Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Putative E3 ubiquitin-protein ligase UBR7

Gene

UBR7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity).By similarity

Pathway: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri44 – 11673UBR-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri132 – 18857PHD-type; atypicalAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative E3 ubiquitin-protein ligase UBR7 (EC:6.3.2.-)
Alternative name(s):
N-recognin-7
Gene namesi
Name:UBR7
Synonyms:C14orf130
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componentsi: Chromosome 14, Unplaced

Organism-specific databases

HGNCiHGNC:20344. UBR7.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162408298.

Polymorphism and mutation databases

BioMutaiUBR7.
DMDMi37999713.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 425425Putative E3 ubiquitin-protein ligase UBR7PRO_0000089932Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei264 – 2641Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8N806.
PaxDbiQ8N806.
PeptideAtlasiQ8N806.
PRIDEiQ8N806.

PTM databases

PhosphoSiteiQ8N806.

Expressioni

Tissue specificityi

Expressed in sperm (at protein level).1 Publication

Gene expression databases

BgeeiQ8N806.
CleanExiHS_UBR7.
ExpressionAtlasiQ8N806. baseline and differential.
GenevisibleiQ8N806. HS.

Organism-specific databases

HPAiHPA000861.

Interactioni

Protein-protein interaction databases

BioGridi120451. 33 interactions.
IntActiQ8N806. 3 interactions.
MINTiMINT-2810601.
STRINGi9606.ENSP00000013070.

Structurei

3D structure databases

ProteinModelPortaliQ8N806.
SMRiQ8N806. Positions 133-186.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 PHD-type zinc finger.Curated
Contains 1 UBR-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri44 – 11673UBR-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri132 – 18857PHD-type; atypicalAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG130848.
GeneTreeiENSGT00390000017610.
HOGENOMiHOG000246997.
HOVERGENiHBG051029.
InParanoidiQ8N806.
KOiK11979.
OMAiKMYGELD.
OrthoDBiEOG7SV0VN.
PhylomeDBiQ8N806.
TreeFamiTF105941.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR011011. Znf_FYVE_PHD.
IPR003126. Znf_N-recognin.
IPR001965. Znf_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF02207. zf-UBR. 1 hit.
[Graphical view]
SMARTiSM00249. PHD. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS51157. ZF_UBR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N806-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGAEGAAGR QSELEPVVSL VDVLEEDEEL ENEACAVLGG SDSEKCSYSQ
60 70 80 90 100
GSVKRQALYA CSTCTPEGEE PAGICLACSY ECHGSHKLFE LYTKRNFRCD
110 120 130 140 150
CGNSKFKNLE CKLLPDKAKV NSGNKYNDNF FGLYCICKRP YPDPEDEIPD
160 170 180 190 200
EMIQCVVCED WFHGRHLGAI PPESGDFQEM VCQACMKRCS FLWAYAAQLA
210 220 230 240 250
VTKISTEDDG LVRNIDGIGD QEVIKPENGE HQDSTLKEDV PEQGKDDVRE
260 270 280 290 300
VKVEQNSEPC AGSSSESDLQ TVFKNESLNA ESKSGCKLQE LKAKQLIKKD
310 320 330 340 350
TATYWPLNWR SKLCTCQDCM KMYGDLDVLF LTDEYDTVLA YENKGKIAQA
360 370 380 390 400
TDRSDPLMDT LSSMNRVQQV ELICEYNDLK TELKDYLKRF ADEGTVVKRE
410 420
DIQQFFEEFQ SKKRRRVDGM QYYCS
Length:425
Mass (Da):47,999
Last modified:October 24, 2003 - v2
Checksum:i6FFE5795E6737BE5
GO

Sequence cautioni

The sequence AAH15046.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAH51819.4 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAA91639.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti41 – 411S → G in BAC05069 (PubMed:14702039).Curated
Sequence conflicti170 – 1701I → T in BAA91639 (PubMed:14702039).Curated
Sequence conflicti179 – 1791E → K in BAC05069 (PubMed:14702039).Curated
Sequence conflicti344 – 3441K → R in BAC05069 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001345 mRNA. Translation: BAA91639.1. Different initiation.
AK097477 mRNA. Translation: BAC05069.1.
BC015046 mRNA. Translation: AAH15046.1. Different initiation.
BC051819 mRNA. Translation: AAH51819.4. Different initiation.
BX248249 mRNA. Translation: CAD62577.1.
CCDSiCCDS9909.1.
RefSeqiNP_786924.2. NM_175748.3.
UniGeneiHs.648806.

Genome annotation databases

EnsembliENST00000013070; ENSP00000013070; ENSG00000012963.
ENST00000619583; ENSP00000483908; ENSG00000278787.
GeneIDi55148.
KEGGihsa:55148.
UCSCiuc001ybm.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001345 mRNA. Translation: BAA91639.1. Different initiation.
AK097477 mRNA. Translation: BAC05069.1.
BC015046 mRNA. Translation: AAH15046.1. Different initiation.
BC051819 mRNA. Translation: AAH51819.4. Different initiation.
BX248249 mRNA. Translation: CAD62577.1.
CCDSiCCDS9909.1.
RefSeqiNP_786924.2. NM_175748.3.
UniGeneiHs.648806.

3D structure databases

ProteinModelPortaliQ8N806.
SMRiQ8N806. Positions 133-186.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120451. 33 interactions.
IntActiQ8N806. 3 interactions.
MINTiMINT-2810601.
STRINGi9606.ENSP00000013070.

PTM databases

PhosphoSiteiQ8N806.

Polymorphism and mutation databases

BioMutaiUBR7.
DMDMi37999713.

Proteomic databases

MaxQBiQ8N806.
PaxDbiQ8N806.
PeptideAtlasiQ8N806.
PRIDEiQ8N806.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000013070; ENSP00000013070; ENSG00000012963.
ENST00000619583; ENSP00000483908; ENSG00000278787.
GeneIDi55148.
KEGGihsa:55148.
UCSCiuc001ybm.4. human.

Organism-specific databases

CTDi55148.
GeneCardsiGC14P093673.
HGNCiHGNC:20344. UBR7.
HPAiHPA000861.
MIMi613816. gene.
neXtProtiNX_Q8N806.
PharmGKBiPA162408298.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG130848.
GeneTreeiENSGT00390000017610.
HOGENOMiHOG000246997.
HOVERGENiHBG051029.
InParanoidiQ8N806.
KOiK11979.
OMAiKMYGELD.
OrthoDBiEOG7SV0VN.
PhylomeDBiQ8N806.
TreeFamiTF105941.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

ChiTaRSiUBR7. human.
GenomeRNAii55148.
NextBioi58870.
PROiQ8N806.
SOURCEiSearch...

Gene expression databases

BgeeiQ8N806.
CleanExiHS_UBR7.
ExpressionAtlasiQ8N806. baseline and differential.
GenevisibleiQ8N806. HS.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR011011. Znf_FYVE_PHD.
IPR003126. Znf_N-recognin.
IPR001965. Znf_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF02207. zf-UBR. 1 hit.
[Graphical view]
SMARTiSM00249. PHD. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS51157. ZF_UBR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Teratocarcinoma and Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Leiomyosarcoma and Retinoblastoma.
  3. "Full-length cDNA libraries and normalization."
    Li W.B., Gruber C., Jessee J., Polayes D.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-425.
    Tissue: Neuroblastoma.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "Identification and characterization of RING-finger ubiquitin ligase UBR7 in mammalian spermatozoa."
    Zimmerman S.W., Yi Y.J., Sutovsky M., van Leeuwen F.W., Conant G., Sutovsky P.
    Cell Tissue Res. 356:261-278(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-264, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiUBR7_HUMAN
AccessioniPrimary (citable) accession number: Q8N806
Secondary accession number(s): Q86U21
, Q86UA9, Q96BY0, Q9NVV6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: October 24, 2003
Last modified: June 24, 2015
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.