Reviewed, UniProtKB/Swiss-Prot Q8N7Z5 (ANR31_HUMAN)

Names and origin

Protein names

Recommended name:
    Ankyrin repeat domain-containing protein 31

Gene names

Name:

ANKRD31

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1873 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities

Contains 6 ANK repeats.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	ANK repeat Repeat
Technical term	Complete proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1873	1873	Ankyrin repeat domain-containing protein 31		PRO_0000328839
Regions
	Repeat	488 – 517	30	ANK 1
	Repeat	521 – 550	30	ANK 2
	Repeat	554 – 583	30	ANK 3
	Repeat	1154 – 1183	30	ANK 4
	Repeat	1187 – 1216	30	ANK 5
	Repeat	1220 – 1249	30	ANK 6
Natural variations
	Natural variant	702	1	D → N: dbSNP rs1422698.		VAR_042542
	Natural variant	758	1	R → G: dbSNP rs6893216.		VAR_042543
	Natural variant	1609	1	D → E: dbSNP rs961098.		VAR_042544
	Natural variant	1777	1	R → K: dbSNP rs4489037.		VAR_042545
Experimental info
	Sequence conflict	444	1	K → R in BAC05081. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q8N7Z5-1 [UniParc]. Last modified April 8, 2008. Version 2. Checksum: 3491754C9B0923ED	FASTA	1,873	210,816
	10 20 30 40 50 60 MEEGVQAPDW DSDETVIEGS VTESDLEEKE LPWRRLLFDQ DASLKSEFSL HPDTRGMCKG 70 80 90 100 110 120 MPSPEIQLGF KLREDLQEQM NKNKMMPVLS EDTILQSQDE TERNQALLQT RKNCSMFIGS 130 140 150 160 170 180 FRQSGLSLNH QNIEGPEAES PEVLPHIEKE LSEGRDSPEV SLLSGTAITV SDTVAVKETS 190 200 210 220 230 240 LVEPEKILAA PNTFFEPRKE VTMTMTSEET KDEESSLETF VSALESLLTS PESTQEERLF 250 260 270 280 290 300 ELVSDFDRKE LMNPLSDSLS SISIPLNSWS ACHRDLLEDA KDDALPAELL EALNTLSEAK 310 320 330 340 350 360 VETICHRKEG GSSLIARNEC LEVEFNTSQT NEDCTQIAET LQDPNPSGLQ TLAHQNITSC 370 380 390 400 410 420 EPLSNKRNSN SVTNSSDQET ACVLRRSSRL EKLKVSRDAK YSDHMYKMPE KILPKILGCE 430 440 450 460 470 480 DLTNNNSSAQ NFRMQDPALM IDGKEKNMHS ARFKNGKQIR KNEQFSGKKE KMKVNKISLH 490 500 510 520 530 540 SINRRNIFGE NLVYKAALHD DADLVHHCIK KGGNVNQPSY AGWTALHEAS VGGFYRTASE 550 560 570 580 590 600 LLKGGADVNI KGLYQITPLH DAVMNGHYKV AELLLLNGAD PLFRNDDGKC ALDEAKDLCM 610 620 630 640 650 660 KRLLERYIPK HQKCLTSAQR SSIDPLDIED VYQHKKPKFS SKSHIWHVYN ENSNRQKLEH 670 680 690 700 710 720 VKVNKGSKAS LFINKEDVYE YYQKDPKNTK FGKSKHKQST LDQIYSTGLR KGNLHNVKDP 730 740 750 760 770 780 NTNVPKGIGR RKTQHKRTQV DDVDCNPRKI LAVSPSRRIN RLVTYQQHIP ETHNDLPEEL 790 800 810 820 830 840 CEPSSLTLSS LRNGLDSSTE ACSVSKEKHI QNLDLSDSQE VQCLELESVD QTEAVSFPGL 850 860 870 880 890 900 LLHKEIKLPV VTTDKQPHTL QEQHHVLYKS HENSNLVPKD ERFNKWENSF LSFVKENSDN 910 920 930 940 950 960 DDDDDCSTSE KAITSKKVLC STGGKKHYNF KENLTNKKEM GFQQFLLSED HLSQENELKA 970 980 990 1000 1010 1020 VSLTTLPEQE AVNFSYSDNA VISEHVANYE QCIFGPSFDH SNGNPEQNSL ACMRTLLTHE 1030 1040 1050 1060 1070 1080 ASKLTNHVEL FKKPQDYIPR APTFLMNQTD THIVEKMAKN CDTERNYIDR DQKIIYSNEP 1090 1100 1110 1120 1130 1140 LSIVAHSQVI ETTKVEKRRQ NHLESETIHN IDSHSTDNMS KELANISKLS QREKKEISHK 1150 1160 1170 1180 1190 1200 PGMKAGRINK RNARGESQLH LAVRRGNLPL VKALIESGAD VNLNDNAGWT PLHEASNEGS 1210 1220 1230 1240 1250 1260 IDIIVELLKA GAKVNCENID GILPLHDAVA NNHLKAAEIL LQNGANPNQK DQKQKSALDE 1270 1280 1290 1300 1310 1320 ADDEKMKELL RSYGAIETVN RDESDAIVNE KIPAVRSKRH KQCFCDDGKT IDSSSLSHQE 1330 1340 1350 1360 1370 1380 RSRESLSVHQ TLSAILQDIE EKQEYLLEFE IRNPEDAEQY IEKMLKIKKI MDNVLAKQKA 1390 1400 1410 1420 1430 1440 ERDDLAKKYR VSIESFKHGA LREQLANLAA RQKSLLVVAK KQKKISLKIQ NCRNVTSLPC 1450 1460 1470 1480 1490 1500 LSLRKLPPRS EISSEKDSQE LTSLENLEHP QSGSLSPVSG SMQETQLSLE TWNYSQNTNI 1510 1520 1530 1540 1550 1560 CLNSEAVRRG EFSGNDMNSK QNGSDCTLDG FPKSRHSDGT EKNKLPSQPV AFIGQTEYSQ 1570 1580 1590 1600 1610 1620 KENDLTEATD KDHEFYVSSP VIGKLNISET ASVLAENAAH PSNIICDQDL SNYDPKRGNR 1630 1640 1650 1660 1670 1680 KTSSQQSPTG ASESLAHQGI AVLGSDTVHQ MKPYLKKSVS VVPCADDSQI SSSSGSGQQD 1690 1700 1710 1720 1730 1740 TIKKALNYST APKKKCIQIK DLILLGRINP GNNILEFKTQ ETTHKASILL NGKLKVESGQ 1750 1760 1770 1780 1790 1800 IYKNPVTWLK DLLGGNSYVT WNYAWSKVTY LGKELLRYVS EDAPILPEPN SVPQQYQPCL 1810 1820 1830 1840 1850 1860 PEVACLDDPV QEPNKSMFEK TKFGQGTSRE SMQSSPRYLQ INEILLISDQ EFLPCHIMDQ 1870 HWKFCVECEE LTP

References

[1]

"The DNA sequence and comparative analysis of human chromosome 5." Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M. Nature 431:268-274(2004) [PubMed: 15372022] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-725. Tissue: Testis.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AC008769 Genomic DNA. No translation available. AC093259 Genomic DNA. No translation available. AK097510 mRNA. Translation: BAC05081.1.
IPI	IPI00740057.
RefSeq	NP_001157915.1. XP_001714521.2. XP_942490.4.
UniGene	Hs.711809
3D structure databases
HSSP	HSSP built from PDB template 2MYO based on UniProtKB P62775.
ModBase	Search...
PTM databases
PhosphoSite	Q8N7Z5.
Proteomic databases
PRIDE	Q8N7Z5.
Genome annotation databases
Ensembl	ENST00000274361; ENSP00000274361; ENSG00000145700; Homo sapiens. [Genome view]
GeneID	256006.
KEGG	hsa:256006.
Organism-specific databases
CTD	256006.
GeneCards	GC05M074477.
HGNC	HGNC:26853. ANKRD31.
PharmGKB	PA134879237.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q8N7Z5.
OrthoDB	EOG97DD21
Enzyme and pathway databases
BioCyc	CATTLE:ENSBTAG00000034135-MON.
Gene expression databases
ArrayExpress	Q8N7Z5.
Bgee	Q8N7Z5.
CleanEx	HS_ANKRD31.
Genevestigator	Q8N7Z5.
Family and domain databases
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. [Graphical view]
Gene3D	G3DSA:1.25.40.20. ANK. 1 hit.
Pfam	PF00023. Ank. 6 hits. [Graphical view]
SMART	SM00248. ANK. 6 hits. [Graphical view]
PROSITE	PS50297. ANK_REP_REGION. 2 hits. PS50088. ANK_REPEAT. 5 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ANR31_HUMAN

Accession

Primary (citable) accession number: Q8N7Z5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	April 8, 2008
Last modified:	November 24, 2009
This is version 45 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.