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Protein

Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B

Gene

ANKRD44

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B
Short name:
PP6-ARS-B
Short name:
Serine/threonine-protein phosphatase 6 regulatory subunit ARS-B
Alternative name(s):
Ankyrin repeat domain-containing protein 44
Gene namesi
Name:ANKRD44
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000065413.16
HGNCiHGNC:25259 ANKRD44
neXtProtiNX_Q8N8A2

Pathology & Biotechi

Organism-specific databases

DisGeNETi91526
OpenTargetsiENSG00000065413
PharmGKBiPA142672611

Polymorphism and mutation databases

BioMutaiANKRD44
DMDMi218512105

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002445721 – 993Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit BAdd BLAST993

Proteomic databases

EPDiQ8N8A2
MaxQBiQ8N8A2
PaxDbiQ8N8A2
PeptideAtlasiQ8N8A2
PRIDEiQ8N8A2

PTM databases

iPTMnetiQ8N8A2
PhosphoSitePlusiQ8N8A2

Expressioni

Gene expression databases

BgeeiENSG00000065413
CleanExiHS_ANKRD44
ExpressionAtlasiQ8N8A2 baseline and differential
GenevisibleiQ8N8A2 HS

Organism-specific databases

HPAiHPA030122
HPA056549

Interactioni

Subunit structurei

Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS). Interacts with PPP6R1.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi124841, 25 interactors
IntActiQ8N8A2, 14 interactors
MINTiQ8N8A2
STRINGi9606.ENSP00000387233

Structurei

3D structure databases

ProteinModelPortaliQ8N8A2
SMRiQ8N8A2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati7 – 36ANK 1Add BLAST30
Repeati40 – 69ANK 2Add BLAST30
Repeati73 – 102ANK 3Add BLAST30
Repeati106 – 135ANK 4Add BLAST30
Repeati139 – 168ANK 5Add BLAST30
Repeati172 – 201ANK 6Add BLAST30
Repeati205 – 234ANK 7Add BLAST30
Repeati238 – 267ANK 8Add BLAST30
Repeati271 – 301ANK 9Add BLAST31
Repeati305 – 334ANK 10Add BLAST30
Repeati338 – 367ANK 11Add BLAST30
Repeati371 – 400ANK 12Add BLAST30
Repeati404 – 433ANK 13Add BLAST30
Repeati437 – 466ANK 14Add BLAST30
Repeati470 – 498ANK 15Add BLAST29
Repeati531 – 561ANK 16Add BLAST31
Repeati566 – 595ANK 17Add BLAST30
Repeati599 – 628ANK 18Add BLAST30
Repeati633 – 662ANK 19Add BLAST30
Repeati669 – 698ANK 20Add BLAST30
Repeati702 – 731ANK 21Add BLAST30
Repeati735 – 764ANK 22Add BLAST30
Repeati771 – 800ANK 23Add BLAST30
Repeati803 – 832ANK 24Add BLAST30
Repeati838 – 867ANK 25Add BLAST30
Repeati871 – 901ANK 26Add BLAST31
Repeati905 – 934ANK 27Add BLAST30
Repeati941 – 970ANK 28Add BLAST30

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

GeneTreeiENSGT00840000129677
HOGENOMiHOG000033959
HOVERGENiHBG067697
InParanoidiQ8N8A2
KOiK15503
OMAiKCGIHSM
OrthoDBiEOG091G02S4
PhylomeDBiQ8N8A2
TreeFamiTF329520

Family and domain databases

CDDicd00204 ANK, 7 hits
Gene3Di1.25.40.20, 9 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF00023 Ank, 1 hit
PF12796 Ank_2, 10 hits
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 28 hits
SUPFAMiSSF48403 SSF48403, 4 hits
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 23 hits

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N8A2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAVLKLTDQP PLVQAIFSGD PEEIRMLIHK TEDVNTLDSE KRTPLHVAAF
60 70 80 90 100
LGDAEIIELL ILSGARVNAK DNMWLTPLHR AVASRSEEAV QVLIKHSADV
110 120 130 140 150
NARDKNWQTP LHVAAANKAV KCAEVIIPLL SSVNVSDRGG RTALHHAALN
160 170 180 190 200
GHVEMVNLLL AKGANINAFD KKDRRALHWA AYMGHLDVVA LLINHGAEVT
210 220 230 240 250
CKDKKGYTPL HAAASNGQIN VVKHLLNLGV EIDEINVYGN TALHIACYNG
260 270 280 290 300
QDAVVNELID YGANVNQPNN NGFTPLHFAA ASTHGALCLE LLVNNGADVN
310 320 330 340 350
IQSKDGKSPL HMTAVHGRFT RSQTLIQNGG EIDCVDKDGN TPLHVAARYG
360 370 380 390 400
HELLINTLIT SGADTAKCGI HSMFPLHLAA LNAHSDCCRK LLSSGFEIDT
410 420 430 440 450
PDKFGRTCLH AAAAGGNVEC IKLLQSSGAD FHKKDKCGRT PLHYAAANCH
460 470 480 490 500
FHCIETLVTT GANVNETDDW GRTALHYAAA SDMDRNKTIL GNAHDNSEEL
510 520 530 540 550
ERARELKEKE ATLCLEFLLQ NDANPSIRDK EGYNSIHYAA AYGHRQCLEL
560 570 580 590 600
LLERTNSGFE ESDSGATKSP LHLAAYNGHH QALEVLLQSL VDLDIRDEKG
610 620 630 640 650
RTALDLAAFK GHTECVEALI NQGASIFVKD NVTKRTPLHA SVINGHTLCL
660 670 680 690 700
RLLLEIADNP EAVDVKDAKG QTPLMLAVAY GHIDAVSLLL EKEANVDTVD
710 720 730 740 750
ILGCTALHRG IMTGHEECVQ MLLEQEVSIL CKDSRGRTPL HYAAARGHAT
760 770 780 790 800
WLSELLQMAL SEEDCCFKDN QGYTPLHWAC YNGNENCIEV LLEQKCFRKF
810 820 830 840 850
IGNPFTPLHC AIINDHGNCA SLLLGAIDSS IVSCRDDKGR TPLHAAAFAD
860 870 880 890 900
HVECLQLLLR HSAPVNAVDN SGKTALMMAA ENGQAGAVDI LVNSAQADLT
910 920 930 940 950
VKDKDLNTPL HLACSKGHEK CALLILDKIQ DESLINEKNN ALQTPLHVAA
960 970 980 990
RNGLKVVVEE LLAKGACVLA VDENASRSNG PRSTPGTAVQ KEE
Length:993
Mass (Da):107,603
Last modified:December 16, 2008 - v3
Checksum:i3502EBBD0D093566
GO
Isoform 2 (identifier: Q8N8A2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     395-395: G → GQKYSIVSLFSNEHVLSAG
     975-993: ASRSNGPRSTPGTAVQKEE → GC

Note: No experimental confirmation available.
Show »
Length:994
Mass (Da):107,770
Checksum:i8096CE732F8643C3
GO
Isoform 3 (identifier: Q8N8A2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     551-579: LLERTNSGFEESDSGATKSPLHLAAYNGH → VSCFVLFSLTHTHTHTPNHRGINCFFPEL
     580-993: Missing.

Note: No experimental confirmation available.
Show »
Length:579
Mass (Da):63,092
Checksum:i84AAE41B54E12A5B
GO
Isoform 4 (identifier: Q8N8A2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: Missing.
     945-993: Missing.

Note: No experimental confirmation available.
Show »
Length:919
Mass (Da):99,788
Checksum:i84329430141AE9B8
GO
Isoform 5 (identifier: Q8N8A2-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     368-993: Missing.

Show »
Length:367
Mass (Da):39,601
Checksum:i1618211DB6AC424D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti205K → R in CAB61404 (PubMed:17974005).Curated1
Sequence conflicti359I → R in BAC04946 (PubMed:14702039).Curated1
Sequence conflicti622Q → P in BAC04946 (PubMed:14702039).Curated1
Sequence conflicti844H → R in BAC04946 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0196001 – 25Missing in isoform 4. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_035966368 – 993Missing in isoform 5. 1 PublicationAdd BLAST626
Alternative sequenceiVSP_019601395G → GQKYSIVSLFSNEHVLSAG in isoform 2. 1 Publication1
Alternative sequenceiVSP_019602551 – 579LLERT…AYNGH → VSCFVLFSLTHTHTHTPNHR GINCFFPEL in isoform 3. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_019603580 – 993Missing in isoform 3. 1 PublicationAdd BLAST414
Alternative sequenceiVSP_035965945 – 993Missing in isoform 4. 1 PublicationAdd BLAST49
Alternative sequenceiVSP_019604975 – 993ASRSN…VQKEE → GC in isoform 2. 1 PublicationAdd BLAST19

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097086 mRNA Translation: BAC04946.1
AC010746 Genomic DNA No translation available.
AC013264 Genomic DNA No translation available.
AC017035 Genomic DNA Translation: AAY15060.1
AW629326 mRNA No translation available.
BC016985 mRNA Translation: AAH16985.2
BC050586 mRNA Translation: AAH50586.2
BC063622 mRNA Translation: AAH63622.1
AL133087 mRNA Translation: CAB61404.1
CCDSiCCDS33355.2 [Q8N8A2-5]
CCDS74619.1 [Q8N8A2-1]
PIRiT42691
RefSeqiNP_001182073.1, NM_001195144.1 [Q8N8A2-1]
NP_710181.2, NM_153697.2 [Q8N8A2-5]
XP_005247005.1, XM_005246948.2 [Q8N8A2-2]
UniGeneiHs.432706

Genome annotation databases

EnsembliENST00000282272; ENSP00000282272; ENSG00000065413 [Q8N8A2-1]
ENST00000328737; ENSP00000331516; ENSG00000065413 [Q8N8A2-4]
ENST00000409153; ENSP00000387141; ENSG00000065413 [Q8N8A2-3]
ENST00000409919; ENSP00000387233; ENSG00000065413 [Q8N8A2-5]
GeneIDi91526
KEGGihsa:91526
UCSCiuc002uub.5 human [Q8N8A2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiANR44_HUMAN
AccessioniPrimary (citable) accession number: Q8N8A2
Secondary accession number(s): Q53SL9
, Q6P480, Q86VL5, Q8IZ72, Q9UFA4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: December 16, 2008
Last modified: April 25, 2018
This is version 137 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM

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