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Protein

Zinc finger protein 614

Gene

ZNF614

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri205 – 22723C2H2-type 1; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri257 – 28125C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri287 – 30923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri315 – 33723C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri343 – 36523C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri371 – 39323C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri399 – 42123C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri427 – 44923C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri455 – 47723C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri483 – 50523C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri511 – 53323C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri539 – 56123C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 614
Gene namesi
Name:ZNF614
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:24722. ZNF614.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134914044.

Polymorphism and mutation databases

BioMutaiZNF614.
DMDMi97219309.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 585585Zinc finger protein 614PRO_0000234598Add
BLAST

Proteomic databases

MaxQBiQ8N883.
PaxDbiQ8N883.
PeptideAtlasiQ8N883.
PRIDEiQ8N883.

PTM databases

iPTMnetiQ8N883.
PhosphoSiteiQ8N883.

Expressioni

Gene expression databases

BgeeiENSG00000142556.
CleanExiHS_ZNF614.
ExpressionAtlasiQ8N883. baseline and differential.
GenevisibleiQ8N883. HS.

Organism-specific databases

HPAiHPA021197.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FAM9BQ8IZU03EBI-9675993,EBI-10175124
NFIXQ149383EBI-9675993,EBI-8476987
taxP140793EBI-9675993,EBI-9675698From a different organism.

Protein-protein interaction databases

BioGridi123116. 3 interactions.
IntActiQ8N883. 4 interactions.
STRINGi9606.ENSP00000270649.

Structurei

3D structure databases

ProteinModelPortaliQ8N883.
SMRiQ8N883. Positions 8-49, 168-563.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 7972KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri205 – 22723C2H2-type 1; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri257 – 28125C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri287 – 30923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri315 – 33723C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri343 – 36523C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri371 – 39323C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri399 – 42123C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri427 – 44923C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri455 – 47723C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri483 – 50523C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri511 – 53323C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri539 – 56123C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129783.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8N883.
KOiK09228.
OMAiVKHKKMH.
OrthoDBiEOG091G02KC.
PhylomeDBiQ8N883.
TreeFamiTF350804.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 5 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 11 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N883-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIKTQESLTL EDVAVEFSWE EWQLLDTAQK NLYRDVMVEN YNHLVSLGYQ
60 70 80 90 100
TSKPDVLSKL AHGQEPWTTD AKIQNKNCPG IGKVDSHLQE HSPNQRLLKS
110 120 130 140 150
VQQCNGQNTL RNIVHLSKTH FPIVQNHDTF DLYRKNLKSS LSLINQKRRH
160 170 180 190 200
GINNPVEFIG GEKTLLHGKH ERTHTKTRFS ENAKCIHTKF QVFKHQRTQK
210 220 230 240 250
IEKPHACIEC EQTFLRKSQL IYHENICIQE NPGSGQCEKL SRSVLFTKHL
260 270 280 290 300
KTNTTDKICI PNEYRKGSTV KSSLITHQQT HTEEKSYMCS ECGKGFTMKR
310 320 330 340 350
YLIAHQRTHS GEKPYVCKEC GKGFTVKSNL IVHQRTHTGE KPYICSECGK
360 370 380 390 400
GFTMKRYLVV HQRTHTGEKP YMCSECGKGF TVKSNLIVHQ RSHTGEKSYI
410 420 430 440 450
CSECGKGFTV KRTLVIHQRT HTGEKSYICN ECGKGFTTKR TLIIHQRTHT
460 470 480 490 500
GEKPYECNEC GKAFSQKICL IQHERCHTGK TPFVCTECGK SYSHKYGLIT
510 520 530 540 550
HQRIHTGEKP YECNECGKAF TTKSVLNVHQ RTHTGERPYG CSDCEKAFSH
560 570 580
LSNLVKHKKM HTREMGRISQ VENSCNGESQ LLPYK
Length:585
Mass (Da):67,215
Last modified:May 16, 2006 - v2
Checksum:i761FFD8B035CDAA4
GO
Isoform 2 (identifier: Q8N883-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     161-198: GEKTLLHGKH...KFQVFKHQRT → ETGSLERPRQ...LCLLKIHTKN
     199-585: Missing.

Note: No experimental confirmation available.
Show »
Length:198
Mass (Da):22,783
Checksum:i6FE01C3BEE09643F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti250 – 2501L → P in BAC04966 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti68 – 681T → I.
Corresponds to variant rs9636139 [ dbSNP | Ensembl ].
VAR_052878
Natural varianti160 – 1601G → E.
Corresponds to variant rs45596739 [ dbSNP | Ensembl ].
VAR_061959
Natural varianti223 – 2231H → R.
Corresponds to variant rs35098634 [ dbSNP | Ensembl ].
VAR_052879
Natural varianti415 – 4151V → I.
Corresponds to variant rs8104890 [ dbSNP | Ensembl ].
VAR_052880

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei161 – 19838GEKTL…KHQRT → ETGSLERPRQADHLRSEVQD QPGQRGETLCLLKIHTKN in isoform 2. 1 PublicationVSP_056549Add
BLAST
Alternative sequencei199 – 585387Missing in isoform 2. 1 PublicationVSP_056550Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097156 mRNA. Translation: BAC04966.1.
AC011468 Genomic DNA. No translation available.
CH471135 Genomic DNA. Translation: EAW72058.1.
BC004930 mRNA. Translation: AAH04930.1.
BC022246 mRNA. Translation: AAH22246.1.
BC101392 mRNA. Translation: AAI01393.1.
BC101393 mRNA. Translation: AAI01394.1.
BC101394 mRNA. Translation: AAI01395.1.
BC101395 mRNA. Translation: AAI01396.1.
CCDSiCCDS12847.1. [Q8N883-1]
RefSeqiNP_079316.2. NM_025040.3. [Q8N883-1]
UniGeneiHs.292336.

Genome annotation databases

EnsembliENST00000270649; ENSP00000270649; ENSG00000142556. [Q8N883-1]
ENST00000356322; ENSP00000348674; ENSG00000142556. [Q8N883-2]
GeneIDi80110.
KEGGihsa:80110.
UCSCiuc002pyi.5. human. [Q8N883-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097156 mRNA. Translation: BAC04966.1.
AC011468 Genomic DNA. No translation available.
CH471135 Genomic DNA. Translation: EAW72058.1.
BC004930 mRNA. Translation: AAH04930.1.
BC022246 mRNA. Translation: AAH22246.1.
BC101392 mRNA. Translation: AAI01393.1.
BC101393 mRNA. Translation: AAI01394.1.
BC101394 mRNA. Translation: AAI01395.1.
BC101395 mRNA. Translation: AAI01396.1.
CCDSiCCDS12847.1. [Q8N883-1]
RefSeqiNP_079316.2. NM_025040.3. [Q8N883-1]
UniGeneiHs.292336.

3D structure databases

ProteinModelPortaliQ8N883.
SMRiQ8N883. Positions 8-49, 168-563.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123116. 3 interactions.
IntActiQ8N883. 4 interactions.
STRINGi9606.ENSP00000270649.

PTM databases

iPTMnetiQ8N883.
PhosphoSiteiQ8N883.

Polymorphism and mutation databases

BioMutaiZNF614.
DMDMi97219309.

Proteomic databases

MaxQBiQ8N883.
PaxDbiQ8N883.
PeptideAtlasiQ8N883.
PRIDEiQ8N883.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000270649; ENSP00000270649; ENSG00000142556. [Q8N883-1]
ENST00000356322; ENSP00000348674; ENSG00000142556. [Q8N883-2]
GeneIDi80110.
KEGGihsa:80110.
UCSCiuc002pyi.5. human. [Q8N883-1]

Organism-specific databases

CTDi80110.
GeneCardsiZNF614.
HGNCiHGNC:24722. ZNF614.
HPAiHPA021197.
neXtProtiNX_Q8N883.
PharmGKBiPA134914044.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129783.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8N883.
KOiK09228.
OMAiVKHKKMH.
OrthoDBiEOG091G02KC.
PhylomeDBiQ8N883.
TreeFamiTF350804.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii80110.
PROiQ8N883.

Gene expression databases

BgeeiENSG00000142556.
CleanExiHS_ZNF614.
ExpressionAtlasiQ8N883. baseline and differential.
GenevisibleiQ8N883. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 5 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 11 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN614_HUMAN
AccessioniPrimary (citable) accession number: Q8N883
Secondary accession number(s): Q494T8, Q8TCF4, Q9BSN8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 16, 2006
Last modified: September 7, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.