Q8N8D7 (NKAI3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3
Short name=Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 3

Alternative name(s):
Protein FAM77D

Gene names

Name:	NKAIN3
Synonyms:	FAM77D

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	197 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subunit structure	Interacts with ATP1B1 By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the NKAIN family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 197	197	Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3		PRO_0000263093
Regions
	Transmembrane	2 – 22	21	Helical; Potential
	Transmembrane	35 – 55	21	Helical; Potential
	Transmembrane	62 – 82	21	Helical; Potential
	Transmembrane	152 – 172	21	Helical; Potential
Natural variations
	Natural variant	140	1	V → I. Corresponds to variant rs4739003 [ dbSNP | Ensembl ].		VAR_029583

Sequences

	Sequence		Length	Mass (Da)
	Q8N8D7 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 1891A3188A9296DC	FASTA	197	22,620
	10 20 30 40 50 60 MGCCTGRCSL ICLCALQLVS ALERQIFDFL GFQWAPILGN FLHIIVVILG LFGTIQYRPR 70 80 90 100 110 120 YIMVYTVWTA LWVTWNVFII CFYLEVGGLS KDTDLMTFNI SVHRSWWREH GPGCVRRVLP 130 140 150 160 170 180 PSAHGMMDDY TYVSVTGCIV DFQYLEVIHS AVQILLSLVG FVYACYVISI SMEEEDTYSC 190 DLQVCKHLFI QMLQIIE

References

[1]

"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Small intestine.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK096949 mRNA. Translation: BAC04909.1.
IPI	IPI00167450.
RefSeq	NP_775959.1. NM_173688.2.
UniGene	Hs.654662.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000333627.
Polymorphism databases
DMDM	74729419.
Protocols and materials databases
DNASU	286183.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000328472; ENSP00000333627; ENSG00000185942. ENST00000523211; ENSP00000429073; ENSG00000185942.
GeneID	286183.
KEGG	hsa:286183.
UCSC	uc010lyq.1. human.
Organism-specific databases
CTD	286183.
GeneCards	GC08P063161.
HGNC	HGNC:26829. NKAIN3.
HPA	HPA018833.
MIM	612872. gene.
neXtProt	NX_Q8N8D7.
PharmGKB	PA162397582.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG295349.
HOGENOM	HOG000293382.
HOVERGEN	HBG108190.
InParanoid	Q8N8D7.
OMA	QFRPRYI.
OrthoDB	EOG40GCRW.
Gene expression databases
ArrayExpress	Q8N8D7.
Bgee	Q8N8D7.
CleanEx	HS_NKAIN3.
Genevestigator	Q8N8D7.
Family and domain databases
InterPro	IPR008516. Na/K-Atpase_Interacting. [Graphical view]
PANTHER	PTHR13084. PTHR13084. 1 hit.
Pfam	PF05640. NKAIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	286183.
NextBio	96062.
SOURCE	Search...

Entry information

Entry name

NKAI3_HUMAN

Accession

Primary (citable) accession number: Q8N8D7

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	October 1, 2002
Last modified:	April 3, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.