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Protein

Uncharacterized protein C2orf61

Gene

C2orf61

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C2orf61
Gene namesi
Name:C2orf61
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:26850. C2orf61.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162379319.

Polymorphism and mutation databases

BioMutaiC2orf61.
DMDMi544584734.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 248248Uncharacterized protein C2orf61PRO_0000311684Add
BLAST

Proteomic databases

PaxDbiQ8N801.
PRIDEiQ8N801.
TopDownProteomicsiQ8N801-2. [Q8N801-2]

PTM databases

PhosphoSiteiQ8N801.

Expressioni

Gene expression databases

BgeeiQ8N801.
CleanExiHS_C2orf61.
ExpressionAtlasiQ8N801. baseline and differential.
GenevisibleiQ8N801. HS.

Organism-specific databases

HPAiHPA047366.
HPA052691.

Structurei

3D structure databases

ProteinModelPortaliQ8N801.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi241 – 2444Poly-Asn

Phylogenomic databases

eggNOGiENOG410IY6R. Eukaryota.
ENOG4111R2U. LUCA.
GeneTreeiENSGT00390000008095.
HOGENOMiHOG000111326.
HOVERGENiHBG094873.
InParanoidiQ8N801.
OMAiEHSLFFN.
PhylomeDBiQ8N801.
TreeFamiTF329156.

Family and domain databases

InterProiIPR010736. SHIPPO-rpt.
[Graphical view]
PfamiPF07004. SHIPPO-rpt. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N801-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDQPAVATAS TSIREDLVGG ESFITASKPA QKTSSFEREG WWRIALTDTP
60 70 80 90 100
IPGTYHLKTF IEESLLNPVI ATYNFKNEGR KKPPLVQRNN PVLNDLPQYM
110 120 130 140 150
PPDFLDLLKK QVATYSFKDK PRPSPSTLVD KDQSLQLSPG QYNVLPAPVP
160 170 180 190 200
KYASRSCVFR STVQRFPTTY FIPHEGPGPG HYNVKMPPTS SVTSCFQSRV
210 220 230 240
PRFLPSCSKT PGPGAYTTLR QFPKQSPTIA KMGQEHSLFF NNNNWLLK
Length:248
Mass (Da):27,807
Last modified:September 18, 2013 - v2
Checksum:iF485CCA6A7BA3417
GO
Isoform 2 (identifier: Q8N801-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     174-248: HEGPGPGHYN...FFNNNNWLLK → VSIM

Show »
Length:177
Mass (Da):19,923
Checksum:iCEFF86C1A79BD536
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti17 – 171L → M.
Corresponds to variant rs815804 [ dbSNP | Ensembl ].
VAR_050715
Natural varianti31 – 311Q → R.
Corresponds to variant rs17036300 [ dbSNP | Ensembl ].
VAR_050716

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei174 – 24875HEGPG…NWLLK → VSIM in isoform 2. 1 PublicationVSP_047926Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097491 mRNA. Translation: BAC05075.1.
AC073283 Genomic DNA. Translation: AAY24084.1.
CH471053 Genomic DNA. Translation: EAX00224.1.
CH471053 Genomic DNA. Translation: EAX00225.1.
HY239491 mRNA. No translation available.
CCDSiCCDS1831.1. [Q8N801-2]
CCDS54356.1. [Q8N801-1]
RefSeqiNP_001157033.1. NM_001163561.1. [Q8N801-1]
NP_775920.1. NM_173649.2. [Q8N801-2]
UniGeneiHs.531575.

Genome annotation databases

EnsembliENST00000294947; ENSP00000294947; ENSG00000239605. [Q8N801-2]
ENST00000445927; ENSP00000408527; ENSG00000239605. [Q8N801-1]
GeneIDi285051.
KEGGihsa:285051.
UCSCiuc002rvs.3. human. [Q8N801-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097491 mRNA. Translation: BAC05075.1.
AC073283 Genomic DNA. Translation: AAY24084.1.
CH471053 Genomic DNA. Translation: EAX00224.1.
CH471053 Genomic DNA. Translation: EAX00225.1.
HY239491 mRNA. No translation available.
CCDSiCCDS1831.1. [Q8N801-2]
CCDS54356.1. [Q8N801-1]
RefSeqiNP_001157033.1. NM_001163561.1. [Q8N801-1]
NP_775920.1. NM_173649.2. [Q8N801-2]
UniGeneiHs.531575.

3D structure databases

ProteinModelPortaliQ8N801.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ8N801.

Polymorphism and mutation databases

BioMutaiC2orf61.
DMDMi544584734.

Proteomic databases

PaxDbiQ8N801.
PRIDEiQ8N801.
TopDownProteomicsiQ8N801-2. [Q8N801-2]

Protocols and materials databases

DNASUi285051.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000294947; ENSP00000294947; ENSG00000239605. [Q8N801-2]
ENST00000445927; ENSP00000408527; ENSG00000239605. [Q8N801-1]
GeneIDi285051.
KEGGihsa:285051.
UCSCiuc002rvs.3. human. [Q8N801-1]

Organism-specific databases

CTDi285051.
GeneCardsiC2orf61.
HGNCiHGNC:26850. C2orf61.
HPAiHPA047366.
HPA052691.
neXtProtiNX_Q8N801.
PharmGKBiPA162379319.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IY6R. Eukaryota.
ENOG4111R2U. LUCA.
GeneTreeiENSGT00390000008095.
HOGENOMiHOG000111326.
HOVERGENiHBG094873.
InParanoidiQ8N801.
OMAiEHSLFFN.
PhylomeDBiQ8N801.
TreeFamiTF329156.

Miscellaneous databases

ChiTaRSiC2orf61. human.
GenomeRNAii285051.
NextBioi95247.
PROiQ8N801.

Gene expression databases

BgeeiQ8N801.
CleanExiHS_C2orf61.
ExpressionAtlasiQ8N801. baseline and differential.
GenevisibleiQ8N801. HS.

Family and domain databases

InterProiIPR010736. SHIPPO-rpt.
[Graphical view]
PfamiPF07004. SHIPPO-rpt. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 103-248 (ISOFORM 1).
    Tissue: Testis.

Entry informationi

Entry nameiCB061_HUMAN
AccessioniPrimary (citable) accession number: Q8N801
Secondary accession number(s): H7C2Z2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: September 18, 2013
Last modified: March 16, 2016
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.