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Protein

Transcription cofactor vestigial-like protein 2

Gene

VGLL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May act as a specific coactivator for the mammalian TEFs. May play a role in the development of skeletal muscles.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription cofactor vestigial-like protein 2
Short name:
Vgl-2
Alternative name(s):
Protein VITO1
Gene namesi
Name:VGLL2
Synonyms:VITO1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:20232. VGLL2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134881890.

Polymorphism and mutation databases

BioMutaiVGLL2.
DMDMi50401602.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 317317Transcription cofactor vestigial-like protein 2PRO_0000191349Add
BLAST

Proteomic databases

PaxDbiQ8N8G2.
PRIDEiQ8N8G2.

PTM databases

PhosphoSiteiQ8N8G2.

Expressioni

Tissue specificityi

Skeletal muscle.1 Publication

Gene expression databases

BgeeiQ8N8G2.
CleanExiHS_VGLL2.
GenevisibleiQ8N8G2. HS.

Interactioni

Subunit structurei

Interacts with TEFs. Binds to TEAD1/TEF1.

Binary interactionsi

WithEntry#Exp.IntActNotes
TEAD3Q995943EBI-10267981,EBI-746720

Protein-protein interaction databases

BioGridi128830. 1 interaction.
IntActiQ8N8G2. 1 interaction.
STRINGi9606.ENSP00000320957.

Structurei

3D structure databases

ProteinModelPortaliQ8N8G2.
SMRiQ8N8G2. Positions 76-107.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the vestigial family.Curated

Phylogenomic databases

eggNOGiNOG39971.
GeneTreeiENSGT00530000063353.
HOGENOMiHOG000143402.
HOVERGENiHBG057778.
InParanoidiQ8N8G2.
OMAiTEPWHHA.
OrthoDBiEOG7K9K52.
PhylomeDBiQ8N8G2.
TreeFamiTF326340.

Family and domain databases

InterProiIPR006627. TDU_repeat.
IPR011520. Vg_Tdu.
[Graphical view]
PANTHERiPTHR15950. PTHR15950. 1 hit.
PfamiPF07545. Vg_Tdu. 1 hit.
[Graphical view]
SMARTiSM00711. TDU. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N8G2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSCLDVMYQV YGPPQPYFAA AYTPYHQKLA YYSKMQEAQE CNASPSSSGS
60 70 80 90 100
GSSSFSSQTP ASIKEEEGSP EKERPPEAEY INSRCVLFTY FQGDISSVVD
110 120 130 140 150
EHFSRALSQP SSYSPSCTSS KAPRSSGPWR DCSFPMSQRS FPASFWNSAY
160 170 180 190 200
QAPVPPPLGS PLATAHSELP FAAADPYSPA ALHGHLHQGA TEPWHHAHPH
210 220 230 240 250
HAHPHHPYAL GGALGAQAAP YPRPAAVHEV YAPHFDPRYG PLLMPAASGR
260 270 280 290 300
PARLATAPAP APGSPPCELS GKGEPAGAAW AGPGGPFASP SGDVAQGLGL
310
SVDSARRYSL CGASLLS
Length:317
Mass (Da):33,426
Last modified:October 1, 2002 - v1
Checksum:i2C08E5D1070FF10D
GO
Isoform 2 (identifier: Q8N8G2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     131-304: Missing.

Show »
Length:143
Mass (Da):15,701
Checksum:i8DF01823AE66F5F3
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei131 – 304174Missing in isoform 2. 2 PublicationsVSP_032166Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ578053 mRNA. Translation: CAE17331.1.
AY056583 mRNA. Translation: AAL17720.1.
AK096878 mRNA. Translation: BAC04881.1.
Z98880 Genomic DNA. Translation: CAI42376.1.
CH471051 Genomic DNA. Translation: EAW48211.1.
BC069316 mRNA. Translation: AAH69316.1.
BC100798 mRNA. Translation: AAI00799.1.
BC100799 mRNA. Translation: AAI00800.1.
BC118545 mRNA. Translation: AAI18546.1.
BC118622 mRNA. Translation: AAI18623.1.
CCDSiCCDS5114.1. [Q8N8G2-2]
CCDS5115.1. [Q8N8G2-1]
RefSeqiNP_703154.1. NM_153453.1. [Q8N8G2-2]
NP_872586.1. NM_182645.3. [Q8N8G2-1]
UniGeneiHs.99324.

Genome annotation databases

EnsembliENST00000326274; ENSP00000320957; ENSG00000170162. [Q8N8G2-1]
ENST00000352536; ENSP00000305405; ENSG00000170162. [Q8N8G2-2]
GeneIDi245806.
KEGGihsa:245806.
UCSCiuc003pxn.3. human. [Q8N8G2-1]
uc003pxo.3. human. [Q8N8G2-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ578053 mRNA. Translation: CAE17331.1.
AY056583 mRNA. Translation: AAL17720.1.
AK096878 mRNA. Translation: BAC04881.1.
Z98880 Genomic DNA. Translation: CAI42376.1.
CH471051 Genomic DNA. Translation: EAW48211.1.
BC069316 mRNA. Translation: AAH69316.1.
BC100798 mRNA. Translation: AAI00799.1.
BC100799 mRNA. Translation: AAI00800.1.
BC118545 mRNA. Translation: AAI18546.1.
BC118622 mRNA. Translation: AAI18623.1.
CCDSiCCDS5114.1. [Q8N8G2-2]
CCDS5115.1. [Q8N8G2-1]
RefSeqiNP_703154.1. NM_153453.1. [Q8N8G2-2]
NP_872586.1. NM_182645.3. [Q8N8G2-1]
UniGeneiHs.99324.

3D structure databases

ProteinModelPortaliQ8N8G2.
SMRiQ8N8G2. Positions 76-107.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128830. 1 interaction.
IntActiQ8N8G2. 1 interaction.
STRINGi9606.ENSP00000320957.

PTM databases

PhosphoSiteiQ8N8G2.

Polymorphism and mutation databases

BioMutaiVGLL2.
DMDMi50401602.

Proteomic databases

PaxDbiQ8N8G2.
PRIDEiQ8N8G2.

Protocols and materials databases

DNASUi245806.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326274; ENSP00000320957; ENSG00000170162. [Q8N8G2-1]
ENST00000352536; ENSP00000305405; ENSG00000170162. [Q8N8G2-2]
GeneIDi245806.
KEGGihsa:245806.
UCSCiuc003pxn.3. human. [Q8N8G2-1]
uc003pxo.3. human. [Q8N8G2-2]

Organism-specific databases

CTDi245806.
GeneCardsiGC06P117632.
HGNCiHGNC:20232. VGLL2.
MIMi609979. gene.
neXtProtiNX_Q8N8G2.
PharmGKBiPA134881890.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG39971.
GeneTreeiENSGT00530000063353.
HOGENOMiHOG000143402.
HOVERGENiHBG057778.
InParanoidiQ8N8G2.
OMAiTEPWHHA.
OrthoDBiEOG7K9K52.
PhylomeDBiQ8N8G2.
TreeFamiTF326340.

Miscellaneous databases

GenomeRNAii245806.
NextBioi91732.
PROiQ8N8G2.
SOURCEiSearch...

Gene expression databases

BgeeiQ8N8G2.
CleanExiHS_VGLL2.
GenevisibleiQ8N8G2. HS.

Family and domain databases

InterProiIPR006627. TDU_repeat.
IPR011520. Vg_Tdu.
[Graphical view]
PANTHERiPTHR15950. PTHR15950. 1 hit.
PfamiPF07545. Vg_Tdu. 1 hit.
[Graphical view]
SMARTiSM00711. TDU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "VITO-1, a novel vestigial related protein is predominantly expressed in the skeletal muscle lineage."
    Mielcarek M., Gunther S., Kruger M., Braun T.
    Gene Expr. Patterns 2:305-310(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  2. "Mammalian vestigial-like 2, a cofactor of TEF-1 and MEF2 transcription factors that promotes skeletal muscle differentiation."
    Maeda T., Chapman D.L., Stewart A.F.R.
    J. Biol. Chem. 277:48889-48898(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Skeletal muscle.
  4. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).

Entry informationi

Entry nameiVGLL2_HUMAN
AccessioniPrimary (citable) accession number: Q8N8G2
Secondary accession number(s): Q8WWX1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: October 1, 2002
Last modified: June 24, 2015
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.