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Q8N7Z5

- ANR31_HUMAN

UniProt

Q8N7Z5 - ANR31_HUMAN

Protein

Putative ankyrin repeat domain-containing protein 31

Gene

ANKRD31

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein uncertaini
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 2 (08 Apr 2008)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative ankyrin repeat domain-containing protein 31
    Gene namesi
    Name:ANKRD31
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:26853. ANKRD31.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134879237.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 18731873Putative ankyrin repeat domain-containing protein 31PRO_0000328839Add
    BLAST

    Proteomic databases

    PaxDbiQ8N7Z5.
    PRIDEiQ8N7Z5.

    PTM databases

    PhosphoSiteiQ8N7Z5.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8N7Z5.
    BgeeiQ8N7Z5.
    CleanExiHS_ANKRD31.
    GenevestigatoriQ8N7Z5.

    Organism-specific databases

    HPAiHPA038028.

    Interactioni

    Protein-protein interaction databases

    BioGridi129131. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N7Z5.
    SMRiQ8N7Z5. Positions 439-713, 1077-1270.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati488 – 51730ANK 1Add
    BLAST
    Repeati521 – 55030ANK 2Add
    BLAST
    Repeati554 – 58330ANK 3Add
    BLAST
    Repeati1154 – 118330ANK 4Add
    BLAST
    Repeati1187 – 121630ANK 5Add
    BLAST
    Repeati1220 – 124930ANK 6Add
    BLAST

    Sequence similaritiesi

    Contains 6 ANK repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    ANK repeat, Repeat

    Phylogenomic databases

    eggNOGiCOG0666.
    HOGENOMiHOG000033960.
    InParanoidiQ8N7Z5.
    OMAiCENIDGI.
    PhylomeDBiQ8N7Z5.
    TreeFamiTF326440.

    Family and domain databases

    Gene3Di1.25.40.20. 2 hits.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    [Graphical view]
    PfamiPF00023. Ank. 1 hit.
    PF12796. Ank_2. 2 hits.
    [Graphical view]
    PRINTSiPR01415. ANKYRIN.
    SMARTiSM00248. ANK. 6 hits.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 2 hits.
    PROSITEiPS50297. ANK_REP_REGION. 2 hits.
    PS50088. ANK_REPEAT. 5 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8N7Z5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEEGVQAPDW DSDETVIEGS VTESDLEEKE LPWRRLLFDQ DASLKSEFSL     50
    HPDTRGMCKG MPSPEIQLGF KLREDLQEQM NKNKMMPVLS EDTILQSQDE 100
    TERNQALLQT RKNCSMFIGS FRQSGLSLNH QNIEGPEAES PEVLPHIEKE 150
    LSEGRDSPEV SLLSGTAITV SDTVAVKETS LVEPEKILAA PNTFFEPRKE 200
    VTMTMTSEET KDEESSLETF VSALESLLTS PESTQEERLF ELVSDFDRKE 250
    LMNPLSDSLS SISIPLNSWS ACHRDLLEDA KDDALPAELL EALNTLSEAK 300
    VETICHRKEG GSSLIARNEC LEVEFNTSQT NEDCTQIAET LQDPNPSGLQ 350
    TLAHQNITSC EPLSNKRNSN SVTNSSDQET ACVLRRSSRL EKLKVSRDAK 400
    YSDHMYKMPE KILPKILGCE DLTNNNSSAQ NFRMQDPALM IDGKEKNMHS 450
    ARFKNGKQIR KNEQFSGKKE KMKVNKISLH SINRRNIFGE NLVYKAALHD 500
    DADLVHHCIK KGGNVNQPSY AGWTALHEAS VGGFYRTASE LLKGGADVNI 550
    KGLYQITPLH DAVMNGHYKV AELLLLNGAD PLFRNDDGKC ALDEAKDLCM 600
    KRLLERYIPK HQKCLTSAQR SSIDPLDIED VYQHKKPKFS SKSHIWHVYN 650
    ENSNRQKLEH VKVNKGSKAS LFINKEDVYE YYQKDPKNTK FGKSKHKQST 700
    LDQIYSTGLR KGNLHNVKDP NTNVPKGIGR RKTQHKRTQV DDVDCNPRKI 750
    LAVSPSRRIN RLVTYQQHIP ETHNDLPEEL CEPSSLTLSS LRNGLDSSTE 800
    ACSVSKEKHI QNLDLSDSQE VQCLELESVD QTEAVSFPGL LLHKEIKLPV 850
    VTTDKQPHTL QEQHHVLYKS HENSNLVPKD ERFNKWENSF LSFVKENSDN 900
    DDDDDCSTSE KAITSKKVLC STGGKKHYNF KENLTNKKEM GFQQFLLSED 950
    HLSQENELKA VSLTTLPEQE AVNFSYSDNA VISEHVANYE QCIFGPSFDH 1000
    SNGNPEQNSL ACMRTLLTHE ASKLTNHVEL FKKPQDYIPR APTFLMNQTD 1050
    THIVEKMAKN CDTERNYIDR DQKIIYSNEP LSIVAHSQVI ETTKVEKRRQ 1100
    NHLESETIHN IDSHSTDNMS KELANISKLS QREKKEISHK PGMKAGRINK 1150
    RNARGESQLH LAVRRGNLPL VKALIESGAD VNLNDNAGWT PLHEASNEGS 1200
    IDIIVELLKA GAKVNCENID GILPLHDAVA NNHLKAAEIL LQNGANPNQK 1250
    DQKQKSALDE ADDEKMKELL RSYGAIETVN RDESDAIVNE KIPAVRSKRH 1300
    KQCFCDDGKT IDSSSLSHQE RSRESLSVHQ TLSAILQDIE EKQEYLLEFE 1350
    IRNPEDAEQY IEKMLKIKKI MDNVLAKQKA ERDDLAKKYR VSIESFKHGA 1400
    LREQLANLAA RQKSLLVVAK KQKKISLKIQ NCRNVTSLPC LSLRKLPPRS 1450
    EISSEKDSQE LTSLENLEHP QSGSLSPVSG SMQETQLSLE TWNYSQNTNI 1500
    CLNSEAVRRG EFSGNDMNSK QNGSDCTLDG FPKSRHSDGT EKNKLPSQPV 1550
    AFIGQTEYSQ KENDLTEATD KDHEFYVSSP VIGKLNISET ASVLAENAAH 1600
    PSNIICDQDL SNYDPKRGNR KTSSQQSPTG ASESLAHQGI AVLGSDTVHQ 1650
    MKPYLKKSVS VVPCADDSQI SSSSGSGQQD TIKKALNYST APKKKCIQIK 1700
    DLILLGRINP GNNILEFKTQ ETTHKASILL NGKLKVESGQ IYKNPVTWLK 1750
    DLLGGNSYVT WNYAWSKVTY LGKELLRYVS EDAPILPEPN SVPQQYQPCL 1800
    PEVACLDDPV QEPNKSMFEK TKFGQGTSRE SMQSSPRYLQ INEILLISDQ 1850
    EFLPCHIMDQ HWKFCVECEE LTP 1873
    Length:1,873
    Mass (Da):210,816
    Last modified:April 8, 2008 - v2
    Checksum:i3491754C9B0923ED
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti444 – 4441K → R in BAC05081. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti702 – 7021D → N.
    Corresponds to variant rs1422698 [ dbSNP | Ensembl ].
    VAR_042542
    Natural varianti758 – 7581R → G.
    Corresponds to variant rs6893216 [ dbSNP | Ensembl ].
    VAR_042543
    Natural varianti1609 – 16091D → E.
    Corresponds to variant rs961098 [ dbSNP | Ensembl ].
    VAR_042544
    Natural varianti1777 – 17771R → K.
    Corresponds to variant rs4489037 [ dbSNP | Ensembl ].
    VAR_042545

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC008769 Genomic DNA. No translation available.
    AC093259 Genomic DNA. No translation available.
    AK097510 mRNA. Translation: BAC05081.1.
    CCDSiCCDS47233.1.
    RefSeqiNP_001157915.1. NM_001164443.1.
    UniGeneiHs.482533.

    Genome annotation databases

    EnsembliENST00000274361; ENSP00000274361; ENSG00000145700.
    GeneIDi256006.
    KEGGihsa:256006.
    UCSCiuc003kdo.2. human.

    Polymorphism databases

    DMDMi182627587.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC008769 Genomic DNA. No translation available.
    AC093259 Genomic DNA. No translation available.
    AK097510 mRNA. Translation: BAC05081.1 .
    CCDSi CCDS47233.1.
    RefSeqi NP_001157915.1. NM_001164443.1.
    UniGenei Hs.482533.

    3D structure databases

    ProteinModelPortali Q8N7Z5.
    SMRi Q8N7Z5. Positions 439-713, 1077-1270.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 129131. 1 interaction.

    PTM databases

    PhosphoSitei Q8N7Z5.

    Polymorphism databases

    DMDMi 182627587.

    Proteomic databases

    PaxDbi Q8N7Z5.
    PRIDEi Q8N7Z5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000274361 ; ENSP00000274361 ; ENSG00000145700 .
    GeneIDi 256006.
    KEGGi hsa:256006.
    UCSCi uc003kdo.2. human.

    Organism-specific databases

    CTDi 256006.
    GeneCardsi GC05M074364.
    HGNCi HGNC:26853. ANKRD31.
    HPAi HPA038028.
    neXtProti NX_Q8N7Z5.
    PharmGKBi PA134879237.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0666.
    HOGENOMi HOG000033960.
    InParanoidi Q8N7Z5.
    OMAi CENIDGI.
    PhylomeDBi Q8N7Z5.
    TreeFami TF326440.

    Miscellaneous databases

    GenomeRNAii 256006.
    NextBioi 92693.

    Gene expression databases

    ArrayExpressi Q8N7Z5.
    Bgeei Q8N7Z5.
    CleanExi HS_ANKRD31.
    Genevestigatori Q8N7Z5.

    Family and domain databases

    Gene3Di 1.25.40.20. 2 hits.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    [Graphical view ]
    Pfami PF00023. Ank. 1 hit.
    PF12796. Ank_2. 2 hits.
    [Graphical view ]
    PRINTSi PR01415. ANKYRIN.
    SMARTi SM00248. ANK. 6 hits.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 2 hits.
    PROSITEi PS50297. ANK_REP_REGION. 2 hits.
    PS50088. ANK_REPEAT. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-725.
      Tissue: Testis.

    Entry informationi

    Entry nameiANR31_HUMAN
    AccessioniPrimary (citable) accession number: Q8N7Z5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: April 8, 2008
    Last modified: October 1, 2014
    This is version 85 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Product of a dubious CDS prediction.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3