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Protein

Zinc finger protein 611

Gene

ZNF611

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri231 – 25323C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri259 – 28123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri287 – 30923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri315 – 33723C2H2-type 4; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri343 – 36422C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri370 – 39223C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri398 – 42023C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri426 – 44823C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri454 – 47623C2H2-type 9; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri482 – 50423C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri510 – 53223C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri538 – 56023C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri566 – 58823C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri594 – 61623C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri622 – 64423C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri650 – 67223C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri678 – 70023C2H2-type 17PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 611
Gene namesi
Name:ZNF611
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:28766. ZNF611.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134988282.

Polymorphism and mutation databases

BioMutaiZNF611.
DMDMi269849530.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 705705Zinc finger protein 611PRO_0000234596Add
BLAST

Proteomic databases

PaxDbiQ8N823.
PRIDEiQ8N823.

PTM databases

iPTMnetiQ8N823.
PhosphoSiteiQ8N823.

Expressioni

Gene expression databases

BgeeiQ8N823.
CleanExiHS_ZNF611.
ExpressionAtlasiQ8N823. baseline and differential.
GenevisibleiQ8N823. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000322427.

Structurei

3D structure databases

ProteinModelPortaliQ8N823.
SMRiQ8N823. Positions 229-705.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 9774KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 17 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri231 – 25323C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri259 – 28123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri287 – 30923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri315 – 33723C2H2-type 4; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri343 – 36422C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri370 – 39223C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri398 – 42023C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri426 – 44823C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri454 – 47623C2H2-type 9; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri482 – 50423C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri510 – 53223C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri538 – 56023C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri566 – 58823C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri594 – 61623C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri622 – 64423C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri650 – 67223C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri678 – 70023C2H2-type 17PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00690000102079.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8N823.
KOiK09228.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ8N823.
TreeFamiTF341892.

Family and domain databases

Gene3Di3.30.160.60. 17 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 15 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 17 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N823-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLREEAAQKR KGKEPGMALP QGRLTFRDVA IEFSLAEWKC LNPSQRALYR
60 70 80 90 100
EVMLENYRNL EAVDISSKCM MKEVLSTGQG NTEVIHTGTL QRHESHHIGD
110 120 130 140 150
FCFQEIEKEI HDIEFQCQED ERNGLEAPMT KIKKLTGSTD QHDHRHAGNK
160 170 180 190 200
PIKDQLGSSF YSHLPELHIF QIKGEIGNQL EKSTNDAPSV STFQRISCRP
210 220 230 240 250
QTQISNNYGN NPLNSSLLPQ KQEVHMREKS FQCNKSGKAF NCSSLLRKHQ
260 270 280 290 300
IPHLGDKQYK CDVCGKLFNH EQYLACHDRC HTVEKPYKCK ECGKTFSQES
310 320 330 340 350
SLTCHRRLHT GVKRYNCNEC GKIFGQNSAL LIDKAIDTGE NPYKCNECDK
360 370 380 390 400
AFNQQSQLSH HRIHTGEKPY KCEECDKVFS RKSTIETHKR IHTGEKPYRC
410 420 430 440 450
KVCDTAFTWH SQLARHRRIH TAKKTYKCNE CGKTFSHKSS LVCHHRLHGG
460 470 480 490 500
EKSYKCKVCD KAFVWSSQLA KHTRIDCGEK PYKCNECGKT FGQNSDLLIH
510 520 530 540 550
KSIHTGEQPY KCDECEKVFS RKSSLETHKI GHTGEKPYKC KVCDKAFACH
560 570 580 590 600
SYLAKHTRIH SGEKPYKCNE CSKTFSHRSY LVCHHRVHSG EKPYKCNECS
610 620 630 640 650
KTFSRRSSLH CHRRLHSGEK PYKCNECGNT FRHCSSLIYH RRLHTGEKSY
660 670 680 690 700
KCTICDKAFV RNSLLSRHTR IHTAEKPYKC NECGKAFNQQ SHLSRHHRIH

TGEKP
Length:705
Mass (Da):81,449
Last modified:November 24, 2009 - v2
Checksum:iF11342304C5C0CA8
GO
Isoform 2 (identifier: Q8N823-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-69: Missing.

Show »
Length:636
Mass (Da):73,480
Checksum:i8023F8699568E636
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti123 – 1231N → D in BAC05052 (PubMed:14702039).Curated
Sequence conflicti379 – 3791F → S in BAC05052 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti234 – 2341N → I.
Corresponds to variant rs3884051 [ dbSNP | Ensembl ].
VAR_060429
Natural varianti252 – 2521P → I Requires 2 nucleotide substitutions. 2 Publications
Corresponds to variant rs34846371 [ dbSNP | Ensembl ].
VAR_060722
Natural varianti252 – 2521P → L.
Corresponds to variant rs4085566 [ dbSNP | Ensembl ].
VAR_052876
Natural varianti252 – 2521P → T.
Corresponds to variant rs4085565 [ dbSNP | Ensembl ].
VAR_059927
Natural varianti340 – 3401E → G.
Corresponds to variant rs4087790 [ dbSNP | Ensembl ].
VAR_052877

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6969Missing in isoform 2. 2 PublicationsVSP_038425Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091389 mRNA. Translation: BAG52347.1.
AK097434 mRNA. Translation: BAC05052.1.
AC022150 Genomic DNA. No translation available.
CH471135 Genomic DNA. Translation: EAW72093.1.
BC136343 mRNA. Translation: AAI36344.1.
AL834123 mRNA. Translation: CAH10596.1.
CCDSiCCDS12855.1. [Q8N823-1]
CCDS54312.1. [Q8N823-2]
RefSeqiNP_001154971.1. NM_001161499.1. [Q8N823-1]
NP_001154972.1. NM_001161500.1. [Q8N823-1]
NP_001154973.1. NM_001161501.1. [Q8N823-2]
NP_112234.3. NM_030972.3. [Q8N823-1]
XP_011525654.1. XM_011527352.1. [Q8N823-2]
UniGeneiHs.143951.

Genome annotation databases

EnsembliENST00000319783; ENSP00000322427; ENSG00000213020. [Q8N823-1]
ENST00000453741; ENSP00000443505; ENSG00000213020. [Q8N823-2]
ENST00000540744; ENSP00000439211; ENSG00000213020. [Q8N823-1]
ENST00000543227; ENSP00000437616; ENSG00000213020. [Q8N823-1]
ENST00000595798; ENSP00000469376; ENSG00000213020. [Q8N823-2]
ENST00000602162; ENSP00000472648; ENSG00000213020. [Q8N823-2]
GeneIDi81856.
KEGGihsa:81856.
UCSCiuc002pzz.4. human. [Q8N823-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091389 mRNA. Translation: BAG52347.1.
AK097434 mRNA. Translation: BAC05052.1.
AC022150 Genomic DNA. No translation available.
CH471135 Genomic DNA. Translation: EAW72093.1.
BC136343 mRNA. Translation: AAI36344.1.
AL834123 mRNA. Translation: CAH10596.1.
CCDSiCCDS12855.1. [Q8N823-1]
CCDS54312.1. [Q8N823-2]
RefSeqiNP_001154971.1. NM_001161499.1. [Q8N823-1]
NP_001154972.1. NM_001161500.1. [Q8N823-1]
NP_001154973.1. NM_001161501.1. [Q8N823-2]
NP_112234.3. NM_030972.3. [Q8N823-1]
XP_011525654.1. XM_011527352.1. [Q8N823-2]
UniGeneiHs.143951.

3D structure databases

ProteinModelPortaliQ8N823.
SMRiQ8N823. Positions 229-705.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000322427.

PTM databases

iPTMnetiQ8N823.
PhosphoSiteiQ8N823.

Polymorphism and mutation databases

BioMutaiZNF611.
DMDMi269849530.

Proteomic databases

PaxDbiQ8N823.
PRIDEiQ8N823.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000319783; ENSP00000322427; ENSG00000213020. [Q8N823-1]
ENST00000453741; ENSP00000443505; ENSG00000213020. [Q8N823-2]
ENST00000540744; ENSP00000439211; ENSG00000213020. [Q8N823-1]
ENST00000543227; ENSP00000437616; ENSG00000213020. [Q8N823-1]
ENST00000595798; ENSP00000469376; ENSG00000213020. [Q8N823-2]
ENST00000602162; ENSP00000472648; ENSG00000213020. [Q8N823-2]
GeneIDi81856.
KEGGihsa:81856.
UCSCiuc002pzz.4. human. [Q8N823-1]

Organism-specific databases

CTDi81856.
GeneCardsiZNF611.
HGNCiHGNC:28766. ZNF611.
neXtProtiNX_Q8N823.
PharmGKBiPA134988282.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00690000102079.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8N823.
KOiK09228.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ8N823.
TreeFamiTF341892.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF611. human.
GenomeRNAii81856.
PROiQ8N823.

Gene expression databases

BgeeiQ8N823.
CleanExiHS_ZNF611.
ExpressionAtlasiQ8N823. baseline and differential.
GenevisibleiQ8N823. HS.

Family and domain databases

Gene3Di3.30.160.60. 17 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 15 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 17 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT ILE-252.
    Tissue: Testis.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 108-705, VARIANT ILE-252.
    Tissue: Amygdala.

Entry informationi

Entry nameiZN611_HUMAN
AccessioniPrimary (citable) accession number: Q8N823
Secondary accession number(s): B3KRD5, Q69YG9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: November 24, 2009
Last modified: June 8, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.