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Q8N8F6

- YIPF7_HUMAN

UniProt

Q8N8F6 - YIPF7_HUMAN

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Protein

Protein YIPF7

Gene

YIPF7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein YIPF7
Alternative name(s):
Five-pass transmembrane protein localizing in the Golgi apparatus and the endoplasmic reticulum 9
YIP1 family member 7
Gene namesi
Name:YIPF7
Synonyms:FINGER9, YIP1B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:26825. YIPF7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei150 – 17021HelicalSequence AnalysisAdd
BLAST
Transmembranei172 – 19221HelicalSequence AnalysisAdd
BLAST
Transmembranei197 – 21721HelicalSequence AnalysisAdd
BLAST
Transmembranei232 – 25423HelicalSequence AnalysisAdd
BLAST
Transmembranei260 – 28021HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670550.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 280280Protein YIPF7PRO_0000333007Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi39 – 391N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PeptideAtlasiQ8N8F6.
PRIDEiQ8N8F6.

PTM databases

PhosphoSiteiQ8N8F6.

Expressioni

Gene expression databases

BgeeiQ8N8F6.
CleanExiHS_YIPF7.
ExpressionAtlasiQ8N8F6. baseline.
GenevestigatoriQ8N8F6.

Organism-specific databases

HPAiHPA030642.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000412696.

Structurei

3D structure databases

ProteinModelPortaliQ8N8F6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the YIP1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5080.
GeneTreeiENSGT00510000046817.
HOGENOMiHOG000037706.
HOVERGENiHBG055241.
InParanoidiQ8N8F6.
OMAiMSAIGCL.
PhylomeDBiQ8N8F6.
TreeFamiTF313100.

Family and domain databases

InterProiIPR006977. Yip1.
[Graphical view]
PfamiPF04893. Yip1. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8N8F6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDLLKISHTK LHLLEDLSIK NKQRMSNLAQ FDSDFYQSNF TIDNQEQSGN
60 70 80 90 100
DSNAYGNLYG SRKQQAGEQP QPASFVPSEM LMSSGYAGQF FQPASNSDYY
110 120 130 140 150
SQSPYIDSFD EEPPLLEELG IHFDHIWQKT LTVLNPMKPV DGSIMNETDL
160 170 180 190 200
TGPILFCVAL GATLLLAGKV QFGYVYGMSA IGCLVIHALL NLMSSSGVSY
210 220 230 240 250
GCVASVLGYC LLPMVILSGC AMFFSLQGIF GIMSSLVIIG WCSLSASKIF
260 270 280
IAALHMEGQQ LLVAYPCAIL YGLFALLTIF
Length:280
Mass (Da):30,632
Last modified:May 20, 2008 - v2
Checksum:iAF30804CB8B3FB36
GO
Isoform 2 (identifier: Q8N8F6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     167-280: AGKVQFGYVY...YGLFALLTIF → VMCHRKHQIL...YIVNFLSERE

Note: No experimental confirmation available.

Show »
Length:208
Mass (Da):23,451
Checksum:i32B2284DDA9B38AB
GO
Isoform 3 (identifier: Q8N8F6-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     64-68: QQAGE → TWNPF
     69-280: Missing.

Note: No experimental confirmation available.

Show »
Length:68
Mass (Da):7,930
Checksum:i0F596C0EFAE09A46
GO
Isoform 4 (identifier: Q8N8F6-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     118-132: ELGIHFDHIWQKTLT → DKNLESILITYGKKL
     133-280: Missing.

Note: No experimental confirmation available.

Show »
Length:132
Mass (Da):14,977
Checksum:iA49AC6311303B48F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti50 – 501N → D in BAC04887. (PubMed:14702039)Curated
Sequence conflicti138 – 1381K → E in BAC04887. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti54 – 541A → T.1 Publication
Corresponds to variant rs2348353 [ dbSNP | Ensembl ].
VAR_043036

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei64 – 685QQAGE → TWNPF in isoform 3. 1 PublicationVSP_033431
Alternative sequencei69 – 280212Missing in isoform 3. 1 PublicationVSP_033432Add
BLAST
Alternative sequencei118 – 13215ELGIH…QKTLT → DKNLESILITYGKKL in isoform 4. 1 PublicationVSP_033433Add
BLAST
Alternative sequencei133 – 280148Missing in isoform 4. 1 PublicationVSP_033434Add
BLAST
Alternative sequencei167 – 280114AGKVQ…LLTIF → VMCHRKHQILMLVLSSAGFE AICINIRETVSPYIVNFLSE RE in isoform 2. 1 PublicationVSP_033435Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096895 mRNA. Translation: BAC04887.1.
AC093852 Genomic DNA. No translation available.
AC096586 Genomic DNA. No translation available.
AC108478 Genomic DNA. No translation available.
BC103995 mRNA. Translation: AAI03996.1.
BC103996 mRNA. Translation: AAI03997.1.
CCDSiCCDS54766.1. [Q8N8F6-1]
RefSeqiNP_872398.2. NM_182592.2. [Q8N8F6-1]
UniGeneiHs.596000.

Genome annotation databases

EnsembliENST00000332990; ENSP00000332772; ENSG00000177752. [Q8N8F6-1]
GeneIDi285525.
KEGGihsa:285525.
UCSCiuc010ify.2. human. [Q8N8F6-4]
uc021xnx.1. human. [Q8N8F6-1]

Polymorphism databases

DMDMi189030344.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096895 mRNA. Translation: BAC04887.1 .
AC093852 Genomic DNA. No translation available.
AC096586 Genomic DNA. No translation available.
AC108478 Genomic DNA. No translation available.
BC103995 mRNA. Translation: AAI03996.1 .
BC103996 mRNA. Translation: AAI03997.1 .
CCDSi CCDS54766.1. [Q8N8F6-1 ]
RefSeqi NP_872398.2. NM_182592.2. [Q8N8F6-1 ]
UniGenei Hs.596000.

3D structure databases

ProteinModelPortali Q8N8F6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000412696.

PTM databases

PhosphoSitei Q8N8F6.

Polymorphism databases

DMDMi 189030344.

Proteomic databases

PeptideAtlasi Q8N8F6.
PRIDEi Q8N8F6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000332990 ; ENSP00000332772 ; ENSG00000177752 . [Q8N8F6-1 ]
GeneIDi 285525.
KEGGi hsa:285525.
UCSCi uc010ify.2. human. [Q8N8F6-4 ]
uc021xnx.1. human. [Q8N8F6-1 ]

Organism-specific databases

CTDi 285525.
GeneCardsi GC04M044624.
H-InvDB HIX0004184.
HGNCi HGNC:26825. YIPF7.
HPAi HPA030642.
neXtProti NX_Q8N8F6.
PharmGKBi PA142670550.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5080.
GeneTreei ENSGT00510000046817.
HOGENOMi HOG000037706.
HOVERGENi HBG055241.
InParanoidi Q8N8F6.
OMAi MSAIGCL.
PhylomeDBi Q8N8F6.
TreeFami TF313100.

Miscellaneous databases

ChiTaRSi YIPF7. human.
GenomeRNAii 285525.
NextBioi 95579.
PROi Q8N8F6.

Gene expression databases

Bgeei Q8N8F6.
CleanExi HS_YIPF7.
ExpressionAtlasi Q8N8F6. baseline.
Genevestigatori Q8N8F6.

Family and domain databases

InterProi IPR006977. Yip1.
[Graphical view ]
Pfami PF04893. Yip1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT THR-54.
    Tissue: Skeletal muscle.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4).

Entry informationi

Entry nameiYIPF7_HUMAN
AccessioniPrimary (citable) accession number: Q8N8F6
Secondary accession number(s): Q3SY21, Q3SY22
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: November 26, 2014
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3