Reviewed, UniProtKB/Swiss-Prot Q8N808 (AMAC1_HUMAN)

Names and origin

Protein names

Recommended name:
    Protein AMAC1
Alternative name(s):
    Acyl-malonyl-condensing enzyme 1
    Transmembrane protein 21A

Gene names

Name:	AMAC1
Synonyms:	TMEM21A

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	338 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Tissue specificity	Expressed in testis. Ref.2
Miscellaneous	The gene encoding this protein appears to have arisen by SVA-mediated retrotransposition of the AMAC1L3 gene in the primate lineage.
Sequence similarities	Contains 2 DUF6 domains.

Ontologies

Keywords
Cellular component	Membrane
Domain	Repeat Transmembrane
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 338	338	Protein AMAC1		PRO_0000269553
Regions
	Transmembrane	37 – 57	21	Potential
	Transmembrane	67 – 87	21	Potential
	Transmembrane	105 – 125	21	Potential
	Transmembrane	160 – 180	21	Potential
	Transmembrane	185 – 205	21	Potential
	Transmembrane	221 – 241	21	Potential
	Transmembrane	250 – 270	21	Potential
	Transmembrane	281 – 301	21	Potential
	Transmembrane	305 – 325	21	Potential
	Domain	49 – 174	126	DUF6 1
	Domain	272 – 325	54	DUF6 2

Sequences

	Sequence		Length	Mass (Da)
	Q8N808-1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 6BD0FD8D7A797A35	FASTA	338	35,381
	10 20 30 40 50 60 MAGSHPYFNQ PDSTHPSPPS APPSLRWYQR CQPSDATSGL LVALLGGGLP AGFVGPLSRM 70 80 90 100 110 120 AYQASNLPSL ELLIWRCLFH LPIALLLKLR GDPLLGTPDI RSRAFFCALL NILSIGCAYS 130 140 150 160 170 180 AVQVVPAGNA ATVRKGSSTV CSAVLTLCLE SQGLSGYDWC GLLGCILGLI IIVGPGLWTL 190 200 210 220 230 240 QEGTTGVYTA LGYVEAFLGG LALSLRLLVY RSLHFPPCLP TVAFLSGLVG LLGSVPGLFV 250 260 270 280 290 300 LQAPVLPSDL LSWSCVGAVG ILALVSFTCV GYAVTKAHPA LVCAVLHSEV VVALILQYYM 310 320 330 LHETVAPSDI VAAGVVLGSI AIITAQNLSC ERTGRVEE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[2]	"Emergence of primate genes by retrotransposon-mediated sequence transduction." Xing J., Wang H., Belancio V.P., Cordaux R., Deininger P.L., Batzer M.A. Proc. Natl. Acad. Sci. U.S.A. 103:17608-17613(2006) [PubMed: 17101974] [Abstract] Cited for: TISSUE SPECIFICITY, GENE EVOLUTION.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK097473 mRNA. Translation: BAC05067.1.
IPI	IPI00167273.
RefSeq	NP_689675.1.
UniGene	Hs.514814
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q8N808.
Proteomic databases
PRIDE	Q8N808.
Genome annotation databases
Ensembl	ENST00000297307; ENSP00000297307; ENSG00000164729; Homo sapiens. [Genome view]
GeneID	146861.
KEGG	hsa:146861.
UCSC	uc002hjd.1. human.
Organism-specific databases
CTD	146861.
GeneCards	GC17M030544.
HGNC	HGNC:26848. AMAC1.
PharmGKB	PA134902447.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG505905.
HOVERGEN	Q8N808.
InParanoid	Q8N808.
OrthoDB	EOG9KPWWP.
Gene expression databases
ArrayExpress	Q8N808.
Bgee	Q8N808.
CleanEx	HS_AMAC1.
Genevestigator	Q8N808.
Family and domain databases
InterPro	IPR000620. DUF6_TM. [Graphical view]
Pfam	PF00892. DUF6. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	85491.

Entry information

Entry name

AMAC1_HUMAN

Accession

Primary (citable) accession number: Q8N808

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	October 1, 2002
Last modified:	December 15, 2009
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.