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Protein

Zinc finger protein 781

Gene

ZNF781

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri33 – 5523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri61 – 8323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri89 – 11123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri117 – 13317C2H2-type 4; degeneratePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 781
Gene namesi
Name:ZNF781
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:26745. ZNF781.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162410427.

Polymorphism and mutation databases

BioMutaiZNF781.
DMDMi74760005.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 355355Zinc finger protein 781PRO_0000293693Add
BLAST

Proteomic databases

PaxDbiQ8N8C0.
PRIDEiQ8N8C0.

PTM databases

iPTMnetiQ8N8C0.
PhosphoSiteiQ8N8C0.

Expressioni

Gene expression databases

BgeeiQ8N8C0.
ExpressionAtlasiQ8N8C0. baseline and differential.
GenevisibleiQ8N8C0. HS.

Organism-specific databases

HPAiHPA062512.

Interactioni

Protein-protein interaction databases

IntActiQ8N8C0. 1 interaction.
STRINGi9606.ENSP00000351391.

Structurei

3D structure databases

ProteinModelPortaliQ8N8C0.
SMRiQ8N8C0. Positions 3-127.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 4 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri33 – 5523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri61 – 8323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri89 – 11123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri117 – 13317C2H2-type 4; degeneratePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000064407.
HOGENOMiHOG000234617.
InParanoidiQ8N8C0.
OMAiNIREHIL.
PhylomeDBiQ8N8C0.
TreeFamiTF340562.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N8C0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQRNAMYLKN VAETACNFQL TQYQISHANQ KPYECQICGK PFRKRAHLTQ
60 70 80 90 100
HNRIHTGGKP YECKECGKVF ICCSTLIQHK RTHTSEKPYE CLECRKTFRR
110 120 130 140 150
SAHLIRHQRI HTGEKPYKCK QCWKAFASVS DLIDIGKFTL MRDFTNVQNV
160 170 180 190 200
GRHLTIAQLL FSIREFTLVR SPLNVRNVAK HSIIAQHLLN TRELILMRNL
210 220 230 240 250
MNVRNVKRLL GKVHILLNIK EFILVRNHMS VSNVGRLSLV FLILIDIREF
260 270 280 290 300
TLVKNPMNVK NVVELLTIVQ LLFNTREFTL VRRLMNISSV GRFLSPVQHL
310 320 330 340 350
FNIREHILMK NLMNVSNARR PSSIMHILFD IKEFILVRNL INVSNVGRPL

LLFLI
Length:355
Mass (Da):41,526
Last modified:October 1, 2002 - v1
Checksum:i728D243A9F9F0DB1
GO
Isoform 2 (identifier: Q8N8C0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     328-355: Missing.

Note: No experimental confirmation available.
Show »
Length:327
Mass (Da):38,274
Checksum:i1AE1E09B3F00D043
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei328 – 35528Missing in isoform 2. 1 PublicationVSP_026560Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097019 mRNA. Translation: BAC04927.1.
BC108687 mRNA. Translation: AAI08688.1.
CCDSiCCDS12507.1. [Q8N8C0-2]
RefSeqiNP_689818.2. NM_152605.3. [Q8N8C0-2]
XP_006723129.1. XM_006723066.2. [Q8N8C0-2]
XP_011524893.1. XM_011526591.1. [Q8N8C0-2]
UniGeneiHs.722657.

Genome annotation databases

EnsembliENST00000358582; ENSP00000351391; ENSG00000196381. [Q8N8C0-2]
ENST00000590008; ENSP00000466370; ENSG00000196381. [Q8N8C0-2]
GeneIDi163115.
KEGGihsa:163115.
UCSCiuc002ogy.3. human. [Q8N8C0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097019 mRNA. Translation: BAC04927.1.
BC108687 mRNA. Translation: AAI08688.1.
CCDSiCCDS12507.1. [Q8N8C0-2]
RefSeqiNP_689818.2. NM_152605.3. [Q8N8C0-2]
XP_006723129.1. XM_006723066.2. [Q8N8C0-2]
XP_011524893.1. XM_011526591.1. [Q8N8C0-2]
UniGeneiHs.722657.

3D structure databases

ProteinModelPortaliQ8N8C0.
SMRiQ8N8C0. Positions 3-127.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8N8C0. 1 interaction.
STRINGi9606.ENSP00000351391.

PTM databases

iPTMnetiQ8N8C0.
PhosphoSiteiQ8N8C0.

Polymorphism and mutation databases

BioMutaiZNF781.
DMDMi74760005.

Proteomic databases

PaxDbiQ8N8C0.
PRIDEiQ8N8C0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358582; ENSP00000351391; ENSG00000196381. [Q8N8C0-2]
ENST00000590008; ENSP00000466370; ENSG00000196381. [Q8N8C0-2]
GeneIDi163115.
KEGGihsa:163115.
UCSCiuc002ogy.3. human. [Q8N8C0-1]

Organism-specific databases

CTDi163115.
GeneCardsiZNF781.
HGNCiHGNC:26745. ZNF781.
HPAiHPA062512.
neXtProtiNX_Q8N8C0.
PharmGKBiPA162410427.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000064407.
HOGENOMiHOG000234617.
InParanoidiQ8N8C0.
OMAiNIREHIL.
PhylomeDBiQ8N8C0.
TreeFamiTF340562.

Miscellaneous databases

GenomeRNAii163115.
NextBioi88305.
PROiQ8N8C0.

Gene expression databases

BgeeiQ8N8C0.
ExpressionAtlasiQ8N8C0. baseline and differential.
GenevisibleiQ8N8C0. HS.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Small intestine.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Skin.

Entry informationi

Entry nameiZN781_HUMAN
AccessioniPrimary (citable) accession number: Q8N8C0
Secondary accession number(s): Q2VPJ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: October 1, 2002
Last modified: March 16, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.