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Q8N8G2

- VGLL2_HUMAN

UniProt

Q8N8G2 - VGLL2_HUMAN

Protein

Transcription cofactor vestigial-like protein 2

Gene

VGLL2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    May act as a specific coactivator for the mammalian TEFs. May play a role in the development of skeletal muscles.

    GO - Molecular functioni

    1. transcription coactivator activity Source: Ensembl

    GO - Biological processi

    1. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    2. skeletal muscle tissue development Source: Ensembl
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription cofactor vestigial-like protein 2
    Short name:
    Vgl-2
    Alternative name(s):
    Protein VITO1
    Gene namesi
    Name:VGLL2
    Synonyms:VITO1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:20232. VGLL2.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134881890.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 317317Transcription cofactor vestigial-like protein 2PRO_0000191349Add
    BLAST

    Proteomic databases

    PaxDbiQ8N8G2.
    PRIDEiQ8N8G2.

    PTM databases

    PhosphoSiteiQ8N8G2.

    Expressioni

    Tissue specificityi

    Skeletal muscle.1 Publication

    Gene expression databases

    BgeeiQ8N8G2.
    CleanExiHS_VGLL2.
    GenevestigatoriQ8N8G2.

    Interactioni

    Subunit structurei

    Interacts with TEFs. Binds to TEAD1/TEF1.

    Protein-protein interaction databases

    STRINGi9606.ENSP00000320957.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N8G2.
    SMRiQ8N8G2. Positions 76-107.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the vestigial family.Curated

    Phylogenomic databases

    eggNOGiNOG39971.
    HOGENOMiHOG000143402.
    HOVERGENiHBG057778.
    InParanoidiQ8N8G2.
    OMAiTEPWHHA.
    OrthoDBiEOG7K9K52.
    PhylomeDBiQ8N8G2.
    TreeFamiTF326340.

    Family and domain databases

    InterProiIPR006627. TDU_repeat.
    IPR011520. Vg_Tdu.
    [Graphical view]
    PANTHERiPTHR15950. PTHR15950. 1 hit.
    PfamiPF07545. Vg_Tdu. 1 hit.
    [Graphical view]
    SMARTiSM00711. TDU. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8N8G2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSCLDVMYQV YGPPQPYFAA AYTPYHQKLA YYSKMQEAQE CNASPSSSGS    50
    GSSSFSSQTP ASIKEEEGSP EKERPPEAEY INSRCVLFTY FQGDISSVVD 100
    EHFSRALSQP SSYSPSCTSS KAPRSSGPWR DCSFPMSQRS FPASFWNSAY 150
    QAPVPPPLGS PLATAHSELP FAAADPYSPA ALHGHLHQGA TEPWHHAHPH 200
    HAHPHHPYAL GGALGAQAAP YPRPAAVHEV YAPHFDPRYG PLLMPAASGR 250
    PARLATAPAP APGSPPCELS GKGEPAGAAW AGPGGPFASP SGDVAQGLGL 300
    SVDSARRYSL CGASLLS 317
    Length:317
    Mass (Da):33,426
    Last modified:October 1, 2002 - v1
    Checksum:i2C08E5D1070FF10D
    GO
    Isoform 2 (identifier: Q8N8G2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         131-304: Missing.

    Show »
    Length:143
    Mass (Da):15,701
    Checksum:i8DF01823AE66F5F3
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei131 – 304174Missing in isoform 2. 2 PublicationsVSP_032166Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ578053 mRNA. Translation: CAE17331.1.
    AY056583 mRNA. Translation: AAL17720.1.
    AK096878 mRNA. Translation: BAC04881.1.
    Z98880 Genomic DNA. Translation: CAI42376.1.
    CH471051 Genomic DNA. Translation: EAW48211.1.
    BC069316 mRNA. Translation: AAH69316.1.
    BC100798 mRNA. Translation: AAI00799.1.
    BC100799 mRNA. Translation: AAI00800.1.
    BC118545 mRNA. Translation: AAI18546.1.
    BC118622 mRNA. Translation: AAI18623.1.
    CCDSiCCDS5114.1. [Q8N8G2-2]
    CCDS5115.1. [Q8N8G2-1]
    RefSeqiNP_703154.1. NM_153453.1. [Q8N8G2-2]
    NP_872586.1. NM_182645.3. [Q8N8G2-1]
    UniGeneiHs.99324.

    Genome annotation databases

    EnsembliENST00000326274; ENSP00000320957; ENSG00000170162. [Q8N8G2-1]
    ENST00000352536; ENSP00000305405; ENSG00000170162. [Q8N8G2-2]
    GeneIDi245806.
    KEGGihsa:245806.
    UCSCiuc003pxn.3. human. [Q8N8G2-1]
    uc003pxo.3. human. [Q8N8G2-2]

    Polymorphism databases

    DMDMi50401602.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ578053 mRNA. Translation: CAE17331.1 .
    AY056583 mRNA. Translation: AAL17720.1 .
    AK096878 mRNA. Translation: BAC04881.1 .
    Z98880 Genomic DNA. Translation: CAI42376.1 .
    CH471051 Genomic DNA. Translation: EAW48211.1 .
    BC069316 mRNA. Translation: AAH69316.1 .
    BC100798 mRNA. Translation: AAI00799.1 .
    BC100799 mRNA. Translation: AAI00800.1 .
    BC118545 mRNA. Translation: AAI18546.1 .
    BC118622 mRNA. Translation: AAI18623.1 .
    CCDSi CCDS5114.1. [Q8N8G2-2 ]
    CCDS5115.1. [Q8N8G2-1 ]
    RefSeqi NP_703154.1. NM_153453.1. [Q8N8G2-2 ]
    NP_872586.1. NM_182645.3. [Q8N8G2-1 ]
    UniGenei Hs.99324.

    3D structure databases

    ProteinModelPortali Q8N8G2.
    SMRi Q8N8G2. Positions 76-107.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000320957.

    PTM databases

    PhosphoSitei Q8N8G2.

    Polymorphism databases

    DMDMi 50401602.

    Proteomic databases

    PaxDbi Q8N8G2.
    PRIDEi Q8N8G2.

    Protocols and materials databases

    DNASUi 245806.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000326274 ; ENSP00000320957 ; ENSG00000170162 . [Q8N8G2-1 ]
    ENST00000352536 ; ENSP00000305405 ; ENSG00000170162 . [Q8N8G2-2 ]
    GeneIDi 245806.
    KEGGi hsa:245806.
    UCSCi uc003pxn.3. human. [Q8N8G2-1 ]
    uc003pxo.3. human. [Q8N8G2-2 ]

    Organism-specific databases

    CTDi 245806.
    GeneCardsi GC06P117632.
    HGNCi HGNC:20232. VGLL2.
    MIMi 609979. gene.
    neXtProti NX_Q8N8G2.
    PharmGKBi PA134881890.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG39971.
    HOGENOMi HOG000143402.
    HOVERGENi HBG057778.
    InParanoidi Q8N8G2.
    OMAi TEPWHHA.
    OrthoDBi EOG7K9K52.
    PhylomeDBi Q8N8G2.
    TreeFami TF326340.

    Miscellaneous databases

    GenomeRNAii 245806.
    NextBioi 91732.
    PROi Q8N8G2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8N8G2.
    CleanExi HS_VGLL2.
    Genevestigatori Q8N8G2.

    Family and domain databases

    InterProi IPR006627. TDU_repeat.
    IPR011520. Vg_Tdu.
    [Graphical view ]
    PANTHERi PTHR15950. PTHR15950. 1 hit.
    Pfami PF07545. Vg_Tdu. 1 hit.
    [Graphical view ]
    SMARTi SM00711. TDU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "VITO-1, a novel vestigial related protein is predominantly expressed in the skeletal muscle lineage."
      Mielcarek M., Gunther S., Kruger M., Braun T.
      Gene Expr. Patterns 2:305-310(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    2. "Mammalian vestigial-like 2, a cofactor of TEF-1 and MEF2 transcription factors that promotes skeletal muscle differentiation."
      Maeda T., Chapman D.L., Stewart A.F.R.
      J. Biol. Chem. 277:48889-48898(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Skeletal muscle.
    4. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).

    Entry informationi

    Entry nameiVGLL2_HUMAN
    AccessioniPrimary (citable) accession number: Q8N8G2
    Secondary accession number(s): Q8WWX1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3