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Q8N819

- PPM1N_HUMAN

UniProt

Q8N819 - PPM1N_HUMAN

Protein

Probable protein phosphatase 1N

Gene

PPM1N

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 2 (02 Sep 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 magnesium or manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi103 – 1031Manganese 1By similarity
    Metal bindingi103 – 1031Manganese 2By similarity
    Metal bindingi104 – 1041Manganese 1; via carbonyl oxygenBy similarity
    Metal bindingi274 – 2741Manganese 2By similarity
    Metal bindingi317 – 3171Manganese 2By similarity

    GO - Molecular functioni

    1. magnesium ion binding Source: InterPro
    2. manganese ion binding Source: InterPro
    3. phosphoprotein phosphatase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable protein phosphatase 1N (EC:3.1.3.16)
    Gene namesi
    Name:PPM1N
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:26845. PPM1N.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA165394107.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 430430Probable protein phosphatase 1NPRO_0000349231Add
    BLAST

    Proteomic databases

    PaxDbiQ8N819.
    PRIDEiQ8N819.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8N819.
    BgeeiQ8N819.
    GenevestigatoriQ8N819.

    Organism-specific databases

    HPAiHPA043577.
    HPA048463.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N819.
    SMRiQ8N819. Positions 56-399.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini65 – 319255PP2C-likeAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi27 – 337Poly-Glu
    Compositional biasi219 – 2224Poly-Arg

    Sequence similaritiesi

    Belongs to the PP2C family.Curated
    Contains 1 PP2C-like domain.Curated

    Phylogenomic databases

    eggNOGiCOG0631.
    HOGENOMiHOG000233895.
    HOVERGENiHBG053647.
    OMAiHMEDAHC.
    OrthoDBiEOG7B8S62.
    PhylomeDBiQ8N819.

    Family and domain databases

    Gene3Di1.10.10.430. 1 hit.
    3.60.40.10. 1 hit.
    InterProiIPR001932. PP2C-like_dom.
    IPR012911. PP2C_C.
    IPR015655. Protein_Pase_2C.
    [Graphical view]
    PANTHERiPTHR13832. PTHR13832. 1 hit.
    PfamiPF00481. PP2C. 1 hit.
    PF07830. PP2C_C. 1 hit.
    [Graphical view]
    SMARTiSM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view]
    SUPFAMiSSF81601. SSF81601. 1 hit.
    SSF81606. SSF81606. 1 hit.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8N819-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAVLARQLQR LLWTACKKKE REKEGREEEE EEEAGRRAPE GPRSLLTAPR    50
    RAQRPHGGAE ASGGLRFGAS AAQGWRARME DAHCTWLSLP GLPPGWALFA 100
    VLDGHGGARA ARFGARHLPG HVLQELGPEP SEPEGVREAL RRAFLSADER 150
    LRSLWPRVET GGCTAVVLLV SPRFLYLAHC GDSRAVLSRA GAVAFSTEDH 200
    RPLRPRERER IHAAGGTIRR RRVEGSLAVS RALGDFTYKE APGRPPELQL 250
    VSAEPEVAAL ARQAEDEFML LASDGVWDTV SGAALAGLVA SRLRLGLAPE 300
    LLCAQLLDTC LCKGSLDNMT CILVCFPGAP RPSEEAIRRE LALDAALGCR 350
    IAELCASAQK PPSLNTVFRT LASEDIPDLP PGGGLDCKAT VIAEVYSQIC 400
    QVSEECGEKG QDGAGKSNPT HLGSALDMEA 430
    Length:430
    Mass (Da):46,170
    Last modified:September 2, 2008 - v2
    Checksum:i297363BEB0E73F22
    GO
    Isoform 2 (identifier: Q8N819-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-78: Missing.
         314-430: GSLDNMTCIL...HLGSALDMEA → VLGAWRGTFG...LISAGRWKSR

    Show »
    Length:340
    Mass (Da):37,165
    Checksum:i8F1E0C00BBE5128A
    GO
    Isoform 3 (identifier: Q8N819-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-318: Missing.

    Show »
    Length:112
    Mass (Da):11,674
    Checksum:i5B7BD06837D3E628
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 318318Missing in isoform 3. 1 PublicationVSP_035233Add
    BLAST
    Alternative sequencei1 – 7878Missing in isoform 2. 2 PublicationsVSP_035234Add
    BLAST
    Alternative sequencei314 – 430117GSLDN…LDMEA → VLGAWRGTFGAWCSRGREPR GFGEEGFDREARVKLAKEGI GLKRRAWPEVGRAKIQGRSL RDALRHGRVSGRDLRERAWS FGKGRFWVVGAGPEVLISAG RWKSR in isoform 2. 2 PublicationsVSP_035235Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC138534 Genomic DNA. No translation available.
    CH471126 Genomic DNA. Translation: EAW57360.1.
    AK097444 mRNA. Translation: BAC05056.1.
    BC028228 mRNA. Translation: AAH28228.1.
    BC062452 mRNA. Translation: AAH62452.1.
    CCDSiCCDS46115.1. [Q8N819-1]
    RefSeqiNP_001073870.1. NM_001080401.1. [Q8N819-1]
    UniGeneiHs.532872.

    Genome annotation databases

    EnsembliENST00000396735; ENSP00000379961; ENSG00000213889. [Q8N819-3]
    ENST00000396737; ENSP00000379963; ENSG00000213889. [Q8N819-3]
    ENST00000401705; ENSP00000384318; ENSG00000213889. [Q8N819-3]
    ENST00000451287; ENSP00000397050; ENSG00000213889. [Q8N819-1]
    GeneIDi147699.
    KEGGihsa:147699.
    UCSCiuc002pce.3. human. [Q8N819-1]
    uc002pcf.3. human. [Q8N819-3]

    Polymorphism databases

    DMDMi205829293.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC138534 Genomic DNA. No translation available.
    CH471126 Genomic DNA. Translation: EAW57360.1 .
    AK097444 mRNA. Translation: BAC05056.1 .
    BC028228 mRNA. Translation: AAH28228.1 .
    BC062452 mRNA. Translation: AAH62452.1 .
    CCDSi CCDS46115.1. [Q8N819-1 ]
    RefSeqi NP_001073870.1. NM_001080401.1. [Q8N819-1 ]
    UniGenei Hs.532872.

    3D structure databases

    ProteinModelPortali Q8N819.
    SMRi Q8N819. Positions 56-399.
    ModBasei Search...
    MobiDBi Search...

    Polymorphism databases

    DMDMi 205829293.

    Proteomic databases

    PaxDbi Q8N819.
    PRIDEi Q8N819.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000396735 ; ENSP00000379961 ; ENSG00000213889 . [Q8N819-3 ]
    ENST00000396737 ; ENSP00000379963 ; ENSG00000213889 . [Q8N819-3 ]
    ENST00000401705 ; ENSP00000384318 ; ENSG00000213889 . [Q8N819-3 ]
    ENST00000451287 ; ENSP00000397050 ; ENSG00000213889 . [Q8N819-1 ]
    GeneIDi 147699.
    KEGGi hsa:147699.
    UCSCi uc002pce.3. human. [Q8N819-1 ]
    uc002pcf.3. human. [Q8N819-3 ]

    Organism-specific databases

    CTDi 147699.
    GeneCardsi GC19P045992.
    HGNCi HGNC:26845. PPM1N.
    HPAi HPA043577.
    HPA048463.
    neXtProti NX_Q8N819.
    PharmGKBi PA165394107.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0631.
    HOGENOMi HOG000233895.
    HOVERGENi HBG053647.
    OMAi HMEDAHC.
    OrthoDBi EOG7B8S62.
    PhylomeDBi Q8N819.

    Miscellaneous databases

    GenomeRNAii 147699.
    NextBioi 85691.
    PROi Q8N819.

    Gene expression databases

    ArrayExpressi Q8N819.
    Bgeei Q8N819.
    Genevestigatori Q8N819.

    Family and domain databases

    Gene3Di 1.10.10.430. 1 hit.
    3.60.40.10. 1 hit.
    InterProi IPR001932. PP2C-like_dom.
    IPR012911. PP2C_C.
    IPR015655. Protein_Pase_2C.
    [Graphical view ]
    PANTHERi PTHR13832. PTHR13832. 1 hit.
    Pfami PF00481. PP2C. 1 hit.
    PF07830. PP2C_C. 1 hit.
    [Graphical view ]
    SMARTi SM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81601. SSF81601. 1 hit.
    SSF81606. SSF81606. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Testis.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
      Tissue: Brain.

    Entry informationi

    Entry nameiPPM1N_HUMAN
    AccessioniPrimary (citable) accession number: Q8N819
    Secondary accession number(s): Q6P662
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 2, 2008
    Last sequence update: September 2, 2008
    Last modified: October 1, 2014
    This is version 96 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3