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Q8N7Z5

- ANR31_HUMAN

UniProt

Q8N7Z5 - ANR31_HUMAN

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Protein

Putative ankyrin repeat domain-containing protein 31

Gene

ANKRD31

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein uncertaini

Names & Taxonomyi

Protein namesi
Recommended name:
Putative ankyrin repeat domain-containing protein 31
Gene namesi
Name:ANKRD31
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:26853. ANKRD31.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134879237.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 18731873Putative ankyrin repeat domain-containing protein 31PRO_0000328839Add
BLAST

Proteomic databases

PaxDbiQ8N7Z5.
PRIDEiQ8N7Z5.

PTM databases

PhosphoSiteiQ8N7Z5.

Expressioni

Gene expression databases

BgeeiQ8N7Z5.
CleanExiHS_ANKRD31.
ExpressionAtlasiQ8N7Z5. baseline and differential.
GenevestigatoriQ8N7Z5.

Organism-specific databases

HPAiHPA038028.

Interactioni

Protein-protein interaction databases

BioGridi129131. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8N7Z5.
SMRiQ8N7Z5. Positions 439-668, 1077-1286.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati488 – 51730ANK 1Add
BLAST
Repeati521 – 55030ANK 2Add
BLAST
Repeati554 – 58330ANK 3Add
BLAST
Repeati1154 – 118330ANK 4Add
BLAST
Repeati1187 – 121630ANK 5Add
BLAST
Repeati1220 – 124930ANK 6Add
BLAST

Sequence similaritiesi

Contains 6 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiCOG0666.
GeneTreeiENSGT00760000119090.
HOGENOMiHOG000033960.
InParanoidiQ8N7Z5.
OMAiCENIDGI.
PhylomeDBiQ8N7Z5.
TreeFamiTF326440.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 2 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 6 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 2 hits.
PROSITEiPS50297. ANK_REP_REGION. 2 hits.
PS50088. ANK_REPEAT. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N7Z5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEEGVQAPDW DSDETVIEGS VTESDLEEKE LPWRRLLFDQ DASLKSEFSL
60 70 80 90 100
HPDTRGMCKG MPSPEIQLGF KLREDLQEQM NKNKMMPVLS EDTILQSQDE
110 120 130 140 150
TERNQALLQT RKNCSMFIGS FRQSGLSLNH QNIEGPEAES PEVLPHIEKE
160 170 180 190 200
LSEGRDSPEV SLLSGTAITV SDTVAVKETS LVEPEKILAA PNTFFEPRKE
210 220 230 240 250
VTMTMTSEET KDEESSLETF VSALESLLTS PESTQEERLF ELVSDFDRKE
260 270 280 290 300
LMNPLSDSLS SISIPLNSWS ACHRDLLEDA KDDALPAELL EALNTLSEAK
310 320 330 340 350
VETICHRKEG GSSLIARNEC LEVEFNTSQT NEDCTQIAET LQDPNPSGLQ
360 370 380 390 400
TLAHQNITSC EPLSNKRNSN SVTNSSDQET ACVLRRSSRL EKLKVSRDAK
410 420 430 440 450
YSDHMYKMPE KILPKILGCE DLTNNNSSAQ NFRMQDPALM IDGKEKNMHS
460 470 480 490 500
ARFKNGKQIR KNEQFSGKKE KMKVNKISLH SINRRNIFGE NLVYKAALHD
510 520 530 540 550
DADLVHHCIK KGGNVNQPSY AGWTALHEAS VGGFYRTASE LLKGGADVNI
560 570 580 590 600
KGLYQITPLH DAVMNGHYKV AELLLLNGAD PLFRNDDGKC ALDEAKDLCM
610 620 630 640 650
KRLLERYIPK HQKCLTSAQR SSIDPLDIED VYQHKKPKFS SKSHIWHVYN
660 670 680 690 700
ENSNRQKLEH VKVNKGSKAS LFINKEDVYE YYQKDPKNTK FGKSKHKQST
710 720 730 740 750
LDQIYSTGLR KGNLHNVKDP NTNVPKGIGR RKTQHKRTQV DDVDCNPRKI
760 770 780 790 800
LAVSPSRRIN RLVTYQQHIP ETHNDLPEEL CEPSSLTLSS LRNGLDSSTE
810 820 830 840 850
ACSVSKEKHI QNLDLSDSQE VQCLELESVD QTEAVSFPGL LLHKEIKLPV
860 870 880 890 900
VTTDKQPHTL QEQHHVLYKS HENSNLVPKD ERFNKWENSF LSFVKENSDN
910 920 930 940 950
DDDDDCSTSE KAITSKKVLC STGGKKHYNF KENLTNKKEM GFQQFLLSED
960 970 980 990 1000
HLSQENELKA VSLTTLPEQE AVNFSYSDNA VISEHVANYE QCIFGPSFDH
1010 1020 1030 1040 1050
SNGNPEQNSL ACMRTLLTHE ASKLTNHVEL FKKPQDYIPR APTFLMNQTD
1060 1070 1080 1090 1100
THIVEKMAKN CDTERNYIDR DQKIIYSNEP LSIVAHSQVI ETTKVEKRRQ
1110 1120 1130 1140 1150
NHLESETIHN IDSHSTDNMS KELANISKLS QREKKEISHK PGMKAGRINK
1160 1170 1180 1190 1200
RNARGESQLH LAVRRGNLPL VKALIESGAD VNLNDNAGWT PLHEASNEGS
1210 1220 1230 1240 1250
IDIIVELLKA GAKVNCENID GILPLHDAVA NNHLKAAEIL LQNGANPNQK
1260 1270 1280 1290 1300
DQKQKSALDE ADDEKMKELL RSYGAIETVN RDESDAIVNE KIPAVRSKRH
1310 1320 1330 1340 1350
KQCFCDDGKT IDSSSLSHQE RSRESLSVHQ TLSAILQDIE EKQEYLLEFE
1360 1370 1380 1390 1400
IRNPEDAEQY IEKMLKIKKI MDNVLAKQKA ERDDLAKKYR VSIESFKHGA
1410 1420 1430 1440 1450
LREQLANLAA RQKSLLVVAK KQKKISLKIQ NCRNVTSLPC LSLRKLPPRS
1460 1470 1480 1490 1500
EISSEKDSQE LTSLENLEHP QSGSLSPVSG SMQETQLSLE TWNYSQNTNI
1510 1520 1530 1540 1550
CLNSEAVRRG EFSGNDMNSK QNGSDCTLDG FPKSRHSDGT EKNKLPSQPV
1560 1570 1580 1590 1600
AFIGQTEYSQ KENDLTEATD KDHEFYVSSP VIGKLNISET ASVLAENAAH
1610 1620 1630 1640 1650
PSNIICDQDL SNYDPKRGNR KTSSQQSPTG ASESLAHQGI AVLGSDTVHQ
1660 1670 1680 1690 1700
MKPYLKKSVS VVPCADDSQI SSSSGSGQQD TIKKALNYST APKKKCIQIK
1710 1720 1730 1740 1750
DLILLGRINP GNNILEFKTQ ETTHKASILL NGKLKVESGQ IYKNPVTWLK
1760 1770 1780 1790 1800
DLLGGNSYVT WNYAWSKVTY LGKELLRYVS EDAPILPEPN SVPQQYQPCL
1810 1820 1830 1840 1850
PEVACLDDPV QEPNKSMFEK TKFGQGTSRE SMQSSPRYLQ INEILLISDQ
1860 1870
EFLPCHIMDQ HWKFCVECEE LTP
Length:1,873
Mass (Da):210,816
Last modified:April 8, 2008 - v2
Checksum:i3491754C9B0923ED
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti444 – 4441K → R in BAC05081. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti702 – 7021D → N.
Corresponds to variant rs1422698 [ dbSNP | Ensembl ].
VAR_042542
Natural varianti758 – 7581R → G.
Corresponds to variant rs6893216 [ dbSNP | Ensembl ].
VAR_042543
Natural varianti1609 – 16091D → E.
Corresponds to variant rs961098 [ dbSNP | Ensembl ].
VAR_042544
Natural varianti1777 – 17771R → K.
Corresponds to variant rs4489037 [ dbSNP | Ensembl ].
VAR_042545

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC008769 Genomic DNA. No translation available.
AC093259 Genomic DNA. No translation available.
AK097510 mRNA. Translation: BAC05081.1.
CCDSiCCDS47233.1.
RefSeqiNP_001157915.1. NM_001164443.1.
UniGeneiHs.482533.

Genome annotation databases

EnsembliENST00000274361; ENSP00000274361; ENSG00000145700.
GeneIDi256006.
KEGGihsa:256006.
UCSCiuc003kdo.2. human.

Polymorphism databases

DMDMi182627587.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC008769 Genomic DNA. No translation available.
AC093259 Genomic DNA. No translation available.
AK097510 mRNA. Translation: BAC05081.1 .
CCDSi CCDS47233.1.
RefSeqi NP_001157915.1. NM_001164443.1.
UniGenei Hs.482533.

3D structure databases

ProteinModelPortali Q8N7Z5.
SMRi Q8N7Z5. Positions 439-668, 1077-1286.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 129131. 1 interaction.

PTM databases

PhosphoSitei Q8N7Z5.

Polymorphism databases

DMDMi 182627587.

Proteomic databases

PaxDbi Q8N7Z5.
PRIDEi Q8N7Z5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000274361 ; ENSP00000274361 ; ENSG00000145700 .
GeneIDi 256006.
KEGGi hsa:256006.
UCSCi uc003kdo.2. human.

Organism-specific databases

CTDi 256006.
GeneCardsi GC05M074364.
HGNCi HGNC:26853. ANKRD31.
HPAi HPA038028.
neXtProti NX_Q8N7Z5.
PharmGKBi PA134879237.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0666.
GeneTreei ENSGT00760000119090.
HOGENOMi HOG000033960.
InParanoidi Q8N7Z5.
OMAi CENIDGI.
PhylomeDBi Q8N7Z5.
TreeFami TF326440.

Miscellaneous databases

GenomeRNAii 256006.
NextBioi 92693.

Gene expression databases

Bgeei Q8N7Z5.
CleanExi HS_ANKRD31.
ExpressionAtlasi Q8N7Z5. baseline and differential.
Genevestigatori Q8N7Z5.

Family and domain databases

Gene3Di 1.25.40.20. 2 hits.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view ]
Pfami PF00023. Ank. 1 hit.
PF12796. Ank_2. 2 hits.
[Graphical view ]
PRINTSi PR01415. ANKYRIN.
SMARTi SM00248. ANK. 6 hits.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 2 hits.
PROSITEi PS50297. ANK_REP_REGION. 2 hits.
PS50088. ANK_REPEAT. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-725.
    Tissue: Testis.

Entry informationi

Entry nameiANR31_HUMAN
AccessioniPrimary (citable) accession number: Q8N7Z5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 8, 2008
Last modified: October 29, 2014
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Product of a dubious CDS prediction.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3