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Q8N8F6

- YIPF7_HUMAN

UniProt

Q8N8F6 - YIPF7_HUMAN

Protein

Protein YIPF7

Gene

YIPF7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 2 (20 May 2008)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein YIPF7
    Alternative name(s):
    Five-pass transmembrane protein localizing in the Golgi apparatus and the endoplasmic reticulum 9
    YIP1 family member 7
    Gene namesi
    Name:YIPF7
    Synonyms:FINGER9, YIP1B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:26825. YIPF7.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142670550.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 280280Protein YIPF7PRO_0000333007Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi39 – 391N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PeptideAtlasiQ8N8F6.
    PRIDEiQ8N8F6.

    PTM databases

    PhosphoSiteiQ8N8F6.

    Expressioni

    Gene expression databases

    BgeeiQ8N8F6.
    CleanExiHS_YIPF7.
    GenevestigatoriQ8N8F6.

    Organism-specific databases

    HPAiHPA030642.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000412696.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N8F6.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei150 – 17021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei172 – 19221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei197 – 21721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei232 – 25423HelicalSequence AnalysisAdd
    BLAST
    Transmembranei260 – 28021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the YIP1 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5080.
    HOGENOMiHOG000037706.
    HOVERGENiHBG055241.
    OMAiMSAIGCL.
    PhylomeDBiQ8N8F6.
    TreeFamiTF313100.

    Family and domain databases

    InterProiIPR006977. Yip1.
    [Graphical view]
    PfamiPF04893. Yip1. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8N8F6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDLLKISHTK LHLLEDLSIK NKQRMSNLAQ FDSDFYQSNF TIDNQEQSGN    50
    DSNAYGNLYG SRKQQAGEQP QPASFVPSEM LMSSGYAGQF FQPASNSDYY 100
    SQSPYIDSFD EEPPLLEELG IHFDHIWQKT LTVLNPMKPV DGSIMNETDL 150
    TGPILFCVAL GATLLLAGKV QFGYVYGMSA IGCLVIHALL NLMSSSGVSY 200
    GCVASVLGYC LLPMVILSGC AMFFSLQGIF GIMSSLVIIG WCSLSASKIF 250
    IAALHMEGQQ LLVAYPCAIL YGLFALLTIF 280
    Length:280
    Mass (Da):30,632
    Last modified:May 20, 2008 - v2
    Checksum:iAF30804CB8B3FB36
    GO
    Isoform 2 (identifier: Q8N8F6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         167-280: AGKVQFGYVY...YGLFALLTIF → VMCHRKHQIL...YIVNFLSERE

    Note: No experimental confirmation available.

    Show »
    Length:208
    Mass (Da):23,451
    Checksum:i32B2284DDA9B38AB
    GO
    Isoform 3 (identifier: Q8N8F6-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         64-68: QQAGE → TWNPF
         69-280: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:68
    Mass (Da):7,930
    Checksum:i0F596C0EFAE09A46
    GO
    Isoform 4 (identifier: Q8N8F6-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         118-132: ELGIHFDHIWQKTLT → DKNLESILITYGKKL
         133-280: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:132
    Mass (Da):14,977
    Checksum:iA49AC6311303B48F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti50 – 501N → D in BAC04887. (PubMed:14702039)Curated
    Sequence conflicti138 – 1381K → E in BAC04887. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti54 – 541A → T.1 Publication
    Corresponds to variant rs2348353 [ dbSNP | Ensembl ].
    VAR_043036

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei64 – 685QQAGE → TWNPF in isoform 3. 1 PublicationVSP_033431
    Alternative sequencei69 – 280212Missing in isoform 3. 1 PublicationVSP_033432Add
    BLAST
    Alternative sequencei118 – 13215ELGIH…QKTLT → DKNLESILITYGKKL in isoform 4. 1 PublicationVSP_033433Add
    BLAST
    Alternative sequencei133 – 280148Missing in isoform 4. 1 PublicationVSP_033434Add
    BLAST
    Alternative sequencei167 – 280114AGKVQ…LLTIF → VMCHRKHQILMLVLSSAGFE AICINIRETVSPYIVNFLSE RE in isoform 2. 1 PublicationVSP_033435Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK096895 mRNA. Translation: BAC04887.1.
    AC093852 Genomic DNA. No translation available.
    AC096586 Genomic DNA. No translation available.
    AC108478 Genomic DNA. No translation available.
    BC103995 mRNA. Translation: AAI03996.1.
    BC103996 mRNA. Translation: AAI03997.1.
    CCDSiCCDS54766.1. [Q8N8F6-1]
    RefSeqiNP_872398.2. NM_182592.2. [Q8N8F6-1]
    UniGeneiHs.596000.

    Genome annotation databases

    EnsembliENST00000332990; ENSP00000332772; ENSG00000177752. [Q8N8F6-1]
    GeneIDi285525.
    KEGGihsa:285525.
    UCSCiuc010ify.2. human. [Q8N8F6-4]
    uc021xnx.1. human. [Q8N8F6-1]

    Polymorphism databases

    DMDMi189030344.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK096895 mRNA. Translation: BAC04887.1 .
    AC093852 Genomic DNA. No translation available.
    AC096586 Genomic DNA. No translation available.
    AC108478 Genomic DNA. No translation available.
    BC103995 mRNA. Translation: AAI03996.1 .
    BC103996 mRNA. Translation: AAI03997.1 .
    CCDSi CCDS54766.1. [Q8N8F6-1 ]
    RefSeqi NP_872398.2. NM_182592.2. [Q8N8F6-1 ]
    UniGenei Hs.596000.

    3D structure databases

    ProteinModelPortali Q8N8F6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000412696.

    PTM databases

    PhosphoSitei Q8N8F6.

    Polymorphism databases

    DMDMi 189030344.

    Proteomic databases

    PeptideAtlasi Q8N8F6.
    PRIDEi Q8N8F6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000332990 ; ENSP00000332772 ; ENSG00000177752 . [Q8N8F6-1 ]
    GeneIDi 285525.
    KEGGi hsa:285525.
    UCSCi uc010ify.2. human. [Q8N8F6-4 ]
    uc021xnx.1. human. [Q8N8F6-1 ]

    Organism-specific databases

    CTDi 285525.
    GeneCardsi GC04M044624.
    H-InvDB HIX0004184.
    HGNCi HGNC:26825. YIPF7.
    HPAi HPA030642.
    neXtProti NX_Q8N8F6.
    PharmGKBi PA142670550.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5080.
    HOGENOMi HOG000037706.
    HOVERGENi HBG055241.
    OMAi MSAIGCL.
    PhylomeDBi Q8N8F6.
    TreeFami TF313100.

    Miscellaneous databases

    GenomeRNAii 285525.
    NextBioi 95579.
    PROi Q8N8F6.

    Gene expression databases

    Bgeei Q8N8F6.
    CleanExi HS_YIPF7.
    Genevestigatori Q8N8F6.

    Family and domain databases

    InterProi IPR006977. Yip1.
    [Graphical view ]
    Pfami PF04893. Yip1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT THR-54.
      Tissue: Skeletal muscle.
    2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4).

    Entry informationi

    Entry nameiYIPF7_HUMAN
    AccessioniPrimary (citable) accession number: Q8N8F6
    Secondary accession number(s): Q3SY21, Q3SY22
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: May 20, 2008
    Last modified: October 1, 2014
    This is version 77 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3