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Protein

Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3

Gene

NKAIN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3
Short name:
Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 3
Alternative name(s):
Protein FAM77D
Gene namesi
Name:NKAIN3
Synonyms:FAM77D
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:26829. NKAIN3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei2 – 2221HelicalSequence AnalysisAdd
BLAST
Transmembranei35 – 5521HelicalSequence AnalysisAdd
BLAST
Transmembranei62 – 8221HelicalSequence AnalysisAdd
BLAST
Transmembranei152 – 17221HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162397582.

Polymorphism and mutation databases

BioMutaiNKAIN3.
DMDMi74729419.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 197197Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3PRO_0000263093Add
BLAST

Proteomic databases

PRIDEiQ8N8D7.

Expressioni

Gene expression databases

BgeeiQ8N8D7.
CleanExiHS_NKAIN3.
ExpressionAtlasiQ8N8D7. baseline and differential.
GenevisibleiQ8N8D7. HS.

Organism-specific databases

HPAiHPA018833.

Interactioni

Subunit structurei

Interacts with ATP1B1.By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000333627.

Family & Domainsi

Sequence similaritiesi

Belongs to the NKAIN family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG295349.
GeneTreeiENSGT00390000013699.
HOGENOMiHOG000293382.
HOVERGENiHBG108190.
InParanoidiQ8N8D7.
OMAiPGCIRRV.
OrthoDBiEOG77DJ78.
PhylomeDBiQ8N8D7.
TreeFamiTF321348.

Family and domain databases

InterProiIPR008516. Na/K-Atpase_Interacting.
[Graphical view]
PANTHERiPTHR13084. PTHR13084. 1 hit.
PfamiPF05640. NKAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N8D7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCCTGRCSL ICLCALQLVS ALERQIFDFL GFQWAPILGN FLHIIVVILG
60 70 80 90 100
LFGTIQYRPR YIMVYTVWTA LWVTWNVFII CFYLEVGGLS KDTDLMTFNI
110 120 130 140 150
SVHRSWWREH GPGCVRRVLP PSAHGMMDDY TYVSVTGCIV DFQYLEVIHS
160 170 180 190
AVQILLSLVG FVYACYVISI SMEEEDTYSC DLQVCKHLFI QMLQIIE
Length:197
Mass (Da):22,620
Last modified:October 1, 2002 - v1
Checksum:i1891A3188A9296DC
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti140 – 1401V → I.
Corresponds to variant rs4739003 [ dbSNP | Ensembl ].
VAR_029583

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096949 mRNA. Translation: BAC04909.1.
UniGeneiHs.654662.

Genome annotation databases

EnsembliENST00000523211; ENSP00000429073; ENSG00000185942.
UCSCiuc010lyq.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096949 mRNA. Translation: BAC04909.1.
UniGeneiHs.654662.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000333627.

Polymorphism and mutation databases

BioMutaiNKAIN3.
DMDMi74729419.

Proteomic databases

PRIDEiQ8N8D7.

Protocols and materials databases

DNASUi286183.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000523211; ENSP00000429073; ENSG00000185942.
UCSCiuc010lyq.1. human.

Organism-specific databases

GeneCardsiGC08P063161.
HGNCiHGNC:26829. NKAIN3.
HPAiHPA018833.
MIMi612872. gene.
neXtProtiNX_Q8N8D7.
PharmGKBiPA162397582.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG295349.
GeneTreeiENSGT00390000013699.
HOGENOMiHOG000293382.
HOVERGENiHBG108190.
InParanoidiQ8N8D7.
OMAiPGCIRRV.
OrthoDBiEOG77DJ78.
PhylomeDBiQ8N8D7.
TreeFamiTF321348.

Miscellaneous databases

ChiTaRSiNKAIN3. human.
GenomeRNAii286183.
NextBioi96062.
PROiQ8N8D7.
SOURCEiSearch...

Gene expression databases

BgeeiQ8N8D7.
CleanExiHS_NKAIN3.
ExpressionAtlasiQ8N8D7. baseline and differential.
GenevisibleiQ8N8D7. HS.

Family and domain databases

InterProiIPR008516. Na/K-Atpase_Interacting.
[Graphical view]
PANTHERiPTHR13084. PTHR13084. 1 hit.
PfamiPF05640. NKAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Small intestine.

Entry informationi

Entry nameiNKAI3_HUMAN
AccessioniPrimary (citable) accession number: Q8N8D7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: October 1, 2002
Last modified: July 22, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.