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Protein

Leucine-rich single-pass membrane protein 1

Gene

LSMEM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich single-pass membrane protein 1
Gene namesi
Name:LSMEM1
Synonyms:C7orf53
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:22036. LSMEM1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei65 – 8521HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162380593.

Polymorphism and mutation databases

BioMutaiLSMEM1.
DMDMi74729436.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 131131Leucine-rich single-pass membrane protein 1PRO_0000309272Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei24 – 241PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8N8F7.
PaxDbiQ8N8F7.
PRIDEiQ8N8F7.

PTM databases

PhosphoSiteiQ8N8F7.

Expressioni

Gene expression databases

BgeeiQ8N8F7.
CleanExiHS_C7orf53.
GenevisibleiQ8N8F7. HS.

Organism-specific databases

HPAiHPA013753.
HPA047988.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
LSMEM2Q8N1125EBI-10200825,EBI-10264855
MALP211453EBI-10200825,EBI-3932027

Protein-protein interaction databases

BioGridi130271. 3 interactions.
IntActiQ8N8F7. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ8N8F7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili90 – 12536Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J05H. Eukaryota.
ENOG41116UM. LUCA.
GeneTreeiENSGT00390000010292.
HOGENOMiHOG000060266.
HOVERGENiHBG107667.
InParanoidiQ8N8F7.
OMAiIQTGNKM.
OrthoDBiEOG7RBZBP.
PhylomeDBiQ8N8F7.
TreeFamiTF336352.

Family and domain databases

InterProiIPR028099. DUF4577.
[Graphical view]
PfamiPF15145. DUF4577. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N8F7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTHSSQDTGS CGIQEDGKLY VVDSINDLNK LNLCPAGSQH LFPLEDKIPV
60 70 80 90 100
LGTNSGNGSR SLFFVGLLIV LIVSLALVFF VIFLIVQTGN KMDDVSRRLT
110 120 130
AEGKDIDDLK RINNMIVKRL NQLNQLDSEQ N
Length:131
Mass (Da):14,462
Last modified:October 1, 2002 - v1
Checksum:iAA6B79D6C7D144BD
GO
Isoform 2 (identifier: Q8N8F7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-131: PLEDKIPVLG...QLNQLDSEQN → LLRQSSKNFPKRSKEIA

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.
Show »
Length:59
Mass (Da):6,521
Checksum:i06C26916976A704A
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei43 – 13189PLEDK…DSEQN → LLRQSSKNFPKRSKEIA in isoform 2. 1 PublicationVSP_029104Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096894 mRNA. Translation: BAC04886.1.
CH236947 Genomic DNA. Translation: EAL24374.1.
CH471070 Genomic DNA. Translation: EAW83465.1.
BC031976 mRNA. No translation available.
BC126149 mRNA. Translation: AAI26150.1.
BC130568 mRNA. Translation: AAI30569.1.
CCDSiCCDS5756.1. [Q8N8F7-1]
RefSeqiNP_001127940.1. NM_001134468.1. [Q8N8F7-1]
NP_872403.1. NM_182597.2. [Q8N8F7-1]
XP_006715994.1. XM_006715931.2. [Q8N8F7-1]
XP_006715995.1. XM_006715932.2. [Q8N8F7-1]
XP_011514376.1. XM_011516074.1. [Q8N8F7-1]
XP_011514377.1. XM_011516075.1. [Q8N8F7-1]
XP_011514378.1. XM_011516076.1. [Q8N8F7-1]
UniGeneiHs.396189.

Genome annotation databases

EnsembliENST00000312849; ENSP00000323304; ENSG00000181016. [Q8N8F7-1]
ENST00000439068; ENSP00000389278; ENSG00000181016. [Q8N8F7-1]
ENST00000455302; ENSP00000412823; ENSG00000181016. [Q8N8F7-2]
GeneIDi286006.
KEGGihsa:286006.
UCSCiuc003vgm.4. human. [Q8N8F7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096894 mRNA. Translation: BAC04886.1.
CH236947 Genomic DNA. Translation: EAL24374.1.
CH471070 Genomic DNA. Translation: EAW83465.1.
BC031976 mRNA. No translation available.
BC126149 mRNA. Translation: AAI26150.1.
BC130568 mRNA. Translation: AAI30569.1.
CCDSiCCDS5756.1. [Q8N8F7-1]
RefSeqiNP_001127940.1. NM_001134468.1. [Q8N8F7-1]
NP_872403.1. NM_182597.2. [Q8N8F7-1]
XP_006715994.1. XM_006715931.2. [Q8N8F7-1]
XP_006715995.1. XM_006715932.2. [Q8N8F7-1]
XP_011514376.1. XM_011516074.1. [Q8N8F7-1]
XP_011514377.1. XM_011516075.1. [Q8N8F7-1]
XP_011514378.1. XM_011516076.1. [Q8N8F7-1]
UniGeneiHs.396189.

3D structure databases

ProteinModelPortaliQ8N8F7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130271. 3 interactions.
IntActiQ8N8F7. 2 interactions.

PTM databases

PhosphoSiteiQ8N8F7.

Polymorphism and mutation databases

BioMutaiLSMEM1.
DMDMi74729436.

Proteomic databases

EPDiQ8N8F7.
PaxDbiQ8N8F7.
PRIDEiQ8N8F7.

Protocols and materials databases

DNASUi286006.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000312849; ENSP00000323304; ENSG00000181016. [Q8N8F7-1]
ENST00000439068; ENSP00000389278; ENSG00000181016. [Q8N8F7-1]
ENST00000455302; ENSP00000412823; ENSG00000181016. [Q8N8F7-2]
GeneIDi286006.
KEGGihsa:286006.
UCSCiuc003vgm.4. human. [Q8N8F7-1]

Organism-specific databases

CTDi286006.
GeneCardsiLSMEM1.
HGNCiHGNC:22036. LSMEM1.
HPAiHPA013753.
HPA047988.
neXtProtiNX_Q8N8F7.
PharmGKBiPA162380593.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J05H. Eukaryota.
ENOG41116UM. LUCA.
GeneTreeiENSGT00390000010292.
HOGENOMiHOG000060266.
HOVERGENiHBG107667.
InParanoidiQ8N8F7.
OMAiIQTGNKM.
OrthoDBiEOG7RBZBP.
PhylomeDBiQ8N8F7.
TreeFamiTF336352.

Miscellaneous databases

GenomeRNAii286006.
PROiQ8N8F7.

Gene expression databases

BgeeiQ8N8F7.
CleanExiHS_C7orf53.
GenevisibleiQ8N8F7. HS.

Family and domain databases

InterProiIPR028099. DUF4577.
[Graphical view]
PfamiPF15145. DUF4577. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Skeletal muscle.
  2. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Testis.

Entry informationi

Entry nameiLSME1_HUMAN
AccessioniPrimary (citable) accession number: Q8N8F7
Secondary accession number(s): Q49AR6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: October 1, 2002
Last modified: July 6, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.