ID   YIPF7_HUMAN             Reviewed;         256 AA.
AC   Q8N8F6; J3KR00; Q3SY21; Q3SY22;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2024, sequence version 3.
DT   27-MAR-2024, entry version 131.
DE   RecName: Full=Protein YIPF7;
DE   AltName: Full=Five-pass transmembrane protein localizing in the Golgi apparatus and the endoplasmic reticulum 9;
DE   AltName: Full=YIP1 family member 7;
GN   Name=YIPF7; Synonyms=FINGER9, YIP1B;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 5), AND VARIANT
RP   THR-30.
RC   TISSUE=Skeletal muscle;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4).
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   SUBCELLULAR LOCATION, AND TOPOLOGY.
RX   PubMed=27999994; DOI=10.1007/s00418-016-1527-3;
RA   Kranjc T., Dempsey E., Cagney G., Nakamura N., Shields D.C., Simpson J.C.;
RT   "Functional characterisation of the YIPF protein family in mammalian
RT   cells.";
RL   Histochem. Cell Biol. 147:439-451(2017).
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q9JIM5}; Multi-pass membrane protein. Golgi
CC       apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:27999994}.
CC       Golgi apparatus, trans-Golgi network membrane
CC       {ECO:0000269|PubMed:27999994}. Note=Evenly distributed between cis- and
CC       trans-Golgi apparatus. {ECO:0000269|PubMed:27999994}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=5;
CC       Name=1;
CC         IsoId=Q8N8F6-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8N8F6-2; Sequence=VSP_033435;
CC       Name=3;
CC         IsoId=Q8N8F6-3; Sequence=VSP_033431, VSP_033432;
CC       Name=4;
CC         IsoId=Q8N8F6-4; Sequence=VSP_033433, VSP_033434;
CC       Name=5;
CC         IsoId=Q8N8F6-5; Sequence=VSP_062194, VSP_062195;
CC   -!- SIMILARITY: Belongs to the YIP1 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI03996.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC       Sequence=AAI03997.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC       Sequence=BAC04887.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; DA899652; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; AK096895; BAC04887.1; ALT_INIT; mRNA.
DR   EMBL; AC093852; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC096586; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC108478; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC103995; AAI03996.1; ALT_INIT; mRNA.
DR   EMBL; BC103996; AAI03997.1; ALT_INIT; mRNA.
DR   RefSeq; NP_872398.2; NM_182592.2. [Q8N8F6-1]
DR   AlphaFoldDB; Q8N8F6; -.
DR   STRING; 9606.ENSP00000332772; -.
DR   iPTMnet; Q8N8F6; -.
DR   PhosphoSitePlus; Q8N8F6; -.
DR   BioMuta; YIPF7; -.
DR   DMDM; 189030344; -.
DR   MassIVE; Q8N8F6; -.
DR   PaxDb; 9606-ENSP00000332772; -.
DR   PeptideAtlas; Q8N8F6; -.
DR   Antibodypedia; 23722; 36 antibodies from 15 providers.
DR   DNASU; 285525; -.
DR   Ensembl; ENST00000332990.6; ENSP00000332772.6; ENSG00000177752.15. [Q8N8F6-5]
DR   Ensembl; ENST00000415895.9; ENSP00000412696.4; ENSG00000177752.15. [Q8N8F6-1]
DR   GeneID; 285525; -.
DR   KEGG; hsa:285525; -.
DR   MANE-Select; ENST00000415895.9; ENSP00000412696.4; NM_182592.3; NP_872398.3.
DR   UCSC; uc062wht.1; human. [Q8N8F6-1]
DR   AGR; HGNC:26825; -.
DR   CTD; 285525; -.
DR   DisGeNET; 285525; -.
DR   GeneCards; YIPF7; -.
DR   HGNC; HGNC:26825; YIPF7.
DR   HPA; ENSG00000177752; Group enriched (skeletal muscle, tongue).
DR   MIM; 619754; gene.
DR   neXtProt; NX_Q8N8F6; -.
DR   PharmGKB; PA142670550; -.
DR   VEuPathDB; HostDB:ENSG00000177752; -.
DR   eggNOG; KOG3103; Eukaryota.
DR   GeneTree; ENSGT00940000153168; -.
DR   HOGENOM; CLU_074741_2_0_1; -.
DR   InParanoid; Q8N8F6; -.
DR   OMA; TGQFFQP; -.
DR   OrthoDB; 37764at2759; -.
DR   PhylomeDB; Q8N8F6; -.
DR   TreeFam; TF313100; -.
DR   PathwayCommons; Q8N8F6; -.
DR   BioGRID-ORCS; 285525; 15 hits in 1141 CRISPR screens.
DR   GenomeRNAi; 285525; -.
DR   Pharos; Q8N8F6; Tdark.
DR   PRO; PR:Q8N8F6; -.
DR   Proteomes; UP000005640; Chromosome 4.
DR   RNAct; Q8N8F6; Protein.
DR   Bgee; ENSG00000177752; Expressed in quadriceps femoris and 93 other cell types or tissues.
DR   ExpressionAtlas; Q8N8F6; baseline and differential.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005802; C:trans-Golgi network; IBA:GO_Central.
DR   GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR   GO; GO:0048280; P:vesicle fusion with Golgi apparatus; IBA:GO_Central.
DR   InterPro; IPR045231; Yip1/4-like.
DR   InterPro; IPR006977; Yip1_dom.
DR   PANTHER; PTHR21236; GOLGI MEMBRANE PROTEIN YIP1; 1.
DR   PANTHER; PTHR21236:SF5; PROTEIN YIPF7; 1.
DR   Pfam; PF04893; Yip1; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Endoplasmic reticulum; Golgi apparatus; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..256
FT                   /note="Protein YIPF7"
FT                   /id="PRO_0000333007"
FT   TOPO_DOM        1..125
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305|PubMed:27999994"
FT   TRANSMEM        126..146
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        147
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        148..168
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        169..172
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        173..193
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        194..196
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        197..217
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        218..235
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        236..256
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          18..48
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         39
FT                   /note="K -> KLNRKHGDSCSWGGHRELLLMVEGTGASSHRAGAGSRER (in
FT                   isoform 5)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_062194"
FT   VAR_SEQ         40..44
FT                   /note="QQAGE -> TWNPF (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_033431"
FT   VAR_SEQ         45..256
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_033432"
FT   VAR_SEQ         94..108
FT                   /note="ELGIHFDHIWQKTLT -> DKNLESILITYGKKL (in isoform 4)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_033433"
FT   VAR_SEQ         109..256
FT                   /note="Missing (in isoform 4)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_033434"
FT   VAR_SEQ         123..256
FT                   /note="Missing (in isoform 5)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_062195"
FT   VAR_SEQ         143..256
FT                   /note="AGKVQFGYVYGMSAIGCLVIHALLNLMSSSGVSYGCVASVLGYCLLPMVILS
FT                   GCAMFFSLQGIFGIMSSLVIIGWCSLSASKIFIAALHMEGQQLLVAYPCAILYGLFALL
FT                   TIF -> VMCHRKHQILMLVLSSAGFEAICINIRETVSPYIVNFLSERE (in
FT                   isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_033435"
FT   VARIANT         30
FT                   /note="A -> T (in dbSNP:rs2348353)"
FT                   /evidence="ECO:0000269|PubMed:14702039"
FT                   /id="VAR_043036"
FT   CONFLICT        26
FT                   /note="N -> D (in Ref. 1; BAC04887)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        114
FT                   /note="K -> E (in Ref. 1; BAC04887)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   256 AA;  27776 MW;  90A72594F902C196 CRC64;
     MSNLAQFDSD FYQSNFTIDN QEQSGNDSNA YGNLYGSRKQ QAGEQPQPAS FVPSEMLMSS
     GYAGQFFQPA SNSDYYSQSP YIDSFDEEPP LLEELGIHFD HIWQKTLTVL NPMKPVDGSI
     MNETDLTGPI LFCVALGATL LLAGKVQFGY VYGMSAIGCL VIHALLNLMS SSGVSYGCVA
     SVLGYCLLPM VILSGCAMFF SLQGIFGIMS SLVIIGWCSL SASKIFIAAL HMEGQQLLVA
     YPCAILYGLF ALLTIF
//