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Protein

Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3

Gene

NKAIN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:HS11955-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3
Short name:
Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 3
Alternative name(s):
Protein FAM77D
Gene namesi
Name:NKAIN3
Synonyms:FAM77D
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:26829. NKAIN3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei2 – 22HelicalSequence analysisAdd BLAST21
Transmembranei35 – 55HelicalSequence analysisAdd BLAST21
Transmembranei62 – 82HelicalSequence analysisAdd BLAST21
Transmembranei152 – 172HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi286183.
OpenTargetsiENSG00000185942.
PharmGKBiPA162397582.

Polymorphism and mutation databases

BioMutaiNKAIN3.
DMDMi74729419.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002630931 – 197Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3Add BLAST197

Proteomic databases

PaxDbiQ8N8D7.
PRIDEiQ8N8D7.

PTM databases

PhosphoSitePlusiQ8N8D7.

Expressioni

Gene expression databases

BgeeiENSG00000185942.
CleanExiHS_NKAIN3.
ExpressionAtlasiQ8N8D7. baseline and differential.
GenevisibleiQ8N8D7. HS.

Organism-specific databases

HPAiHPA018833.

Interactioni

Subunit structurei

Interacts with ATP1B1.By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000333627.

Structurei

3D structure databases

ProteinModelPortaliQ8N8D7.
SMRiQ8N8D7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NKAIN family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4556. Eukaryota.
ENOG410XS8X. LUCA.
GeneTreeiENSGT00390000013699.
HOGENOMiHOG000293382.
HOVERGENiHBG108190.
InParanoidiQ8N8D7.
OMAiPGCIRRV.
OrthoDBiEOG091G0X6F.
PhylomeDBiQ8N8D7.
TreeFamiTF321348.

Family and domain databases

InterProiIPR008516. Na/K-Atpase_Interacting.
[Graphical view]
PANTHERiPTHR13084. PTHR13084. 1 hit.
PfamiPF05640. NKAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N8D7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCCTGRCSL ICLCALQLVS ALERQIFDFL GFQWAPILGN FLHIIVVILG
60 70 80 90 100
LFGTIQYRPR YIMVYTVWTA LWVTWNVFII CFYLEVGGLS KDTDLMTFNI
110 120 130 140 150
SVHRSWWREH GPGCVRRVLP PSAHGMMDDY TYVSVTGCIV DFQYLEVIHS
160 170 180 190
AVQILLSLVG FVYACYVISI SMEEEDTYSC DLQVCKHLFI QMLQIIE
Length:197
Mass (Da):22,620
Last modified:October 1, 2002 - v1
Checksum:i1891A3188A9296DC
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_029583140V → I.Corresponds to variant rs4739003dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096949 mRNA. Translation: BAC04909.1.
UniGeneiHs.654662.

Genome annotation databases

EnsembliENST00000523211; ENSP00000429073; ENSG00000185942.
UCSCiuc010lyq.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096949 mRNA. Translation: BAC04909.1.
UniGeneiHs.654662.

3D structure databases

ProteinModelPortaliQ8N8D7.
SMRiQ8N8D7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000333627.

PTM databases

PhosphoSitePlusiQ8N8D7.

Polymorphism and mutation databases

BioMutaiNKAIN3.
DMDMi74729419.

Proteomic databases

PaxDbiQ8N8D7.
PRIDEiQ8N8D7.

Protocols and materials databases

DNASUi286183.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000523211; ENSP00000429073; ENSG00000185942.
UCSCiuc010lyq.2. human.

Organism-specific databases

DisGeNETi286183.
GeneCardsiNKAIN3.
HGNCiHGNC:26829. NKAIN3.
HPAiHPA018833.
MIMi612872. gene.
neXtProtiNX_Q8N8D7.
OpenTargetsiENSG00000185942.
PharmGKBiPA162397582.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4556. Eukaryota.
ENOG410XS8X. LUCA.
GeneTreeiENSGT00390000013699.
HOGENOMiHOG000293382.
HOVERGENiHBG108190.
InParanoidiQ8N8D7.
OMAiPGCIRRV.
OrthoDBiEOG091G0X6F.
PhylomeDBiQ8N8D7.
TreeFamiTF321348.

Enzyme and pathway databases

BioCyciZFISH:HS11955-MONOMER.

Miscellaneous databases

ChiTaRSiNKAIN3. human.
PROiQ8N8D7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000185942.
CleanExiHS_NKAIN3.
ExpressionAtlasiQ8N8D7. baseline and differential.
GenevisibleiQ8N8D7. HS.

Family and domain databases

InterProiIPR008516. Na/K-Atpase_Interacting.
[Graphical view]
PANTHERiPTHR13084. PTHR13084. 1 hit.
PfamiPF05640. NKAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNKAI3_HUMAN
AccessioniPrimary (citable) accession number: Q8N8D7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.