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Protein

Uncharacterized protein C7orf31

Gene

C7orf31

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C7orf31
Gene namesi
Name:C7orf31
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:21722. C7orf31.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: UniProtKB
  • cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000153790.
PharmGKBiPA134924921.

Polymorphism and mutation databases

BioMutaiC7orf31.
DMDMi269849700.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000895871 – 590Uncharacterized protein C7orf31Add BLAST590

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei219PhosphothreonineBy similarity1
Modified residuei407PhosphoserineBy similarity1
Modified residuei422PhosphoserineBy similarity1
Modified residuei442PhosphotyrosineBy similarity1
Modified residuei485PhosphoserineBy similarity1
Modified residuei547PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8N865.
PaxDbiQ8N865.
PeptideAtlasiQ8N865.
PRIDEiQ8N865.

PTM databases

iPTMnetiQ8N865.
PhosphoSitePlusiQ8N865.

Expressioni

Gene expression databases

BgeeiENSG00000153790.
CleanExiHS_C7orf31.
ExpressionAtlasiQ8N865. baseline and differential.
GenevisibleiQ8N865. HS.

Organism-specific databases

HPAiHPA020346.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
A8K5H93EBI-10174456,EBI-10174421

Protein-protein interaction databases

BioGridi126465. 5 interactors.
IntActiQ8N865. 3 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ8N865.
SMRiQ8N865.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IIJZ. Eukaryota.
ENOG410YGE7. LUCA.
GeneTreeiENSGT00390000015236.
HOVERGENiHBG081124.
InParanoidiQ8N865.
OMAiPDCTPRV.
OrthoDBiEOG091G066S.
PhylomeDBiQ8N865.
TreeFamiTF336164.

Family and domain databases

InterProiIPR027886. DUF4555.
[Graphical view]
PfamiPF15093. DUF4555. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N865-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVIHGRPYC CRELEGADIL SNTFYSNELH NPLQTVTRPT ASEDRYQELR
60 70 80 90 100
ESLQQCRLPW GAEREYGGII PISLPEDHRP KYEPPRVMGK GHQHYGFGGE
110 120 130 140 150
TWPRKLPVEQ FYYLTQNKKS DVYGNDSLIP KPPNSTVGEI CLPYPIEHPY
160 170 180 190 200
HTHICRGAMF PTFTSPEDLY TGIKARTQQP FPPTVPTKAY DSTVLKTRGN
210 220 230 240 250
PYRYELIDIP MDSKKKALTW PGQGVYYDFP RGVEKNKPVF YPKPPKTFAP
260 270 280 290 300
NTSLNSWDPI CSAKEANIQR NLERSHWLTS YTHDFTGLGP MDPLELDDYH
310 320 330 340 350
EKMVAELTRK IGFDPEPQEK FHPVFKPPRP LEGRIARLIQ NRRSLEAIVQ
360 370 380 390 400
QRPRSCPDCT PRVLCNFHTF VPSSKEMVAL SDNIPAGVTH KNQDIEEKII
410 420 430 440 450
EEQSLLSTYE LPSCYPTKDL TSIYDIKPFP KITDTKKTED LYWRQQSLKT
460 470 480 490 500
QPTPYCKPDH WIHYENLKSP LRDQYNMCPD PVSLSKPSVL QNKQDTEAFT
510 520 530 540 550
LEHFLSKPEE ELFLNMENNE ETRPVLGWIP RAGVTKPQTN LLELKNSFSK
560 570 580 590
TGAQKRFHKS ILEDHKDLRD NEHSGMKHQF YGHNSYYFYN
Length:590
Mass (Da):68,464
Last modified:November 24, 2009 - v3
Checksum:iE2FCDAA48BB8ED8E
GO

Sequence cautioni

The sequence AAP22338 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAC05255 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05680913E → K.Corresponds to variant rs11980216dbSNPEnsembl.1
Natural variantiVAR_02278182Y → C.1 PublicationCorresponds to variant rs2717858dbSNPEnsembl.1
Natural variantiVAR_05681086R → C.Corresponds to variant rs3213642dbSNPEnsembl.1
Natural variantiVAR_060608143P → Q.1 PublicationCorresponds to variant rs17855102dbSNPEnsembl.1
Natural variantiVAR_022782158A → T.3 PublicationsCorresponds to variant rs12535348dbSNPEnsembl.1
Natural variantiVAR_022783187T → S.4 PublicationsCorresponds to variant rs2523072dbSNPEnsembl.1
Natural variantiVAR_056811238P → Q.1 PublicationCorresponds to variant rs11984293dbSNPEnsembl.1
Natural variantiVAR_056812249A → T.Corresponds to variant rs17150982dbSNPEnsembl.1
Natural variantiVAR_022784300H → R.4 PublicationsCorresponds to variant rs2285738dbSNPEnsembl.1
Natural variantiVAR_060609518N → D.1 PublicationCorresponds to variant rs17857512dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097248 mRNA. Translation: BAC04985.1.
AK098189 mRNA. Translation: BAC05255.1. Different initiation.
AC004129 Genomic DNA. Translation: AAP22338.1. Sequence problems.
CH236948 Genomic DNA. Translation: EAL24238.1.
CH471073 Genomic DNA. Translation: EAW93827.1.
BC015397 mRNA. Translation: AAH15397.2.
BC043269 mRNA. Translation: AAH43269.1.
BC060879 mRNA. Translation: AAH60879.1.
BX640851 mRNA. Translation: CAE45919.1.
CCDSiCCDS5394.1.
RefSeqiNP_620166.3. NM_138811.3.
XP_005249676.1. XM_005249619.3.
XP_005249677.1. XM_005249620.3.
XP_011513427.1. XM_011515125.2.
UniGeneiHs.122055.

Genome annotation databases

EnsembliENST00000283905; ENSP00000283905; ENSG00000153790.
ENST00000409280; ENSP00000386604; ENSG00000153790.
GeneIDi136895.
KEGGihsa:136895.
UCSCiuc003sxn.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097248 mRNA. Translation: BAC04985.1.
AK098189 mRNA. Translation: BAC05255.1. Different initiation.
AC004129 Genomic DNA. Translation: AAP22338.1. Sequence problems.
CH236948 Genomic DNA. Translation: EAL24238.1.
CH471073 Genomic DNA. Translation: EAW93827.1.
BC015397 mRNA. Translation: AAH15397.2.
BC043269 mRNA. Translation: AAH43269.1.
BC060879 mRNA. Translation: AAH60879.1.
BX640851 mRNA. Translation: CAE45919.1.
CCDSiCCDS5394.1.
RefSeqiNP_620166.3. NM_138811.3.
XP_005249676.1. XM_005249619.3.
XP_005249677.1. XM_005249620.3.
XP_011513427.1. XM_011515125.2.
UniGeneiHs.122055.

3D structure databases

ProteinModelPortaliQ8N865.
SMRiQ8N865.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126465. 5 interactors.
IntActiQ8N865. 3 interactors.

PTM databases

iPTMnetiQ8N865.
PhosphoSitePlusiQ8N865.

Polymorphism and mutation databases

BioMutaiC7orf31.
DMDMi269849700.

Proteomic databases

EPDiQ8N865.
PaxDbiQ8N865.
PeptideAtlasiQ8N865.
PRIDEiQ8N865.

Protocols and materials databases

DNASUi136895.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000283905; ENSP00000283905; ENSG00000153790.
ENST00000409280; ENSP00000386604; ENSG00000153790.
GeneIDi136895.
KEGGihsa:136895.
UCSCiuc003sxn.2. human.

Organism-specific databases

CTDi136895.
GeneCardsiC7orf31.
H-InvDBHIX0201151.
HGNCiHGNC:21722. C7orf31.
HPAiHPA020346.
MIMi616071. gene.
neXtProtiNX_Q8N865.
OpenTargetsiENSG00000153790.
PharmGKBiPA134924921.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIJZ. Eukaryota.
ENOG410YGE7. LUCA.
GeneTreeiENSGT00390000015236.
HOVERGENiHBG081124.
InParanoidiQ8N865.
OMAiPDCTPRV.
OrthoDBiEOG091G066S.
PhylomeDBiQ8N865.
TreeFamiTF336164.

Miscellaneous databases

ChiTaRSiC7orf31. human.
GenomeRNAii136895.
PROiQ8N865.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000153790.
CleanExiHS_C7orf31.
ExpressionAtlasiQ8N865. baseline and differential.
GenevisibleiQ8N865. HS.

Family and domain databases

InterProiIPR027886. DUF4555.
[Graphical view]
PfamiPF15093. DUF4555. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCG031_HUMAN
AccessioniPrimary (citable) accession number: Q8N865
Secondary accession number(s): A4D165
, Q6MZV8, Q6P989, Q7LE28, Q86XK1, Q8N1H5, Q96BN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: November 24, 2009
Last modified: November 30, 2016
This is version 95 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.