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Q8N895

- ZN366_HUMAN

UniProt

Q8N895 - ZN366_HUMAN

Protein

Zinc finger protein 366

Gene

ZNF366

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Has transcriptional repression activity. Acts as corepressor of ESR1; the function seems to involve CTBP1 and histone deacetylases.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri253 – 27523C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri281 – 30323C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri309 – 33123C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri337 – 35923C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri365 – 38723C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri393 – 41523C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri421 – 44323C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri449 – 47123C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri477 – 49923C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri505 – 52723C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri533 – 55624C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. estrogen receptor binding Source: UniProtKB
    3. metal ion binding Source: UniProtKB-KW
    4. protein binding Source: IntAct
    5. transcription corepressor activity Source: UniProtKB

    GO - Biological processi

    1. negative regulation of intracellular estrogen receptor signaling pathway Source: UniProtKB
    2. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    3. response to estrogen Source: UniProtKB
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 366
    Gene namesi
    Name:ZNF366
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:18316. ZNF366.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi590 – 5901P → A: Abolishes interaction with CTBP1 and in part relieves transcription repression; when associated with A-592. 1 Publication
    Mutagenesisi592 – 5921D → A: Abolishes interaction with CTBP1 and in part relieves transcription repression; when associated with A-590. 1 Publication
    Mutagenesisi645 – 6451P → A: Decreases interaction with CTBP1; when associated with A-647. 1 Publication
    Mutagenesisi647 – 6471D → A: Decreases interaction with CTBP1; when associated with A-645. 1 Publication

    Organism-specific databases

    PharmGKBiPA38314.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 744744Zinc finger protein 366PRO_0000047548Add
    BLAST

    Proteomic databases

    PaxDbiQ8N895.
    PRIDEiQ8N895.

    PTM databases

    PhosphoSiteiQ8N895.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8N895.
    BgeeiQ8N895.
    CleanExiHS_ZNF366.
    GenevestigatoriQ8N895.

    Organism-specific databases

    HPAiHPA023128.
    HPA023526.

    Interactioni

    Subunit structurei

    Interacts with ESR1, NRIP1 and CTBP1.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CTBP1Q133635EBI-2813661,EBI-908846
    ESR1P033726EBI-2813661,EBI-78473
    NRIP1P485522EBI-2813661,EBI-746484

    Protein-protein interaction databases

    IntActiQ8N895. 5 interactions.
    STRINGi9606.ENSP00000313158.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N895.
    SMRiQ8N895. Positions 250-590.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni455 – 744290Interaction with NRIP1Add
    BLAST
    Regioni558 – 744187Interaction with CTBP1Add
    BLAST

    Sequence similaritiesi

    Contains 11 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri253 – 27523C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri281 – 30323C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri309 – 33123C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri337 – 35923C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri365 – 38723C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri393 – 41523C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri421 – 44323C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri449 – 47123C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri477 – 49923C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri505 – 52723C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri533 – 55624C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000138030.
    HOVERGENiHBG055962.
    InParanoidiQ8N895.
    OMAiHMMQHSE.
    OrthoDBiEOG7MPRDM.
    PhylomeDBiQ8N895.
    TreeFamiTF331510.

    Family and domain databases

    Gene3Di3.30.160.60. 10 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF00096. zf-C2H2. 6 hits.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 11 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 11 hits.
    PS50157. ZINC_FINGER_C2H2_2. 11 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8N895-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQKEMKMIKD EDVHFDLAVK KTPSFPHCLQ PVASRGKAPQ RHPFPEALRG    50
    PFSQFRYEPP PGDLDGFPGV FEGAGSRKRK SMPTKMPYNH PAEEVTLALH 100
    SEENKNHGLP NLPLLFPQPP RPKYDSQMID LCNVGFQFYR SLEHFGGKPV 150
    KQEPIKPSAV WPQPTPTPFL PTPYPYYPKV HPGLMFPFFV PSSSPFPFSR 200
    HTFLPKQPPE PLLPRKAEPQ ESEETKQKVE RVDVNVQIDD SYYVDVGGSQ 250
    KRWQCPTCEK SYTSKYNLVT HILGHSGIKP HACTHCGKLF KQLSHLHTHM 300
    LTHQGTRPHK CQVCHKAFTQ TSHLKRHMMQ HSEVKPHNCR VCGRGFAYPS 350
    ELKAHEAKHA SGRENICVEC GLDFPTLAQL KRHLTTHRGP IQYNCSECDK 400
    TFQYPSQLQN HMMKHKDIRP YICSECGMEF VQPHHLKQHS LTHKGVKEHK 450
    CGICGREFTL LANMKRHVLI HTNIRAYQCH LCYKSFVQKQ TLKAHMIVHS 500
    DVKPFKCKLC GKEFNRMHNL MGHMHLHSDS KPFKCLYCPS KFTLKGNLTR 550
    HMKVKHGVME RGLHSQGLGR GRIALAQTAG VLRSLEQEEP FDLSQKRRAK 600
    VPVFQSDGES AQGSHCHEEE EEDNCYEVEP YSPGLAPQSQ QLCTPEDLST 650
    KSEHAPEVLE EACKEEKEDA SKGEWEKRSK GDLGAEGGQE RDCAGRDECL 700
    SLRAFQSTRR GPSFSDYLYF KHRDESLKEL LERKMEKQAV LLGI 744
    Length:744
    Mass (Da):85,107
    Last modified:October 1, 2002 - v1
    Checksum:iD4E12259280727B1
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti739 – 7391A → G.
    Corresponds to variant rs13188519 [ dbSNP | Ensembl ].
    VAR_033564

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK097115 mRNA. Translation: BAC04954.1.
    BX647592 mRNA. Translation: CAI46096.1.
    CH471084 Genomic DNA. Translation: EAW95707.1.
    BC121053 mRNA. Translation: AAI21054.1.
    BK000210 mRNA. Translation: DAA00066.1.
    CCDSiCCDS4015.1.
    RefSeqiNP_689838.1. NM_152625.1.
    UniGeneiHs.370303.

    Genome annotation databases

    EnsembliENST00000318442; ENSP00000313158; ENSG00000178175.
    GeneIDi167465.
    KEGGihsa:167465.
    UCSCiuc003kce.1. human.

    Polymorphism databases

    DMDMi28380235.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK097115 mRNA. Translation: BAC04954.1 .
    BX647592 mRNA. Translation: CAI46096.1 .
    CH471084 Genomic DNA. Translation: EAW95707.1 .
    BC121053 mRNA. Translation: AAI21054.1 .
    BK000210 mRNA. Translation: DAA00066.1 .
    CCDSi CCDS4015.1.
    RefSeqi NP_689838.1. NM_152625.1.
    UniGenei Hs.370303.

    3D structure databases

    ProteinModelPortali Q8N895.
    SMRi Q8N895. Positions 250-590.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8N895. 5 interactions.
    STRINGi 9606.ENSP00000313158.

    PTM databases

    PhosphoSitei Q8N895.

    Polymorphism databases

    DMDMi 28380235.

    Proteomic databases

    PaxDbi Q8N895.
    PRIDEi Q8N895.

    Protocols and materials databases

    DNASUi 167465.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000318442 ; ENSP00000313158 ; ENSG00000178175 .
    GeneIDi 167465.
    KEGGi hsa:167465.
    UCSCi uc003kce.1. human.

    Organism-specific databases

    CTDi 167465.
    GeneCardsi GC05M071774.
    HGNCi HGNC:18316. ZNF366.
    HPAi HPA023128.
    HPA023526.
    MIMi 610159. gene.
    neXtProti NX_Q8N895.
    PharmGKBi PA38314.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000138030.
    HOVERGENi HBG055962.
    InParanoidi Q8N895.
    OMAi HMMQHSE.
    OrthoDBi EOG7MPRDM.
    PhylomeDBi Q8N895.
    TreeFami TF331510.

    Miscellaneous databases

    GeneWikii ZNF366.
    GenomeRNAii 167465.
    NextBioi 88674.
    PROi Q8N895.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8N895.
    Bgeei Q8N895.
    CleanExi HS_ZNF366.
    Genevestigatori Q8N895.

    Family and domain databases

    Gene3Di 3.30.160.60. 10 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF00096. zf-C2H2. 6 hits.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 11 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 11 hits.
    PS50157. ZINC_FINGER_C2H2_2. 11 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Spleen.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Heart.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "Fugu and human sequence comparison identifies novel human genes and conserved non-coding sequences."
      Gilligan P., Brenner S., Venkatesh B.
      Gene 294:35-44(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    6. "ZNF366 is an estrogen receptor corepressor that acts through CtBP and histone deacetylases."
      Lopez-Garcia J., Periyasamy M., Thomas R.S., Christian M., Leao M., Jat P., Kindle K.B., Heery D.M., Parker M.G., Buluwela L., Kamalati T., Ali S.
      Nucleic Acids Res. 34:6126-6136(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH ESR1; NRIP1 AND CTBP1, MUTAGENESIS OF PRO-590; ASP-592; PRO-645 AND ASP-647.

    Entry informationi

    Entry nameiZN366_HUMAN
    AccessioniPrimary (citable) accession number: Q8N895
    Secondary accession number(s): Q5HYI9, Q7RTV4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 12, 2003
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3