80 90 100
ASKPDALSKL ERGEETCTTE DEIYSRICSE IRKIDDPLQH HLQNQSIQKS
110 120 130 140 150
VKQCHEQNMF GNIVNQNKGH FLLKQDCDTF DLHEKPLKSN LSFENQKRSS
160 170 180 190 200
GLKNSAEFNR DGKSLFHANH KQFYTEMKFP AIAKPINKSQ FIKQQRTHNI
210 220 230 240 250
ENAHVCSECG KAFLKLSQFI DHQRVHTGEK PHVCSMCGKA FSRKSRLMDH
260 270 280 290 300
QRTHTELKHY ECTECDKTFL KKSQLNIHQK THMGGKPYTC SQCGKAFIKK
310 320 330 340 350
CRLIYHQRTH TGEKPHGCSV CGKAFSTKFS LTTHQKTHTG EKPYICSECG
360 370 380 390 400
KGFIEKRRLT AHHRTHTGEK PFICNKCGKG FTLKNSLITH QQTHTGEKLY
410 420 430 440 450
TCSECGKGFS MKHCLMVHQR THTGEKPYKC NECGKGFALK SPLIRHQRTH
460 470 480 490 500
TGEKPYVCTE CRKGFTMKSD LIVHQRTHTA EKPYICNDCG KGFTVKSRLI
510 520 530 540 550
VHQRTHTGEK PYVCGECGKG FPAKIRLMGH QRTHTGEKPY ICNECGKGFT
560 570 580 590 600
EKSHLNVHRR THTGEKPYVC SECGKGLTGK SMLIAHQRTH TGEKPYICNE
610 620 630 640 650
CGKGFTMKST LSIHQQTHTG EKPYKCNECD KTFRKKTCLI QHQRFHTGKT
660 670 680 690 700
SFACTECGKF SLRKNDLITH QRIHTGEKPY KCSDCGKAFT TKSGLNVHQR
710 720 730
KHTGERPYGC SDCGKAFAHL SILVKHRRIH R
Length:731
Mass (Da):83,739
Last modified:December 4, 2007 - v2
Checksum:i4FE44AC660649A85
GO
Isoform 2 (identifier: Q8N8J6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     79-79: S → SDSGGASGGAYA

Show »
Length:742
Mass (Da):84,633
Checksum:i276ED355E6EA73B0
GO
Isoform 3 (identifier: Q8N8J6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-5: MMQAQ → M
     79-79: S → SDSGGASGGAYA

Show »
Length:738
Mass (Da):84,174
Checksum:i522FD931D0B35131
GO

Sequence cautioni

The sequence BAC87399 differs from that shown. aberrant splicing.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti576G → D in BAD18638 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037285129T → M.2 PublicationsCorresponds to variant rs10500311dbSNPEnsembl.1
Natural variantiVAR_037286360T → I.2 PublicationsCorresponds to variant rs1978717dbSNPEnsembl.1
Natural variantiVAR_037287727R → K.2 PublicationsCorresponds to variant rs16983353dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0397171 – 5MMQAQ → M in isoform 3. 1 Publication5
Alternative sequenceiVSP_02958279S → SDSGGASGGAYA in isoform 2 and isoform 3. 3 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK128361 mRNA. Translation: BAC87399.1. Sequence problems.
AK131494 mRNA. Translation: BAD18638.1.
CR936612 mRNA. Translation: CAI56755.1.
AC011460 Genomic DNA. No translation available.
AC011468 Genomic DNA. No translation available.
BC105100 mRNA. Translation: AAI05101.1.
BC105102 mRNA. Translation: AAI05103.1.
BC143429 mRNA. Translation: AAI43430.1.
CCDSiCCDS12846.1. [Q8N8J6-1]
CCDS59418.1. [Q8N8J6-2]
RefSeqiNP_001186253.1. NM_001199324.1. [Q8N8J6-2]
NP_001308247.1. NM_001321318.1. [Q8N8J6-3]
NP_001308248.1. NM_001321319.1. [Q8N8J6-2]
NP_001308249.1. NM_001321320.1. [Q8N8J6-1]
NP_001308250.1. NM_001321321.1. [Q8N8J6-2]
NP_940882.3. NM_198480.3. [Q8N8J6-1]
XP_011525126.1. XM_011526824.1. [Q8N8J6-2]
XP_011525127.1. XM_011526825.1. [Q8N8J6-2]
XP_011525128.1. XM_011526826.1. [Q8N8J6-2]
XP_016882137.1. XM_017026648.1. [Q8N8J6-1]
XP_016882138.1. XM_017026649.1. [Q8N8J6-1]
UniGeneiHs.368355.

Genome annotation databases

EnsembliENST00000376716; ENSP00000365906; ENSG00000197619. [Q8N8J6-1]
ENST00000594083; ENSP00000471549; ENSG00000197619. [Q8N8J6-2]
ENST00000598071; ENSP00000471041; ENSG00000197619. [Q8N8J6-2]
ENST00000602063; ENSP00000473089; ENSG00000197619. [Q8N8J6-1]
ENST00000618487; ENSP00000483676; ENSG00000197619. [Q8N8J6-2]
GeneIDi284370.
KEGGihsa:284370.
UCSCiuc002pye.3. human. [Q8N8J6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK128361 mRNA. Translation: BAC87399.1. Sequence problems.
AK131494 mRNA. Translation: BAD18638.1.
CR936612 mRNA. Translation: CAI56755.1.
AC011460 Genomic DNA. No translation available.
AC011468 Genomic DNA. No translation available.
BC105100 mRNA. Translation: AAI05101.1.
BC105102 mRNA. Translation: AAI05103.1.
BC143429 mRNA. Translation: AAI43430.1.
CCDSiCCDS12846.1. [Q8N8J6-1]
CCDS59418.1. [Q8N8J6-2]
RefSeqiNP_001186253.1. NM_001199324.1. [Q8N8J6-2]
NP_001308247.1. NM_001321318.1. [Q8N8J6-3]
NP_001308248.1. NM_001321319.1. [Q8N8J6-2]
NP_001308249.1. NM_001321320.1. [Q8N8J6-1]
NP_001308250.1. NM_001321321.1. [Q8N8J6-2]
NP_940882.3. NM_198480.3. [Q8N8J6-1]
XP_011525126.1. XM_011526824.1. [Q8N8J6-2]
XP_011525127.1. XM_011526825.1. [Q8N8J6-2]
XP_011525128.1. XM_011526826.1. [Q8N8J6-2]
XP_016882137.1. XM_017026648.1. [Q8N8J6-1]
XP_016882138.1. XM_017026649.1. [Q8N8J6-1]
UniGeneiHs.368355.

3D structure databases

ProteinModelPortaliQ8N8J6.
SMRiQ8N8J6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000365906.

PTM databases

iPTMnetiQ8N8J6.
PhosphoSitePlusiQ8N8J6.

Polymorphism and mutation databases

BioMutaiZNF615.
DMDMi161784348.

Proteomic databases

MaxQBiQ8N8J6.
PaxDbiQ8N8J6.
PeptideAtlasiQ8N8J6.
PRIDEiQ8N8J6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376716; ENSP00000365906; ENSG00000197619. [Q8N8J6-1]
ENST00000594083; ENSP00000471549; ENSG00000197619. [Q8N8J6-2]
ENST00000598071; ENSP00000471041; ENSG00000197619. [Q8N8J6-2]
ENST00000602063; ENSP00000473089; ENSG00000197619. [Q8N8J6-1]
ENST00000618487; ENSP00000483676; ENSG00000197619. [Q8N8J6-2]
GeneIDi284370.
KEGGihsa:284370.
UCSCiuc002pye.3. human. [Q8N8J6-1]

Organism-specific databases

CTDi284370.
GeneCardsiZNF615.
HGNCiHGNC:24740. ZNF615.
HPAiHPA052422.
neXtProtiNX_Q8N8J6.
OpenTargetsiENSG00000197619.
PharmGKBiPA134872929.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133681.
HOVERGENiHBG018163.
InParanoidiQ8N8J6.
KOiK09228.
OMAiFSLRKND.
OrthoDBiEOG091G02KC.
PhylomeDBiQ8N8J6.
TreeFamiTF350804.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000176089-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii284370.
PROiQ8N8J6.

Gene expression databases

BgeeiENSG00000197619.
CleanExiHS_ZNF615.
ExpressionAtlasiQ8N8J6. baseline and differential.
GenevisibleiQ8N8J6. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 19 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 19 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 18 hits.
PS50157. ZINC_FINGER_C2H2_2. 19 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN615_HUMAN
AccessioniPrimary (citable) accession number: Q8N8J6
Secondary accession number(s): B7ZKW9
, Q2M2Y6, Q5CZB0, Q6ZMT7, Q6ZRB3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: December 4, 2007
Last modified: November 30, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-2 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.