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Protein

Programmed cell death protein 7

Gene

PDCD7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Promotes apoptosis when overexpressed.By similarity

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • mRNA splicing, via spliceosome Source: Reactome
  • response to glucocorticoid Source: HGNC
  • RNA splicing Source: HGNC
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

ReactomeiR-HSA-72165. mRNA Splicing - Minor Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Programmed cell death protein 7
Alternative name(s):
ES18
Short name:
hES18
Gene namesi
Name:PDCD7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:8767. PDCD7.

Subcellular locationi

GO - Cellular componenti

  • nucleoplasm Source: Reactome
  • U12-type spliceosomal complex Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33117.

Polymorphism and mutation databases

BioMutaiPDCD7.
DMDMi38258174.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 485485Programmed cell death protein 7PRO_0000058269Add
BLAST

Proteomic databases

EPDiQ8N8D1.
MaxQBiQ8N8D1.
PaxDbiQ8N8D1.
PRIDEiQ8N8D1.

PTM databases

iPTMnetiQ8N8D1.
PhosphoSiteiQ8N8D1.

Expressioni

Gene expression databases

BgeeiQ8N8D1.
CleanExiHS_PDCD7.
ExpressionAtlasiQ8N8D1. baseline and differential.
GenevisibleiQ8N8D1. HS.

Organism-specific databases

HPAiHPA049388.

Interactioni

Subunit structurei

Interacts with RBM40. Component of the U11/U12 snRNPs that are part of the U12-type spliceosome.2 Publications

Protein-protein interaction databases

BioGridi115390. 24 interactions.
IntActiQ8N8D1. 9 interactions.
MINTiMINT-1180347.
STRINGi9606.ENSP00000204549.

Structurei

3D structure databases

ProteinModelPortaliQ8N8D1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili232 – 335104Sequence analysisAdd
BLAST
Coiled coili362 – 41150Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi4 – 129126Pro-richAdd
BLAST
Compositional biasi236 – 27843Arg/Glu-richAdd
BLAST

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410IVC0. Eukaryota.
ENOG41124DX. LUCA.
GeneTreeiENSGT00390000017392.
HOGENOMiHOG000115476.
HOVERGENiHBG053537.
InParanoidiQ8N8D1.
OMAiPVPQRTH.
OrthoDBiEOG700890.
PhylomeDBiQ8N8D1.
TreeFamiTF332996.

Family and domain databases

InterProiIPR031974. PDCD7.
[Graphical view]
PfamiPF16021. PDCD7. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N8D1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALPPFFGQG RPGPPPPQPP PPAPFGCPPP PLPSPAFPPP LPQRPGPFPG
60 70 80 90 100
ASAPFLQPPL ALQPRASAEA SRGGGGAGAF YPVPPPPLPP PPPQCRPFPG
110 120 130 140 150
TDAGERPRPP PPGPGPPWSP RWPEAPPPPA DVLGDAALQR LRDRQWLEAV
160 170 180 190 200
FGTPRRAGCP VPQRTHAGPS LGEVRARLLR ALRLVRRLRG LSQALREAEA
210 220 230 240 250
DGAAWVLLYS QTAPLRAELA ERLQPLTQAA YVGEARRRLE RVRRRRLRLR
260 270 280 290 300
ERAREREAER EAEAARAVER EQEIDRWRVK CVQEVEEKKR EQELKAAADG
310 320 330 340 350
VLSEVRKKQA DTKRMVDILR ALEKLRKLRK EAAARKGVCP PASADETFTH
360 370 380 390 400
HLQRLRKLIK KRSELYEAEE RALRVMLEGE QEEERKRELE KKQRKEKEKI
410 420 430 440 450
LLQKREIESK LFGDPDEFPL AHLLEPFRQY YLQAEHSLPA LIQIRHDWDQ
460 470 480
YLVPSDHPKG NFVPQGWVLP PLPSNDIWAT AVKLH
Length:485
Mass (Da):54,700
Last modified:October 1, 2002 - v1
Checksum:iFF907D6D2187832A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti292 – 2921Q → GE in AAD20241 (PubMed:10037816).Curated
Sequence conflicti303 – 3031S → A in AAD20241 (PubMed:10037816).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096970 mRNA. Translation: BAC04915.1.
AF083930 mRNA. Translation: AAD20241.1.
BC016992 mRNA. Translation: AAH16992.2.
BT007395 mRNA. Translation: AAP36059.1.
CCDSiCCDS10201.1.
RefSeqiNP_005698.1. NM_005707.1.
UniGeneiHs.458596.

Genome annotation databases

EnsembliENST00000204549; ENSP00000204549; ENSG00000090470.
GeneIDi10081.
KEGGihsa:10081.
UCSCiuc002aol.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096970 mRNA. Translation: BAC04915.1.
AF083930 mRNA. Translation: AAD20241.1.
BC016992 mRNA. Translation: AAH16992.2.
BT007395 mRNA. Translation: AAP36059.1.
CCDSiCCDS10201.1.
RefSeqiNP_005698.1. NM_005707.1.
UniGeneiHs.458596.

3D structure databases

ProteinModelPortaliQ8N8D1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115390. 24 interactions.
IntActiQ8N8D1. 9 interactions.
MINTiMINT-1180347.
STRINGi9606.ENSP00000204549.

PTM databases

iPTMnetiQ8N8D1.
PhosphoSiteiQ8N8D1.

Polymorphism and mutation databases

BioMutaiPDCD7.
DMDMi38258174.

Proteomic databases

EPDiQ8N8D1.
MaxQBiQ8N8D1.
PaxDbiQ8N8D1.
PRIDEiQ8N8D1.

Protocols and materials databases

DNASUi10081.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000204549; ENSP00000204549; ENSG00000090470.
GeneIDi10081.
KEGGihsa:10081.
UCSCiuc002aol.3. human.

Organism-specific databases

CTDi10081.
GeneCardsiPDCD7.
HGNCiHGNC:8767. PDCD7.
HPAiHPA049388.
MIMi608138. gene.
neXtProtiNX_Q8N8D1.
PharmGKBiPA33117.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVC0. Eukaryota.
ENOG41124DX. LUCA.
GeneTreeiENSGT00390000017392.
HOGENOMiHOG000115476.
HOVERGENiHBG053537.
InParanoidiQ8N8D1.
OMAiPVPQRTH.
OrthoDBiEOG700890.
PhylomeDBiQ8N8D1.
TreeFamiTF332996.

Enzyme and pathway databases

ReactomeiR-HSA-72165. mRNA Splicing - Minor Pathway.

Miscellaneous databases

ChiTaRSiPDCD7. human.
GeneWikiiPDCD7.
GenomeRNAii10081.
PROiQ8N8D1.
SOURCEiSearch...

Gene expression databases

BgeeiQ8N8D1.
CleanExiHS_PDCD7.
ExpressionAtlasiQ8N8D1. baseline and differential.
GenevisibleiQ8N8D1. HS.

Family and domain databases

InterProiIPR031974. PDCD7.
[Graphical view]
PfamiPF16021. PDCD7. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Small intestine.
  2. "Characterization of a novel mouse cDNA, ES18, involved in apoptotic cell death of T-cells."
    Park E.J., Kim J.H., Seong R.H., Kim C.G., Park S.D., Hong S.H.
    Nucleic Acids Res. 27:1524-1530(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 269-485.
    Tissue: Thymus.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 340-485.
    Tissue: Duodenum.
  4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 376-485.
  5. "The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome."
    Will C.L., Schneider C., Hossbach M., Urlaub H., Rauhut R., Elbashir S., Tuschl T., Luehrmann R.
    RNA 10:929-941(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN A COMPLEX WITH THE U11/U12 SPLICEOSOME, IDENTIFICATION BY MASS SPECTROMETRY.
  6. "The U11/U12 snRNP 65K protein acts as a molecular bridge, binding the U12 snRNA and U11-59K protein."
    Benecke H., Luehrmann R., Will C.L.
    EMBO J. 24:3057-3069(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RBM40.

Entry informationi

Entry nameiPDCD7_HUMAN
AccessioniPrimary (citable) accession number: Q8N8D1
Secondary accession number(s): Q96AK8, Q9Y6D7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: October 1, 2002
Last modified: June 8, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.