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Q8N8F6 (YIPF7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein YIPF7
Alternative name(s):
Five-pass transmembrane protein localizing in the Golgi apparatus and the endoplasmic reticulum 9
YIP1 family member 7
Gene names
Name:YIPF7
Synonyms:FINGER9, YIP1B
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length280 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the YIP1 family.

Caution

It is uncertain whether Met-1 or Met-25 is the initiator.

Ontologies

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8N8F6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8N8F6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     167-280: AGKVQFGYVY...YGLFALLTIF → VMCHRKHQIL...YIVNFLSERE
Note: No experimental confirmation available.
Isoform 3 (identifier: Q8N8F6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     64-68: QQAGE → TWNPF
     69-280: Missing.
Note: No experimental confirmation available.
Isoform 4 (identifier: Q8N8F6-4)

The sequence of this isoform differs from the canonical sequence as follows:
     118-132: ELGIHFDHIWQKTLT → DKNLESILITYGKKL
     133-280: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 280280Protein YIPF7
PRO_0000333007

Regions

Transmembrane150 – 17021Helical; Potential
Transmembrane172 – 19221Helical; Potential
Transmembrane197 – 21721Helical; Potential
Transmembrane232 – 25423Helical; Potential
Transmembrane260 – 28021Helical; Potential

Amino acid modifications

Glycosylation391N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence64 – 685QQAGE → TWNPF in isoform 3.
VSP_033431
Alternative sequence69 – 280212Missing in isoform 3.
VSP_033432
Alternative sequence118 – 13215ELGIH…QKTLT → DKNLESILITYGKKL in isoform 4.
VSP_033433
Alternative sequence133 – 280148Missing in isoform 4.
VSP_033434
Alternative sequence167 – 280114AGKVQ…LLTIF → VMCHRKHQILMLVLSSAGFE AICINIRETVSPYIVNFLSE RE in isoform 2.
VSP_033435
Natural variant541A → T. Ref.1
Corresponds to variant rs2348353 [ dbSNP | Ensembl ].
VAR_043036

Experimental info

Sequence conflict501N → D in BAC04887. Ref.1
Sequence conflict1381K → E in BAC04887. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 20, 2008. Version 2.
Checksum: AF30804CB8B3FB36

FASTA28030,632
        10         20         30         40         50         60 
MDLLKISHTK LHLLEDLSIK NKQRMSNLAQ FDSDFYQSNF TIDNQEQSGN DSNAYGNLYG 

        70         80         90        100        110        120 
SRKQQAGEQP QPASFVPSEM LMSSGYAGQF FQPASNSDYY SQSPYIDSFD EEPPLLEELG 

       130        140        150        160        170        180 
IHFDHIWQKT LTVLNPMKPV DGSIMNETDL TGPILFCVAL GATLLLAGKV QFGYVYGMSA 

       190        200        210        220        230        240 
IGCLVIHALL NLMSSSGVSY GCVASVLGYC LLPMVILSGC AMFFSLQGIF GIMSSLVIIG 

       250        260        270        280 
WCSLSASKIF IAALHMEGQQ LLVAYPCAIL YGLFALLTIF 

« Hide

Isoform 2 [UniParc].

Checksum: 32B2284DDA9B38AB
Show »

FASTA20823,451
Isoform 3 [UniParc].

Checksum: 0F596C0EFAE09A46
Show »

FASTA687,930
Isoform 4 [UniParc].

Checksum: A49AC6311303B48F
Show »

FASTA13214,977

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT THR-54.
Tissue: Skeletal muscle.
[2]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK096895 mRNA. Translation: BAC04887.1.
AC093852 Genomic DNA. No translation available.
AC096586 Genomic DNA. No translation available.
AC108478 Genomic DNA. No translation available.
BC103995 mRNA. Translation: AAI03996.1.
BC103996 mRNA. Translation: AAI03997.1.
CCDSCCDS54766.1. [Q8N8F6-1]
RefSeqNP_872398.2. NM_182592.2. [Q8N8F6-1]
UniGeneHs.596000.

3D structure databases

ProteinModelPortalQ8N8F6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000412696.

PTM databases

PhosphoSiteQ8N8F6.

Polymorphism databases

DMDM189030344.

Proteomic databases

PeptideAtlasQ8N8F6.
PRIDEQ8N8F6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000332990; ENSP00000332772; ENSG00000177752. [Q8N8F6-1]
GeneID285525.
KEGGhsa:285525.
UCSCuc010ify.2. human. [Q8N8F6-4]
uc021xnx.1. human. [Q8N8F6-1]

Organism-specific databases

CTD285525.
GeneCardsGC04M044624.
H-InvDBHIX0004184.
HGNCHGNC:26825. YIPF7.
HPAHPA030642.
neXtProtNX_Q8N8F6.
PharmGKBPA142670550.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5080.
HOGENOMHOG000037706.
HOVERGENHBG055241.
OMAMSAIGCL.
PhylomeDBQ8N8F6.
TreeFamTF313100.

Gene expression databases

BgeeQ8N8F6.
CleanExHS_YIPF7.
GenevestigatorQ8N8F6.

Family and domain databases

InterProIPR006977. Yip1.
[Graphical view]
PfamPF04893. Yip1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi285525.
NextBio95579.
PROQ8N8F6.

Entry information

Entry nameYIPF7_HUMAN
AccessionPrimary (citable) accession number: Q8N8F6
Secondary accession number(s): Q3SY21, Q3SY22
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: July 9, 2014
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM