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Protein

Androglobin

Gene

ADGB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Protein family/group databases

MEROPSiC02.972.

Names & Taxonomyi

Protein namesi
Recommended name:
Androglobin
Alternative name(s):
Calpain-7-like protein
Gene namesi
Name:ADGB
Synonyms:C6orf103, CAPN7L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21212. ADGB.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134944476.

Polymorphism and mutation databases

BioMutaiADGB.
DMDMi298286920.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 16671667AndroglobinPRO_0000232525Add
BLAST

Proteomic databases

MaxQBiQ8N7X0.
PaxDbiQ8N7X0.
PRIDEiQ8N7X0.

PTM databases

PhosphoSiteiQ8N7X0.

Expressioni

Gene expression databases

BgeeiQ8N7X0.
CleanExiHS_C6orf103.
ExpressionAtlasiQ8N7X0. baseline and differential.
GenevisibleiQ8N7X0. HS.

Organism-specific databases

HPAiHPA036340.
HPA036341.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000381036.

Structurei

3D structure databases

ProteinModelPortaliQ8N7X0.
SMRiQ8N7X0. Positions 784-872.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini70 – 411342Calpain catalyticPROSITE-ProRule annotationAdd
BLAST
Domaini906 – 93530IQPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1588 – 162942Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C2 family.Curated
Contains 1 calpain catalytic domain.PROSITE-ProRule annotation
Contains 1 IQ domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG70817.
GeneTreeiENSGT00390000014904.
HOGENOMiHOG000169304.
HOVERGENiHBG058494.
InParanoidiQ8N7X0.
OMAiQITKPPP.
OrthoDBiEOG7MD4Q3.
PhylomeDBiQ8N7X0.
TreeFamiTF329120.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR012292. Globin/Proto.
IPR000048. IQ_motif_EF-hand-BS.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view]
PfamiPF00648. Peptidase_C2. 1 hit.
[Graphical view]
SMARTiSM00230. CysPc. 1 hit.
SM00015. IQ. 1 hit.
[Graphical view]
PROSITEiPS50203. CALPAIN_CAT. 1 hit.
PS50096. IQ. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N7X0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASKQTKKKE VHRINSAHGS DKSKDFYPFG SNVQSGSTEQ KKGKFPLWPE
60 70 80 90 100
WSEADINSEK WDAGKGAKEK DKTGKSPVFH FFEDPEGKIE LPPSLKIYSW
110 120 130 140 150
KRPQDILFSQ TPVVVKNEIT FDLFSANEHL LCSELMRWII SEIYAVWKIF
160 170 180 190 200
NGGILSNYFK GTSGEPPLLP WKPWEHIYSL CKAVKGHMPL FNSYGKYVVK
210 220 230 240 250
LYWMGCWRKI TIDDFLPFDE DNNLLLPATT YEFELWPMLL SKAIIKLANI
260 270 280 290 300
DIHVADRREL GEFTVIHALT GWLPEVISLH PGYMDKVWEL LKEILPEFKL
310 320 330 340 350
SDEASSESKI AVLDSKLKEP GKEGKEGKEI KDGKEVKDVK EFKPESSLTT
360 370 380 390 400
LKAPEKSDKV PKEKADARDI GKKRSKDGEK EKFKFSLHGS RPSSEVQYSV
410 420 430 440 450
QSLSDCSSAI QTSHMVVYAT FTPLYLFENK IFSLEKMADS AEKLREYGLS
460 470 480 490 500
HICSHPVLVT RSRSCPLVAP PKPPPLPPWK LIRQKKETVI TDEAQELIVK
510 520 530 540 550
KPERFLEISS PFLNYRMTPF TIPTEMHFVR SLIKKGIPPG SDLPSVSETD
560 570 580 590 600
ETATHSQTDL SQITKATSQG NTASQVILGK GTDEQTDFGL GDAHQSDGLN
610 620 630 640 650
LEREIVSQTT ATQEKSQEEL PTTNNSVSKE IWLDFEDFCV CFQNIYIFHK
660 670 680 690 700
PSSYCLNFQK SEFKFSEERV SYYLFVDSLK PIELLVCFSA LVRWGEYGAL
710 720 730 740 750
TKDSPPIEPG LLTAETFSWK SLKPGSLVLK IHTYATKATV VRLPVGRHML
760 770 780 790 800
LFNAYSPVGH SIHICSMVSF VIGDEHVVLP NFEPESCRFT EQSLLIMKAI
810 820 830 840 850
GNVIANFKDK GKLSAALKDL QTAHYPVPFH DKELTAQHFR VFHLSLWRLM
860 870 880 890 900
KKVQITKPPP NFKFAFRAMV LDLELLNSSL EEVSLVEWLD VKYCMPTSDK
910 920 930 940 950
EYSAEEVAAA IKIQAMWRGT YVRLLMKARI PDTKENISVA DTLQKVWAVL
960 970 980 990 1000
EMNLEQYAVS LLRLMFKSKC KSLESYPCYQ DEETKIAFAD YTVTYQEQPP
1010 1020 1030 1040 1050
NSWFIVFRET FLVHQDMILV PKVYTTLPIC ILHIVNNDTM EQVPKVFQKV
1060 1070 1080 1090 1100
VPYLYTKNKK GYTFVAEAFT GDTYVAASRW KLRLIGSSAP LPCLSRDSPC
1110 1120 1130 1140 1150
NSFAIKEIRD YYIPNDKKIL FRYSVKVLTP QPATIQVRTS KPDAFIKLQV
1160 1170 1180 1190 1200
LENEETMVSS TGKGQAIIPA FHFLKSEKGL SSQSSKHILS FHSASKKEQE
1210 1220 1230 1240 1250
VYVKKKAAQG IQKSPKGRAV SAIQDIGLPL VEEETTSTPT REDSSSTPLQ
1260 1270 1280 1290 1300
NYKYIIQCSV LYNSWPLTES QLTFVQALKD LKKSNTKAYG ERHEELINLG
1310 1320 1330 1340 1350
SPDSHTISEG QKSSVTSKTT RKGKEKSSEK EKTAKEKQAP RFEPQISTVH
1360 1370 1380 1390 1400
PQQEDPNKPY WILRLVTEHN ESELFEVKKD TERADEIRAM KQAWETTEPG
1410 1420 1430 1440 1450
RAIKASQARL HYLSGFIKKT SDAESPPISE SQTKPKEEVE TAARGVKEPN
1460 1470 1480 1490 1500
SKNSAGSESK EMTQTGSGSA VWKKWQLTKG LRDVAKSTSS ESGGVSSPGK
1510 1520 1530 1540 1550
EEREQSTRKE NIQTGPRTRS PTILETSPRL IRKALEFMDL SQYVRKTDTD
1560 1570 1580 1590 1600
PLLQTDELNQ QQAMQKAEEI HQFRQHRTRV LSIRNIDQEE RLKLKDEVLD
1610 1620 1630 1640 1650
MYKEMQDSLD EARQKIFDIR EEYRNKLLEA EHLKLETLAA QEAAMKLETE
1660
KMTPAPDTQK KKKGKKK
Length:1,667
Mass (Da):189,713
Last modified:June 15, 2010 - v3
Checksum:i46732C56A6C63B3F
GO
Isoform 2 (identifier: Q8N7X0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-951: Missing.
     1185-1288: Missing.

Note: Gene prediction based on EST data.
Show »
Length:612
Mass (Da):70,082
Checksum:i884B8EB975F203EC
GO

Sequence cautioni

The sequence AL832192 differs from that shown.Intron retention.Curated
The sequence AL832192 differs from that shown. Reason: Frameshift at positions 81, 281 and 581. Curated
The sequence CAI16490.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI20488.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence DN831198 differs from that shown. Reason: Frameshift at positions 944, 946 and 960. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti205 – 28076Missing in AL832192 (PubMed:17974005).CuratedAdd
BLAST
Sequence conflicti570 – 58011Missing in AL832192 (PubMed:17974005).CuratedAdd
BLAST
Sequence conflicti716 – 7161T → R in DN831198 (Ref. 4) Curated
Sequence conflicti747 – 7548RHMLLFNA → YEVASFFP in BAC05106 (PubMed:14702039).Curated
Sequence conflicti810 – 8101K → M in AL832192 (PubMed:17974005).Curated
Sequence conflicti931 – 9311P → R in DN831198 (Ref. 4) Curated
Sequence conflicti944 – 9441Q → L in DN831198 (Ref. 4) Curated
Sequence conflicti1639 – 16391A → S in CAI14697 (PubMed:14574404).Curated
Sequence conflicti1639 – 16391A → S in CAI20489 (PubMed:14574404).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti310 – 3101I → T.1 Publication
Corresponds to variant rs9497606 [ dbSNP | Ensembl ].
VAR_025948
Natural varianti1637 – 16371T → A.1 Publication
Corresponds to variant rs1052445 [ dbSNP | Ensembl ].
VAR_063158

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 951951Missing in isoform 2. CuratedVSP_039243Add
BLAST
Alternative sequencei1185 – 1288104Missing in isoform 2. CuratedVSP_039244Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL832192 mRNA. No translation available.
AL138916, AL158199 Genomic DNA. Translation: CAI14697.1.
AL138916, AL158199 Genomic DNA. Translation: CAI14698.1.
AL158199, AL359547 Genomic DNA. Translation: CAI20488.1. Sequence problems.
AL158199, AL138916 Genomic DNA. Translation: CAI20489.1.
AL158199, AL138916 Genomic DNA. Translation: CAI20490.1.
AL359547, AL158199 Genomic DNA. Translation: CAI16490.1. Sequence problems.
AK097570 mRNA. Translation: BAC05106.1.
DN831198 mRNA. No translation available.
RefSeqiNP_078970.3. NM_024694.3. [Q8N7X0-1]
UniGeneiHs.720870.

Genome annotation databases

EnsembliENST00000397944; ENSP00000381036; ENSG00000118492.
GeneIDi79747.
KEGGihsa:79747.
UCSCiuc003qlp.3. human. [Q8N7X0-1]
uc003qlr.3. human. [Q8N7X0-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL832192 mRNA. No translation available.
AL138916, AL158199 Genomic DNA. Translation: CAI14697.1.
AL138916, AL158199 Genomic DNA. Translation: CAI14698.1.
AL158199, AL359547 Genomic DNA. Translation: CAI20488.1. Sequence problems.
AL158199, AL138916 Genomic DNA. Translation: CAI20489.1.
AL158199, AL138916 Genomic DNA. Translation: CAI20490.1.
AL359547, AL158199 Genomic DNA. Translation: CAI16490.1. Sequence problems.
AK097570 mRNA. Translation: BAC05106.1.
DN831198 mRNA. No translation available.
RefSeqiNP_078970.3. NM_024694.3. [Q8N7X0-1]
UniGeneiHs.720870.

3D structure databases

ProteinModelPortaliQ8N7X0.
SMRiQ8N7X0. Positions 784-872.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000381036.

Protein family/group databases

MEROPSiC02.972.

PTM databases

PhosphoSiteiQ8N7X0.

Polymorphism and mutation databases

BioMutaiADGB.
DMDMi298286920.

Proteomic databases

MaxQBiQ8N7X0.
PaxDbiQ8N7X0.
PRIDEiQ8N7X0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000397944; ENSP00000381036; ENSG00000118492.
GeneIDi79747.
KEGGihsa:79747.
UCSCiuc003qlp.3. human. [Q8N7X0-1]
uc003qlr.3. human. [Q8N7X0-2]

Organism-specific databases

CTDi79747.
GeneCardsiGC06P146920.
H-InvDBHIX0006280.
HGNCiHGNC:21212. ADGB.
HPAiHPA036340.
HPA036341.
MIMi614630. gene.
neXtProtiNX_Q8N7X0.
PharmGKBiPA134944476.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG70817.
GeneTreeiENSGT00390000014904.
HOGENOMiHOG000169304.
HOVERGENiHBG058494.
InParanoidiQ8N7X0.
OMAiQITKPPP.
OrthoDBiEOG7MD4Q3.
PhylomeDBiQ8N7X0.
TreeFamiTF329120.

Miscellaneous databases

GenomeRNAii79747.
NextBioi69181.
PROiQ8N7X0.
SOURCEiSearch...

Gene expression databases

BgeeiQ8N7X0.
CleanExiHS_C6orf103.
ExpressionAtlasiQ8N7X0. baseline and differential.
GenevisibleiQ8N7X0. HS.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR012292. Globin/Proto.
IPR000048. IQ_motif_EF-hand-BS.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view]
PfamiPF00648. Peptidase_C2. 1 hit.
[Graphical view]
SMARTiSM00230. CysPc. 1 hit.
SM00015. IQ. 1 hit.
[Graphical view]
PROSITEiPS50203. CALPAIN_CAT. 1 hit.
PS50096. IQ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ALA-1637.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-754 (ISOFORM 1), VARIANT THR-310.
    Tissue: Testis.
  4. "Exhaustive RT-PCR and sequencing of all novel TWINSCAN predictions in human."
    Stevens M., Wei C., Gross S.S., McPherson J., Brent M.R.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 697-964.

Entry informationi

Entry nameiADGB_HUMAN
AccessioniPrimary (citable) accession number: Q8N7X0
Secondary accession number(s): Q5T402, Q5T904, Q5T905
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: June 15, 2010
Last modified: July 22, 2015
This is version 97 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Lacks the conserved active site residues. Probably catalytically inactive.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.