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Q8N819

- PPM1N_HUMAN

UniProt

Q8N819 - PPM1N_HUMAN

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Protein

Probable protein phosphatase 1N

Gene

PPM1N

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi103 – 1031Manganese 1By similarity
Metal bindingi103 – 1031Manganese 2By similarity
Metal bindingi104 – 1041Manganese 1; via carbonyl oxygenBy similarity
Metal bindingi274 – 2741Manganese 2By similarity
Metal bindingi317 – 3171Manganese 2By similarity

GO - Molecular functioni

  1. magnesium ion binding Source: InterPro
  2. manganese ion binding Source: InterPro
  3. phosphoprotein phosphatase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable protein phosphatase 1N (EC:3.1.3.16)
Gene namesi
Name:PPM1N
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:26845. PPM1N.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165394107.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 430430Probable protein phosphatase 1NPRO_0000349231Add
BLAST

Proteomic databases

PaxDbiQ8N819.
PRIDEiQ8N819.

Expressioni

Gene expression databases

BgeeiQ8N819.
ExpressionAtlasiQ8N819. baseline and differential.
GenevestigatoriQ8N819.

Organism-specific databases

HPAiHPA043577.
HPA048463.

Structurei

3D structure databases

ProteinModelPortaliQ8N819.
SMRiQ8N819. Positions 56-399.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini65 – 319255PP2C-likeAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi27 – 337Poly-Glu
Compositional biasi219 – 2224Poly-Arg

Sequence similaritiesi

Belongs to the PP2C family.Curated
Contains 1 PP2C-like domain.Curated

Phylogenomic databases

eggNOGiCOG0631.
GeneTreeiENSGT00740000115384.
HOGENOMiHOG000233895.
HOVERGENiHBG053647.
InParanoidiQ8N819.
OMAiHMEDAHC.
OrthoDBiEOG7B8S62.
PhylomeDBiQ8N819.

Family and domain databases

Gene3Di1.10.10.430. 1 hit.
3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
IPR012911. PP2C_C.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
PF07830. PP2C_C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81601. SSF81601. 1 hit.
SSF81606. SSF81606. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8N819-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAVLARQLQR LLWTACKKKE REKEGREEEE EEEAGRRAPE GPRSLLTAPR
60 70 80 90 100
RAQRPHGGAE ASGGLRFGAS AAQGWRARME DAHCTWLSLP GLPPGWALFA
110 120 130 140 150
VLDGHGGARA ARFGARHLPG HVLQELGPEP SEPEGVREAL RRAFLSADER
160 170 180 190 200
LRSLWPRVET GGCTAVVLLV SPRFLYLAHC GDSRAVLSRA GAVAFSTEDH
210 220 230 240 250
RPLRPRERER IHAAGGTIRR RRVEGSLAVS RALGDFTYKE APGRPPELQL
260 270 280 290 300
VSAEPEVAAL ARQAEDEFML LASDGVWDTV SGAALAGLVA SRLRLGLAPE
310 320 330 340 350
LLCAQLLDTC LCKGSLDNMT CILVCFPGAP RPSEEAIRRE LALDAALGCR
360 370 380 390 400
IAELCASAQK PPSLNTVFRT LASEDIPDLP PGGGLDCKAT VIAEVYSQIC
410 420 430
QVSEECGEKG QDGAGKSNPT HLGSALDMEA
Length:430
Mass (Da):46,170
Last modified:September 2, 2008 - v2
Checksum:i297363BEB0E73F22
GO
Isoform 2 (identifier: Q8N819-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-78: Missing.
     314-430: GSLDNMTCIL...HLGSALDMEA → VLGAWRGTFG...LISAGRWKSR

Show »
Length:340
Mass (Da):37,165
Checksum:i8F1E0C00BBE5128A
GO
Isoform 3 (identifier: Q8N819-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-318: Missing.

Show »
Length:112
Mass (Da):11,674
Checksum:i5B7BD06837D3E628
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 318318Missing in isoform 3. 1 PublicationVSP_035233Add
BLAST
Alternative sequencei1 – 7878Missing in isoform 2. 2 PublicationsVSP_035234Add
BLAST
Alternative sequencei314 – 430117GSLDN…LDMEA → VLGAWRGTFGAWCSRGREPR GFGEEGFDREARVKLAKEGI GLKRRAWPEVGRAKIQGRSL RDALRHGRVSGRDLRERAWS FGKGRFWVVGAGPEVLISAG RWKSR in isoform 2. 2 PublicationsVSP_035235Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC138534 Genomic DNA. No translation available.
CH471126 Genomic DNA. Translation: EAW57360.1.
AK097444 mRNA. Translation: BAC05056.1.
BC028228 mRNA. Translation: AAH28228.1.
BC062452 mRNA. Translation: AAH62452.1.
CCDSiCCDS46115.1. [Q8N819-1]
RefSeqiNP_001073870.1. NM_001080401.1. [Q8N819-1]
UniGeneiHs.532872.

Genome annotation databases

EnsembliENST00000396735; ENSP00000379961; ENSG00000213889. [Q8N819-3]
ENST00000396737; ENSP00000379963; ENSG00000213889. [Q8N819-3]
ENST00000401705; ENSP00000384318; ENSG00000213889. [Q8N819-3]
ENST00000451287; ENSP00000397050; ENSG00000213889. [Q8N819-1]
GeneIDi147699.
KEGGihsa:147699.
UCSCiuc002pce.3. human. [Q8N819-1]
uc002pcf.3. human. [Q8N819-3]

Polymorphism databases

DMDMi205829293.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC138534 Genomic DNA. No translation available.
CH471126 Genomic DNA. Translation: EAW57360.1 .
AK097444 mRNA. Translation: BAC05056.1 .
BC028228 mRNA. Translation: AAH28228.1 .
BC062452 mRNA. Translation: AAH62452.1 .
CCDSi CCDS46115.1. [Q8N819-1 ]
RefSeqi NP_001073870.1. NM_001080401.1. [Q8N819-1 ]
UniGenei Hs.532872.

3D structure databases

ProteinModelPortali Q8N819.
SMRi Q8N819. Positions 56-399.
ModBasei Search...
MobiDBi Search...

Polymorphism databases

DMDMi 205829293.

Proteomic databases

PaxDbi Q8N819.
PRIDEi Q8N819.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000396735 ; ENSP00000379961 ; ENSG00000213889 . [Q8N819-3 ]
ENST00000396737 ; ENSP00000379963 ; ENSG00000213889 . [Q8N819-3 ]
ENST00000401705 ; ENSP00000384318 ; ENSG00000213889 . [Q8N819-3 ]
ENST00000451287 ; ENSP00000397050 ; ENSG00000213889 . [Q8N819-1 ]
GeneIDi 147699.
KEGGi hsa:147699.
UCSCi uc002pce.3. human. [Q8N819-1 ]
uc002pcf.3. human. [Q8N819-3 ]

Organism-specific databases

CTDi 147699.
GeneCardsi GC19P045992.
HGNCi HGNC:26845. PPM1N.
HPAi HPA043577.
HPA048463.
neXtProti NX_Q8N819.
PharmGKBi PA165394107.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0631.
GeneTreei ENSGT00740000115384.
HOGENOMi HOG000233895.
HOVERGENi HBG053647.
InParanoidi Q8N819.
OMAi HMEDAHC.
OrthoDBi EOG7B8S62.
PhylomeDBi Q8N819.

Miscellaneous databases

GenomeRNAii 147699.
NextBioi 85691.
PROi Q8N819.

Gene expression databases

Bgeei Q8N819.
ExpressionAtlasi Q8N819. baseline and differential.
Genevestigatori Q8N819.

Family and domain databases

Gene3Di 1.10.10.430. 1 hit.
3.60.40.10. 1 hit.
InterProi IPR001932. PP2C-like_dom.
IPR012911. PP2C_C.
IPR015655. Protein_Pase_2C.
[Graphical view ]
PANTHERi PTHR13832. PTHR13832. 1 hit.
Pfami PF00481. PP2C. 1 hit.
PF07830. PP2C_C. 1 hit.
[Graphical view ]
SMARTi SM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view ]
SUPFAMi SSF81601. SSF81601. 1 hit.
SSF81606. SSF81606. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Brain.

Entry informationi

Entry nameiPPM1N_HUMAN
AccessioniPrimary (citable) accession number: Q8N819
Secondary accession number(s): Q6P662
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 2, 2008
Last modified: November 26, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3