Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cyclin N-terminal domain-containing protein 1

Gene

CNTD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ8N815.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin N-terminal domain-containing protein 1
Gene namesi
Name:CNTD1
Synonyms:CNTD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:26847. CNTD1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672089.

Polymorphism and mutation databases

BioMutaiCNTD1.
DMDMi166216083.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 330330Cyclin N-terminal domain-containing protein 1PRO_0000313715Add
BLAST

Proteomic databases

PaxDbiQ8N815.
PeptideAtlasiQ8N815.
PRIDEiQ8N815.

Expressioni

Gene expression databases

BgeeiENSG00000176563.
CleanExiHS_CNTD1.
ExpressionAtlasiQ8N815. baseline and differential.
GenevisibleiQ8N815. HS.

Organism-specific databases

HPAiHPA023324.

Interactioni

Protein-protein interaction databases

BioGridi125891. 1 interaction.
STRINGi9606.ENSP00000465204.

Structurei

3D structure databases

ProteinModelPortaliQ8N815.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 178152Cyclin N-terminalAdd
BLAST

Sequence similaritiesi

Contains 1 cyclin N-terminal domain.Curated

Phylogenomic databases

eggNOGiENOG410IE73. Eukaryota.
ENOG4111VV0. LUCA.
GeneTreeiENSGT00440000033966.
HOGENOMiHOG000111847.
HOVERGENiHBG103696.
InParanoidiQ8N815.
OMAiMDGPMRP.
OrthoDBiEOG091G0SDV.
PhylomeDBiQ8N815.

Family and domain databases

Gene3Di1.10.472.10. 1 hit.
InterProiIPR013763. Cyclin-like.
IPR006671. Cyclin_N.
[Graphical view]
PfamiPF00134. Cyclin_N. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N815-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDGPMRPRSA SLVDFQFGVV ATETIEDALL HLAQQNEQAV REASGRLGRF
60 70 80 90 100
REPQIVEFVF LLSEQWCLEK SVSYQAVEIL ERFMVKQAEN ICRQATIQPR
110 120 130 140 150
DNKRESQNWR ALKQQLVNKF TLRLVSCVQL ASKLSFRNKI ISNITVLNFL
160 170 180 190 200
QALGYLHTKE ELLESELDVL KSLNFRINLP TPLAYVETLL EVLGYNGCLV
210 220 230 240 250
PAMRLHATCL TLLDLVYLLH EPIYESLLRA SIENSTPSQL QGEKFTSVKE
260 270 280 290 300
DFMLLAVGII AASAFIQNHE CWSQVVGHLQ SITGIALASI AEFSYAILTH
310 320 330
GVGANTPGRQ QSIPPHLAAR ALKTVASSNT
Length:330
Mass (Da):36,921
Last modified:January 15, 2008 - v2
Checksum:i6A08ED50392706ED
GO
Isoform 2 (identifier: Q8N815-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-202: Missing.

Note: No experimental confirmation available.
Show »
Length:128
Mass (Da):13,813
Checksum:i41B012C89E267EFD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti4 – 41P → S in BAC05060 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti145 – 1451T → P.
Corresponds to variant rs12947820 [ dbSNP | Ensembl ].
VAR_037708

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 202202Missing in isoform 2. 1 PublicationVSP_030111Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097456 mRNA. Translation: BAC05060.1.
AL833052 mRNA. Translation: CAH56287.1.
CH471152 Genomic DNA. Translation: EAW60886.1.
BC026187 mRNA. Translation: AAH26187.1.
CCDSiCCDS11440.1. [Q8N815-1]
RefSeqiNP_775749.2. NM_173478.2. [Q8N815-1]
UniGeneiHs.12272.

Genome annotation databases

EnsembliENST00000588408; ENSP00000465204; ENSG00000176563. [Q8N815-1]
GeneIDi124817.
KEGGihsa:124817.
UCSCiuc002ibm.5. human. [Q8N815-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097456 mRNA. Translation: BAC05060.1.
AL833052 mRNA. Translation: CAH56287.1.
CH471152 Genomic DNA. Translation: EAW60886.1.
BC026187 mRNA. Translation: AAH26187.1.
CCDSiCCDS11440.1. [Q8N815-1]
RefSeqiNP_775749.2. NM_173478.2. [Q8N815-1]
UniGeneiHs.12272.

3D structure databases

ProteinModelPortaliQ8N815.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125891. 1 interaction.
STRINGi9606.ENSP00000465204.

Polymorphism and mutation databases

BioMutaiCNTD1.
DMDMi166216083.

Proteomic databases

PaxDbiQ8N815.
PeptideAtlasiQ8N815.
PRIDEiQ8N815.

Protocols and materials databases

DNASUi124817.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000588408; ENSP00000465204; ENSG00000176563. [Q8N815-1]
GeneIDi124817.
KEGGihsa:124817.
UCSCiuc002ibm.5. human. [Q8N815-1]

Organism-specific databases

CTDi124817.
GeneCardsiCNTD1.
HGNCiHGNC:26847. CNTD1.
HPAiHPA023324.
neXtProtiNX_Q8N815.
PharmGKBiPA142672089.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE73. Eukaryota.
ENOG4111VV0. LUCA.
GeneTreeiENSGT00440000033966.
HOGENOMiHOG000111847.
HOVERGENiHBG103696.
InParanoidiQ8N815.
OMAiMDGPMRP.
OrthoDBiEOG091G0SDV.
PhylomeDBiQ8N815.

Enzyme and pathway databases

SignaLinkiQ8N815.

Miscellaneous databases

ChiTaRSiCNTD1. human.
GenomeRNAii124817.
PROiQ8N815.

Gene expression databases

BgeeiENSG00000176563.
CleanExiHS_CNTD1.
ExpressionAtlasiQ8N815. baseline and differential.
GenevisibleiQ8N815. HS.

Family and domain databases

Gene3Di1.10.472.10. 1 hit.
InterProiIPR013763. Cyclin-like.
IPR006671. Cyclin_N.
[Graphical view]
PfamiPF00134. Cyclin_N. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiCNTD1_HUMAN
AccessioniPrimary (citable) accession number: Q8N815
Secondary accession number(s): Q658Q6, Q8NEP1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: September 7, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.