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Q8N8G2

- VGLL2_HUMAN

UniProt

Q8N8G2 - VGLL2_HUMAN

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Protein
Transcription cofactor vestigial-like protein 2
Gene
VGLL2, VITO1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

May act as a specific coactivator for the mammalian TEFs. May play a role in the development of skeletal muscles.

GO - Molecular functioni

  1. transcription coactivator activity Source: Ensembl

GO - Biological processi

  1. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  2. skeletal muscle tissue development Source: Ensembl
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription cofactor vestigial-like protein 2
Short name:
Vgl-2
Alternative name(s):
Protein VITO1
Gene namesi
Name:VGLL2
Synonyms:VITO1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:20232. VGLL2.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134881890.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 317317Transcription cofactor vestigial-like protein 2
PRO_0000191349Add
BLAST

Proteomic databases

PaxDbiQ8N8G2.
PRIDEiQ8N8G2.

PTM databases

PhosphoSiteiQ8N8G2.

Expressioni

Tissue specificityi

Skeletal muscle.1 Publication

Gene expression databases

BgeeiQ8N8G2.
CleanExiHS_VGLL2.
GenevestigatoriQ8N8G2.

Interactioni

Subunit structurei

Interacts with TEFs. Binds to TEAD1/TEF1.

Protein-protein interaction databases

STRINGi9606.ENSP00000320957.

Structurei

3D structure databases

ProteinModelPortaliQ8N8G2.
SMRiQ8N8G2. Positions 76-107.

Family & Domainsi

Sequence similaritiesi

Belongs to the vestigial family.

Phylogenomic databases

eggNOGiNOG39971.
HOGENOMiHOG000143402.
HOVERGENiHBG057778.
InParanoidiQ8N8G2.
OMAiTEPWHHA.
OrthoDBiEOG7K9K52.
PhylomeDBiQ8N8G2.
TreeFamiTF326340.

Family and domain databases

InterProiIPR006627. TDU_repeat.
IPR011520. Vg_Tdu.
[Graphical view]
PANTHERiPTHR15950. PTHR15950. 1 hit.
PfamiPF07545. Vg_Tdu. 1 hit.
[Graphical view]
SMARTiSM00711. TDU. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8N8G2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSCLDVMYQV YGPPQPYFAA AYTPYHQKLA YYSKMQEAQE CNASPSSSGS    50
GSSSFSSQTP ASIKEEEGSP EKERPPEAEY INSRCVLFTY FQGDISSVVD 100
EHFSRALSQP SSYSPSCTSS KAPRSSGPWR DCSFPMSQRS FPASFWNSAY 150
QAPVPPPLGS PLATAHSELP FAAADPYSPA ALHGHLHQGA TEPWHHAHPH 200
HAHPHHPYAL GGALGAQAAP YPRPAAVHEV YAPHFDPRYG PLLMPAASGR 250
PARLATAPAP APGSPPCELS GKGEPAGAAW AGPGGPFASP SGDVAQGLGL 300
SVDSARRYSL CGASLLS 317
Length:317
Mass (Da):33,426
Last modified:October 1, 2002 - v1
Checksum:i2C08E5D1070FF10D
GO
Isoform 2 (identifier: Q8N8G2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     131-304: Missing.

Show »
Length:143
Mass (Da):15,701
Checksum:i8DF01823AE66F5F3
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei131 – 304174Missing in isoform 2.
VSP_032166Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ578053 mRNA. Translation: CAE17331.1.
AY056583 mRNA. Translation: AAL17720.1.
AK096878 mRNA. Translation: BAC04881.1.
Z98880 Genomic DNA. Translation: CAI42376.1.
CH471051 Genomic DNA. Translation: EAW48211.1.
BC069316 mRNA. Translation: AAH69316.1.
BC100798 mRNA. Translation: AAI00799.1.
BC100799 mRNA. Translation: AAI00800.1.
BC118545 mRNA. Translation: AAI18546.1.
BC118622 mRNA. Translation: AAI18623.1.
CCDSiCCDS5114.1. [Q8N8G2-2]
CCDS5115.1. [Q8N8G2-1]
RefSeqiNP_703154.1. NM_153453.1. [Q8N8G2-2]
NP_872586.1. NM_182645.3. [Q8N8G2-1]
UniGeneiHs.99324.

Genome annotation databases

EnsembliENST00000326274; ENSP00000320957; ENSG00000170162. [Q8N8G2-1]
ENST00000352536; ENSP00000305405; ENSG00000170162. [Q8N8G2-2]
GeneIDi245806.
KEGGihsa:245806.
UCSCiuc003pxn.3. human. [Q8N8G2-1]
uc003pxo.3. human. [Q8N8G2-2]

Polymorphism databases

DMDMi50401602.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ578053 mRNA. Translation: CAE17331.1 .
AY056583 mRNA. Translation: AAL17720.1 .
AK096878 mRNA. Translation: BAC04881.1 .
Z98880 Genomic DNA. Translation: CAI42376.1 .
CH471051 Genomic DNA. Translation: EAW48211.1 .
BC069316 mRNA. Translation: AAH69316.1 .
BC100798 mRNA. Translation: AAI00799.1 .
BC100799 mRNA. Translation: AAI00800.1 .
BC118545 mRNA. Translation: AAI18546.1 .
BC118622 mRNA. Translation: AAI18623.1 .
CCDSi CCDS5114.1. [Q8N8G2-2 ]
CCDS5115.1. [Q8N8G2-1 ]
RefSeqi NP_703154.1. NM_153453.1. [Q8N8G2-2 ]
NP_872586.1. NM_182645.3. [Q8N8G2-1 ]
UniGenei Hs.99324.

3D structure databases

ProteinModelPortali Q8N8G2.
SMRi Q8N8G2. Positions 76-107.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000320957.

PTM databases

PhosphoSitei Q8N8G2.

Polymorphism databases

DMDMi 50401602.

Proteomic databases

PaxDbi Q8N8G2.
PRIDEi Q8N8G2.

Protocols and materials databases

DNASUi 245806.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000326274 ; ENSP00000320957 ; ENSG00000170162 . [Q8N8G2-1 ]
ENST00000352536 ; ENSP00000305405 ; ENSG00000170162 . [Q8N8G2-2 ]
GeneIDi 245806.
KEGGi hsa:245806.
UCSCi uc003pxn.3. human. [Q8N8G2-1 ]
uc003pxo.3. human. [Q8N8G2-2 ]

Organism-specific databases

CTDi 245806.
GeneCardsi GC06P117632.
HGNCi HGNC:20232. VGLL2.
MIMi 609979. gene.
neXtProti NX_Q8N8G2.
PharmGKBi PA134881890.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG39971.
HOGENOMi HOG000143402.
HOVERGENi HBG057778.
InParanoidi Q8N8G2.
OMAi TEPWHHA.
OrthoDBi EOG7K9K52.
PhylomeDBi Q8N8G2.
TreeFami TF326340.

Miscellaneous databases

GenomeRNAii 245806.
NextBioi 91732.
PROi Q8N8G2.
SOURCEi Search...

Gene expression databases

Bgeei Q8N8G2.
CleanExi HS_VGLL2.
Genevestigatori Q8N8G2.

Family and domain databases

InterProi IPR006627. TDU_repeat.
IPR011520. Vg_Tdu.
[Graphical view ]
PANTHERi PTHR15950. PTHR15950. 1 hit.
Pfami PF07545. Vg_Tdu. 1 hit.
[Graphical view ]
SMARTi SM00711. TDU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "VITO-1, a novel vestigial related protein is predominantly expressed in the skeletal muscle lineage."
    Mielcarek M., Gunther S., Kruger M., Braun T.
    Gene Expr. Patterns 2:305-310(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  2. "Mammalian vestigial-like 2, a cofactor of TEF-1 and MEF2 transcription factors that promotes skeletal muscle differentiation."
    Maeda T., Chapman D.L., Stewart A.F.R.
    J. Biol. Chem. 277:48889-48898(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Skeletal muscle.
  4. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).

Entry informationi

Entry nameiVGLL2_HUMAN
AccessioniPrimary (citable) accession number: Q8N8G2
Secondary accession number(s): Q8WWX1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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