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Q8N8D7

- NKAI3_HUMAN

UniProt

Q8N8D7 - NKAI3_HUMAN

Protein

Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3

Gene

NKAIN3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3
    Short name:
    Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 3
    Alternative name(s):
    Protein FAM77D
    Gene namesi
    Name:NKAIN3
    Synonyms:FAM77D
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:26829. NKAIN3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162397582.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 197197Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3PRO_0000263093Add
    BLAST

    Proteomic databases

    PRIDEiQ8N8D7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8N8D7.
    BgeeiQ8N8D7.
    CleanExiHS_NKAIN3.
    GenevestigatoriQ8N8D7.

    Organism-specific databases

    HPAiHPA018833.

    Interactioni

    Subunit structurei

    Interacts with ATP1B1.By similarity

    Protein-protein interaction databases

    STRINGi9606.ENSP00000333627.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei2 – 2221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei35 – 5521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei62 – 8221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei152 – 17221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NKAIN family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG295349.
    HOGENOMiHOG000293382.
    HOVERGENiHBG108190.
    InParanoidiQ8N8D7.
    OMAiCYVISVF.
    OrthoDBiEOG77DJ78.
    PhylomeDBiQ8N8D7.
    TreeFamiTF321348.

    Family and domain databases

    InterProiIPR008516. Na/K-Atpase_Interacting.
    [Graphical view]
    PANTHERiPTHR13084. PTHR13084. 1 hit.
    PfamiPF05640. NKAIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8N8D7-1 [UniParc]FASTAAdd to Basket

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    MGCCTGRCSL ICLCALQLVS ALERQIFDFL GFQWAPILGN FLHIIVVILG    50
    LFGTIQYRPR YIMVYTVWTA LWVTWNVFII CFYLEVGGLS KDTDLMTFNI 100
    SVHRSWWREH GPGCVRRVLP PSAHGMMDDY TYVSVTGCIV DFQYLEVIHS 150
    AVQILLSLVG FVYACYVISI SMEEEDTYSC DLQVCKHLFI QMLQIIE 197
    Length:197
    Mass (Da):22,620
    Last modified:October 1, 2002 - v1
    Checksum:i1891A3188A9296DC
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti140 – 1401V → I.
    Corresponds to variant rs4739003 [ dbSNP | Ensembl ].
    VAR_029583

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK096949 mRNA. Translation: BAC04909.1.
    CCDSiCCDS55239.1.
    RefSeqiNP_775959.1. NM_173688.2.
    UniGeneiHs.654662.

    Genome annotation databases

    EnsembliENST00000523211; ENSP00000429073; ENSG00000185942.
    GeneIDi286183.
    KEGGihsa:286183.
    UCSCiuc010lyq.1. human.

    Polymorphism databases

    DMDMi74729419.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK096949 mRNA. Translation: BAC04909.1 .
    CCDSi CCDS55239.1.
    RefSeqi NP_775959.1. NM_173688.2.
    UniGenei Hs.654662.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000333627.

    Polymorphism databases

    DMDMi 74729419.

    Proteomic databases

    PRIDEi Q8N8D7.

    Protocols and materials databases

    DNASUi 286183.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000523211 ; ENSP00000429073 ; ENSG00000185942 .
    GeneIDi 286183.
    KEGGi hsa:286183.
    UCSCi uc010lyq.1. human.

    Organism-specific databases

    CTDi 286183.
    GeneCardsi GC08P063161.
    HGNCi HGNC:26829. NKAIN3.
    HPAi HPA018833.
    MIMi 612872. gene.
    neXtProti NX_Q8N8D7.
    PharmGKBi PA162397582.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG295349.
    HOGENOMi HOG000293382.
    HOVERGENi HBG108190.
    InParanoidi Q8N8D7.
    OMAi CYVISVF.
    OrthoDBi EOG77DJ78.
    PhylomeDBi Q8N8D7.
    TreeFami TF321348.

    Miscellaneous databases

    GenomeRNAii 286183.
    NextBioi 96062.
    PROi Q8N8D7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8N8D7.
    Bgeei Q8N8D7.
    CleanExi HS_NKAIN3.
    Genevestigatori Q8N8D7.

    Family and domain databases

    InterProi IPR008516. Na/K-Atpase_Interacting.
    [Graphical view ]
    PANTHERi PTHR13084. PTHR13084. 1 hit.
    Pfami PF05640. NKAIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Small intestine.

    Entry informationi

    Entry nameiNKAI3_HUMAN
    AccessioniPrimary (citable) accession number: Q8N8D7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 12, 2006
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3