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Q8N7X0

- ADGB_HUMAN

UniProt

Q8N7X0 - ADGB_HUMAN

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Protein
Androglobin
Gene
ADGB, C6orf103, CAPN7L
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. calcium-dependent cysteine-type endopeptidase activity Source: RefGenome
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
  4. oxygen binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. oxygen transport Source: InterPro
  2. proteolysis Source: RefGenome
Complete GO annotation...

Protein family/group databases

MEROPSiC02.972.

Names & Taxonomyi

Protein namesi
Recommended name:
Androglobin
Alternative name(s):
Calpain-7-like protein
Gene namesi
Name:ADGB
Synonyms:C6orf103, CAPN7L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:21212. ADGB.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: RefGenome
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134944476.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 16671667Androglobin
PRO_0000232525Add
BLAST

Proteomic databases

MaxQBiQ8N7X0.
PaxDbiQ8N7X0.
PRIDEiQ8N7X0.

PTM databases

PhosphoSiteiQ8N7X0.

Expressioni

Gene expression databases

ArrayExpressiQ8N7X0.
BgeeiQ8N7X0.
CleanExiHS_C6orf103.
GenevestigatoriQ8N7X0.

Organism-specific databases

HPAiHPA036340.
HPA036341.

Interactioni

Protein-protein interaction databases

BioGridi122859. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8N7X0.
SMRiQ8N7X0. Positions 784-872.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini70 – 411342Calpain catalytic
Add
BLAST
Domaini906 – 93530IQ
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1588 – 162942 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Belongs to the peptidase C2 family.
Contains 1 IQ domain.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG70817.
HOGENOMiHOG000169304.
HOVERGENiHBG058494.
InParanoidiQ8N7X0.
OMAiYKYIIQC.
OrthoDBiEOG7MD4Q3.
PhylomeDBiQ8N7X0.
TreeFamiTF329120.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR012292. Globin_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view]
PfamiPF00648. Peptidase_C2. 1 hit.
[Graphical view]
SMARTiSM00230. CysPc. 1 hit.
SM00015. IQ. 1 hit.
[Graphical view]
PROSITEiPS50203. CALPAIN_CAT. 1 hit.
PS50096. IQ. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8N7X0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MASKQTKKKE VHRINSAHGS DKSKDFYPFG SNVQSGSTEQ KKGKFPLWPE     50
WSEADINSEK WDAGKGAKEK DKTGKSPVFH FFEDPEGKIE LPPSLKIYSW 100
KRPQDILFSQ TPVVVKNEIT FDLFSANEHL LCSELMRWII SEIYAVWKIF 150
NGGILSNYFK GTSGEPPLLP WKPWEHIYSL CKAVKGHMPL FNSYGKYVVK 200
LYWMGCWRKI TIDDFLPFDE DNNLLLPATT YEFELWPMLL SKAIIKLANI 250
DIHVADRREL GEFTVIHALT GWLPEVISLH PGYMDKVWEL LKEILPEFKL 300
SDEASSESKI AVLDSKLKEP GKEGKEGKEI KDGKEVKDVK EFKPESSLTT 350
LKAPEKSDKV PKEKADARDI GKKRSKDGEK EKFKFSLHGS RPSSEVQYSV 400
QSLSDCSSAI QTSHMVVYAT FTPLYLFENK IFSLEKMADS AEKLREYGLS 450
HICSHPVLVT RSRSCPLVAP PKPPPLPPWK LIRQKKETVI TDEAQELIVK 500
KPERFLEISS PFLNYRMTPF TIPTEMHFVR SLIKKGIPPG SDLPSVSETD 550
ETATHSQTDL SQITKATSQG NTASQVILGK GTDEQTDFGL GDAHQSDGLN 600
LEREIVSQTT ATQEKSQEEL PTTNNSVSKE IWLDFEDFCV CFQNIYIFHK 650
PSSYCLNFQK SEFKFSEERV SYYLFVDSLK PIELLVCFSA LVRWGEYGAL 700
TKDSPPIEPG LLTAETFSWK SLKPGSLVLK IHTYATKATV VRLPVGRHML 750
LFNAYSPVGH SIHICSMVSF VIGDEHVVLP NFEPESCRFT EQSLLIMKAI 800
GNVIANFKDK GKLSAALKDL QTAHYPVPFH DKELTAQHFR VFHLSLWRLM 850
KKVQITKPPP NFKFAFRAMV LDLELLNSSL EEVSLVEWLD VKYCMPTSDK 900
EYSAEEVAAA IKIQAMWRGT YVRLLMKARI PDTKENISVA DTLQKVWAVL 950
EMNLEQYAVS LLRLMFKSKC KSLESYPCYQ DEETKIAFAD YTVTYQEQPP 1000
NSWFIVFRET FLVHQDMILV PKVYTTLPIC ILHIVNNDTM EQVPKVFQKV 1050
VPYLYTKNKK GYTFVAEAFT GDTYVAASRW KLRLIGSSAP LPCLSRDSPC 1100
NSFAIKEIRD YYIPNDKKIL FRYSVKVLTP QPATIQVRTS KPDAFIKLQV 1150
LENEETMVSS TGKGQAIIPA FHFLKSEKGL SSQSSKHILS FHSASKKEQE 1200
VYVKKKAAQG IQKSPKGRAV SAIQDIGLPL VEEETTSTPT REDSSSTPLQ 1250
NYKYIIQCSV LYNSWPLTES QLTFVQALKD LKKSNTKAYG ERHEELINLG 1300
SPDSHTISEG QKSSVTSKTT RKGKEKSSEK EKTAKEKQAP RFEPQISTVH 1350
PQQEDPNKPY WILRLVTEHN ESELFEVKKD TERADEIRAM KQAWETTEPG 1400
RAIKASQARL HYLSGFIKKT SDAESPPISE SQTKPKEEVE TAARGVKEPN 1450
SKNSAGSESK EMTQTGSGSA VWKKWQLTKG LRDVAKSTSS ESGGVSSPGK 1500
EEREQSTRKE NIQTGPRTRS PTILETSPRL IRKALEFMDL SQYVRKTDTD 1550
PLLQTDELNQ QQAMQKAEEI HQFRQHRTRV LSIRNIDQEE RLKLKDEVLD 1600
MYKEMQDSLD EARQKIFDIR EEYRNKLLEA EHLKLETLAA QEAAMKLETE 1650
KMTPAPDTQK KKKGKKK 1667
Length:1,667
Mass (Da):189,713
Last modified:June 15, 2010 - v3
Checksum:i46732C56A6C63B3F
GO
Isoform 2 (identifier: Q8N7X0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-951: Missing.
     1185-1288: Missing.

Note: Gene prediction based on EST data.

Show »
Length:612
Mass (Da):70,082
Checksum:i884B8EB975F203EC
GO

Sequence cautioni

The sequence AL832192 differs from that shown. Reason: Intron retention.
The sequence AL832192 differs from that shown. Reason: Frameshift at positions 81, 281 and 581.
The sequence DN831198 differs from that shown. Reason: Frameshift at positions 944, 946 and 960.
The sequence CAI16490.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence CAI20488.1 differs from that shown. Reason: Erroneous gene model prediction.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti310 – 3101I → T.1 Publication
Corresponds to variant rs9497606 [ dbSNP | Ensembl ].
VAR_025948
Natural varianti1637 – 16371T → A.1 Publication
Corresponds to variant rs1052445 [ dbSNP | Ensembl ].
VAR_063158

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 951951Missing in isoform 2.
VSP_039243Add
BLAST
Alternative sequencei1185 – 1288104Missing in isoform 2.
VSP_039244Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti205 – 28076Missing in AL832192. 1 Publication
Add
BLAST
Sequence conflicti570 – 58011Missing in AL832192. 1 Publication
Add
BLAST
Sequence conflicti716 – 7161T → R in DN831198. 1 Publication
Sequence conflicti747 – 7548RHMLLFNA → YEVASFFP in BAC05106. 1 Publication
Sequence conflicti810 – 8101K → M in AL832192. 1 Publication
Sequence conflicti931 – 9311P → R in DN831198. 1 Publication
Sequence conflicti944 – 9441Q → L in DN831198. 1 Publication
Sequence conflicti1639 – 16391A → S in CAI14697. 1 Publication
Sequence conflicti1639 – 16391A → S in CAI20489. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL832192 mRNA. No translation available.
AL138916, AL158199 Genomic DNA. Translation: CAI14697.1.
AL138916, AL158199 Genomic DNA. Translation: CAI14698.1.
AL158199, AL359547 Genomic DNA. Translation: CAI20488.1. Sequence problems.
AL158199, AL138916 Genomic DNA. Translation: CAI20489.1.
AL158199, AL138916 Genomic DNA. Translation: CAI20490.1.
AL359547, AL158199 Genomic DNA. Translation: CAI16490.1. Sequence problems.
AK097570 mRNA. Translation: BAC05106.1.
DN831198 mRNA. No translation available.
RefSeqiNP_078970.3. NM_024694.3. [Q8N7X0-1]
UniGeneiHs.720870.

Genome annotation databases

EnsembliENST00000397944; ENSP00000381036; ENSG00000118492. [Q8N7X0-1]
GeneIDi79747.
KEGGihsa:79747.
UCSCiuc003qlp.3. human. [Q8N7X0-1]
uc003qlr.3. human. [Q8N7X0-2]

Polymorphism databases

DMDMi298286920.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL832192 mRNA. No translation available.
AL138916 , AL158199 Genomic DNA. Translation: CAI14697.1 .
AL138916 , AL158199 Genomic DNA. Translation: CAI14698.1 .
AL158199 , AL359547 Genomic DNA. Translation: CAI20488.1 . Sequence problems.
AL158199 , AL138916 Genomic DNA. Translation: CAI20489.1 .
AL158199 , AL138916 Genomic DNA. Translation: CAI20490.1 .
AL359547 , AL158199 Genomic DNA. Translation: CAI16490.1 . Sequence problems.
AK097570 mRNA. Translation: BAC05106.1 .
DN831198 mRNA. No translation available.
RefSeqi NP_078970.3. NM_024694.3. [Q8N7X0-1 ]
UniGenei Hs.720870.

3D structure databases

ProteinModelPortali Q8N7X0.
SMRi Q8N7X0. Positions 784-872.
ModBasei Search...

Protein-protein interaction databases

BioGridi 122859. 1 interaction.

Protein family/group databases

MEROPSi C02.972.

PTM databases

PhosphoSitei Q8N7X0.

Polymorphism databases

DMDMi 298286920.

Proteomic databases

MaxQBi Q8N7X0.
PaxDbi Q8N7X0.
PRIDEi Q8N7X0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000397944 ; ENSP00000381036 ; ENSG00000118492 . [Q8N7X0-1 ]
GeneIDi 79747.
KEGGi hsa:79747.
UCSCi uc003qlp.3. human. [Q8N7X0-1 ]
uc003qlr.3. human. [Q8N7X0-2 ]

Organism-specific databases

CTDi 79747.
GeneCardsi GC06P146920.
H-InvDB HIX0006280.
HGNCi HGNC:21212. ADGB.
HPAi HPA036340.
HPA036341.
MIMi 614630. gene.
neXtProti NX_Q8N7X0.
PharmGKBi PA134944476.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG70817.
HOGENOMi HOG000169304.
HOVERGENi HBG058494.
InParanoidi Q8N7X0.
OMAi YKYIIQC.
OrthoDBi EOG7MD4Q3.
PhylomeDBi Q8N7X0.
TreeFami TF329120.

Miscellaneous databases

GenomeRNAii 79747.
NextBioi 69181.
PROi Q8N7X0.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8N7X0.
Bgeei Q8N7X0.
CleanExi HS_C6orf103.
Genevestigatori Q8N7X0.

Family and domain databases

Gene3Di 1.10.490.10. 1 hit.
InterProi IPR012292. Globin_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view ]
Pfami PF00648. Peptidase_C2. 1 hit.
[Graphical view ]
SMARTi SM00230. CysPc. 1 hit.
SM00015. IQ. 1 hit.
[Graphical view ]
PROSITEi PS50203. CALPAIN_CAT. 1 hit.
PS50096. IQ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ALA-1637.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-754 (ISOFORM 1), VARIANT THR-310.
    Tissue: Testis.
  4. "Exhaustive RT-PCR and sequencing of all novel TWINSCAN predictions in human."
    Stevens M., Wei C., Gross S.S., McPherson J., Brent M.R.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 697-964.

Entry informationi

Entry nameiADGB_HUMAN
AccessioniPrimary (citable) accession number: Q8N7X0
Secondary accession number(s): Q5T402, Q5T904, Q5T905
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: June 15, 2010
Last modified: June 11, 2014
This is version 89 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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