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Protein

ATP-dependent RNA helicase DDX51

Gene

DDX51

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits.By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi256 – 263ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHelicase, Hydrolase, RNA-binding
Biological processRibosome biogenesis, rRNA processing
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent RNA helicase DDX51 (EC:3.6.4.13)
Alternative name(s):
DEAD box protein 51
Gene namesi
Name:DDX51
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000185163.9
HGNCiHGNC:20082 DDX51
neXtProtiNX_Q8N8A6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi317781
OpenTargetsiENSG00000185163
PharmGKBiPA134974036

Polymorphism and mutation databases

BioMutaiDDX51
DMDMi229462978

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002280962 – 666ATP-dependent RNA helicase DDX51Add BLAST665

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei83PhosphoserineCombined sources1
Modified residuei103PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8N8A6
MaxQBiQ8N8A6
PaxDbiQ8N8A6
PeptideAtlasiQ8N8A6
PRIDEiQ8N8A6

PTM databases

iPTMnetiQ8N8A6
PhosphoSitePlusiQ8N8A6

Expressioni

Gene expression databases

BgeeiENSG00000185163
CleanExiHS_DDX51
GenevisibleiQ8N8A6 HS

Organism-specific databases

HPAiHPA039503

Interactioni

Protein-protein interaction databases

BioGridi130475, 33 interactors
IntActiQ8N8A6, 11 interactors
STRINGi9606.ENSP00000380495

Structurei

3D structure databases

ProteinModelPortaliQ8N8A6
SMRiQ8N8A6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini243 – 452Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST210
Domaini494 – 640Helicase C-terminalPROSITE-ProRule annotationAdd BLAST147

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi221 – 229Q motif9
Motifi371 – 374DEAD box4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi30 – 75Arg-richAdd BLAST46

Domaini

The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0350 Eukaryota
ENOG410XRWM LUCA
GeneTreeiENSGT00550000075141
HOGENOMiHOG000239572
HOVERGENiHBG081427
InParanoidiQ8N8A6
KOiK14807
OMAiCHIRALV
OrthoDBiEOG091G05VT
PhylomeDBiQ8N8A6
TreeFamiTF314505

Family and domain databases

CDDicd00079 HELICc, 1 hit
InterProiView protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR000629 RNA-helicase_DEAD-box_CS
PfamiView protein in Pfam
PF00270 DEAD, 1 hit
PF00271 Helicase_C, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00039 DEAD_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8N8A6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALFYVARYP GPDAAAAAGP EGAEAGAHGR ARALLERLQS RARERQQQRE
60 70 80 90 100
PAQTEAAAST EPATRRRRRP RRRRRVNDAE PGSPEAPQGK RRKADGEDAG
110 120 130 140 150
AESNEEAPGE PSAGSSEEAP GEPSAGSSEE APGERSTSAS AEAAPDGPAL
160 170 180 190 200
EEAAGPLVPG LVLGGFGKRK APKVQPFLPR WLAEPNCVRR NVTEDLVPIE
210 220 230 240 250
DIPDVHPDLQ KQLRAHGISS YFPVQAAVIP ALLESAACGF LVGRGGYRPS
260 270 280 290 300
DLCVSAPTGS GKTLAFVIPV VQALLSRVVC HIRALVVLPT KELAQQVSKV
310 320 330 340 350
FNIYTDATPL RVSLVTGQKS LAKEQESLVQ KTADGYRCLA DIVVATPGRL
360 370 380 390 400
VDHIDQTPGF SLQQLRFLII DEADRMIDSM HQSWLPRVVA AAFQSEDPAD
410 420 430 440 450
PCALLQRRQA QAVTAASTCC PQMPLQKLLF SATLTQNPEK LQQLGLHQPR
460 470 480 490 500
LFSTGLAHRG LEDTDGDGDS GKYAFPVGLT HHYVPCSLSS KPLVVLHLVL
510 520 530 540 550
EMGFSRVLCF TNSRENSHRL FLLVQAFGGV DVAEFSSRYG PGQRRMILKQ
560 570 580 590 600
FEQGKIQLLI STDATARGID VQGVELVVNY DAPQYLRTYV HRVGRTARAG
610 620 630 640 650
KTGQAFTLLL KVQERRFLRM LTEAGAPELQ RHELSSKLLQ PLVPRYEEAL
660
SQLEESVKEE RKQRAA
Length:666
Mass (Da):72,457
Last modified:May 5, 2009 - v3
Checksum:iB1A8D275918B194C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti120 – 122PGE → QGG in AAH40185 (PubMed:15489334).Curated3
Sequence conflicti592R → RR in CAI59782 (PubMed:17974005).Curated1
Sequence conflicti617F → L in CAI59782 (PubMed:17974005).Curated1
Sequence conflicti654E → G in CAI59782 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05529941R → Q1 PublicationCorresponds to variant dbSNP:rs17857214Ensembl.1
Natural variantiVAR_055300134E → V1 PublicationCorresponds to variant dbSNP:rs17855642Ensembl.1
Natural variantiVAR_055301175Q → K1 PublicationCorresponds to variant dbSNP:rs17855639Ensembl.1
Natural variantiVAR_055302249P → L1 PublicationCorresponds to variant dbSNP:rs17857213Ensembl.1
Natural variantiVAR_055303295Q → R1 PublicationCorresponds to variant dbSNP:rs1133690Ensembl.1
Natural variantiVAR_061825322A → V1 PublicationCorresponds to variant dbSNP:rs60927391Ensembl.1
Natural variantiVAR_055304406Q → K1 PublicationCorresponds to variant dbSNP:rs17853968Ensembl.1
Natural variantiVAR_055305652Q → K1 PublicationCorresponds to variant dbSNP:rs17853969Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097078 mRNA Translation: BAC04942.1
AC138466 Genomic DNA No translation available.
BC012461 mRNA Translation: AAH12461.2
BC040185 mRNA Translation: AAH40185.1
CR936870 Transcribed RNA Translation: CAI59782.1
CCDSiCCDS41865.1
RefSeqiNP_778236.2, NM_175066.3
UniGeneiHs.445168

Genome annotation databases

EnsembliENST00000397333; ENSP00000380495; ENSG00000185163
GeneIDi317781
KEGGihsa:317781
UCSCiuc001ujy.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiDDX51_HUMAN
AccessioniPrimary (citable) accession number: Q8N8A6
Secondary accession number(s): A8MPT9
, Q5CZ71, Q8IXK5, Q96ED1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: May 5, 2009
Last modified: May 23, 2018
This is version 136 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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