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Protein

Protein disulfide-isomerase-like protein of the testis

Gene

PDILT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable redox-inactive chaperone involved in spermatogenesis.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone, Developmental protein, Isomerase
Biological processDifferentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein disulfide-isomerase-like protein of the testis
Gene namesi
Name:PDILT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000169340.9
HGNCiHGNC:27338 PDILT
neXtProtiNX_Q8N807

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi135C → A: Does not affect homodimerization; when associated with A-420. 1 Publication1
Mutagenesisi420C → A: Does not affect homodimerization; when associated with A-135. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000169340
PharmGKBiPA164724442

Polymorphism and mutation databases

BioMutaiPDILT
DMDMi172045780

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000032584921 – 584Protein disulfide-isomerase-like protein of the testisAdd BLAST564

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi58N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi128N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi160N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi340N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi540N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8N807
PeptideAtlasiQ8N807
PRIDEiQ8N807

PTM databases

iPTMnetiQ8N807
PhosphoSitePlusiQ8N807

Expressioni

Tissue specificityi

Testis-specific.2 Publications

Gene expression databases

BgeeiENSG00000169340
ExpressionAtlasiQ8N807 baseline and differential
GenevisibleiQ8N807 HS

Organism-specific databases

HPAiHPA041913

Interactioni

Subunit structurei

Homodimer. The homodimer is not disulfide-linked. Interacts with ERO1A and CLGN.2 Publications

Protein-protein interaction databases

BioGridi1284864 interactors.
STRINGi9606.ENSP00000305465

Structurei

Secondary structure

1584
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi45 – 47Combined sources3
Helixi50 – 59Combined sources10
Beta strandi61 – 68Combined sources8
Helixi73 – 89Combined sources17
Beta strandi96 – 102Combined sources7
Turni103 – 105Combined sources3
Helixi107 – 112Combined sources6
Beta strandi120 – 125Combined sources6
Helixi141 – 153Combined sources13
Beta strandi156 – 161Combined sources6
Helixi162 – 171Combined sources10
Beta strandi172 – 181Combined sources10
Helixi186 – 194Combined sources9
Helixi195 – 197Combined sources3
Beta strandi203 – 207Combined sources5
Beta strandi219 – 226Combined sources8
Beta strandi229 – 235Combined sources7
Turni239 – 241Combined sources3
Helixi242 – 251Combined sources10
Beta strandi258 – 260Combined sources3
Helixi263 – 265Combined sources3
Helixi267 – 270Combined sources4
Beta strandi275 – 282Combined sources8
Helixi289 – 300Combined sources12
Helixi301 – 303Combined sources3
Turni304 – 306Combined sources3
Beta strandi308 – 313Combined sources6
Helixi317 – 319Combined sources3
Helixi320 – 325Combined sources6
Helixi330 – 332Combined sources3
Beta strandi334 – 340Combined sources7
Turni341 – 343Combined sources3
Beta strandi346 – 348Combined sources3
Helixi356 – 367Combined sources12
Helixi370 – 374Combined sources5
Helixi383 – 385Combined sources3
Beta strandi388 – 392Combined sources5
Helixi394 – 401Combined sources8
Beta strandi407 – 413Combined sources7
Helixi418 – 421Combined sources4
Helixi424 – 433Combined sources10
Turni434 – 436Combined sources3
Beta strandi438 – 450Combined sources13
Helixi454 – 456Combined sources3
Beta strandi459 – 466Combined sources8
Turni468 – 470Combined sources3
Helixi482 – 493Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4NWYX-ray2.00A/B/C/D258-386[»]
5XF7X-ray2.38A21-584[»]
ProteinModelPortaliQ8N807
SMRiQ8N807
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini388 – 451ThioredoxinPROSITE-ProRule annotationAdd BLAST64

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi581 – 584Prevents secretion from ERPROSITE-ProRule annotation4

Domaini

The thioredoxin domain lacks the conserved redox-active Cys at position 417 which is replaced by a Ser residue, suggesting that it lacks thioredoxin activity.

Sequence similaritiesi

Belongs to the protein disulfide isomerase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0191 Eukaryota
COG0526 LUCA
GeneTreeiENSGT00860000133691
HOGENOMiHOG000115479
HOVERGENiHBG108240
InParanoidiQ8N807
KOiK20354
OMAiYFRITEV
OrthoDBiEOG091G0B2I
PhylomeDBiQ8N807
TreeFamiTF106381

Family and domain databases

InterProiView protein in InterPro
IPR036249 Thioredoxin-like_sf
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF00085 Thioredoxin, 2 hits
SUPFAMiSSF52833 SSF52833, 4 hits
PROSITEiView protein in PROSITE
PS00014 ER_TARGET, 1 hit
PS51352 THIOREDOXIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8N807-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLLWMPLLL VAACVSAVHS SPEVNAGVSS IHITKPVHIL EERSLLVLTP
60 70 80 90 100
AGLTQMLNQT RFLMVLFHNP SSKQSRNLAE ELGKAVEIMG KGKNGIGFGK
110 120 130 140 150
VDITIEKELQ QEFGITKAPE LKLFFEGNRS EPISCKGVVE SAALVVWLRR
160 170 180 190 200
QISQKAFLFN SSEQVAEFVI SRPLVIVGFF QDLEEEVAEL FYDVIKDFPE
210 220 230 240 250
LTFGVITIGN VIGRFHVTLD SVLVFKKGKI VNRQKLINDS TNKQELNRVI
260 270 280 290 300
KQHLTDFVIE YNTENKDLIS ELHIMSHMLL FVSKSSESYG IIIQHYKLAS
310 320 330 340 350
KEFQNKILFI LVDADEPRNG RVFKYFRVTE VDIPSVQILN LSSDARYKMP
360 370 380 390 400
SDDITYESLK KFGRSFLSKN ATKHQSSEEI PKYWDQGLVK QLVGKNFNVV
410 420 430 440 450
VFDKEKDVFV MFYAPWSKKC KMLFPLLEEL GRKYQNHSTI IIAKIDVTAN
460 470 480 490 500
DIQLMYLDRY PFFRLFPSGS QQAVLYKGEH TLKGFSDFLE SHIKTKIEDE
510 520 530 540 550
DELLSVEQNE VIEEEVLAEE KEVPMMRKGL PEQQSPELEN MTKYVSKLEE
560 570 580
PAGKKKTSEE VVVVVAKPKG PPVQKKKPKV KEEL
Length:584
Mass (Da):66,657
Last modified:March 18, 2008 - v2
Checksum:i03F7EAD418B3494C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti561V → E in BAC05068 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03993726A → T. Corresponds to variant dbSNP:rs9926580Ensembl.1
Natural variantiVAR_039938106E → Q in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs773495613Ensembl.1
Natural variantiVAR_039939446D → N. Corresponds to variant dbSNP:rs11648131Ensembl.1
Natural variantiVAR_039940447V → I. Corresponds to variant dbSNP:rs11865916Ensembl.1
Natural variantiVAR_039941475L → R. Corresponds to variant dbSNP:rs4500734Ensembl.1
Natural variantiVAR_039942527R → K1 PublicationCorresponds to variant dbSNP:rs9652589Ensembl.1
Natural variantiVAR_039943529G → E1 PublicationCorresponds to variant dbSNP:rs9652588Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097476 mRNA Translation: BAC05068.1
CH471186 Genomic DNA Translation: EAW50316.1
BC042607 mRNA Translation: AAH42607.1
BC044936 mRNA Translation: AAH44936.1
CCDSiCCDS10584.1
RefSeqiNP_777584.1, NM_174924.1
UniGeneiHs.376025

Genome annotation databases

EnsembliENST00000302451; ENSP00000305465; ENSG00000169340
GeneIDi204474
KEGGihsa:204474
UCSCiuc002dhc.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPDILT_HUMAN
AccessioniPrimary (citable) accession number: Q8N807
Secondary accession number(s): Q8IVQ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: March 28, 2018
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome