Reviewed, UniProtKB/Swiss-Prot Q8N7S2 (DNJ5G_HUMAN)

Names and origin

Protein names

Recommended name:
    DnaJ homolog subfamily C member 5G
Alternative name(s):
    Gamma-cysteine string protein
      Short name=Gamma-CSP

Gene names

Name:

DNAJC5G

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	189 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subcellular location	Membrane; Lipid-anchor By similarity.
Tissue specificity	Testis specific.
Post-translational modification	Palmitoylated By similarity.
Sequence similarities	Contains 1 J domain.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Molecular function	Chaperone
PTM	Lipoprotein Palmitate Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein folding Inferred from electronic annotation. Source: InterPro
Cellular component	anchored to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	heat shock protein binding Inferred from electronic annotation. Source: InterPro unfolded protein binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 189	189	DnaJ homolog subfamily C member 5G		PRO_0000071057
Regions
	Domain	17 – 98	82	J
	Compositional bias	131 – 147	17	Cys-rich
Amino acid modifications
	Modified residue	3	1	Phosphothreonine Ref.4
Natural variations
	Natural variant	4	1	V → G: dbSNP rs17005979.		VAR_033882
	Natural variant	51	1	H → R: dbSNP rs13414011.		VAR_033883

Sequences

	Sequence		Length	Mass (Da)
	Q8N7S2-1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: EF8FCAE0F1A841A1	FASTA	189	21,433
	10 20 30 40 50 60 MSTVKEAAHR LSKSEMSLYA VLDLKKGASP EDFKKSYSHS ALLPHPPFEY HLGRKLALRY 70 80 90 100 110 120 HPDKNPGNAQ AAEIFKEINA AHAILSDSKK RKIYDQHGSL GIYLYDHFGE EGVRYYFILN 130 140 150 160 170 180 SCWFKTLVIL CTLLTCCCFC CCCCFCCGAL KPPPEQDSGR KYQQNVQSQP PRSGAKCDFR SEENSEDDF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[3]	"Novel isoforms of the cysteine string protein." Tobaben S., Stahl B. Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 57-165.
[4]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-3, MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK097736 mRNA. Translation: BAC05155.1. BC035194 mRNA. Translation: AAH35194.2. AF368277 mRNA. Translation: AAK60572.1.
IPI	IPI00175217.
RefSeq	NP_775921.1.
UniGene	Hs.116303
3D structure databases
SMR	Q8N7S2. Positions 9-119.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8N7S2.
Proteomic databases
PRIDE	Q8N7S2.
Genome annotation databases
Ensembl	ENST00000296097; ENSP00000296097; ENSG00000163793; Homo sapiens. [Genome view] ENST00000402462; ENSP00000384305; ENSG00000163793; Homo sapiens. [Genome view]
GeneID	285126.
KEGG	hsa:285126.
UCSC	uc002rjl.1. human.
Organism-specific databases
CTD	285126.
GeneCards	GC02P027412.
H-InvDB	HIX0001915.
HGNC	HGNC:24844. DNAJC5G.
PharmGKB	PA134880296.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG713019.
HOVERGEN	Q8N7S2.
InParanoid	Q8N7S2.
OMA	CTLLTCC.
PhylomeDB	Q8N7S2.
Gene expression databases
ArrayExpress	Q8N7S2.
Bgee	Q8N7S2.
CleanEx	HS_DNAJC5G.
Genevestigator	Q8N7S2.
GermOnline	ENSG00000163793. Homo sapiens.
Family and domain databases
InterPro	IPR001623. DnaJ_N. IPR018253. Heat_shock_DnaJ_CS. IPR015609. Hsp40/DnaJ_Rel. IPR003095. Hsp_DnaJ. [Graphical view]
PANTHER	PTHR11821. Hsp40/DnaJ_Rel. 1 hit.
Pfam	PF00226. DnaJ. 1 hit. [Graphical view]
PRINTS	PR00625. DNAJPROTEIN.
SMART	SM00271. DnaJ. 1 hit. [Graphical view]
PROSITE	PS00636. DNAJ_1. 1 hit. PS50076. DNAJ_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	95281.

Entry information

Entry name

DNJ5G_HUMAN

Accession

Primary (citable) accession number: Q8N7S2
Secondary accession number(s): Q8IYQ4, Q96RJ8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	October 1, 2002
Last modified:	January 19, 2010
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.