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Q8N806

- UBR7_HUMAN

UniProt

Q8N806 - UBR7_HUMAN

Protein

Putative E3 ubiquitin-protein ligase UBR7

Gene

UBR7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 2 (24 Oct 2003)
      Previous versions | rss
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    Functioni

    E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation By similarity.By similarity

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri44 – 11673UBR-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri132 – 18857PHD-type; atypicalAdd
    BLAST

    GO - Molecular functioni

    1. ligase activity Source: UniProtKB-KW
    2. ubiquitin-protein transferase activity Source: InterPro
    3. zinc ion binding Source: InterPro

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Ubl conjugation pathway

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative E3 ubiquitin-protein ligase UBR7 (EC:6.3.2.-)
    Alternative name(s):
    N-recognin-7
    Gene namesi
    Name:UBR7
    Synonyms:C14orf130
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:20344. UBR7.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162408298.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 425425Putative E3 ubiquitin-protein ligase UBR7PRO_0000089932Add
    BLAST

    Proteomic databases

    MaxQBiQ8N806.
    PaxDbiQ8N806.
    PeptideAtlasiQ8N806.
    PRIDEiQ8N806.

    PTM databases

    PhosphoSiteiQ8N806.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8N806.
    BgeeiQ8N806.
    CleanExiHS_UBR7.
    GenevestigatoriQ8N806.

    Organism-specific databases

    HPAiHPA000861.

    Interactioni

    Protein-protein interaction databases

    BioGridi120451. 24 interactions.
    IntActiQ8N806. 2 interactions.
    MINTiMINT-2810601.
    STRINGi9606.ENSP00000013070.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N806.
    SMRiQ8N806. Positions 133-188.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 PHD-type zinc finger.Curated
    Contains 1 UBR-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri44 – 11673UBR-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri132 – 18857PHD-type; atypicalAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG130848.
    HOGENOMiHOG000246997.
    HOVERGENiHBG051029.
    InParanoidiQ8N806.
    KOiK11979.
    OMAiKMYGELD.
    OrthoDBiEOG7SV0VN.
    PhylomeDBiQ8N806.
    TreeFamiTF105941.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    InterProiIPR011011. Znf_FYVE_PHD.
    IPR003126. Znf_N-recognin.
    IPR001965. Znf_PHD.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PfamiPF02207. zf-UBR. 1 hit.
    [Graphical view]
    SMARTiSM00249. PHD. 1 hit.
    [Graphical view]
    SUPFAMiSSF57903. SSF57903. 1 hit.
    PROSITEiPS51157. ZF_UBR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8N806-1 [UniParc]FASTAAdd to Basket

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    MAGAEGAAGR QSELEPVVSL VDVLEEDEEL ENEACAVLGG SDSEKCSYSQ    50
    GSVKRQALYA CSTCTPEGEE PAGICLACSY ECHGSHKLFE LYTKRNFRCD 100
    CGNSKFKNLE CKLLPDKAKV NSGNKYNDNF FGLYCICKRP YPDPEDEIPD 150
    EMIQCVVCED WFHGRHLGAI PPESGDFQEM VCQACMKRCS FLWAYAAQLA 200
    VTKISTEDDG LVRNIDGIGD QEVIKPENGE HQDSTLKEDV PEQGKDDVRE 250
    VKVEQNSEPC AGSSSESDLQ TVFKNESLNA ESKSGCKLQE LKAKQLIKKD 300
    TATYWPLNWR SKLCTCQDCM KMYGDLDVLF LTDEYDTVLA YENKGKIAQA 350
    TDRSDPLMDT LSSMNRVQQV ELICEYNDLK TELKDYLKRF ADEGTVVKRE 400
    DIQQFFEEFQ SKKRRRVDGM QYYCS 425
    Length:425
    Mass (Da):47,999
    Last modified:October 24, 2003 - v2
    Checksum:i6FFE5795E6737BE5
    GO

    Sequence cautioni

    The sequence AAH15046.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAH51819.4 differs from that shown. Reason: Erroneous initiation.
    The sequence BAA91639.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti41 – 411S → G in BAC05069. (PubMed:14702039)Curated
    Sequence conflicti170 – 1701I → T in BAA91639. (PubMed:14702039)Curated
    Sequence conflicti179 – 1791E → K in BAC05069. (PubMed:14702039)Curated
    Sequence conflicti344 – 3441K → R in BAC05069. (PubMed:14702039)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK001345 mRNA. Translation: BAA91639.1. Different initiation.
    AK097477 mRNA. Translation: BAC05069.1.
    BC015046 mRNA. Translation: AAH15046.1. Different initiation.
    BC051819 mRNA. Translation: AAH51819.4. Different initiation.
    BX248249 mRNA. Translation: CAD62577.1.
    CCDSiCCDS9909.1.
    RefSeqiNP_786924.2. NM_175748.3.
    UniGeneiHs.648806.

    Genome annotation databases

    EnsembliENST00000013070; ENSP00000013070; ENSG00000012963.
    GeneIDi55148.
    KEGGihsa:55148.
    UCSCiuc001ybm.4. human.

    Polymorphism databases

    DMDMi37999713.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK001345 mRNA. Translation: BAA91639.1 . Different initiation.
    AK097477 mRNA. Translation: BAC05069.1 .
    BC015046 mRNA. Translation: AAH15046.1 . Different initiation.
    BC051819 mRNA. Translation: AAH51819.4 . Different initiation.
    BX248249 mRNA. Translation: CAD62577.1 .
    CCDSi CCDS9909.1.
    RefSeqi NP_786924.2. NM_175748.3.
    UniGenei Hs.648806.

    3D structure databases

    ProteinModelPortali Q8N806.
    SMRi Q8N806. Positions 133-188.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120451. 24 interactions.
    IntActi Q8N806. 2 interactions.
    MINTi MINT-2810601.
    STRINGi 9606.ENSP00000013070.

    PTM databases

    PhosphoSitei Q8N806.

    Polymorphism databases

    DMDMi 37999713.

    Proteomic databases

    MaxQBi Q8N806.
    PaxDbi Q8N806.
    PeptideAtlasi Q8N806.
    PRIDEi Q8N806.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000013070 ; ENSP00000013070 ; ENSG00000012963 .
    GeneIDi 55148.
    KEGGi hsa:55148.
    UCSCi uc001ybm.4. human.

    Organism-specific databases

    CTDi 55148.
    GeneCardsi GC14P093673.
    HGNCi HGNC:20344. UBR7.
    HPAi HPA000861.
    MIMi 613816. gene.
    neXtProti NX_Q8N806.
    PharmGKBi PA162408298.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG130848.
    HOGENOMi HOG000246997.
    HOVERGENi HBG051029.
    InParanoidi Q8N806.
    KOi K11979.
    OMAi KMYGELD.
    OrthoDBi EOG7SV0VN.
    PhylomeDBi Q8N806.
    TreeFami TF105941.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .

    Miscellaneous databases

    GenomeRNAii 55148.
    NextBioi 58870.
    PROi Q8N806.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8N806.
    Bgeei Q8N806.
    CleanExi HS_UBR7.
    Genevestigatori Q8N806.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    InterProi IPR011011. Znf_FYVE_PHD.
    IPR003126. Znf_N-recognin.
    IPR001965. Znf_PHD.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    Pfami PF02207. zf-UBR. 1 hit.
    [Graphical view ]
    SMARTi SM00249. PHD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57903. SSF57903. 1 hit.
    PROSITEi PS51157. ZF_UBR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Teratocarcinoma and Testis.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Leiomyosarcoma and Retinoblastoma.
    3. "Full-length cDNA libraries and normalization."
      Li W.B., Gruber C., Jessee J., Polayes D.
      Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-425.
      Tissue: Neuroblastoma.
    4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiUBR7_HUMAN
    AccessioniPrimary (citable) accession number: Q8N806
    Secondary accession number(s): Q86U21
    , Q86UA9, Q96BY0, Q9NVV6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 24, 2003
    Last sequence update: October 24, 2003
    Last modified: October 1, 2014
    This is version 107 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3