Q8N7X0 (ADGB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Androglobin

Alternative name(s):
Calpain-7-like protein

Gene names

Name:	ADGB
Synonyms:	C6orf103, CAPN7L

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1667 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities	Belongs to the peptidase C2 family. Contains 1 calpain catalytic domain. Contains 1 IQ domain.
Caution	Lacks the conserved active site residues. Probably catalytically inactive.
Sequence caution	The sequence AL832192 differs from that shown. Reason: Frameshift at positions 81, 281 and 581. The sequence AL832192 differs from that shown. Reason: Intron retention. The sequence CAI16490.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI20488.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence DN831198 differs from that shown. Reason: Frameshift at positions 944, 946 and 960.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	oxygen transport Inferred from electronic annotation. Source: InterPro proteolysis Inferred from electronic annotation. Source: InterPro
Cellular_component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular_function	calcium-dependent cysteine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: InterPro oxygen binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8N7X0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8N7X0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-951: Missing.
     1185-1288: Missing.

Note: Gene prediction based on EST data.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1667	1667	Androglobin		PRO_0000232525
Regions
	Domain	70 – 411	342	Calpain catalytic
	Domain	906 – 935	30	IQ
	Coiled coil	1588 – 1629	42	Potential
Natural variations
	Alternative sequence	1 – 951	951	Missing in isoform 2.		VSP_039243
	Alternative sequence	1185 – 1288	104	Missing in isoform 2.		VSP_039244
	Natural variant	310	1	I → T. Ref.3 Corresponds to variant rs9497606 [ dbSNP | Ensembl ].		VAR_025948
	Natural variant	1637	1	T → A. Ref.2 Corresponds to variant rs1052445 [ dbSNP | Ensembl ].		VAR_063158
Experimental info
	Sequence conflict	205 – 280	76	Missing in AL832192. Ref.1
	Sequence conflict	570 – 580	11	Missing in AL832192. Ref.1
	Sequence conflict	716	1	T → R in DN831198. Ref.4
	Sequence conflict	747 – 754	8	RHMLLFNA → YEVASFFP in BAC05106. Ref.3
	Sequence conflict	810	1	K → M in AL832192. Ref.1
	Sequence conflict	931	1	P → R in DN831198. Ref.4
	Sequence conflict	944	1	Q → L in DN831198. Ref.4
	Sequence conflict	1639	1	A → S in CAI14697. Ref.2
	Sequence conflict	1639	1	A → S in CAI20489. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 15, 2010. Version 3. Checksum: 46732C56A6C63B3F	FASTA	1,667	189,713
	10 20 30 40 50 60 MASKQTKKKE VHRINSAHGS DKSKDFYPFG SNVQSGSTEQ KKGKFPLWPE WSEADINSEK 70 80 90 100 110 120 WDAGKGAKEK DKTGKSPVFH FFEDPEGKIE LPPSLKIYSW KRPQDILFSQ TPVVVKNEIT 130 140 150 160 170 180 FDLFSANEHL LCSELMRWII SEIYAVWKIF NGGILSNYFK GTSGEPPLLP WKPWEHIYSL 190 200 210 220 230 240 CKAVKGHMPL FNSYGKYVVK LYWMGCWRKI TIDDFLPFDE DNNLLLPATT YEFELWPMLL 250 260 270 280 290 300 SKAIIKLANI DIHVADRREL GEFTVIHALT GWLPEVISLH PGYMDKVWEL LKEILPEFKL 310 320 330 340 350 360 SDEASSESKI AVLDSKLKEP GKEGKEGKEI KDGKEVKDVK EFKPESSLTT LKAPEKSDKV 370 380 390 400 410 420 PKEKADARDI GKKRSKDGEK EKFKFSLHGS RPSSEVQYSV QSLSDCSSAI QTSHMVVYAT 430 440 450 460 470 480 FTPLYLFENK IFSLEKMADS AEKLREYGLS HICSHPVLVT RSRSCPLVAP PKPPPLPPWK 490 500 510 520 530 540 LIRQKKETVI TDEAQELIVK KPERFLEISS PFLNYRMTPF TIPTEMHFVR SLIKKGIPPG 550 560 570 580 590 600 SDLPSVSETD ETATHSQTDL SQITKATSQG NTASQVILGK GTDEQTDFGL GDAHQSDGLN 610 620 630 640 650 660 LEREIVSQTT ATQEKSQEEL PTTNNSVSKE IWLDFEDFCV CFQNIYIFHK PSSYCLNFQK 670 680 690 700 710 720 SEFKFSEERV SYYLFVDSLK PIELLVCFSA LVRWGEYGAL TKDSPPIEPG LLTAETFSWK 730 740 750 760 770 780 SLKPGSLVLK IHTYATKATV VRLPVGRHML LFNAYSPVGH SIHICSMVSF VIGDEHVVLP 790 800 810 820 830 840 NFEPESCRFT EQSLLIMKAI GNVIANFKDK GKLSAALKDL QTAHYPVPFH DKELTAQHFR 850 860 870 880 890 900 VFHLSLWRLM KKVQITKPPP NFKFAFRAMV LDLELLNSSL EEVSLVEWLD VKYCMPTSDK 910 920 930 940 950 960 EYSAEEVAAA IKIQAMWRGT YVRLLMKARI PDTKENISVA DTLQKVWAVL EMNLEQYAVS 970 980 990 1000 1010 1020 LLRLMFKSKC KSLESYPCYQ DEETKIAFAD YTVTYQEQPP NSWFIVFRET FLVHQDMILV 1030 1040 1050 1060 1070 1080 PKVYTTLPIC ILHIVNNDTM EQVPKVFQKV VPYLYTKNKK GYTFVAEAFT GDTYVAASRW 1090 1100 1110 1120 1130 1140 KLRLIGSSAP LPCLSRDSPC NSFAIKEIRD YYIPNDKKIL FRYSVKVLTP QPATIQVRTS 1150 1160 1170 1180 1190 1200 KPDAFIKLQV LENEETMVSS TGKGQAIIPA FHFLKSEKGL SSQSSKHILS FHSASKKEQE 1210 1220 1230 1240 1250 1260 VYVKKKAAQG IQKSPKGRAV SAIQDIGLPL VEEETTSTPT REDSSSTPLQ NYKYIIQCSV 1270 1280 1290 1300 1310 1320 LYNSWPLTES QLTFVQALKD LKKSNTKAYG ERHEELINLG SPDSHTISEG QKSSVTSKTT 1330 1340 1350 1360 1370 1380 RKGKEKSSEK EKTAKEKQAP RFEPQISTVH PQQEDPNKPY WILRLVTEHN ESELFEVKKD 1390 1400 1410 1420 1430 1440 TERADEIRAM KQAWETTEPG RAIKASQARL HYLSGFIKKT SDAESPPISE SQTKPKEEVE 1450 1460 1470 1480 1490 1500 TAARGVKEPN SKNSAGSESK EMTQTGSGSA VWKKWQLTKG LRDVAKSTSS ESGGVSSPGK 1510 1520 1530 1540 1550 1560 EEREQSTRKE NIQTGPRTRS PTILETSPRL IRKALEFMDL SQYVRKTDTD PLLQTDELNQ 1570 1580 1590 1600 1610 1620 QQAMQKAEEI HQFRQHRTRV LSIRNIDQEE RLKLKDEVLD MYKEMQDSLD EARQKIFDIR 1630 1640 1650 1660 EEYRNKLLEA EHLKLETLAA QEAAMKLETE KMTPAPDTQK KKKGKKK
	Isoform 2 [UniParc]. Checksum: 884B8EB975F203EC	FASTA	612	70,082
	10 20 30 40 50 60 MNLEQYAVSL LRLMFKSKCK SLESYPCYQD EETKIAFADY TVTYQEQPPN SWFIVFRETF 70 80 90 100 110 120 LVHQDMILVP KVYTTLPICI LHIVNNDTME QVPKVFQKVV PYLYTKNKKG YTFVAEAFTG 130 140 150 160 170 180 DTYVAASRWK LRLIGSSAPL PCLSRDSPCN SFAIKEIRDY YIPNDKKILF RYSVKVLTPQ 190 200 210 220 230 240 PATIQVRTSK PDAFIKLQVL ENEETMVSST GKGQAIIPAF HFLKSEKGLS SQSYGERHEE 250 260 270 280 290 300 LINLGSPDSH TISEGQKSSV TSKTTRKGKE KSSEKEKTAK EKQAPRFEPQ ISTVHPQQED 310 320 330 340 350 360 PNKPYWILRL VTEHNESELF EVKKDTERAD EIRAMKQAWE TTEPGRAIKA SQARLHYLSG 370 380 390 400 410 420 FIKKTSDAES PPISESQTKP KEEVETAARG VKEPNSKNSA GSESKEMTQT GSGSAVWKKW 430 440 450 460 470 480 QLTKGLRDVA KSTSSESGGV SSPGKEEREQ STRKENIQTG PRTRSPTILE TSPRLIRKAL 490 500 510 520 530 540 EFMDLSQYVR KTDTDPLLQT DELNQQQAMQ KAEEIHQFRQ HRTRVLSIRN IDQEERLKLK 550 560 570 580 590 600 DEVLDMYKEM QDSLDEARQK IFDIREEYRN KLLEAEHLKL ETLAAQEAAM KLETEKMTPA 610 PDTQKKKKGK KK

References

[1]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[2]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ALA-1637.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-754 (ISOFORM 1), VARIANT THR-310. Tissue: Testis.
[4]	"Exhaustive RT-PCR and sequencing of all novel TWINSCAN predictions in human." Stevens M., Wei C., Gross S.S., McPherson J., Brent M.R. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 697-964.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL832192 mRNA. No translation available. AL138916, AL158199 Genomic DNA. Translation: CAI14697.1. AL138916, AL158199 Genomic DNA. Translation: CAI14698.1. AL158199, AL359547 Genomic DNA. Translation: CAI20488.1. Sequence problems. AL158199, AL138916 Genomic DNA. Translation: CAI20489.1. AL158199, AL138916 Genomic DNA. Translation: CAI20490.1. AL359547, AL158199 Genomic DNA. Translation: CAI16490.1. Sequence problems. AK097570 mRNA. Translation: BAC05106.1. DN831198 mRNA. No translation available.
IPI	IPI00332872. IPI00964550.
RefSeq	NP_078970.3. NM_024694.3.
UniGene	Hs.720870.
3D structure databases
ProteinModelPortal	Q8N7X0.
SMR	Q8N7X0. Positions 939-981.
ModBase	Search...
Protein family/group databases
MEROPS	C02.972.
PTM databases
PhosphoSite	Q8N7X0.
Polymorphism databases
DMDM	298286920.
Proteomic databases
PaxDb	Q8N7X0.
PRIDE	Q8N7X0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000397944; ENSP00000381036; ENSG00000118492.
GeneID	79747.
KEGG	hsa:79747.
UCSC	uc003qlp.3. human. uc003qlr.3. human.
Organism-specific databases
CTD	79747.
GeneCards	GC06P146920.
H-InvDB	HIX0006280.
HGNC	HGNC:21212. ADGB.
HPA	HPA036341.
MIM	614630. gene.
neXtProt	NX_Q8N7X0.
PharmGKB	PA134944476.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG70817.
HOGENOM	HOG000169304.
HOVERGEN	HBG058494.
InParanoid	Q8N7X0.
OMA	YKYIIQC.
OrthoDB	EOG4WQ129.
Gene expression databases
ArrayExpress	Q8N7X0.
Bgee	Q8N7X0.
CleanEx	HS_C6orf103.
Genevestigator	Q8N7X0.
GermOnline	ENSG00000118492. Homo sapiens.
Family and domain databases
Gene3D	1.10.490.10. 1 hit.
InterPro	IPR012292. Globin_dom. IPR000048. IQ_motif_EF-hand-BS. IPR001300. Peptidase_C2_calpain_cat. [Graphical view]
Pfam	PF00648. Peptidase_C2. 1 hit. [Graphical view]
SMART	SM00230. CysPc. 1 hit. SM00015. IQ. 1 hit. [Graphical view]
PROSITE	PS50203. CALPAIN_CAT. 1 hit. PS50096. IQ. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	79747.
NextBio	69181.
SOURCE	Search...

Entry information

Entry name

ADGB_HUMAN

Accession

Primary (citable) accession number: Q8N7X0
Secondary accession number(s): Q5T402, Q5T904, Q5T905

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 18, 2006
Last sequence update:	June 15, 2010
Last modified:	May 1, 2013
This is version 79 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.