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Q8N7X4 (MAGB6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Melanoma-associated antigen B6
Alternative name(s):
Cancer/testis antigen 3.4
Short name=CT3.4
MAGE-B6 antigen
Gene names
Name:MAGEB6
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length407 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Tissue specificity

Expressed in testis. Not expressed in other normal tissues, but is expressed in tumors of different histological origins. Ref.3

Sequence similarities

Contains 1 MAGE domain.

Ontologies

Keywords
   Molecular functionTumor antigen
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 407407Melanoma-associated antigen B6
PRO_0000156717

Regions

Domain195 – 394200MAGE
Compositional bias38 – 164127Ser-rich

Experimental info

Sequence conflict1721G → R in BAC05102. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8N7X4 [UniParc].

Last modified September 13, 2005. Version 2.
Checksum: 3674F422020355DA

FASTA40743,992
        10         20         30         40         50         60 
MPRGHKSKLR TCEKRQETNG QPQGLTGPQA TAEKQEESHS SSSSSRACLG DCRRSSDASI 

        70         80         90        100        110        120 
PQESQGVSPT GSPDAVVSYS KSDVAANGQD EKSPSTSRDA SVPQESQGAS PTGSPDAGVS 

       130        140        150        160        170        180 
GSKYDVAANG QDEKSPSTSH DVSVPQESQG ASPTGSPDAG VSGSKYDVAA EGEDEESVSA 

       190        200        210        220        230        240 
SQKAIIFKRL SKDAVKKKAC TLAQFLQKKF EKKESILKAD MLKCVRREYK PYFPQILNRT 

       250        260        270        280        290        300 
SQHLVVAFGV ELKEMDSSGE SYTLVSKLGL PSEGILSGDN ALPKSGLLMS LLVVIFMNGN 

       310        320        330        340        350        360 
CATEEEVWEF LGLLGIYDGI LHSIYGDARK IITEDLVQDK YVVYRQVCNS DPPCYEFLWG 

       370        380        390        400 
PRAYAETTKM RVLRVLADSS NTSPGLYPHL YEDALIDEVE RALRLRA

« Hide

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[3]"MAGE-B5, MAGE-B6, MAGE-C2, and MAGE-C3: four new members of the MAGE family with tumor-specific expression."
Lucas S., De Plaen E., Boon T.
Int. J. Cancer 87:55-60(2000) [PubMed: 10861452] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 49-177, TISSUE SPECIFICITY.
Tissue: Blood.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK097561 mRNA. Translation: BAC05102.1.
BC067286 mRNA. Translation: AAH67286.1.
BC074920 mRNA. Translation: AAH74920.1.
AF320514 Genomic DNA. Translation: AAG48624.1.
IPIIPI00297989.
RefSeqNP_775794.2. NM_173523.2.
UniGeneHs.376011.

3D structure databases

ProteinModelPortalQ8N7X4.
SMRQ8N7X4. Positions 180-397.
ModBaseSearch...

Polymorphism databases

DMDM84027854.

Proteomic databases

PRIDEQ8N7X4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000379034; ENSP00000368320; ENSG00000176746.
ENST00000397565; ENSP00000380696; ENSG00000176746.
GeneID158809.
KEGGhsa:158809.
UCSCuc004dbr.1. human.

Organism-specific databases

CTD158809.
GeneCardsGC0XP026210.
H-InvDBHIX0016709.
HGNCHGNC:23796. MAGEB6.
HPAHPA041853.
MIM300467. gene.
neXtProtNX_Q8N7X4.
PharmGKBPA134864191.
GenAtlasSearch...

Phylogenomic databases

eggNOGmaNOG13594.
GeneTreeENSGT00560000077004.
HOGENOMHBG507249.
HOVERGENHBG006315.
InParanoidQ8N7X4.
OMAVPQESQG.
OrthoDBEOG4GMTX4.
PhylomeDBQ8N7X4.

Gene expression databases

ArrayExpressQ8N7X4.
BgeeQ8N7X4.
CleanExHS_MAGEB6.
GenevestigatorQ8N7X4.
GermOnlineENSG00000176746. Homo sapiens.

Family and domain databases

InterProIPR002190. MAGE.
IPR021072. Melanoma_ass_antigen_N.
[Graphical view]
PANTHERPTHR11736. MAGE. 1 hit.
PfamPF01454. MAGE. 1 hit.
PF12440. MAGE_N. 1 hit.
[Graphical view]
PROSITEPS50838. MAGE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio87819.
SOURCESearch...

Entry information

Entry nameMAGB6_HUMAN
AccessionPrimary (citable) accession number: Q8N7X4
Secondary accession number(s): Q6GS19, Q9H219
Entry history
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: September 13, 2005
Last modified: January 25, 2012
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents