Q8N8F6 (YIPF7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein YIPF7

Alternative name(s):
Five-pass transmembrane protein localizing in the Golgi apparatus and the endoplasmic reticulum 9
YIP1 family member 7

Gene names

Name:	YIPF7
Synonyms:	FINGER9, YIP1B

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	280 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the YIP1 family.
Caution	It is uncertain whether Met-1 or Met-25 is the initiator.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8N8F6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8N8F6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     167-280: AGKVQFGYVY...YGLFALLTIF → VMCHRKHQIL...YIVNFLSERE

Note: No experimental confirmation available.

Isoform 3 (identifier: Q8N8F6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     64-68: QQAGE → TWNPF
     69-280: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q8N8F6-4)

The sequence of this isoform differs from the canonical sequence as follows:
     118-132: ELGIHFDHIWQKTLT → DKNLESILITYGKKL
     133-280: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 280	280	Protein YIPF7		PRO_0000333007
Regions
	Transmembrane	150 – 170	21	Helical; Potential
	Transmembrane	172 – 192	21	Helical; Potential
	Transmembrane	197 – 217	21	Helical; Potential
	Transmembrane	232 – 254	23	Helical; Potential
	Transmembrane	260 – 280	21	Helical; Potential
Amino acid modifications
	Glycosylation	39	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	64 – 68	5	QQAGE → TWNPF in isoform 3.		VSP_033431
	Alternative sequence	69 – 280	212	Missing in isoform 3.		VSP_033432
	Alternative sequence	118 – 132	15	ELGIH…QKTLT → DKNLESILITYGKKL in isoform 4.		VSP_033433
	Alternative sequence	133 – 280	148	Missing in isoform 4.		VSP_033434
	Alternative sequence	167 – 280	114	AGKVQ…LLTIF → VMCHRKHQILMLVLSSAGFE AICINIRETVSPYIVNFLSE RE in isoform 2.		VSP_033435
	Natural variant	54	1	A → T. Ref.1 Corresponds to variant rs2348353 [ dbSNP | Ensembl ].		VAR_043036
Experimental info
	Sequence conflict	50	1	N → D in BAC04887. Ref.1
	Sequence conflict	138	1	K → E in BAC04887. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 20, 2008. Version 2. Checksum: AF30804CB8B3FB36	FASTA	280	30,632
	10 20 30 40 50 60 MDLLKISHTK LHLLEDLSIK NKQRMSNLAQ FDSDFYQSNF TIDNQEQSGN DSNAYGNLYG 70 80 90 100 110 120 SRKQQAGEQP QPASFVPSEM LMSSGYAGQF FQPASNSDYY SQSPYIDSFD EEPPLLEELG 130 140 150 160 170 180 IHFDHIWQKT LTVLNPMKPV DGSIMNETDL TGPILFCVAL GATLLLAGKV QFGYVYGMSA 190 200 210 220 230 240 IGCLVIHALL NLMSSSGVSY GCVASVLGYC LLPMVILSGC AMFFSLQGIF GIMSSLVIIG 250 260 270 280 WCSLSASKIF IAALHMEGQQ LLVAYPCAIL YGLFALLTIF
	Isoform 2 [UniParc]. Checksum: 32B2284DDA9B38AB	FASTA	208	23,451
	10 20 30 40 50 60 MDLLKISHTK LHLLEDLSIK NKQRMSNLAQ FDSDFYQSNF TIDNQEQSGN DSNAYGNLYG 70 80 90 100 110 120 SRKQQAGEQP QPASFVPSEM LMSSGYAGQF FQPASNSDYY SQSPYIDSFD EEPPLLEELG 130 140 150 160 170 180 IHFDHIWQKT LTVLNPMKPV DGSIMNETDL TGPILFCVAL GATLLLVMCH RKHQILMLVL 190 200 SSAGFEAICI NIRETVSPYI VNFLSERE
	Isoform 3 [UniParc]. Checksum: 0F596C0EFAE09A46	FASTA	68	7,930
	10 20 30 40 50 60 MDLLKISHTK LHLLEDLSIK NKQRMSNLAQ FDSDFYQSNF TIDNQEQSGN DSNAYGNLYG SRKTWNPF
	Isoform 4 [UniParc]. Checksum: A49AC6311303B48F	FASTA	132	14,977
	10 20 30 40 50 60 MDLLKISHTK LHLLEDLSIK NKQRMSNLAQ FDSDFYQSNF TIDNQEQSGN DSNAYGNLYG 70 80 90 100 110 120 SRKQQAGEQP QPASFVPSEM LMSSGYAGQF FQPASNSDYY SQSPYIDSFD EEPPLLEDKN 130 LESILITYGK KL

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT THR-54. Tissue: Skeletal muscle.
[2]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4).

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK096895 mRNA. Translation: BAC04887.1. AC093852 Genomic DNA. No translation available. AC096586 Genomic DNA. No translation available. AC108478 Genomic DNA. No translation available. BC103995 mRNA. Translation: AAI03996.1. BC103996 mRNA. Translation: AAI03997.1.
IPI	IPI00298158. IPI00651723. IPI00783057. IPI00893065.
RefSeq	NP_872398.2. NM_182592.2.
UniGene	Hs.596000.
3D structure databases
ProteinModelPortal	Q8N8F6.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000412696.
PTM databases
PhosphoSite	Q8N8F6.
Polymorphism databases
DMDM	189030344.
Proteomic databases
PeptideAtlas	Q8N8F6.
PRIDE	Q8N8F6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000332990; ENSP00000332772; ENSG00000177752.
GeneID	285525.
KEGG	hsa:285525.
UCSC	uc010ify.2. human. uc021xnx.1. human.
Organism-specific databases
CTD	285525.
GeneCards	GC04M044624.
H-InvDB	HIX0004184.
HGNC	HGNC:26825. YIPF7.
HPA	HPA030642.
neXtProt	NX_Q8N8F6.
PharmGKB	PA142670550.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5080.
HOGENOM	HOG000037706.
HOVERGEN	HBG055241.
OMA	WCAISAS.
OrthoDB	EOG40K814.
Gene expression databases
Bgee	Q8N8F6.
CleanEx	HS_YIPF7.
Genevestigator	Q8N8F6.
Family and domain databases
InterPro	IPR006977. Yip1. [Graphical view]
Pfam	PF04893. Yip1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	285525.
NextBio	95579.

Entry information

Entry name

YIPF7_HUMAN

Accession

Primary (citable) accession number: Q8N8F6
Secondary accession number(s): Q3SY21, Q3SY22

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	May 20, 2008
Last modified:	April 3, 2013
This is version 67 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.