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Protein

Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B

Gene

ANKRD44

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B
Short name:
PP6-ARS-B
Short name:
Serine/threonine-protein phosphatase 6 regulatory subunit ARS-B
Alternative name(s):
Ankyrin repeat domain-containing protein 44
Gene namesi
Name:ANKRD44
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:25259. ANKRD44.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672611.

Polymorphism and mutation databases

BioMutaiANKRD44.
DMDMi218512105.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 993993Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit BPRO_0000244572Add
BLAST

Proteomic databases

EPDiQ8N8A2.
MaxQBiQ8N8A2.
PRIDEiQ8N8A2.

PTM databases

iPTMnetiQ8N8A2.
PhosphoSiteiQ8N8A2.

Expressioni

Gene expression databases

BgeeiQ8N8A2.
CleanExiHS_ANKRD44.
ExpressionAtlasiQ8N8A2. baseline and differential.
GenevisibleiQ8N8A2. HS.

Organism-specific databases

HPAiHPA030122.
HPA056549.

Interactioni

Subunit structurei

Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS). Interacts with PPP6R1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PPP6R1Q9UPN74EBI-1245329,EBI-359745
USP6P35125-34EBI-1245329,EBI-954590
WWP2O003083EBI-1245329,EBI-743923

Protein-protein interaction databases

BioGridi124841. 24 interactions.
IntActiQ8N8A2. 12 interactions.
MINTiMINT-6940869.

Structurei

3D structure databases

ProteinModelPortaliQ8N8A2.
SMRiQ8N8A2. Positions 3-975.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati7 – 3630ANK 1Add
BLAST
Repeati40 – 6930ANK 2Add
BLAST
Repeati73 – 10230ANK 3Add
BLAST
Repeati106 – 13530ANK 4Add
BLAST
Repeati139 – 16830ANK 5Add
BLAST
Repeati172 – 20130ANK 6Add
BLAST
Repeati205 – 23430ANK 7Add
BLAST
Repeati238 – 26730ANK 8Add
BLAST
Repeati271 – 30131ANK 9Add
BLAST
Repeati305 – 33430ANK 10Add
BLAST
Repeati338 – 36730ANK 11Add
BLAST
Repeati371 – 40030ANK 12Add
BLAST
Repeati404 – 43330ANK 13Add
BLAST
Repeati437 – 46630ANK 14Add
BLAST
Repeati470 – 49829ANK 15Add
BLAST
Repeati531 – 56131ANK 16Add
BLAST
Repeati566 – 59530ANK 17Add
BLAST
Repeati599 – 62830ANK 18Add
BLAST
Repeati633 – 66230ANK 19Add
BLAST
Repeati669 – 69830ANK 20Add
BLAST
Repeati702 – 73130ANK 21Add
BLAST
Repeati735 – 76430ANK 22Add
BLAST
Repeati771 – 80030ANK 23Add
BLAST
Repeati803 – 83230ANK 24Add
BLAST
Repeati838 – 86730ANK 25Add
BLAST
Repeati871 – 90131ANK 26Add
BLAST
Repeati905 – 93430ANK 27Add
BLAST
Repeati941 – 97030ANK 28Add
BLAST

Sequence similaritiesi

Contains 28 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

GeneTreeiENSGT00840000129677.
HOGENOMiHOG000033959.
HOVERGENiHBG067697.
InParanoidiQ8N8A2.
KOiK15503.
OMAiSSGQKYS.
PhylomeDBiQ8N8A2.
TreeFamiTF329520.

Family and domain databases

Gene3Di1.25.40.20. 4 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 10 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 28 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 4 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 23 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N8A2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAVLKLTDQP PLVQAIFSGD PEEIRMLIHK TEDVNTLDSE KRTPLHVAAF
60 70 80 90 100
LGDAEIIELL ILSGARVNAK DNMWLTPLHR AVASRSEEAV QVLIKHSADV
110 120 130 140 150
NARDKNWQTP LHVAAANKAV KCAEVIIPLL SSVNVSDRGG RTALHHAALN
160 170 180 190 200
GHVEMVNLLL AKGANINAFD KKDRRALHWA AYMGHLDVVA LLINHGAEVT
210 220 230 240 250
CKDKKGYTPL HAAASNGQIN VVKHLLNLGV EIDEINVYGN TALHIACYNG
260 270 280 290 300
QDAVVNELID YGANVNQPNN NGFTPLHFAA ASTHGALCLE LLVNNGADVN
310 320 330 340 350
IQSKDGKSPL HMTAVHGRFT RSQTLIQNGG EIDCVDKDGN TPLHVAARYG
360 370 380 390 400
HELLINTLIT SGADTAKCGI HSMFPLHLAA LNAHSDCCRK LLSSGFEIDT
410 420 430 440 450
PDKFGRTCLH AAAAGGNVEC IKLLQSSGAD FHKKDKCGRT PLHYAAANCH
460 470 480 490 500
FHCIETLVTT GANVNETDDW GRTALHYAAA SDMDRNKTIL GNAHDNSEEL
510 520 530 540 550
ERARELKEKE ATLCLEFLLQ NDANPSIRDK EGYNSIHYAA AYGHRQCLEL
560 570 580 590 600
LLERTNSGFE ESDSGATKSP LHLAAYNGHH QALEVLLQSL VDLDIRDEKG
610 620 630 640 650
RTALDLAAFK GHTECVEALI NQGASIFVKD NVTKRTPLHA SVINGHTLCL
660 670 680 690 700
RLLLEIADNP EAVDVKDAKG QTPLMLAVAY GHIDAVSLLL EKEANVDTVD
710 720 730 740 750
ILGCTALHRG IMTGHEECVQ MLLEQEVSIL CKDSRGRTPL HYAAARGHAT
760 770 780 790 800
WLSELLQMAL SEEDCCFKDN QGYTPLHWAC YNGNENCIEV LLEQKCFRKF
810 820 830 840 850
IGNPFTPLHC AIINDHGNCA SLLLGAIDSS IVSCRDDKGR TPLHAAAFAD
860 870 880 890 900
HVECLQLLLR HSAPVNAVDN SGKTALMMAA ENGQAGAVDI LVNSAQADLT
910 920 930 940 950
VKDKDLNTPL HLACSKGHEK CALLILDKIQ DESLINEKNN ALQTPLHVAA
960 970 980 990
RNGLKVVVEE LLAKGACVLA VDENASRSNG PRSTPGTAVQ KEE
Length:993
Mass (Da):107,603
Last modified:December 16, 2008 - v3
Checksum:i3502EBBD0D093566
GO
Isoform 2 (identifier: Q8N8A2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     395-395: G → GQKYSIVSLFSNEHVLSAG
     975-993: ASRSNGPRSTPGTAVQKEE → GC

Note: No experimental confirmation available.
Show »
Length:994
Mass (Da):107,770
Checksum:i8096CE732F8643C3
GO
Isoform 3 (identifier: Q8N8A2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     551-579: LLERTNSGFEESDSGATKSPLHLAAYNGH → VSCFVLFSLTHTHTHTPNHRGINCFFPEL
     580-993: Missing.

Note: No experimental confirmation available.
Show »
Length:579
Mass (Da):63,092
Checksum:i84AAE41B54E12A5B
GO
Isoform 4 (identifier: Q8N8A2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: Missing.
     945-993: Missing.

Note: No experimental confirmation available.
Show »
Length:919
Mass (Da):99,788
Checksum:i84329430141AE9B8
GO
Isoform 5 (identifier: Q8N8A2-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     368-993: Missing.

Show »
Length:367
Mass (Da):39,601
Checksum:i1618211DB6AC424D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti205 – 2051K → R in CAB61404 (PubMed:17974005).Curated
Sequence conflicti359 – 3591I → R in BAC04946 (PubMed:14702039).Curated
Sequence conflicti622 – 6221Q → P in BAC04946 (PubMed:14702039).Curated
Sequence conflicti844 – 8441H → R in BAC04946 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2525Missing in isoform 4. 1 PublicationVSP_019600Add
BLAST
Alternative sequencei368 – 993626Missing in isoform 5. 1 PublicationVSP_035966Add
BLAST
Alternative sequencei395 – 3951G → GQKYSIVSLFSNEHVLSAG in isoform 2. 1 PublicationVSP_019601
Alternative sequencei551 – 57929LLERT…AYNGH → VSCFVLFSLTHTHTHTPNHR GINCFFPEL in isoform 3. 1 PublicationVSP_019602Add
BLAST
Alternative sequencei580 – 993414Missing in isoform 3. 1 PublicationVSP_019603Add
BLAST
Alternative sequencei945 – 99349Missing in isoform 4. 1 PublicationVSP_035965Add
BLAST
Alternative sequencei975 – 99319ASRSN…VQKEE → GC in isoform 2. 1 PublicationVSP_019604Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097086 mRNA. Translation: BAC04946.1.
AC010746 Genomic DNA. No translation available.
AC013264 Genomic DNA. No translation available.
AC017035 Genomic DNA. Translation: AAY15060.1.
AW629326 mRNA. No translation available.
BC016985 mRNA. Translation: AAH16985.2.
BC050586 mRNA. Translation: AAH50586.2.
BC063622 mRNA. Translation: AAH63622.1.
AL133087 mRNA. Translation: CAB61404.1.
CCDSiCCDS33355.2. [Q8N8A2-5]
CCDS74619.1. [Q8N8A2-1]
PIRiT42691.
RefSeqiNP_001182073.1. NM_001195144.1. [Q8N8A2-1]
NP_710181.2. NM_153697.2. [Q8N8A2-5]
XP_005247005.1. XM_005246948.2. [Q8N8A2-2]
UniGeneiHs.432706.

Genome annotation databases

EnsembliENST00000282272; ENSP00000282272; ENSG00000065413. [Q8N8A2-1]
ENST00000328737; ENSP00000331516; ENSG00000065413. [Q8N8A2-4]
ENST00000409153; ENSP00000387141; ENSG00000065413. [Q8N8A2-3]
ENST00000409919; ENSP00000387233; ENSG00000065413. [Q8N8A2-5]
GeneIDi91526.
KEGGihsa:91526.
UCSCiuc002uub.5. human. [Q8N8A2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097086 mRNA. Translation: BAC04946.1.
AC010746 Genomic DNA. No translation available.
AC013264 Genomic DNA. No translation available.
AC017035 Genomic DNA. Translation: AAY15060.1.
AW629326 mRNA. No translation available.
BC016985 mRNA. Translation: AAH16985.2.
BC050586 mRNA. Translation: AAH50586.2.
BC063622 mRNA. Translation: AAH63622.1.
AL133087 mRNA. Translation: CAB61404.1.
CCDSiCCDS33355.2. [Q8N8A2-5]
CCDS74619.1. [Q8N8A2-1]
PIRiT42691.
RefSeqiNP_001182073.1. NM_001195144.1. [Q8N8A2-1]
NP_710181.2. NM_153697.2. [Q8N8A2-5]
XP_005247005.1. XM_005246948.2. [Q8N8A2-2]
UniGeneiHs.432706.

3D structure databases

ProteinModelPortaliQ8N8A2.
SMRiQ8N8A2. Positions 3-975.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124841. 24 interactions.
IntActiQ8N8A2. 12 interactions.
MINTiMINT-6940869.

PTM databases

iPTMnetiQ8N8A2.
PhosphoSiteiQ8N8A2.

Polymorphism and mutation databases

BioMutaiANKRD44.
DMDMi218512105.

Proteomic databases

EPDiQ8N8A2.
MaxQBiQ8N8A2.
PRIDEiQ8N8A2.

Protocols and materials databases

DNASUi91526.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000282272; ENSP00000282272; ENSG00000065413. [Q8N8A2-1]
ENST00000328737; ENSP00000331516; ENSG00000065413. [Q8N8A2-4]
ENST00000409153; ENSP00000387141; ENSG00000065413. [Q8N8A2-3]
ENST00000409919; ENSP00000387233; ENSG00000065413. [Q8N8A2-5]
GeneIDi91526.
KEGGihsa:91526.
UCSCiuc002uub.5. human. [Q8N8A2-1]

Organism-specific databases

CTDi91526.
GeneCardsiANKRD44.
HGNCiHGNC:25259. ANKRD44.
HPAiHPA030122.
HPA056549.
neXtProtiNX_Q8N8A2.
PharmGKBiPA142672611.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00840000129677.
HOGENOMiHOG000033959.
HOVERGENiHBG067697.
InParanoidiQ8N8A2.
KOiK15503.
OMAiSSGQKYS.
PhylomeDBiQ8N8A2.
TreeFamiTF329520.

Miscellaneous databases

ChiTaRSiANKRD44. human.
GenomeRNAii91526.
NextBioi77280.
PROiQ8N8A2.

Gene expression databases

BgeeiQ8N8A2.
CleanExiHS_ANKRD44.
ExpressionAtlasiQ8N8A2. baseline and differential.
GenevisibleiQ8N8A2. HS.

Family and domain databases

Gene3Di1.25.40.20. 4 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 10 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 28 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 4 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 23 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Spleen.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 5), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 812-989 (ISOFORM 1).
    Tissue: Duodenum and Skin.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 204-993 (ISOFORM 2).
    Tissue: Testis.
  5. "Protein phosphatase 6 regulatory subunits composed of ankyrin repeat domains."
    Stefansson B., Ohama T., Daugherty A.E., Brautigan D.L.
    Biochemistry 47:1442-1451(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PPP6R1.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiANR44_HUMAN
AccessioniPrimary (citable) accession number: Q8N8A2
Secondary accession number(s): Q53SL9
, Q6P480, Q86VL5, Q8IZ72, Q9UFA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: December 16, 2008
Last modified: May 11, 2016
This is version 120 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.