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Protein

Solute carrier family 35 member G3

Gene

SLC35G3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Miscellaneous

The gene encoding this protein appears to have arisen by SVA-mediated retrotransposition of the SLC35G6 gene in the primate lineage.

Protein family/group databases

TCDBi2.A.7.28.7 the drug/metabolite transporter (dmt) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 35 member G3
Alternative name(s):
Acyl-malonyl-condensing enzyme 1
Transmembrane protein 21A
Gene namesi
Name:SLC35G3
Synonyms:AMAC1, TMEM21A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000164729.7
HGNCiHGNC:26848 SLC35G3
neXtProtiNX_Q8N808

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei37 – 57HelicalSequence analysisAdd BLAST21
Transmembranei67 – 87HelicalSequence analysisAdd BLAST21
Transmembranei105 – 125HelicalSequence analysisAdd BLAST21
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21
Transmembranei185 – 205HelicalSequence analysisAdd BLAST21
Transmembranei221 – 241HelicalSequence analysisAdd BLAST21
Transmembranei250 – 270HelicalSequence analysisAdd BLAST21
Transmembranei281 – 301HelicalSequence analysisAdd BLAST21
Transmembranei305 – 325HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134902447

Polymorphism and mutation databases

BioMutaiSLC35G3
DMDMi74729329

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002695531 – 338Solute carrier family 35 member G3Add BLAST338

Proteomic databases

PaxDbiQ8N808
PeptideAtlasiQ8N808
PRIDEiQ8N808
ProteomicsDBi72355

Expressioni

Tissue specificityi

Expressed in testis.1 Publication

Gene expression databases

BgeeiENSG00000164729
CleanExiHS_AMAC1
GenevisibleiQ8N808 HS

Structurei

3D structure databases

ProteinModelPortaliQ8N808
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini49 – 174EamA 1Add BLAST126
Domaini272 – 325EamA 2Add BLAST54

Sequence similaritiesi

Belongs to the SLC35G solute transporter family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEWA Eukaryota
ENOG410YABU LUCA
GeneTreeiENSGT00730000110996
HOGENOMiHOG000033917
HOVERGENiHBG080671
InParanoidiQ8N808
OrthoDBiEOG091G070D
PhylomeDBiQ8N808
TreeFamiTF331838

Family and domain databases

InterProiView protein in InterPro
IPR000620 EamA_dom
PfamiView protein in Pfam
PF00892 EamA, 1 hit

Sequencei

Sequence statusi: Complete.

Q8N808-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGSHPYFNQ PDSTHPSPPS APPSLRWYQR CQPSDATSGL LVALLGGGLP
60 70 80 90 100
AGFVGPLSRM AYQASNLPSL ELLIWRCLFH LPIALLLKLR GDPLLGTPDI
110 120 130 140 150
RSRAFFCALL NILSIGCAYS AVQVVPAGNA ATVRKGSSTV CSAVLTLCLE
160 170 180 190 200
SQGLSGYDWC GLLGCILGLI IIVGPGLWTL QEGTTGVYTA LGYVEAFLGG
210 220 230 240 250
LALSLRLLVY RSLHFPPCLP TVAFLSGLVG LLGSVPGLFV LQAPVLPSDL
260 270 280 290 300
LSWSCVGAVG ILALVSFTCV GYAVTKAHPA LVCAVLHSEV VVALILQYYM
310 320 330
LHETVAPSDI VAAGVVLGSI AIITAQNLSC ERTGRVEE
Length:338
Mass (Da):35,381
Last modified:October 1, 2002 - v1
Checksum:i6BD0FD8D7A797A35
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097473 mRNA Translation: BAC05067.1
CH471147 Genomic DNA Translation: EAW80161.1
BC136422 mRNA Translation: AAI36423.1
BC140700 mRNA Translation: AAI40701.1
CCDSiCCDS11293.1
RefSeqiNP_689675.1, NM_152462.2
UniGeneiHs.514814

Genome annotation databases

EnsembliENST00000297307; ENSP00000297307; ENSG00000164729
GeneIDi146861
KEGGihsa:146861
UCSCiuc002hjd.3 human

Similar proteinsi

Entry informationi

Entry nameiS35G3_HUMAN
AccessioniPrimary (citable) accession number: Q8N808
Secondary accession number(s): B9EGE9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: October 1, 2002
Last modified: June 20, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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