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Protein

Zinc finger protein 366

Gene

ZNF366

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has transcriptional repression activity. Acts as corepressor of ESR1; the function seems to involve CTBP1 and histone deacetylases.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri253 – 27523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri281 – 30323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri309 – 33123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri337 – 35923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri365 – 38723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri393 – 41523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri421 – 44323C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri449 – 47123C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri477 – 49923C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri505 – 52723C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri533 – 55624C2H2-type 11PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • estrogen receptor binding Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW
  • transcription corepressor activity Source: UniProtKB

GO - Biological processi

  • negative regulation of intracellular estrogen receptor signaling pathway Source: UniProtKB
  • negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • response to estrogen Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 366
Gene namesi
Name:ZNF366
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:18316. ZNF366.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi590 – 5901P → A: Abolishes interaction with CTBP1 and in part relieves transcription repression; when associated with A-592. 1 Publication
Mutagenesisi592 – 5921D → A: Abolishes interaction with CTBP1 and in part relieves transcription repression; when associated with A-590. 1 Publication
Mutagenesisi645 – 6451P → A: Decreases interaction with CTBP1; when associated with A-647. 1 Publication
Mutagenesisi647 – 6471D → A: Decreases interaction with CTBP1; when associated with A-645. 1 Publication

Organism-specific databases

PharmGKBiPA38314.

Polymorphism and mutation databases

BioMutaiZNF366.
DMDMi28380235.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 744744Zinc finger protein 366PRO_0000047548Add
BLAST

Proteomic databases

PaxDbiQ8N895.
PRIDEiQ8N895.

PTM databases

PhosphoSiteiQ8N895.

Expressioni

Gene expression databases

BgeeiQ8N895.
CleanExiHS_ZNF366.
ExpressionAtlasiQ8N895. baseline and differential.
GenevisibleiQ8N895. HS.

Organism-specific databases

HPAiHPA023128.
HPA023526.

Interactioni

Subunit structurei

Interacts with ESR1, NRIP1 and CTBP1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CEP70Q8NHQ13EBI-2813661,EBI-739624
CTBP1Q133635EBI-2813661,EBI-908846
ESR1P033726EBI-2813661,EBI-78473
NRIP1P485522EBI-2813661,EBI-746484
PSMA3P257883EBI-2813661,EBI-348380

Protein-protein interaction databases

BioGridi127947. 2 interactions.
IntActiQ8N895. 7 interactions.
STRINGi9606.ENSP00000313158.

Structurei

3D structure databases

ProteinModelPortaliQ8N895.
SMRiQ8N895. Positions 251-557.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni455 – 744290Interaction with NRIP1Add
BLAST
Regioni558 – 744187Interaction with CTBP1Add
BLAST

Sequence similaritiesi

Contains 11 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri253 – 27523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri281 – 30323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri309 – 33123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri337 – 35923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri365 – 38723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri393 – 41523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri421 – 44323C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri449 – 47123C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri477 – 49923C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri505 – 52723C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri533 – 55624C2H2-type 11PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00750000117653.
HOGENOMiHOG000138030.
HOVERGENiHBG055962.
InParanoidiQ8N895.
OMAiHMMQHSE.
OrthoDBiEOG7MPRDM.
PhylomeDBiQ8N895.
TreeFamiTF331510.

Family and domain databases

Gene3Di3.30.160.60. 10 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 6 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 11 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N895-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQKEMKMIKD EDVHFDLAVK KTPSFPHCLQ PVASRGKAPQ RHPFPEALRG
60 70 80 90 100
PFSQFRYEPP PGDLDGFPGV FEGAGSRKRK SMPTKMPYNH PAEEVTLALH
110 120 130 140 150
SEENKNHGLP NLPLLFPQPP RPKYDSQMID LCNVGFQFYR SLEHFGGKPV
160 170 180 190 200
KQEPIKPSAV WPQPTPTPFL PTPYPYYPKV HPGLMFPFFV PSSSPFPFSR
210 220 230 240 250
HTFLPKQPPE PLLPRKAEPQ ESEETKQKVE RVDVNVQIDD SYYVDVGGSQ
260 270 280 290 300
KRWQCPTCEK SYTSKYNLVT HILGHSGIKP HACTHCGKLF KQLSHLHTHM
310 320 330 340 350
LTHQGTRPHK CQVCHKAFTQ TSHLKRHMMQ HSEVKPHNCR VCGRGFAYPS
360 370 380 390 400
ELKAHEAKHA SGRENICVEC GLDFPTLAQL KRHLTTHRGP IQYNCSECDK
410 420 430 440 450
TFQYPSQLQN HMMKHKDIRP YICSECGMEF VQPHHLKQHS LTHKGVKEHK
460 470 480 490 500
CGICGREFTL LANMKRHVLI HTNIRAYQCH LCYKSFVQKQ TLKAHMIVHS
510 520 530 540 550
DVKPFKCKLC GKEFNRMHNL MGHMHLHSDS KPFKCLYCPS KFTLKGNLTR
560 570 580 590 600
HMKVKHGVME RGLHSQGLGR GRIALAQTAG VLRSLEQEEP FDLSQKRRAK
610 620 630 640 650
VPVFQSDGES AQGSHCHEEE EEDNCYEVEP YSPGLAPQSQ QLCTPEDLST
660 670 680 690 700
KSEHAPEVLE EACKEEKEDA SKGEWEKRSK GDLGAEGGQE RDCAGRDECL
710 720 730 740
SLRAFQSTRR GPSFSDYLYF KHRDESLKEL LERKMEKQAV LLGI
Length:744
Mass (Da):85,107
Last modified:October 1, 2002 - v1
Checksum:iD4E12259280727B1
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti739 – 7391A → G.
Corresponds to variant rs13188519 [ dbSNP | Ensembl ].
VAR_033564

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097115 mRNA. Translation: BAC04954.1.
BX647592 mRNA. Translation: CAI46096.1.
CH471084 Genomic DNA. Translation: EAW95707.1.
BC121053 mRNA. Translation: AAI21054.1.
BK000210 mRNA. Translation: DAA00066.1.
CCDSiCCDS4015.1.
RefSeqiNP_689838.1. NM_152625.2.
UniGeneiHs.224794.
Hs.370303.

Genome annotation databases

EnsembliENST00000318442; ENSP00000313158; ENSG00000178175.
GeneIDi167465.
KEGGihsa:167465.
UCSCiuc003kce.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097115 mRNA. Translation: BAC04954.1.
BX647592 mRNA. Translation: CAI46096.1.
CH471084 Genomic DNA. Translation: EAW95707.1.
BC121053 mRNA. Translation: AAI21054.1.
BK000210 mRNA. Translation: DAA00066.1.
CCDSiCCDS4015.1.
RefSeqiNP_689838.1. NM_152625.2.
UniGeneiHs.224794.
Hs.370303.

3D structure databases

ProteinModelPortaliQ8N895.
SMRiQ8N895. Positions 251-557.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127947. 2 interactions.
IntActiQ8N895. 7 interactions.
STRINGi9606.ENSP00000313158.

PTM databases

PhosphoSiteiQ8N895.

Polymorphism and mutation databases

BioMutaiZNF366.
DMDMi28380235.

Proteomic databases

PaxDbiQ8N895.
PRIDEiQ8N895.

Protocols and materials databases

DNASUi167465.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000318442; ENSP00000313158; ENSG00000178175.
GeneIDi167465.
KEGGihsa:167465.
UCSCiuc003kce.1. human.

Organism-specific databases

CTDi167465.
GeneCardsiGC05M071774.
HGNCiHGNC:18316. ZNF366.
HPAiHPA023128.
HPA023526.
MIMi610159. gene.
neXtProtiNX_Q8N895.
PharmGKBiPA38314.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00750000117653.
HOGENOMiHOG000138030.
HOVERGENiHBG055962.
InParanoidiQ8N895.
OMAiHMMQHSE.
OrthoDBiEOG7MPRDM.
PhylomeDBiQ8N895.
TreeFamiTF331510.

Miscellaneous databases

ChiTaRSiZNF366. human.
GeneWikiiZNF366.
GenomeRNAii167465.
NextBioi88674.
PROiQ8N895.
SOURCEiSearch...

Gene expression databases

BgeeiQ8N895.
CleanExiHS_ZNF366.
ExpressionAtlasiQ8N895. baseline and differential.
GenevisibleiQ8N895. HS.

Family and domain databases

Gene3Di3.30.160.60. 10 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 6 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 11 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Spleen.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Fugu and human sequence comparison identifies novel human genes and conserved non-coding sequences."
    Gilligan P., Brenner S., Venkatesh B.
    Gene 294:35-44(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  6. "ZNF366 is an estrogen receptor corepressor that acts through CtBP and histone deacetylases."
    Lopez-Garcia J., Periyasamy M., Thomas R.S., Christian M., Leao M., Jat P., Kindle K.B., Heery D.M., Parker M.G., Buluwela L., Kamalati T., Ali S.
    Nucleic Acids Res. 34:6126-6136(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH ESR1; NRIP1 AND CTBP1, MUTAGENESIS OF PRO-590; ASP-592; PRO-645 AND ASP-647.

Entry informationi

Entry nameiZN366_HUMAN
AccessioniPrimary (citable) accession number: Q8N895
Secondary accession number(s): Q5HYI9, Q7RTV4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: October 1, 2002
Last modified: June 24, 2015
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.