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Q8N7S2

- DNJ5G_HUMAN

UniProt

Q8N7S2 - DNJ5G_HUMAN

Protein

DnaJ homolog subfamily C member 5G

Gene

DNAJC5G

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Keywords - Molecular functioni

    Chaperone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DnaJ homolog subfamily C member 5G
    Alternative name(s):
    Cysteine string protein-gamma
    Short name:
    CSP-gamma
    Gene namesi
    Name:DNAJC5G
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:24844. DNAJC5G.

    Subcellular locationi

    Membrane By similarity; Lipid-anchor By similarity

    GO - Cellular componenti

    1. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134880296.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 189189DnaJ homolog subfamily C member 5GPRO_0000071057Add
    BLAST

    Post-translational modificationi

    Palmitoylated.By similarity

    Keywords - PTMi

    Lipoprotein, Palmitate

    Proteomic databases

    PaxDbiQ8N7S2.
    PRIDEiQ8N7S2.

    PTM databases

    PhosphoSiteiQ8N7S2.

    Expressioni

    Tissue specificityi

    Testis specific.

    Gene expression databases

    ArrayExpressiQ8N7S2.
    BgeeiQ8N7S2.
    CleanExiHS_DNAJC5G.
    GenevestigatoriQ8N7S2.

    Organism-specific databases

    HPAiHPA035504.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000296097.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N7S2.
    SMRiQ8N7S2. Positions 11-118.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini17 – 9882JPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi131 – 14717Cys-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 J domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0484.
    HOGENOMiHOG000231969.
    HOVERGENiHBG005414.
    InParanoidiQ8N7S2.
    KOiK09525.
    OMAiGIYIYDH.
    OrthoDBiEOG7WHHBD.
    PhylomeDBiQ8N7S2.
    TreeFamiTF105164.

    Family and domain databases

    Gene3Di1.10.287.110. 1 hit.
    InterProiIPR001623. DnaJ_domain.
    IPR018253. DnaJ_domain_CS.
    [Graphical view]
    PfamiPF00226. DnaJ. 1 hit.
    [Graphical view]
    PRINTSiPR00625. JDOMAIN.
    SMARTiSM00271. DnaJ. 1 hit.
    [Graphical view]
    SUPFAMiSSF46565. SSF46565. 2 hits.
    PROSITEiPS00636. DNAJ_1. 1 hit.
    PS50076. DNAJ_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8N7S2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTVKEAAHR LSKSEMSLYA VLDLKKGASP EDFKKSYSHS ALLPHPPFEY    50
    HLGRKLALRY HPDKNPGNAQ AAEIFKEINA AHAILSDSKK RKIYDQHGSL 100
    GIYLYDHFGE EGVRYYFILN SCWFKTLVIL CTLLTCCCFC CCCCFCCGAL 150
    KPPPEQDSGR KYQQNVQSQP PRSGAKCDFR SEENSEDDF 189
    Length:189
    Mass (Da):21,433
    Last modified:October 1, 2002 - v1
    Checksum:iEF8FCAE0F1A841A1
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti4 – 41V → G.
    Corresponds to variant rs17005979 [ dbSNP | Ensembl ].
    VAR_033882
    Natural varianti51 – 511H → R.
    Corresponds to variant rs13414011 [ dbSNP | Ensembl ].
    VAR_033883

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK097736 mRNA. Translation: BAC05155.1.
    AC013413 Genomic DNA. Translation: AAY24295.1.
    CH471053 Genomic DNA. Translation: EAX00608.1.
    CH471053 Genomic DNA. Translation: EAX00609.1.
    BC035194 mRNA. Translation: AAH35194.2.
    AF368277 mRNA. Translation: AAK60572.1.
    CCDSiCCDS1744.1.
    RefSeqiNP_775921.1. NM_173650.1.
    XP_006712058.1. XM_006711995.1.
    XP_006712059.1. XM_006711996.1.
    XP_006712060.1. XM_006711997.1.
    XP_006712061.1. XM_006711998.1.
    UniGeneiHs.116303.

    Genome annotation databases

    EnsembliENST00000296097; ENSP00000296097; ENSG00000163793.
    ENST00000402462; ENSP00000384305; ENSG00000163793.
    GeneIDi285126.
    KEGGihsa:285126.
    UCSCiuc002rjl.1. human.

    Polymorphism databases

    DMDMi50400554.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK097736 mRNA. Translation: BAC05155.1 .
    AC013413 Genomic DNA. Translation: AAY24295.1 .
    CH471053 Genomic DNA. Translation: EAX00608.1 .
    CH471053 Genomic DNA. Translation: EAX00609.1 .
    BC035194 mRNA. Translation: AAH35194.2 .
    AF368277 mRNA. Translation: AAK60572.1 .
    CCDSi CCDS1744.1.
    RefSeqi NP_775921.1. NM_173650.1.
    XP_006712058.1. XM_006711995.1.
    XP_006712059.1. XM_006711996.1.
    XP_006712060.1. XM_006711997.1.
    XP_006712061.1. XM_006711998.1.
    UniGenei Hs.116303.

    3D structure databases

    ProteinModelPortali Q8N7S2.
    SMRi Q8N7S2. Positions 11-118.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000296097.

    PTM databases

    PhosphoSitei Q8N7S2.

    Polymorphism databases

    DMDMi 50400554.

    Proteomic databases

    PaxDbi Q8N7S2.
    PRIDEi Q8N7S2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000296097 ; ENSP00000296097 ; ENSG00000163793 .
    ENST00000402462 ; ENSP00000384305 ; ENSG00000163793 .
    GeneIDi 285126.
    KEGGi hsa:285126.
    UCSCi uc002rjl.1. human.

    Organism-specific databases

    CTDi 285126.
    GeneCardsi GC02P027498.
    H-InvDB HIX0029859.
    HGNCi HGNC:24844. DNAJC5G.
    HPAi HPA035504.
    MIMi 613946. gene.
    neXtProti NX_Q8N7S2.
    PharmGKBi PA134880296.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0484.
    HOGENOMi HOG000231969.
    HOVERGENi HBG005414.
    InParanoidi Q8N7S2.
    KOi K09525.
    OMAi GIYIYDH.
    OrthoDBi EOG7WHHBD.
    PhylomeDBi Q8N7S2.
    TreeFami TF105164.

    Miscellaneous databases

    GenomeRNAii 285126.
    NextBioi 95281.
    PROi Q8N7S2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8N7S2.
    Bgeei Q8N7S2.
    CleanExi HS_DNAJC5G.
    Genevestigatori Q8N7S2.

    Family and domain databases

    Gene3Di 1.10.287.110. 1 hit.
    InterProi IPR001623. DnaJ_domain.
    IPR018253. DnaJ_domain_CS.
    [Graphical view ]
    Pfami PF00226. DnaJ. 1 hit.
    [Graphical view ]
    PRINTSi PR00625. JDOMAIN.
    SMARTi SM00271. DnaJ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46565. SSF46565. 2 hits.
    PROSITEi PS00636. DNAJ_1. 1 hit.
    PS50076. DNAJ_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    5. "Novel isoforms of the cysteine string protein."
      Tobaben S., Stahl B.
      Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 57-165.

    Entry informationi

    Entry nameiDNJ5G_HUMAN
    AccessioniPrimary (citable) accession number: Q8N7S2
    Secondary accession number(s): Q53SY5, Q8IYQ4, Q96RJ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3