Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Melanoma-associated antigen B6

Gene

MAGEB6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Keywords - Molecular functioni

Tumor antigen

Names & Taxonomyi

Protein namesi
Recommended name:
Melanoma-associated antigen B6
Alternative name(s):
Cancer/testis antigen 3.4
Short name:
CT3.4
MAGE-B6 antigen
Gene namesi
Name:MAGEB6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:23796. MAGEB6.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134864191.

Polymorphism and mutation databases

BioMutaiMAGEB6.
DMDMi84027854.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 407407Melanoma-associated antigen B6PRO_0000156717Add
BLAST

Proteomic databases

PaxDbiQ8N7X4.
PRIDEiQ8N7X4.

PTM databases

iPTMnetiQ8N7X4.
PhosphoSiteiQ8N7X4.

Expressioni

Tissue specificityi

Expressed in testis. Not expressed in other normal tissues, but is expressed in tumors of different histological origins.1 Publication

Gene expression databases

BgeeiQ8N7X4.
CleanExiHS_MAGEB6.
GenevisibleiQ8N7X4. HS.

Organism-specific databases

HPAiHPA041853.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
HACL1Q9UJ833EBI-6447163,EBI-746580
HTTP428582EBI-6447163,EBI-466029
PHC2Q8IXK03EBI-6447163,EBI-713786

Protein-protein interaction databases

BioGridi127710. 5 interactions.
IntActiQ8N7X4. 4 interactions.
STRINGi9606.ENSP00000368320.

Structurei

3D structure databases

ProteinModelPortaliQ8N7X4.
SMRiQ8N7X4. Positions 190-397.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini195 – 394200MAGEPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi38 – 164127Ser-richAdd
BLAST

Sequence similaritiesi

Contains 1 MAGE domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4562. Eukaryota.
ENOG4111S70. LUCA.
GeneTreeiENSGT00760000118824.
HOGENOMiHOG000231161.
HOVERGENiHBG006315.
InParanoidiQ8N7X4.
OMAiKAIIFKR.
OrthoDBiEOG75F4GM.
PhylomeDBiQ8N7X4.
TreeFamiTF328505.

Family and domain databases

InterProiIPR021072. MAGE_N.
IPR002190. MHD_dom.
[Graphical view]
PfamiPF01454. MAGE. 1 hit.
PF12440. MAGE_N. 3 hits.
[Graphical view]
SMARTiSM01373. MAGE. 1 hit.
SM01392. MAGE_N. 2 hits.
[Graphical view]
PROSITEiPS50838. MAGE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N7X4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRGHKSKLR TCEKRQETNG QPQGLTGPQA TAEKQEESHS SSSSSRACLG
60 70 80 90 100
DCRRSSDASI PQESQGVSPT GSPDAVVSYS KSDVAANGQD EKSPSTSRDA
110 120 130 140 150
SVPQESQGAS PTGSPDAGVS GSKYDVAANG QDEKSPSTSH DVSVPQESQG
160 170 180 190 200
ASPTGSPDAG VSGSKYDVAA EGEDEESVSA SQKAIIFKRL SKDAVKKKAC
210 220 230 240 250
TLAQFLQKKF EKKESILKAD MLKCVRREYK PYFPQILNRT SQHLVVAFGV
260 270 280 290 300
ELKEMDSSGE SYTLVSKLGL PSEGILSGDN ALPKSGLLMS LLVVIFMNGN
310 320 330 340 350
CATEEEVWEF LGLLGIYDGI LHSIYGDARK IITEDLVQDK YVVYRQVCNS
360 370 380 390 400
DPPCYEFLWG PRAYAETTKM RVLRVLADSS NTSPGLYPHL YEDALIDEVE

RALRLRA
Length:407
Mass (Da):43,992
Last modified:September 13, 2005 - v2
Checksum:i3674F422020355DA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti172 – 1721G → R in BAC05102 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097561 mRNA. Translation: BAC05102.1.
BC067286 mRNA. Translation: AAH67286.1.
BC074920 mRNA. Translation: AAH74920.1.
AF320514 Genomic DNA. Translation: AAG48624.1.
CCDSiCCDS14217.1.
RefSeqiNP_775794.2. NM_173523.2.
UniGeneiHs.376011.

Genome annotation databases

EnsembliENST00000379034; ENSP00000368320; ENSG00000176746.
GeneIDi158809.
KEGGihsa:158809.
UCSCiuc004dbr.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097561 mRNA. Translation: BAC05102.1.
BC067286 mRNA. Translation: AAH67286.1.
BC074920 mRNA. Translation: AAH74920.1.
AF320514 Genomic DNA. Translation: AAG48624.1.
CCDSiCCDS14217.1.
RefSeqiNP_775794.2. NM_173523.2.
UniGeneiHs.376011.

3D structure databases

ProteinModelPortaliQ8N7X4.
SMRiQ8N7X4. Positions 190-397.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127710. 5 interactions.
IntActiQ8N7X4. 4 interactions.
STRINGi9606.ENSP00000368320.

PTM databases

iPTMnetiQ8N7X4.
PhosphoSiteiQ8N7X4.

Polymorphism and mutation databases

BioMutaiMAGEB6.
DMDMi84027854.

Proteomic databases

PaxDbiQ8N7X4.
PRIDEiQ8N7X4.

Protocols and materials databases

DNASUi158809.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379034; ENSP00000368320; ENSG00000176746.
GeneIDi158809.
KEGGihsa:158809.
UCSCiuc004dbr.3. human.

Organism-specific databases

CTDi158809.
GeneCardsiMAGEB6.
HGNCiHGNC:23796. MAGEB6.
HPAiHPA041853.
MIMi300467. gene.
neXtProtiNX_Q8N7X4.
PharmGKBiPA134864191.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4562. Eukaryota.
ENOG4111S70. LUCA.
GeneTreeiENSGT00760000118824.
HOGENOMiHOG000231161.
HOVERGENiHBG006315.
InParanoidiQ8N7X4.
OMAiKAIIFKR.
OrthoDBiEOG75F4GM.
PhylomeDBiQ8N7X4.
TreeFamiTF328505.

Miscellaneous databases

GenomeRNAii158809.
PROiQ8N7X4.
SOURCEiSearch...

Gene expression databases

BgeeiQ8N7X4.
CleanExiHS_MAGEB6.
GenevisibleiQ8N7X4. HS.

Family and domain databases

InterProiIPR021072. MAGE_N.
IPR002190. MHD_dom.
[Graphical view]
PfamiPF01454. MAGE. 1 hit.
PF12440. MAGE_N. 3 hits.
[Graphical view]
SMARTiSM01373. MAGE. 1 hit.
SM01392. MAGE_N. 2 hits.
[Graphical view]
PROSITEiPS50838. MAGE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. "MAGE-B5, MAGE-B6, MAGE-C2, and MAGE-C3: four new members of the MAGE family with tumor-specific expression."
    Lucas S., De Plaen E., Boon T.
    Int. J. Cancer 87:55-60(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 49-177, TISSUE SPECIFICITY.
    Tissue: Blood.

Entry informationi

Entry nameiMAGB6_HUMAN
AccessioniPrimary (citable) accession number: Q8N7X4
Secondary accession number(s): Q6GS19, Q9H219
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: September 13, 2005
Last modified: June 8, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.