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Q8N8D7 (NKAI3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3

Short name=Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 3
Alternative name(s):
Protein FAM77D
Gene names
Name:NKAIN3
Synonyms:FAM77D
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length197 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subunit structure

Interacts with ATP1B1 By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the NKAIN family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 197197Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3
PRO_0000263093

Regions

Transmembrane2 – 2221Helical; Potential
Transmembrane35 – 5521Helical; Potential
Transmembrane62 – 8221Helical; Potential
Transmembrane152 – 17221Helical; Potential

Natural variations

Natural variant1401V → I.
Corresponds to variant rs4739003 [ dbSNP | Ensembl ].
VAR_029583

Sequences

Sequence LengthMass (Da)Tools
Q8N8D7 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 1891A3188A9296DC

FASTA19722,620
        10         20         30         40         50         60 
MGCCTGRCSL ICLCALQLVS ALERQIFDFL GFQWAPILGN FLHIIVVILG LFGTIQYRPR 

        70         80         90        100        110        120 
YIMVYTVWTA LWVTWNVFII CFYLEVGGLS KDTDLMTFNI SVHRSWWREH GPGCVRRVLP 

       130        140        150        160        170        180 
PSAHGMMDDY TYVSVTGCIV DFQYLEVIHS AVQILLSLVG FVYACYVISI SMEEEDTYSC 

       190 
DLQVCKHLFI QMLQIIE 

« Hide

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Small intestine.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK096949 mRNA. Translation: BAC04909.1.
RefSeqNP_775959.1. NM_173688.2.
UniGeneHs.654662.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000333627.

Polymorphism databases

DMDM74729419.

Proteomic databases

PRIDEQ8N8D7.

Protocols and materials databases

DNASU286183.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000328472; ENSP00000333627; ENSG00000185942.
ENST00000523211; ENSP00000429073; ENSG00000185942.
GeneID286183.
KEGGhsa:286183.
UCSCuc010lyq.1. human.

Organism-specific databases

CTD286183.
GeneCardsGC08P063161.
HGNCHGNC:26829. NKAIN3.
HPAHPA018833.
MIM612872. gene.
neXtProtNX_Q8N8D7.
PharmGKBPA162397582.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG295349.
HOGENOMHOG000293382.
HOVERGENHBG108190.
InParanoidQ8N8D7.
OMAPGCIRRV.
OrthoDBEOG77DJ78.
PhylomeDBQ8N8D7.
TreeFamTF321348.

Gene expression databases

ArrayExpressQ8N8D7.
BgeeQ8N8D7.
CleanExHS_NKAIN3.
GenevestigatorQ8N8D7.

Family and domain databases

InterProIPR008516. Na/K-Atpase_Interacting.
[Graphical view]
PANTHERPTHR13084. PTHR13084. 1 hit.
PfamPF05640. NKAIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi286183.
NextBio96062.
PROQ8N8D7.
SOURCESearch...

Entry information

Entry nameNKAI3_HUMAN
AccessionPrimary (citable) accession number: Q8N8D7
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM