Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein STPG3

Gene

STPG3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein STPG3
Alternative name(s):
Sperm-tail PG-rich repeat-containing protein 3Imported
Gene namesi
Name:STPG3Imported
Synonyms:C9orf173
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000197768.10
HGNCiHGNC:37285 STPG3
neXtProtiNX_Q8N7X2

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000197768
PharmGKBiPA165585550

Polymorphism and mutation databases

BioMutaiC9orf173
DMDMi74729306

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003256151 – 386Protein STPG3Add BLAST386

Proteomic databases

EPDiQ8N7X2
PaxDbiQ8N7X2
PeptideAtlasiQ8N7X2
PRIDEiQ8N7X2

PTM databases

iPTMnetiQ8N7X2
PhosphoSitePlusiQ8N7X2

Expressioni

Gene expression databases

BgeeiENSG00000197768
ExpressionAtlasiQ8N7X2 baseline and differential
GenevisibleiQ8N7X2 HS

Organism-specific databases

HPAiHPA044352

Interactioni

Protein-protein interaction databases

BioGridi137505, 3 interactors
STRINGi9606.ENSP00000391218

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IX0Q Eukaryota
ENOG4111W6G LUCA
GeneTreeiENSGT00390000009524
HOGENOMiHOG000236307
HOVERGENiHBG070870
InParanoidiQ8N7X2
OMAiTYNILPG
OrthoDBiEOG091G0VYL
PhylomeDBiQ8N7X2
TreeFamiTF329447

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 2 (identifier: Q8N7X2-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMNSDQKAVK FLANFYINGG KHWTHGHLRQ TQPEPTQPKA SVLLLGPEPG
60 70 80 90 100
MAWDETQPPK MKEIPVGLRL QTGTPQESLP TYTQTLRELL LEQRPLITAD
110 120 130 140 150
LEVPSPTRYQ VPSPSVRESS PHPHYSIGCK HQGREGGGRR AWQTLWFQSE
160 170 180 190 200
SPFTQKADFD QEQKWPSPAH YQLLSRPAFP AFSFRGCHSA SKTPEGHTHL
210 220 230 240 250
GLPGARGLGL RVQPQSLLQA SLQAPGKRCP GPNTYNILPG SRLQSPRSPA
260 270 280 290 300
FSMSRSPAFT SWLSTSFSFG SPNPWPSRLP RGGLQLTLPF GAWRGHPGCT
310 320 330 340 350
QTQAPRHRPL LHALEPAGHN LLGPATEWNH GLPRGFPRPP LGLGAPAWPS
360 370 380
DPLGTPMHPS GWPTLLWAVD KAGPAWIPHL PISPLH
Length:386
Mass (Da):42,496
Last modified:March 28, 2018 - v2
Checksum:i62EBD0C134F8449D
GO
Isoform 1 (identifier: Q8N7X2-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     266-266: S → WLPA

Note: Dubious isoform produced through aberrant splice sites.Curated
Show »
Length:389
Mass (Da):42,877
Checksum:iCEF90A9D068FF212
GO
Isoform 3 (identifier: Q8N7X2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     165-219: Missing.

Show »
Length:331
Mass (Da):36,553
Checksum:i25130715DF99D41C
GO
Isoform 4 (identifier: Q8N7X2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     267-386: FSFGSPNPWP...IPHLPISPLH → RTPGPAAYHV...RHDTGPFCTL

Show »
Length:308
Mass (Da):34,134
Checksum:iD22F43CD1DD4C623
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_039898126S → G. Corresponds to variant dbSNP:rs28657439Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_059447165 – 219Missing in isoform 3. 1 PublicationAdd BLAST55
Alternative sequenceiVSP_059448266S → WLPA in isoform 1. 1 Publication1
Alternative sequenceiVSP_059449267 – 386FSFGS…ISPLH → RTPGPAAYHVEDCNSRFPSA PGVVIQGVRRPKRHDTGPFC TL in isoform 4. 1 PublicationAdd BLAST120

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097565 mRNA Translation: BAC05104.1
BC033939 mRNA Translation: AAH33939.2
BX255925 Genomic DNA No translation available.
BC132726 mRNA Translation: AAI32727.1
BC144308 mRNA Translation: AAI44309.1
BC144314 mRNA Translation: AAI44315.1
CCDSiCCDS48065.1 [Q8N7X2-4]
CCDS59156.1 [Q8N7X2-2]
CCDS75940.1 [Q8N7X2-3]
RefSeqiNP_001004353.2, NM_001004353.3 [Q8N7X2-4]
NP_001243628.1, NM_001256699.1 [Q8N7X2-2]
NP_001243629.1, NM_001256700.1 [Q8N7X2-3]
NP_001243630.1, NM_001256701.1
XP_006717176.1, XM_006717113.2 [Q8N7X2-2]
UniGeneiHs.372640

Genome annotation databases

EnsembliENST00000388931; ENSP00000373583; ENSG00000197768 [Q8N7X2-2]
ENST00000412566; ENSP00000391218; ENSG00000197768 [Q8N7X2-4]
ENST00000611378; ENSP00000477998; ENSG00000197768 [Q8N7X2-3]
GeneIDi441476
KEGGihsa:441476
UCSCiuc004cmj.2 human [Q8N7X2-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSTPG3_HUMAN
AccessioniPrimary (citable) accession number: Q8N7X2
Secondary accession number(s): A2RU24
, B7ZM72, B7ZM76, Q8NEA3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 28, 2018
Last modified: April 25, 2018
This is version 92 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health