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Protein

Protein STPG4

Gene

STPG4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Maternal factor that plays a role in epigenetic chromatin reprogramming during early development of the zygote. Involved in the regulation of gametic DNA demethylation by inducing the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator, Developmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Protein STPG4Curated
Alternative name(s):
Gonad-specific expression gene proteinBy similarity
Short name:
GSEBy similarity
Sperm-tail PG-rich repeat-containing protein 4Imported
Gene namesi
Name:STPG4Imported
Synonyms:C2orf61Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000239605.8
HGNCiHGNC:26850 STPG4
neXtProtiNX_Q8N801

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000239605
PharmGKBiPA162379319

Polymorphism and mutation databases

BioMutaiC2orf61
DMDMi544584734

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003116841 – 248Protein STPG4Add BLAST248

Proteomic databases

PaxDbiQ8N801
PeptideAtlasiQ8N801
PRIDEiQ8N801
TopDownProteomicsiQ8N801-2 [Q8N801-2]

PTM databases

iPTMnetiQ8N801
PhosphoSitePlusiQ8N801

Expressioni

Gene expression databases

BgeeiENSG00000239605
CleanExiHS_C2orf61
ExpressionAtlasiQ8N801 baseline and differential
GenevisibleiQ8N801 HS

Organism-specific databases

HPAiHPA047366
HPA052691

Interactioni

Subunit structurei

Interacts with histone H3. Interacts with histone H4.By similarity

Protein-protein interaction databases

BioGridi130008, 2 interactors
IntActiQ8N801, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ8N801
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi241 – 244Poly-Asn4

Phylogenomic databases

eggNOGiENOG410IY6R Eukaryota
ENOG4111R2U LUCA
GeneTreeiENSGT00390000008095
HOGENOMiHOG000111326
HOVERGENiHBG094873
InParanoidiQ8N801
OMAiREGWWRI
OrthoDBiEOG091G0VW3
PhylomeDBiQ8N801
TreeFamiTF329156

Family and domain databases

InterProiView protein in InterPro
IPR010736 SHIPPO-rpt
PfamiView protein in Pfam
PF07004 SHIPPO-rpt, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N801-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDQPAVATAS TSIREDLVGG ESFITASKPA QKTSSFEREG WWRIALTDTP
60 70 80 90 100
IPGTYHLKTF IEESLLNPVI ATYNFKNEGR KKPPLVQRNN PVLNDLPQYM
110 120 130 140 150
PPDFLDLLKK QVATYSFKDK PRPSPSTLVD KDQSLQLSPG QYNVLPAPVP
160 170 180 190 200
KYASRSCVFR STVQRFPTTY FIPHEGPGPG HYNVKMPPTS SVTSCFQSRV
210 220 230 240
PRFLPSCSKT PGPGAYTTLR QFPKQSPTIA KMGQEHSLFF NNNNWLLK
Length:248
Mass (Da):27,807
Last modified:September 18, 2013 - v2
Checksum:iF485CCA6A7BA3417
GO
Isoform 2 (identifier: Q8N801-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     174-248: HEGPGPGHYN...FFNNNNWLLK → VSIM

Show »
Length:177
Mass (Da):19,923
Checksum:iCEFF86C1A79BD536
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05071517L → M. Corresponds to variant dbSNP:rs815804Ensembl.1
Natural variantiVAR_05071631Q → R. Corresponds to variant dbSNP:rs17036300Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_047926174 – 248HEGPG…NWLLK → VSIM in isoform 2. 1 PublicationAdd BLAST75

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097491 mRNA Translation: BAC05075.1
AC073283 Genomic DNA Translation: AAY24084.1
CH471053 Genomic DNA Translation: EAX00224.1
CH471053 Genomic DNA Translation: EAX00225.1
HY239491 mRNA No translation available.
CCDSiCCDS1831.1 [Q8N801-2]
CCDS54356.1 [Q8N801-1]
RefSeqiNP_001157033.1, NM_001163561.1 [Q8N801-1]
NP_775920.1, NM_173649.2 [Q8N801-2]
UniGeneiHs.531575

Genome annotation databases

EnsembliENST00000294947; ENSP00000294947; ENSG00000239605 [Q8N801-2]
ENST00000445927; ENSP00000408527; ENSG00000273269 [Q8N801-1]
GeneIDi285051
KEGGihsa:285051
UCSCiuc002rvs.3 human [Q8N801-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSTPG4_HUMAN
AccessioniPrimary (citable) accession number: Q8N801
Secondary accession number(s): H7C2Z2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: September 18, 2013
Last modified: April 25, 2018
This is version 101 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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