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Protein

Uncharacterized protein C7orf31

Gene

C7orf31

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C7orf31
Gene namesi
Name:C7orf31
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:21722. C7orf31.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: UniProtKB
  • cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134924921.

Polymorphism and mutation databases

BioMutaiC7orf31.
DMDMi269849700.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 590590Uncharacterized protein C7orf31PRO_0000089587Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei219 – 2191PhosphothreonineBy similarity
Modified residuei407 – 4071PhosphoserineBy similarity
Modified residuei422 – 4221PhosphoserineBy similarity
Modified residuei442 – 4421PhosphotyrosineBy similarity
Modified residuei485 – 4851PhosphoserineBy similarity
Modified residuei547 – 5471PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8N865.
PaxDbiQ8N865.
PRIDEiQ8N865.

PTM databases

PhosphoSiteiQ8N865.

Expressioni

Gene expression databases

BgeeiQ8N865.
CleanExiHS_C7orf31.
ExpressionAtlasiQ8N865. baseline and differential.
GenevisibleiQ8N865. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
A8K5H93EBI-10174456,EBI-10174421

Protein-protein interaction databases

BioGridi126465. 5 interactions.
IntActiQ8N865. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8N865.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IIJZ. Eukaryota.
ENOG410YGE7. LUCA.
GeneTreeiENSGT00390000015236.
HOVERGENiHBG081124.
InParanoidiQ8N865.
OMAiPDCTPRV.
OrthoDBiEOG79PJNR.
PhylomeDBiQ8N865.
TreeFamiTF336164.

Family and domain databases

InterProiIPR027886. DUF4555.
[Graphical view]
PfamiPF15093. DUF4555. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N865-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVIHGRPYC CRELEGADIL SNTFYSNELH NPLQTVTRPT ASEDRYQELR
60 70 80 90 100
ESLQQCRLPW GAEREYGGII PISLPEDHRP KYEPPRVMGK GHQHYGFGGE
110 120 130 140 150
TWPRKLPVEQ FYYLTQNKKS DVYGNDSLIP KPPNSTVGEI CLPYPIEHPY
160 170 180 190 200
HTHICRGAMF PTFTSPEDLY TGIKARTQQP FPPTVPTKAY DSTVLKTRGN
210 220 230 240 250
PYRYELIDIP MDSKKKALTW PGQGVYYDFP RGVEKNKPVF YPKPPKTFAP
260 270 280 290 300
NTSLNSWDPI CSAKEANIQR NLERSHWLTS YTHDFTGLGP MDPLELDDYH
310 320 330 340 350
EKMVAELTRK IGFDPEPQEK FHPVFKPPRP LEGRIARLIQ NRRSLEAIVQ
360 370 380 390 400
QRPRSCPDCT PRVLCNFHTF VPSSKEMVAL SDNIPAGVTH KNQDIEEKII
410 420 430 440 450
EEQSLLSTYE LPSCYPTKDL TSIYDIKPFP KITDTKKTED LYWRQQSLKT
460 470 480 490 500
QPTPYCKPDH WIHYENLKSP LRDQYNMCPD PVSLSKPSVL QNKQDTEAFT
510 520 530 540 550
LEHFLSKPEE ELFLNMENNE ETRPVLGWIP RAGVTKPQTN LLELKNSFSK
560 570 580 590
TGAQKRFHKS ILEDHKDLRD NEHSGMKHQF YGHNSYYFYN
Length:590
Mass (Da):68,464
Last modified:November 24, 2009 - v3
Checksum:iE2FCDAA48BB8ED8E
GO

Sequence cautioni

The sequence AAP22338.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence BAC05255.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti13 – 131E → K.
Corresponds to variant rs11980216 [ dbSNP | Ensembl ].
VAR_056809
Natural varianti82 – 821Y → C.1 Publication
Corresponds to variant rs2717858 [ dbSNP | Ensembl ].
VAR_022781
Natural varianti86 – 861R → C.
Corresponds to variant rs3213642 [ dbSNP | Ensembl ].
VAR_056810
Natural varianti143 – 1431P → Q.1 Publication
Corresponds to variant rs17855102 [ dbSNP | Ensembl ].
VAR_060608
Natural varianti158 – 1581A → T.3 Publications
Corresponds to variant rs12535348 [ dbSNP | Ensembl ].
VAR_022782
Natural varianti187 – 1871T → S.4 Publications
Corresponds to variant rs2523072 [ dbSNP | Ensembl ].
VAR_022783
Natural varianti238 – 2381P → Q.1 Publication
Corresponds to variant rs11984293 [ dbSNP | Ensembl ].
VAR_056811
Natural varianti249 – 2491A → T.
Corresponds to variant rs17150982 [ dbSNP | Ensembl ].
VAR_056812
Natural varianti300 – 3001H → R.4 Publications
Corresponds to variant rs2285738 [ dbSNP | Ensembl ].
VAR_022784
Natural varianti518 – 5181N → D.1 Publication
Corresponds to variant rs17857512 [ dbSNP | Ensembl ].
VAR_060609

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097248 mRNA. Translation: BAC04985.1.
AK098189 mRNA. Translation: BAC05255.1. Different initiation.
AC004129 Genomic DNA. Translation: AAP22338.1. Sequence problems.
CH236948 Genomic DNA. Translation: EAL24238.1.
CH471073 Genomic DNA. Translation: EAW93827.1.
BC015397 mRNA. Translation: AAH15397.2.
BC043269 mRNA. Translation: AAH43269.1.
BC060879 mRNA. Translation: AAH60879.1.
BX640851 mRNA. Translation: CAE45919.1.
CCDSiCCDS5394.1.
RefSeqiNP_620166.3. NM_138811.3.
XP_005249676.1. XM_005249619.2.
XP_005249677.1. XM_005249620.2.
XP_011513427.1. XM_011515125.1.
UniGeneiHs.122055.

Genome annotation databases

EnsembliENST00000283905; ENSP00000283905; ENSG00000153790.
ENST00000409280; ENSP00000386604; ENSG00000153790.
GeneIDi136895.
KEGGihsa:136895.
UCSCiuc003sxn.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097248 mRNA. Translation: BAC04985.1.
AK098189 mRNA. Translation: BAC05255.1. Different initiation.
AC004129 Genomic DNA. Translation: AAP22338.1. Sequence problems.
CH236948 Genomic DNA. Translation: EAL24238.1.
CH471073 Genomic DNA. Translation: EAW93827.1.
BC015397 mRNA. Translation: AAH15397.2.
BC043269 mRNA. Translation: AAH43269.1.
BC060879 mRNA. Translation: AAH60879.1.
BX640851 mRNA. Translation: CAE45919.1.
CCDSiCCDS5394.1.
RefSeqiNP_620166.3. NM_138811.3.
XP_005249676.1. XM_005249619.2.
XP_005249677.1. XM_005249620.2.
XP_011513427.1. XM_011515125.1.
UniGeneiHs.122055.

3D structure databases

ProteinModelPortaliQ8N865.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126465. 5 interactions.
IntActiQ8N865. 1 interaction.

PTM databases

PhosphoSiteiQ8N865.

Polymorphism and mutation databases

BioMutaiC7orf31.
DMDMi269849700.

Proteomic databases

EPDiQ8N865.
PaxDbiQ8N865.
PRIDEiQ8N865.

Protocols and materials databases

DNASUi136895.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000283905; ENSP00000283905; ENSG00000153790.
ENST00000409280; ENSP00000386604; ENSG00000153790.
GeneIDi136895.
KEGGihsa:136895.
UCSCiuc003sxn.2. human.

Organism-specific databases

CTDi136895.
GeneCardsiC7orf31.
H-InvDBHIX0201151.
HGNCiHGNC:21722. C7orf31.
MIMi616071. gene.
neXtProtiNX_Q8N865.
PharmGKBiPA134924921.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIJZ. Eukaryota.
ENOG410YGE7. LUCA.
GeneTreeiENSGT00390000015236.
HOVERGENiHBG081124.
InParanoidiQ8N865.
OMAiPDCTPRV.
OrthoDBiEOG79PJNR.
PhylomeDBiQ8N865.
TreeFamiTF336164.

Miscellaneous databases

ChiTaRSiC7orf31. human.
GenomeRNAii136895.
NextBioi83607.
PROiQ8N865.
SOURCEiSearch...

Gene expression databases

BgeeiQ8N865.
CleanExiHS_C7orf31.
ExpressionAtlasiQ8N865. baseline and differential.
GenevisibleiQ8N865. HS.

Family and domain databases

InterProiIPR027886. DUF4555.
[Graphical view]
PfamiPF15093. DUF4555. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS THR-158; SER-187 AND ARG-300.
    Tissue: Spleen and Stomach.
  2. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS THR-158; SER-187 AND ARG-300.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS CYS-82; GLN-143; SER-187; GLN-238; ARG-300 AND ASP-518.
    Tissue: Kidney and Testis.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 124-590, VARIANTS THR-158; SER-187 AND ARG-300.
    Tissue: Small intestine.
  6. "Proteomic analysis of mammalian sperm cells identifies new components of the centrosome."
    Firat-Karalar E.N., Sante J., Elliott S., Stearns T.
    J. Cell Sci. 127:4128-4133(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiCG031_HUMAN
AccessioniPrimary (citable) accession number: Q8N865
Secondary accession number(s): A4D165
, Q6MZV8, Q6P989, Q7LE28, Q86XK1, Q8N1H5, Q96BN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: November 24, 2009
Last modified: March 16, 2016
This is version 89 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.