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Q8N806 (UBR7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative E3 ubiquitin-protein ligase UBR7

EC=6.3.2.-
Alternative name(s):
N-recognin-7
Gene names
Name:UBR7
Synonyms:C14orf130
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length425 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation By similarity.

Pathway

Protein modification; protein ubiquitination.

Sequence similarities

Contains 1 PHD-type zinc finger.

Contains 1 UBR-type zinc finger.

Sequence caution

The sequence AAH15046.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAH51819.4 differs from that shown. Reason: Erroneous initiation.

The sequence BAA91639.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processUbl conjugation pathway
   DomainZinc-finger
   LigandMetal-binding
Zinc
   Molecular functionLigase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionubiquitin-protein transferase activity

Inferred from electronic annotation. Source: InterPro

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 425425Putative E3 ubiquitin-protein ligase UBR7
PRO_0000089932

Regions

Zinc finger44 – 11673UBR-type
Zinc finger132 – 18857PHD-type; atypical

Experimental info

Sequence conflict411S → G in BAC05069. Ref.1
Sequence conflict1701I → T in BAA91639. Ref.1
Sequence conflict1791E → K in BAC05069. Ref.1
Sequence conflict3441K → R in BAC05069. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8N806 [UniParc].

Last modified October 24, 2003. Version 2.
Checksum: 6FFE5795E6737BE5

FASTA42547,999
        10         20         30         40         50         60 
MAGAEGAAGR QSELEPVVSL VDVLEEDEEL ENEACAVLGG SDSEKCSYSQ GSVKRQALYA 

        70         80         90        100        110        120 
CSTCTPEGEE PAGICLACSY ECHGSHKLFE LYTKRNFRCD CGNSKFKNLE CKLLPDKAKV 

       130        140        150        160        170        180 
NSGNKYNDNF FGLYCICKRP YPDPEDEIPD EMIQCVVCED WFHGRHLGAI PPESGDFQEM 

       190        200        210        220        230        240 
VCQACMKRCS FLWAYAAQLA VTKISTEDDG LVRNIDGIGD QEVIKPENGE HQDSTLKEDV 

       250        260        270        280        290        300 
PEQGKDDVRE VKVEQNSEPC AGSSSESDLQ TVFKNESLNA ESKSGCKLQE LKAKQLIKKD 

       310        320        330        340        350        360 
TATYWPLNWR SKLCTCQDCM KMYGDLDVLF LTDEYDTVLA YENKGKIAQA TDRSDPLMDT 

       370        380        390        400        410        420 
LSSMNRVQQV ELICEYNDLK TELKDYLKRF ADEGTVVKRE DIQQFFEEFQ SKKRRRVDGM 


QYYCS 

« Hide

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Teratocarcinoma and Testis.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Leiomyosarcoma and Retinoblastoma.
[3]"Full-length cDNA libraries and normalization."
Li W.B., Gruber C., Jessee J., Polayes D.
Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-425.
Tissue: Neuroblastoma.
[4]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK001345 mRNA. Translation: BAA91639.1. Different initiation.
AK097477 mRNA. Translation: BAC05069.1.
BC015046 mRNA. Translation: AAH15046.1. Different initiation.
BC051819 mRNA. Translation: AAH51819.4. Different initiation.
BX248249 mRNA. Translation: CAD62577.1.
CCDSCCDS9909.1.
RefSeqNP_786924.2. NM_175748.3.
UniGeneHs.648806.

3D structure databases

ProteinModelPortalQ8N806.
SMRQ8N806. Positions 133-188.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120451. 23 interactions.
IntActQ8N806. 2 interactions.
MINTMINT-2810601.
STRING9606.ENSP00000013070.

PTM databases

PhosphoSiteQ8N806.

Polymorphism databases

DMDM37999713.

Proteomic databases

MaxQBQ8N806.
PaxDbQ8N806.
PeptideAtlasQ8N806.
PRIDEQ8N806.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000013070; ENSP00000013070; ENSG00000012963.
GeneID55148.
KEGGhsa:55148.
UCSCuc001ybm.4. human.

Organism-specific databases

CTD55148.
GeneCardsGC14P093673.
HGNCHGNC:20344. UBR7.
HPAHPA000861.
MIM613816. gene.
neXtProtNX_Q8N806.
PharmGKBPA162408298.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG130848.
HOGENOMHOG000246997.
HOVERGENHBG051029.
InParanoidQ8N806.
KOK11979.
OMAKMYGELD.
OrthoDBEOG7SV0VN.
PhylomeDBQ8N806.
TreeFamTF105941.

Enzyme and pathway databases

UniPathwayUPA00143.

Gene expression databases

ArrayExpressQ8N806.
BgeeQ8N806.
CleanExHS_UBR7.
GenevestigatorQ8N806.

Family and domain databases

Gene3D3.30.40.10. 1 hit.
InterProIPR011011. Znf_FYVE_PHD.
IPR003126. Znf_N-recognin.
IPR001965. Znf_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamPF02207. zf-UBR. 1 hit.
[Graphical view]
SMARTSM00249. PHD. 1 hit.
[Graphical view]
SUPFAMSSF57903. SSF57903. 1 hit.
PROSITEPS51157. ZF_UBR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi55148.
NextBio58870.
PROQ8N806.
SOURCESearch...

Entry information

Entry nameUBR7_HUMAN
AccessionPrimary (citable) accession number: Q8N806
Secondary accession number(s): Q86U21 expand/collapse secondary AC list , Q86UA9, Q96BY0, Q9NVV6
Entry history
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: October 24, 2003
Last modified: July 9, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM