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Protein

Zinc finger protein 611

Gene

ZNF611

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri231 – 253C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri259 – 281C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri287 – 309C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri315 – 337C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri343 – 364C2H2-type 5PROSITE-ProRule annotationAdd BLAST22
Zinc fingeri370 – 392C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri398 – 420C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri426 – 448C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri454 – 476C2H2-type 9; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri482 – 504C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri510 – 532C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri538 – 560C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri566 – 588C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri594 – 616C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri622 – 644C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri650 – 672C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri678 – 700C2H2-type 17PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 611
Gene namesi
Name:ZNF611
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000213020.8.
HGNCiHGNC:28766. ZNF611.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000213020.
PharmGKBiPA134988282.

Polymorphism and mutation databases

BioMutaiZNF611.
DMDMi269849530.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002345961 – 705Zinc finger protein 611Add BLAST705

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki173Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki221Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ8N823.
MaxQBiQ8N823.
PaxDbiQ8N823.
PeptideAtlasiQ8N823.
PRIDEiQ8N823.

PTM databases

iPTMnetiQ8N823.
PhosphoSitePlusiQ8N823.

Expressioni

Gene expression databases

BgeeiENSG00000213020.
CleanExiHS_ZNF611.
ExpressionAtlasiQ8N823. baseline and differential.
GenevisibleiQ8N823. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000322427.

Structurei

3D structure databases

ProteinModelPortaliQ8N823.
SMRiQ8N823.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 97KRABPROSITE-ProRule annotationAdd BLAST74

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri231 – 253C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri259 – 281C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri287 – 309C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri315 – 337C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri343 – 364C2H2-type 5PROSITE-ProRule annotationAdd BLAST22
Zinc fingeri370 – 392C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri398 – 420C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri426 – 448C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri454 – 476C2H2-type 9; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri482 – 504C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri510 – 532C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri538 – 560C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri566 – 588C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri594 – 616C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri622 – 644C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri650 – 672C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri678 – 700C2H2-type 17PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00690000102079.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8N823.
KOiK09228.
OMAiSCRPQTQ.
OrthoDBiEOG091G02KC.
PhylomeDBiQ8N823.
TreeFamiTF341892.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR001909. KRAB.
IPR013087. Znf_C2H2_type.
IPR013083. Znf_RING/FYVE/PHD.
PfamiView protein in Pfam
PF01352. KRAB. 1 hit.
SMARTiView protein in SMART
SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 15 hits.
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF57667. SSF57667. 9 hits.
PROSITEiView protein in PROSITE
PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 17 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N823-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLREEAAQKR KGKEPGMALP QGRLTFRDVA IEFSLAEWKC LNPSQRALYR
60 70 80 90 100
EVMLENYRNL EAVDISSKCM MKEVLSTGQG NTEVIHTGTL QRHESHHIGD
110 120 130 140 150
FCFQEIEKEI HDIEFQCQED ERNGLEAPMT KIKKLTGSTD QHDHRHAGNK
160 170 180 190 200
PIKDQLGSSF YSHLPELHIF QIKGEIGNQL EKSTNDAPSV STFQRISCRP
210 220 230 240 250
QTQISNNYGN NPLNSSLLPQ KQEVHMREKS FQCNKSGKAF NCSSLLRKHQ
260 270 280 290 300
IPHLGDKQYK CDVCGKLFNH EQYLACHDRC HTVEKPYKCK ECGKTFSQES
310 320 330 340 350
SLTCHRRLHT GVKRYNCNEC GKIFGQNSAL LIDKAIDTGE NPYKCNECDK
360 370 380 390 400
AFNQQSQLSH HRIHTGEKPY KCEECDKVFS RKSTIETHKR IHTGEKPYRC
410 420 430 440 450
KVCDTAFTWH SQLARHRRIH TAKKTYKCNE CGKTFSHKSS LVCHHRLHGG
460 470 480 490 500
EKSYKCKVCD KAFVWSSQLA KHTRIDCGEK PYKCNECGKT FGQNSDLLIH
510 520 530 540 550
KSIHTGEQPY KCDECEKVFS RKSSLETHKI GHTGEKPYKC KVCDKAFACH
560 570 580 590 600
SYLAKHTRIH SGEKPYKCNE CSKTFSHRSY LVCHHRVHSG EKPYKCNECS
610 620 630 640 650
KTFSRRSSLH CHRRLHSGEK PYKCNECGNT FRHCSSLIYH RRLHTGEKSY
660 670 680 690 700
KCTICDKAFV RNSLLSRHTR IHTAEKPYKC NECGKAFNQQ SHLSRHHRIH

TGEKP
Length:705
Mass (Da):81,449
Last modified:November 24, 2009 - v2
Checksum:iF11342304C5C0CA8
GO
Isoform 2 (identifier: Q8N823-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-69: Missing.

Show »
Length:636
Mass (Da):73,480
Checksum:i8023F8699568E636
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti123N → D in BAC05052 (PubMed:14702039).Curated1
Sequence conflicti379F → S in BAC05052 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_060429234N → I. Corresponds to variant dbSNP:rs3884051Ensembl.1
Natural variantiVAR_060722252P → I Requires 2 nucleotide substitutions. 2 PublicationsCorresponds to variant dbSNP:rs34846371Ensembl.1
Natural variantiVAR_052876252P → L. Corresponds to variant dbSNP:rs4085566Ensembl.1
Natural variantiVAR_059927252P → T. Corresponds to variant dbSNP:rs4085565Ensembl.1
Natural variantiVAR_052877340E → G. Corresponds to variant dbSNP:rs4087790Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0384251 – 69Missing in isoform 2. 2 PublicationsAdd BLAST69

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091389 mRNA. Translation: BAG52347.1.
AK097434 mRNA. Translation: BAC05052.1.
AC022150 Genomic DNA. No translation available.
CH471135 Genomic DNA. Translation: EAW72093.1.
BC136343 mRNA. Translation: AAI36344.1.
AL834123 mRNA. Translation: CAH10596.1.
CCDSiCCDS12855.1. [Q8N823-1]
CCDS54312.1. [Q8N823-2]
RefSeqiNP_001154971.1. NM_001161499.1. [Q8N823-1]
NP_001154972.1. NM_001161500.1. [Q8N823-1]
NP_001154973.1. NM_001161501.1. [Q8N823-2]
NP_112234.3. NM_030972.3. [Q8N823-1]
UniGeneiHs.143951.

Genome annotation databases

EnsembliENST00000319783; ENSP00000322427; ENSG00000213020. [Q8N823-1]
ENST00000453741; ENSP00000443505; ENSG00000213020. [Q8N823-2]
ENST00000540744; ENSP00000439211; ENSG00000213020. [Q8N823-1]
ENST00000543227; ENSP00000437616; ENSG00000213020. [Q8N823-1]
ENST00000595798; ENSP00000469376; ENSG00000213020. [Q8N823-2]
ENST00000602162; ENSP00000472648; ENSG00000213020. [Q8N823-2]
GeneIDi81856.
KEGGihsa:81856.
UCSCiuc002pzz.4. human. [Q8N823-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN611_HUMAN
AccessioniPrimary (citable) accession number: Q8N823
Secondary accession number(s): B3KRD5, Q69YG9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: November 24, 2009
Last modified: September 27, 2017
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families