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Q8N7X0 (ADGB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Androglobin
Alternative name(s):
Calpain-7-like protein
Gene names
Name:ADGB
Synonyms:C6orf103, CAPN7L
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1667 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the peptidase C2 family.

Contains 1 calpain catalytic domain.

Contains 1 IQ domain.

Caution

Lacks the conserved active site residues. Probably catalytically inactive.

Sequence caution

The sequence AL832192 differs from that shown. Reason: Frameshift at positions 81, 281 and 581.

The sequence AL832192 differs from that shown. Reason: Intron retention.

The sequence CAI16490.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence CAI20488.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence DN831198 differs from that shown. Reason: Frameshift at positions 944, 946 and 960.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8N7X0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8N7X0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-951: Missing.
     1185-1288: Missing.
Note: Gene prediction based on EST data.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 16671667Androglobin
PRO_0000232525

Regions

Domain70 – 411342Calpain catalytic
Domain906 – 93530IQ
Coiled coil1588 – 162942 Potential

Natural variations

Alternative sequence1 – 951951Missing in isoform 2.
VSP_039243
Alternative sequence1185 – 1288104Missing in isoform 2.
VSP_039244
Natural variant3101I → T. Ref.3
Corresponds to variant rs9497606 [ dbSNP | Ensembl ].
VAR_025948
Natural variant16371T → A. Ref.2
Corresponds to variant rs1052445 [ dbSNP | Ensembl ].
VAR_063158

Experimental info

Sequence conflict205 – 28076Missing in AL832192. Ref.1
Sequence conflict570 – 58011Missing in AL832192. Ref.1
Sequence conflict7161T → R in DN831198. Ref.4
Sequence conflict747 – 7548RHMLLFNA → YEVASFFP in BAC05106. Ref.3
Sequence conflict8101K → M in AL832192. Ref.1
Sequence conflict9311P → R in DN831198. Ref.4
Sequence conflict9441Q → L in DN831198. Ref.4
Sequence conflict16391A → S in CAI14697. Ref.2
Sequence conflict16391A → S in CAI20489. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 15, 2010. Version 3.
Checksum: 46732C56A6C63B3F

FASTA1,667189,713
        10         20         30         40         50         60 
MASKQTKKKE VHRINSAHGS DKSKDFYPFG SNVQSGSTEQ KKGKFPLWPE WSEADINSEK 

        70         80         90        100        110        120 
WDAGKGAKEK DKTGKSPVFH FFEDPEGKIE LPPSLKIYSW KRPQDILFSQ TPVVVKNEIT 

       130        140        150        160        170        180 
FDLFSANEHL LCSELMRWII SEIYAVWKIF NGGILSNYFK GTSGEPPLLP WKPWEHIYSL 

       190        200        210        220        230        240 
CKAVKGHMPL FNSYGKYVVK LYWMGCWRKI TIDDFLPFDE DNNLLLPATT YEFELWPMLL 

       250        260        270        280        290        300 
SKAIIKLANI DIHVADRREL GEFTVIHALT GWLPEVISLH PGYMDKVWEL LKEILPEFKL 

       310        320        330        340        350        360 
SDEASSESKI AVLDSKLKEP GKEGKEGKEI KDGKEVKDVK EFKPESSLTT LKAPEKSDKV 

       370        380        390        400        410        420 
PKEKADARDI GKKRSKDGEK EKFKFSLHGS RPSSEVQYSV QSLSDCSSAI QTSHMVVYAT 

       430        440        450        460        470        480 
FTPLYLFENK IFSLEKMADS AEKLREYGLS HICSHPVLVT RSRSCPLVAP PKPPPLPPWK 

       490        500        510        520        530        540 
LIRQKKETVI TDEAQELIVK KPERFLEISS PFLNYRMTPF TIPTEMHFVR SLIKKGIPPG 

       550        560        570        580        590        600 
SDLPSVSETD ETATHSQTDL SQITKATSQG NTASQVILGK GTDEQTDFGL GDAHQSDGLN 

       610        620        630        640        650        660 
LEREIVSQTT ATQEKSQEEL PTTNNSVSKE IWLDFEDFCV CFQNIYIFHK PSSYCLNFQK 

       670        680        690        700        710        720 
SEFKFSEERV SYYLFVDSLK PIELLVCFSA LVRWGEYGAL TKDSPPIEPG LLTAETFSWK 

       730        740        750        760        770        780 
SLKPGSLVLK IHTYATKATV VRLPVGRHML LFNAYSPVGH SIHICSMVSF VIGDEHVVLP 

       790        800        810        820        830        840 
NFEPESCRFT EQSLLIMKAI GNVIANFKDK GKLSAALKDL QTAHYPVPFH DKELTAQHFR 

       850        860        870        880        890        900 
VFHLSLWRLM KKVQITKPPP NFKFAFRAMV LDLELLNSSL EEVSLVEWLD VKYCMPTSDK 

       910        920        930        940        950        960 
EYSAEEVAAA IKIQAMWRGT YVRLLMKARI PDTKENISVA DTLQKVWAVL EMNLEQYAVS 

       970        980        990       1000       1010       1020 
LLRLMFKSKC KSLESYPCYQ DEETKIAFAD YTVTYQEQPP NSWFIVFRET FLVHQDMILV 

      1030       1040       1050       1060       1070       1080 
PKVYTTLPIC ILHIVNNDTM EQVPKVFQKV VPYLYTKNKK GYTFVAEAFT GDTYVAASRW 

      1090       1100       1110       1120       1130       1140 
KLRLIGSSAP LPCLSRDSPC NSFAIKEIRD YYIPNDKKIL FRYSVKVLTP QPATIQVRTS 

      1150       1160       1170       1180       1190       1200 
KPDAFIKLQV LENEETMVSS TGKGQAIIPA FHFLKSEKGL SSQSSKHILS FHSASKKEQE 

      1210       1220       1230       1240       1250       1260 
VYVKKKAAQG IQKSPKGRAV SAIQDIGLPL VEEETTSTPT REDSSSTPLQ NYKYIIQCSV 

      1270       1280       1290       1300       1310       1320 
LYNSWPLTES QLTFVQALKD LKKSNTKAYG ERHEELINLG SPDSHTISEG QKSSVTSKTT 

      1330       1340       1350       1360       1370       1380 
RKGKEKSSEK EKTAKEKQAP RFEPQISTVH PQQEDPNKPY WILRLVTEHN ESELFEVKKD 

      1390       1400       1410       1420       1430       1440 
TERADEIRAM KQAWETTEPG RAIKASQARL HYLSGFIKKT SDAESPPISE SQTKPKEEVE 

      1450       1460       1470       1480       1490       1500 
TAARGVKEPN SKNSAGSESK EMTQTGSGSA VWKKWQLTKG LRDVAKSTSS ESGGVSSPGK 

      1510       1520       1530       1540       1550       1560 
EEREQSTRKE NIQTGPRTRS PTILETSPRL IRKALEFMDL SQYVRKTDTD PLLQTDELNQ 

      1570       1580       1590       1600       1610       1620 
QQAMQKAEEI HQFRQHRTRV LSIRNIDQEE RLKLKDEVLD MYKEMQDSLD EARQKIFDIR 

      1630       1640       1650       1660 
EEYRNKLLEA EHLKLETLAA QEAAMKLETE KMTPAPDTQK KKKGKKK 

« Hide

Isoform 2 [UniParc].

Checksum: 884B8EB975F203EC
Show »

FASTA61270,082

References

[1]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[2]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ALA-1637.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-754 (ISOFORM 1), VARIANT THR-310.
Tissue: Testis.
[4]"Exhaustive RT-PCR and sequencing of all novel TWINSCAN predictions in human."
Stevens M., Wei C., Gross S.S., McPherson J., Brent M.R.
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 697-964.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL832192 mRNA. No translation available.
AL138916, AL158199 Genomic DNA. Translation: CAI14697.1.
AL138916, AL158199 Genomic DNA. Translation: CAI14698.1.
AL158199, AL359547 Genomic DNA. Translation: CAI20488.1. Sequence problems.
AL158199, AL138916 Genomic DNA. Translation: CAI20489.1.
AL158199, AL138916 Genomic DNA. Translation: CAI20490.1.
AL359547, AL158199 Genomic DNA. Translation: CAI16490.1. Sequence problems.
AK097570 mRNA. Translation: BAC05106.1.
DN831198 mRNA. No translation available.
RefSeqNP_078970.3. NM_024694.3.
UniGeneHs.720870.

3D structure databases

ProteinModelPortalQ8N7X0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid122859. 1 interaction.

Protein family/group databases

MEROPSC02.972.

PTM databases

PhosphoSiteQ8N7X0.

Polymorphism databases

DMDM298286920.

Proteomic databases

PaxDbQ8N7X0.
PRIDEQ8N7X0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000397944; ENSP00000381036; ENSG00000118492. [Q8N7X0-1]
GeneID79747.
KEGGhsa:79747.
UCSCuc003qlp.3. human. [Q8N7X0-1]
uc003qlr.3. human. [Q8N7X0-2]

Organism-specific databases

CTD79747.
GeneCardsGC06P146920.
H-InvDBHIX0006280.
HGNCHGNC:21212. ADGB.
HPAHPA036340.
HPA036341.
MIM614630. gene.
neXtProtNX_Q8N7X0.
PharmGKBPA134944476.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG70817.
HOGENOMHOG000169304.
HOVERGENHBG058494.
InParanoidQ8N7X0.
OMAYKYIIQC.
OrthoDBEOG7MD4Q3.
PhylomeDBQ8N7X0.
TreeFamTF329120.

Gene expression databases

ArrayExpressQ8N7X0.
BgeeQ8N7X0.
CleanExHS_C6orf103.
GenevestigatorQ8N7X0.

Family and domain databases

Gene3D1.10.490.10. 1 hit.
InterProIPR012292. Globin_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view]
PfamPF00648. Peptidase_C2. 1 hit.
[Graphical view]
SMARTSM00230. CysPc. 1 hit.
SM00015. IQ. 1 hit.
[Graphical view]
PROSITEPS50203. CALPAIN_CAT. 1 hit.
PS50096. IQ. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi79747.
NextBio69181.
PROQ8N7X0.
SOURCESearch...

Entry information

Entry nameADGB_HUMAN
AccessionPrimary (citable) accession number: Q8N7X0
Secondary accession number(s): Q5T402, Q5T904, Q5T905
Entry history
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: June 15, 2010
Last modified: April 16, 2014
This is version 87 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM