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Q8N895 (ZN366_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 366
Gene names
Name:ZNF366
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length744 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Has transcriptional repression activity. Acts as corepressor of ESR1; the function seems to involve CTBP1 and histone deacetylases. Ref.6

Subunit structure

Interacts with ESR1, NRIP1 and CTBP1. Ref.6

Subcellular location

Nucleus Ref.6.

Sequence similarities

Contains 11 C2H2-type zinc fingers.

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 744744Zinc finger protein 366
PRO_0000047548

Regions

Zinc finger253 – 27523C2H2-type 1
Zinc finger281 – 30323C2H2-type 2
Zinc finger309 – 33123C2H2-type 3
Zinc finger337 – 35923C2H2-type 4
Zinc finger365 – 38723C2H2-type 5
Zinc finger393 – 41523C2H2-type 6
Zinc finger421 – 44323C2H2-type 7
Zinc finger449 – 47123C2H2-type 8
Zinc finger477 – 49923C2H2-type 9
Zinc finger505 – 52723C2H2-type 10
Zinc finger533 – 55624C2H2-type 11
Region455 – 744290Interaction with NRIP1
Region558 – 744187Interaction with CTBP1

Natural variations

Natural variant7391A → G.
Corresponds to variant rs13188519 [ dbSNP | Ensembl ].
VAR_033564

Experimental info

Mutagenesis5901P → A: Abolishes interaction with CTBP1 and in part relieves transcription repression; when associated with A-592. Ref.6
Mutagenesis5921D → A: Abolishes interaction with CTBP1 and in part relieves transcription repression; when associated with A-590. Ref.6
Mutagenesis6451P → A: Decreases interaction with CTBP1; when associated with A-647. Ref.6
Mutagenesis6471D → A: Decreases interaction with CTBP1; when associated with A-645. Ref.6

Sequences

Sequence LengthMass (Da)Tools
Q8N895 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: D4E12259280727B1

FASTA74485,107
        10         20         30         40         50         60 
MQKEMKMIKD EDVHFDLAVK KTPSFPHCLQ PVASRGKAPQ RHPFPEALRG PFSQFRYEPP 

        70         80         90        100        110        120 
PGDLDGFPGV FEGAGSRKRK SMPTKMPYNH PAEEVTLALH SEENKNHGLP NLPLLFPQPP 

       130        140        150        160        170        180 
RPKYDSQMID LCNVGFQFYR SLEHFGGKPV KQEPIKPSAV WPQPTPTPFL PTPYPYYPKV 

       190        200        210        220        230        240 
HPGLMFPFFV PSSSPFPFSR HTFLPKQPPE PLLPRKAEPQ ESEETKQKVE RVDVNVQIDD 

       250        260        270        280        290        300 
SYYVDVGGSQ KRWQCPTCEK SYTSKYNLVT HILGHSGIKP HACTHCGKLF KQLSHLHTHM 

       310        320        330        340        350        360 
LTHQGTRPHK CQVCHKAFTQ TSHLKRHMMQ HSEVKPHNCR VCGRGFAYPS ELKAHEAKHA 

       370        380        390        400        410        420 
SGRENICVEC GLDFPTLAQL KRHLTTHRGP IQYNCSECDK TFQYPSQLQN HMMKHKDIRP 

       430        440        450        460        470        480 
YICSECGMEF VQPHHLKQHS LTHKGVKEHK CGICGREFTL LANMKRHVLI HTNIRAYQCH 

       490        500        510        520        530        540 
LCYKSFVQKQ TLKAHMIVHS DVKPFKCKLC GKEFNRMHNL MGHMHLHSDS KPFKCLYCPS 

       550        560        570        580        590        600 
KFTLKGNLTR HMKVKHGVME RGLHSQGLGR GRIALAQTAG VLRSLEQEEP FDLSQKRRAK 

       610        620        630        640        650        660 
VPVFQSDGES AQGSHCHEEE EEDNCYEVEP YSPGLAPQSQ QLCTPEDLST KSEHAPEVLE 

       670        680        690        700        710        720 
EACKEEKEDA SKGEWEKRSK GDLGAEGGQE RDCAGRDECL SLRAFQSTRR GPSFSDYLYF 

       730        740 
KHRDESLKEL LERKMEKQAV LLGI 

« Hide

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Spleen.
[2]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Heart.
[3]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"Fugu and human sequence comparison identifies novel human genes and conserved non-coding sequences."
Gilligan P., Brenner S., Venkatesh B.
Gene 294:35-44(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[6]"ZNF366 is an estrogen receptor corepressor that acts through CtBP and histone deacetylases."
Lopez-Garcia J., Periyasamy M., Thomas R.S., Christian M., Leao M., Jat P., Kindle K.B., Heery D.M., Parker M.G., Buluwela L., Kamalati T., Ali S.
Nucleic Acids Res. 34:6126-6136(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH ESR1; NRIP1 AND CTBP1, MUTAGENESIS OF PRO-590; ASP-592; PRO-645 AND ASP-647.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK097115 mRNA. Translation: BAC04954.1.
BX647592 mRNA. Translation: CAI46096.1.
CH471084 Genomic DNA. Translation: EAW95707.1.
BC121053 mRNA. Translation: AAI21054.1.
BK000210 mRNA. Translation: DAA00066.1.
RefSeqNP_689838.1. NM_152625.1.
UniGeneHs.370303.

3D structure databases

ProteinModelPortalQ8N895.
SMRQ8N895. Positions 250-617.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ8N895. 5 interactions.
STRING9606.ENSP00000313158.

PTM databases

PhosphoSiteQ8N895.

Polymorphism databases

DMDM28380235.

Proteomic databases

PaxDbQ8N895.
PRIDEQ8N895.

Protocols and materials databases

DNASU167465.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000318442; ENSP00000313158; ENSG00000178175.
GeneID167465.
KEGGhsa:167465.
UCSCuc003kce.1. human.

Organism-specific databases

CTD167465.
GeneCardsGC05M071774.
HGNCHGNC:18316. ZNF366.
HPAHPA023128.
HPA023526.
MIM610159. gene.
neXtProtNX_Q8N895.
PharmGKBPA38314.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000138030.
HOVERGENHBG055962.
InParanoidQ8N895.
OMAHMMQHSE.
OrthoDBEOG7MPRDM.
PhylomeDBQ8N895.
TreeFamTF331510.

Gene expression databases

ArrayExpressQ8N895.
BgeeQ8N895.
CleanExHS_ZNF366.
GenevestigatorQ8N895.

Family and domain databases

Gene3D3.30.160.60. 10 hits.
InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF00096. zf-C2H2. 6 hits.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 11 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiZNF366.
GenomeRNAi167465.
NextBio88674.
PROQ8N895.
SOURCESearch...

Entry information

Entry nameZN366_HUMAN
AccessionPrimary (citable) accession number: Q8N895
Secondary accession number(s): Q5HYI9, Q7RTV4
Entry history
Integrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: October 1, 2002
Last modified: March 19, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM