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Protein

Probable protein phosphatase 1N

Gene

PPM1N

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi103 – 1031Manganese 1By similarity
Metal bindingi103 – 1031Manganese 2By similarity
Metal bindingi104 – 1041Manganese 1; via carbonyl oxygenBy similarity
Metal bindingi274 – 2741Manganese 2By similarity
Metal bindingi317 – 3171Manganese 2By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable protein phosphatase 1N (EC:3.1.3.16)
Gene namesi
Name:PPM1N
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:26845. PPM1N.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165394107.

Polymorphism and mutation databases

BioMutaiPPM1N.
DMDMi205829293.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 430430Probable protein phosphatase 1NPRO_0000349231Add
BLAST

Proteomic databases

PaxDbiQ8N819.
PRIDEiQ8N819.

PTM databases

DEPODiQ8N819.

Expressioni

Gene expression databases

BgeeiQ8N819.
ExpressionAtlasiQ8N819. baseline and differential.
GenevisibleiQ8N819. HS.

Organism-specific databases

HPAiHPA043577.
HPA048463.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000397050.

Structurei

3D structure databases

ProteinModelPortaliQ8N819.
SMRiQ8N819. Positions 56-399.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini66 – 326261PPM-type phosphatasePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi27 – 337Poly-Glu
Compositional biasi219 – 2224Poly-Arg

Sequence similaritiesi

Belongs to the PP2C family.Curated
Contains 1 PPM-type phosphatase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0631.
GeneTreeiENSGT00740000115384.
HOGENOMiHOG000233895.
HOVERGENiHBG053647.
InParanoidiQ8N819.
OMAiERARIQN.
OrthoDBiEOG7B8S62.
PhylomeDBiQ8N819.

Family and domain databases

Gene3Di1.10.10.430. 1 hit.
3.60.40.10. 1 hit.
InterProiIPR015655. PP2C.
IPR012911. PP2C_C.
IPR001932. PPM-type_phosphatase_dom.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
PF07830. PP2C_C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81601. SSF81601. 1 hit.
SSF81606. SSF81606. 1 hit.
PROSITEiPS51746. PPM_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N819-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAVLARQLQR LLWTACKKKE REKEGREEEE EEEAGRRAPE GPRSLLTAPR
60 70 80 90 100
RAQRPHGGAE ASGGLRFGAS AAQGWRARME DAHCTWLSLP GLPPGWALFA
110 120 130 140 150
VLDGHGGARA ARFGARHLPG HVLQELGPEP SEPEGVREAL RRAFLSADER
160 170 180 190 200
LRSLWPRVET GGCTAVVLLV SPRFLYLAHC GDSRAVLSRA GAVAFSTEDH
210 220 230 240 250
RPLRPRERER IHAAGGTIRR RRVEGSLAVS RALGDFTYKE APGRPPELQL
260 270 280 290 300
VSAEPEVAAL ARQAEDEFML LASDGVWDTV SGAALAGLVA SRLRLGLAPE
310 320 330 340 350
LLCAQLLDTC LCKGSLDNMT CILVCFPGAP RPSEEAIRRE LALDAALGCR
360 370 380 390 400
IAELCASAQK PPSLNTVFRT LASEDIPDLP PGGGLDCKAT VIAEVYSQIC
410 420 430
QVSEECGEKG QDGAGKSNPT HLGSALDMEA
Length:430
Mass (Da):46,170
Last modified:September 2, 2008 - v2
Checksum:i297363BEB0E73F22
GO
Isoform 2 (identifier: Q8N819-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-78: Missing.
     314-430: GSLDNMTCIL...HLGSALDMEA → VLGAWRGTFG...LISAGRWKSR

Show »
Length:340
Mass (Da):37,165
Checksum:i8F1E0C00BBE5128A
GO
Isoform 3 (identifier: Q8N819-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-318: Missing.

Show »
Length:112
Mass (Da):11,674
Checksum:i5B7BD06837D3E628
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 318318Missing in isoform 3. 1 PublicationVSP_035233Add
BLAST
Alternative sequencei1 – 7878Missing in isoform 2. 2 PublicationsVSP_035234Add
BLAST
Alternative sequencei314 – 430117GSLDN…LDMEA → VLGAWRGTFGAWCSRGREPR GFGEEGFDREARVKLAKEGI GLKRRAWPEVGRAKIQGRSL RDALRHGRVSGRDLRERAWS FGKGRFWVVGAGPEVLISAG RWKSR in isoform 2. 2 PublicationsVSP_035235Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC138534 Genomic DNA. No translation available.
CH471126 Genomic DNA. Translation: EAW57360.1.
AK097444 mRNA. Translation: BAC05056.1.
BC028228 mRNA. Translation: AAH28228.1.
BC062452 mRNA. Translation: AAH62452.1.
CCDSiCCDS46115.1. [Q8N819-1]
RefSeqiNP_001073870.1. NM_001080401.1. [Q8N819-1]
UniGeneiHs.532872.

Genome annotation databases

EnsembliENST00000396735; ENSP00000379961; ENSG00000213889. [Q8N819-3]
ENST00000396737; ENSP00000379963; ENSG00000213889. [Q8N819-3]
ENST00000401705; ENSP00000384318; ENSG00000213889. [Q8N819-3]
ENST00000451287; ENSP00000397050; ENSG00000213889. [Q8N819-1]
GeneIDi147699.
KEGGihsa:147699.
UCSCiuc002pce.3. human. [Q8N819-1]
uc002pcf.3. human. [Q8N819-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC138534 Genomic DNA. No translation available.
CH471126 Genomic DNA. Translation: EAW57360.1.
AK097444 mRNA. Translation: BAC05056.1.
BC028228 mRNA. Translation: AAH28228.1.
BC062452 mRNA. Translation: AAH62452.1.
CCDSiCCDS46115.1. [Q8N819-1]
RefSeqiNP_001073870.1. NM_001080401.1. [Q8N819-1]
UniGeneiHs.532872.

3D structure databases

ProteinModelPortaliQ8N819.
SMRiQ8N819. Positions 56-399.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000397050.

PTM databases

DEPODiQ8N819.

Polymorphism and mutation databases

BioMutaiPPM1N.
DMDMi205829293.

Proteomic databases

PaxDbiQ8N819.
PRIDEiQ8N819.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000396735; ENSP00000379961; ENSG00000213889. [Q8N819-3]
ENST00000396737; ENSP00000379963; ENSG00000213889. [Q8N819-3]
ENST00000401705; ENSP00000384318; ENSG00000213889. [Q8N819-3]
ENST00000451287; ENSP00000397050; ENSG00000213889. [Q8N819-1]
GeneIDi147699.
KEGGihsa:147699.
UCSCiuc002pce.3. human. [Q8N819-1]
uc002pcf.3. human. [Q8N819-3]

Organism-specific databases

CTDi147699.
GeneCardsiGC19P045992.
HGNCiHGNC:26845. PPM1N.
HPAiHPA043577.
HPA048463.
neXtProtiNX_Q8N819.
PharmGKBiPA165394107.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0631.
GeneTreeiENSGT00740000115384.
HOGENOMiHOG000233895.
HOVERGENiHBG053647.
InParanoidiQ8N819.
OMAiERARIQN.
OrthoDBiEOG7B8S62.
PhylomeDBiQ8N819.

Miscellaneous databases

GenomeRNAii147699.
NextBioi85691.
PROiQ8N819.

Gene expression databases

BgeeiQ8N819.
ExpressionAtlasiQ8N819. baseline and differential.
GenevisibleiQ8N819. HS.

Family and domain databases

Gene3Di1.10.10.430. 1 hit.
3.60.40.10. 1 hit.
InterProiIPR015655. PP2C.
IPR012911. PP2C_C.
IPR001932. PPM-type_phosphatase_dom.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
PF07830. PP2C_C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81601. SSF81601. 1 hit.
SSF81606. SSF81606. 1 hit.
PROSITEiPS51746. PPM_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Brain.

Entry informationi

Entry nameiPPM1N_HUMAN
AccessioniPrimary (citable) accession number: Q8N819
Secondary accession number(s): Q6P662
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 2, 2008
Last modified: June 24, 2015
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.