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Q8N806

- UBR7_HUMAN

UniProt

Q8N806 - UBR7_HUMAN

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Protein

Putative E3 ubiquitin-protein ligase UBR7

Gene

UBR7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity).By similarity

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri44 – 11673UBR-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri132 – 18857PHD-type; atypicalAdd
BLAST

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. ubiquitin-protein transferase activity Source: InterPro
  3. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative E3 ubiquitin-protein ligase UBR7 (EC:6.3.2.-)
Alternative name(s):
N-recognin-7
Gene namesi
Name:UBR7
Synonyms:C14orf130
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:20344. UBR7.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162408298.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 425425Putative E3 ubiquitin-protein ligase UBR7PRO_0000089932Add
BLAST

Proteomic databases

MaxQBiQ8N806.
PaxDbiQ8N806.
PeptideAtlasiQ8N806.
PRIDEiQ8N806.

PTM databases

PhosphoSiteiQ8N806.

Expressioni

Gene expression databases

BgeeiQ8N806.
CleanExiHS_UBR7.
ExpressionAtlasiQ8N806. baseline and differential.
GenevestigatoriQ8N806.

Organism-specific databases

HPAiHPA000861.

Interactioni

Protein-protein interaction databases

BioGridi120451. 28 interactions.
IntActiQ8N806. 2 interactions.
MINTiMINT-2810601.
STRINGi9606.ENSP00000013070.

Structurei

3D structure databases

ProteinModelPortaliQ8N806.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 PHD-type zinc finger.Curated
Contains 1 UBR-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri44 – 11673UBR-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri132 – 18857PHD-type; atypicalAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG130848.
GeneTreeiENSGT00390000017610.
HOGENOMiHOG000246997.
HOVERGENiHBG051029.
InParanoidiQ8N806.
KOiK11979.
OMAiKMYGELD.
OrthoDBiEOG7SV0VN.
PhylomeDBiQ8N806.
TreeFamiTF105941.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR011011. Znf_FYVE_PHD.
IPR003126. Znf_N-recognin.
IPR001965. Znf_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF02207. zf-UBR. 1 hit.
[Graphical view]
SMARTiSM00249. PHD. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS51157. ZF_UBR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N806-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGAEGAAGR QSELEPVVSL VDVLEEDEEL ENEACAVLGG SDSEKCSYSQ
60 70 80 90 100
GSVKRQALYA CSTCTPEGEE PAGICLACSY ECHGSHKLFE LYTKRNFRCD
110 120 130 140 150
CGNSKFKNLE CKLLPDKAKV NSGNKYNDNF FGLYCICKRP YPDPEDEIPD
160 170 180 190 200
EMIQCVVCED WFHGRHLGAI PPESGDFQEM VCQACMKRCS FLWAYAAQLA
210 220 230 240 250
VTKISTEDDG LVRNIDGIGD QEVIKPENGE HQDSTLKEDV PEQGKDDVRE
260 270 280 290 300
VKVEQNSEPC AGSSSESDLQ TVFKNESLNA ESKSGCKLQE LKAKQLIKKD
310 320 330 340 350
TATYWPLNWR SKLCTCQDCM KMYGDLDVLF LTDEYDTVLA YENKGKIAQA
360 370 380 390 400
TDRSDPLMDT LSSMNRVQQV ELICEYNDLK TELKDYLKRF ADEGTVVKRE
410 420
DIQQFFEEFQ SKKRRRVDGM QYYCS
Length:425
Mass (Da):47,999
Last modified:October 24, 2003 - v2
Checksum:i6FFE5795E6737BE5
GO

Sequence cautioni

The sequence AAH15046.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAH51819.4 differs from that shown. Reason: Erroneous initiation.
The sequence BAA91639.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti41 – 411S → G in BAC05069. (PubMed:14702039)Curated
Sequence conflicti170 – 1701I → T in BAA91639. (PubMed:14702039)Curated
Sequence conflicti179 – 1791E → K in BAC05069. (PubMed:14702039)Curated
Sequence conflicti344 – 3441K → R in BAC05069. (PubMed:14702039)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK001345 mRNA. Translation: BAA91639.1. Different initiation.
AK097477 mRNA. Translation: BAC05069.1.
BC015046 mRNA. Translation: AAH15046.1. Different initiation.
BC051819 mRNA. Translation: AAH51819.4. Different initiation.
BX248249 mRNA. Translation: CAD62577.1.
CCDSiCCDS9909.1.
RefSeqiNP_786924.2. NM_175748.3.
UniGeneiHs.648806.

Genome annotation databases

EnsembliENST00000013070; ENSP00000013070; ENSG00000012963.
GeneIDi55148.
KEGGihsa:55148.
UCSCiuc001ybm.4. human.

Polymorphism databases

DMDMi37999713.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK001345 mRNA. Translation: BAA91639.1 . Different initiation.
AK097477 mRNA. Translation: BAC05069.1 .
BC015046 mRNA. Translation: AAH15046.1 . Different initiation.
BC051819 mRNA. Translation: AAH51819.4 . Different initiation.
BX248249 mRNA. Translation: CAD62577.1 .
CCDSi CCDS9909.1.
RefSeqi NP_786924.2. NM_175748.3.
UniGenei Hs.648806.

3D structure databases

ProteinModelPortali Q8N806.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120451. 28 interactions.
IntActi Q8N806. 2 interactions.
MINTi MINT-2810601.
STRINGi 9606.ENSP00000013070.

PTM databases

PhosphoSitei Q8N806.

Polymorphism databases

DMDMi 37999713.

Proteomic databases

MaxQBi Q8N806.
PaxDbi Q8N806.
PeptideAtlasi Q8N806.
PRIDEi Q8N806.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000013070 ; ENSP00000013070 ; ENSG00000012963 .
GeneIDi 55148.
KEGGi hsa:55148.
UCSCi uc001ybm.4. human.

Organism-specific databases

CTDi 55148.
GeneCardsi GC14P093673.
HGNCi HGNC:20344. UBR7.
HPAi HPA000861.
MIMi 613816. gene.
neXtProti NX_Q8N806.
PharmGKBi PA162408298.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG130848.
GeneTreei ENSGT00390000017610.
HOGENOMi HOG000246997.
HOVERGENi HBG051029.
InParanoidi Q8N806.
KOi K11979.
OMAi KMYGELD.
OrthoDBi EOG7SV0VN.
PhylomeDBi Q8N806.
TreeFami TF105941.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Miscellaneous databases

GenomeRNAii 55148.
NextBioi 58870.
PROi Q8N806.
SOURCEi Search...

Gene expression databases

Bgeei Q8N806.
CleanExi HS_UBR7.
ExpressionAtlasi Q8N806. baseline and differential.
Genevestigatori Q8N806.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
InterProi IPR011011. Znf_FYVE_PHD.
IPR003126. Znf_N-recognin.
IPR001965. Znf_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF02207. zf-UBR. 1 hit.
[Graphical view ]
SMARTi SM00249. PHD. 1 hit.
[Graphical view ]
SUPFAMi SSF57903. SSF57903. 1 hit.
PROSITEi PS51157. ZF_UBR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Teratocarcinoma and Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Leiomyosarcoma and Retinoblastoma.
  3. "Full-length cDNA libraries and normalization."
    Li W.B., Gruber C., Jessee J., Polayes D.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-425.
    Tissue: Neuroblastoma.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiUBR7_HUMAN
AccessioniPrimary (citable) accession number: Q8N806
Secondary accession number(s): Q86U21
, Q86UA9, Q96BY0, Q9NVV6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: October 24, 2003
Last modified: October 29, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3