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Protein

DnaJ homolog subfamily C member 5G

Gene

DNAJC5G

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Keywords - Molecular functioni

Chaperone

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily C member 5G
Alternative name(s):
Cysteine string protein-gamma
Short name:
CSP-gamma
Gene namesi
Name:DNAJC5G
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:24844. DNAJC5G.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000163793.
PharmGKBiPA134880296.

Polymorphism and mutation databases

BioMutaiDNAJC5G.
DMDMi50400554.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000710571 – 189DnaJ homolog subfamily C member 5GAdd BLAST189

Post-translational modificationi

Palmitoylated.By similarity

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ8N7S2.
PRIDEiQ8N7S2.

PTM databases

iPTMnetiQ8N7S2.
PhosphoSitePlusiQ8N7S2.

Expressioni

Tissue specificityi

Testis specific.

Gene expression databases

BgeeiENSG00000163793.
CleanExiHS_DNAJC5G.
ExpressionAtlasiQ8N7S2. baseline and differential.
GenevisibleiQ8N7S2. HS.

Organism-specific databases

HPAiHPA041445.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000296097.

Structurei

3D structure databases

ProteinModelPortaliQ8N7S2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 98JPROSITE-ProRule annotationAdd BLAST82

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi131 – 147Cys-richAdd BLAST17

Sequence similaritiesi

Contains 1 J domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0716. Eukaryota.
COG0484. LUCA.
GeneTreeiENSGT00760000118947.
HOGENOMiHOG000231969.
HOVERGENiHBG005414.
InParanoidiQ8N7S2.
KOiK09525.
OMAiCCGTLKP.
OrthoDBiEOG091G0QJP.
PhylomeDBiQ8N7S2.
TreeFamiTF105164.

Family and domain databases

CDDicd06257. DnaJ. 1 hit.
Gene3Di1.10.287.110. 1 hit.
InterProiIPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 2 hits.
PROSITEiPS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N7S2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSTVKEAAHR LSKSEMSLYA VLDLKKGASP EDFKKSYSHS ALLPHPPFEY
60 70 80 90 100
HLGRKLALRY HPDKNPGNAQ AAEIFKEINA AHAILSDSKK RKIYDQHGSL
110 120 130 140 150
GIYLYDHFGE EGVRYYFILN SCWFKTLVIL CTLLTCCCFC CCCCFCCGAL
160 170 180
KPPPEQDSGR KYQQNVQSQP PRSGAKCDFR SEENSEDDF
Length:189
Mass (Da):21,433
Last modified:October 1, 2002 - v1
Checksum:iEF8FCAE0F1A841A1
GO
Isoform 2 (identifier: Q8N7S2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     38-104: SHSALLPHPP...DQHGSLGIYL → RHLSSCVLCS...RKIAKMIFKR
     105-189: Missing.

Note: No experimental confirmation available.
Show »
Length:104
Mass (Da):11,579
Checksum:iC1494934DFFABEC8
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0338824V → G.Corresponds to variant rs17005979dbSNPEnsembl.1
Natural variantiVAR_03388351H → R.Corresponds to variant rs13414011dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05696738 – 104SHSAL…LGIYL → RHLSSCVLCSLVAVSVVAAV FAVEHLNHHLSRIVGENISR MSRVSLQGQEPNVILEARKI AKMIFKR in isoform 2. 1 PublicationAdd BLAST67
Alternative sequenceiVSP_056968105 – 189Missing in isoform 2. 1 PublicationAdd BLAST85

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097736 mRNA. Translation: BAC05155.1.
AK302239 mRNA. Translation: BAG63591.1.
AC013413 Genomic DNA. Translation: AAY24295.1.
CH471053 Genomic DNA. Translation: EAX00608.1.
CH471053 Genomic DNA. Translation: EAX00609.1.
BC035194 mRNA. Translation: AAH35194.2.
AF368277 mRNA. Translation: AAK60572.1.
CCDSiCCDS1744.1. [Q8N7S2-1]
CCDS77397.1. [Q8N7S2-2]
RefSeqiNP_001290056.1. NM_001303127.1. [Q8N7S2-1]
NP_001290057.1. NM_001303128.1. [Q8N7S2-2]
NP_775921.1. NM_173650.2. [Q8N7S2-1]
XP_006712058.1. XM_006711995.3. [Q8N7S2-1]
XP_016859361.1. XM_017003872.1. [Q8N7S2-1]
XP_016859362.1. XM_017003873.1. [Q8N7S2-1]
XP_016859363.1. XM_017003874.1. [Q8N7S2-1]
UniGeneiHs.116303.
Hs.709163.

Genome annotation databases

EnsembliENST00000296097; ENSP00000296097; ENSG00000163793. [Q8N7S2-1]
ENST00000402462; ENSP00000384305; ENSG00000163793. [Q8N7S2-1]
ENST00000406962; ENSP00000385533; ENSG00000163793. [Q8N7S2-2]
GeneIDi285126.
KEGGihsa:285126.
UCSCiuc002rjl.2. human. [Q8N7S2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097736 mRNA. Translation: BAC05155.1.
AK302239 mRNA. Translation: BAG63591.1.
AC013413 Genomic DNA. Translation: AAY24295.1.
CH471053 Genomic DNA. Translation: EAX00608.1.
CH471053 Genomic DNA. Translation: EAX00609.1.
BC035194 mRNA. Translation: AAH35194.2.
AF368277 mRNA. Translation: AAK60572.1.
CCDSiCCDS1744.1. [Q8N7S2-1]
CCDS77397.1. [Q8N7S2-2]
RefSeqiNP_001290056.1. NM_001303127.1. [Q8N7S2-1]
NP_001290057.1. NM_001303128.1. [Q8N7S2-2]
NP_775921.1. NM_173650.2. [Q8N7S2-1]
XP_006712058.1. XM_006711995.3. [Q8N7S2-1]
XP_016859361.1. XM_017003872.1. [Q8N7S2-1]
XP_016859362.1. XM_017003873.1. [Q8N7S2-1]
XP_016859363.1. XM_017003874.1. [Q8N7S2-1]
UniGeneiHs.116303.
Hs.709163.

3D structure databases

ProteinModelPortaliQ8N7S2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000296097.

PTM databases

iPTMnetiQ8N7S2.
PhosphoSitePlusiQ8N7S2.

Polymorphism and mutation databases

BioMutaiDNAJC5G.
DMDMi50400554.

Proteomic databases

PaxDbiQ8N7S2.
PRIDEiQ8N7S2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296097; ENSP00000296097; ENSG00000163793. [Q8N7S2-1]
ENST00000402462; ENSP00000384305; ENSG00000163793. [Q8N7S2-1]
ENST00000406962; ENSP00000385533; ENSG00000163793. [Q8N7S2-2]
GeneIDi285126.
KEGGihsa:285126.
UCSCiuc002rjl.2. human. [Q8N7S2-1]

Organism-specific databases

CTDi285126.
GeneCardsiDNAJC5G.
H-InvDBHIX0029859.
HGNCiHGNC:24844. DNAJC5G.
HPAiHPA041445.
MIMi613946. gene.
neXtProtiNX_Q8N7S2.
OpenTargetsiENSG00000163793.
PharmGKBiPA134880296.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0716. Eukaryota.
COG0484. LUCA.
GeneTreeiENSGT00760000118947.
HOGENOMiHOG000231969.
HOVERGENiHBG005414.
InParanoidiQ8N7S2.
KOiK09525.
OMAiCCGTLKP.
OrthoDBiEOG091G0QJP.
PhylomeDBiQ8N7S2.
TreeFamiTF105164.

Miscellaneous databases

GenomeRNAii285126.
PROiQ8N7S2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163793.
CleanExiHS_DNAJC5G.
ExpressionAtlasiQ8N7S2. baseline and differential.
GenevisibleiQ8N7S2. HS.

Family and domain databases

CDDicd06257. DnaJ. 1 hit.
Gene3Di1.10.287.110. 1 hit.
InterProiIPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 2 hits.
PROSITEiPS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDNJ5G_HUMAN
AccessioniPrimary (citable) accession number: Q8N7S2
Secondary accession number(s): B4DY29
, Q53SY5, Q8IYQ4, Q96RJ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.