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Protein

Programmed cell death protein 7

Gene

PDCD7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes apoptosis when overexpressed.By similarity

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • mRNA splicing, via spliceosome Source: Reactome
  • response to glucocorticoid Source: HGNC
  • RNA splicing Source: HGNC

Keywordsi

Biological processApoptosis

Enzyme and pathway databases

ReactomeiR-HSA-72165 mRNA Splicing - Minor Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Programmed cell death protein 7
Alternative name(s):
ES18
Short name:
hES18
Gene namesi
Name:PDCD7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000090470.14
HGNCiHGNC:8767 PDCD7
MIMi608138 gene
neXtProtiNX_Q8N8D1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi10081
OpenTargetsiENSG00000090470
PharmGKBiPA33117

Polymorphism and mutation databases

BioMutaiPDCD7
DMDMi38258174

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000582691 – 485Programmed cell death protein 7Add BLAST485

Proteomic databases

EPDiQ8N8D1
MaxQBiQ8N8D1
PaxDbiQ8N8D1
PeptideAtlasiQ8N8D1
PRIDEiQ8N8D1
ProteomicsDBi72402

PTM databases

iPTMnetiQ8N8D1
PhosphoSitePlusiQ8N8D1

Expressioni

Gene expression databases

BgeeiENSG00000090470
CleanExiHS_PDCD7
ExpressionAtlasiQ8N8D1 baseline and differential
GenevisibleiQ8N8D1 HS

Organism-specific databases

HPAiHPA049388

Interactioni

Subunit structurei

Interacts with RBM40. Component of the U11/U12 snRNPs that are part of the U12-type spliceosome.2 Publications

Protein-protein interaction databases

BioGridi115390, 29 interactors
CORUMiQ8N8D1
IntActiQ8N8D1, 9 interactors
MINTiQ8N8D1
STRINGi9606.ENSP00000204549

Structurei

3D structure databases

ProteinModelPortaliQ8N8D1
SMRiQ8N8D1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili232 – 335Sequence analysisAdd BLAST104
Coiled coili362 – 411Sequence analysisAdd BLAST50

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi4 – 129Pro-richAdd BLAST126
Compositional biasi236 – 278Arg/Glu-richAdd BLAST43

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410IVC0 Eukaryota
ENOG41124DX LUCA
GeneTreeiENSGT00390000017392
HOGENOMiHOG000115476
HOVERGENiHBG053537
InParanoidiQ8N8D1
OMAiWDSFIRA
OrthoDBiEOG091G0R7S
PhylomeDBiQ8N8D1
TreeFamiTF332996

Family and domain databases

InterProiView protein in InterPro
IPR031974 PDCD7
PfamiView protein in Pfam
PF16021 PDCD7, 1 hit

Sequencei

Sequence statusi: Complete.

Q8N8D1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALPPFFGQG RPGPPPPQPP PPAPFGCPPP PLPSPAFPPP LPQRPGPFPG
60 70 80 90 100
ASAPFLQPPL ALQPRASAEA SRGGGGAGAF YPVPPPPLPP PPPQCRPFPG
110 120 130 140 150
TDAGERPRPP PPGPGPPWSP RWPEAPPPPA DVLGDAALQR LRDRQWLEAV
160 170 180 190 200
FGTPRRAGCP VPQRTHAGPS LGEVRARLLR ALRLVRRLRG LSQALREAEA
210 220 230 240 250
DGAAWVLLYS QTAPLRAELA ERLQPLTQAA YVGEARRRLE RVRRRRLRLR
260 270 280 290 300
ERAREREAER EAEAARAVER EQEIDRWRVK CVQEVEEKKR EQELKAAADG
310 320 330 340 350
VLSEVRKKQA DTKRMVDILR ALEKLRKLRK EAAARKGVCP PASADETFTH
360 370 380 390 400
HLQRLRKLIK KRSELYEAEE RALRVMLEGE QEEERKRELE KKQRKEKEKI
410 420 430 440 450
LLQKREIESK LFGDPDEFPL AHLLEPFRQY YLQAEHSLPA LIQIRHDWDQ
460 470 480
YLVPSDHPKG NFVPQGWVLP PLPSNDIWAT AVKLH
Length:485
Mass (Da):54,700
Last modified:October 1, 2002 - v1
Checksum:iFF907D6D2187832A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti292Q → GE in AAD20241 (PubMed:10037816).Curated1
Sequence conflicti303S → A in AAD20241 (PubMed:10037816).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096970 mRNA Translation: BAC04915.1
AF083930 mRNA Translation: AAD20241.1
BC016992 mRNA Translation: AAH16992.2
BT007395 mRNA Translation: AAP36059.1
CCDSiCCDS10201.1
RefSeqiNP_005698.1, NM_005707.1
UniGeneiHs.458596

Genome annotation databases

EnsembliENST00000204549; ENSP00000204549; ENSG00000090470
GeneIDi10081
KEGGihsa:10081
UCSCiuc002aol.3 human

Similar proteinsi

Entry informationi

Entry nameiPDCD7_HUMAN
AccessioniPrimary (citable) accession number: Q8N8D1
Secondary accession number(s): Q96AK8, Q9Y6D7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: October 1, 2002
Last modified: June 20, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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