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Q8N7S2

- DNJ5G_HUMAN

UniProt

Q8N7S2 - DNJ5G_HUMAN

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Protein

DnaJ homolog subfamily C member 5G

Gene

DNAJC5G

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Keywords - Molecular functioni

Chaperone

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily C member 5G
Alternative name(s):
Cysteine string protein-gamma
Short name:
CSP-gamma
Gene namesi
Name:DNAJC5G
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:24844. DNAJC5G.

Subcellular locationi

Membrane By similarity; Lipid-anchor By similarity

GO - Cellular componenti

  1. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134880296.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 189189DnaJ homolog subfamily C member 5GPRO_0000071057Add
BLAST

Post-translational modificationi

Palmitoylated.By similarity

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ8N7S2.
PRIDEiQ8N7S2.

PTM databases

PhosphoSiteiQ8N7S2.

Expressioni

Tissue specificityi

Testis specific.

Gene expression databases

BgeeiQ8N7S2.
CleanExiHS_DNAJC5G.
ExpressionAtlasiQ8N7S2. baseline and differential.
GenevestigatoriQ8N7S2.

Organism-specific databases

HPAiHPA035504.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000296097.

Structurei

3D structure databases

ProteinModelPortaliQ8N7S2.
SMRiQ8N7S2. Positions 11-118.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 9882JPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi131 – 14717Cys-richAdd
BLAST

Sequence similaritiesi

Contains 1 J domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0484.
GeneTreeiENSGT00760000118947.
HOGENOMiHOG000231969.
HOVERGENiHBG005414.
InParanoidiQ8N7S2.
KOiK09525.
OMAiGIYIYDH.
OrthoDBiEOG7WHHBD.
PhylomeDBiQ8N7S2.
TreeFamiTF105164.

Family and domain databases

Gene3Di1.10.287.110. 1 hit.
InterProiIPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 2 hits.
PROSITEiPS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8N7S2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSTVKEAAHR LSKSEMSLYA VLDLKKGASP EDFKKSYSHS ALLPHPPFEY
60 70 80 90 100
HLGRKLALRY HPDKNPGNAQ AAEIFKEINA AHAILSDSKK RKIYDQHGSL
110 120 130 140 150
GIYLYDHFGE EGVRYYFILN SCWFKTLVIL CTLLTCCCFC CCCCFCCGAL
160 170 180
KPPPEQDSGR KYQQNVQSQP PRSGAKCDFR SEENSEDDF
Length:189
Mass (Da):21,433
Last modified:October 1, 2002 - v1
Checksum:iEF8FCAE0F1A841A1
GO
Isoform 2 (identifier: Q8N7S2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     38-104: SHSALLPHPP...DQHGSLGIYL → RHLSSCVLCS...RKIAKMIFKR
     105-189: Missing.

Note: No experimental confirmation available

Show »
Length:104
Mass (Da):11,579
Checksum:iC1494934DFFABEC8
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti4 – 41V → G.
Corresponds to variant rs17005979 [ dbSNP | Ensembl ].
VAR_033882
Natural varianti51 – 511H → R.
Corresponds to variant rs13414011 [ dbSNP | Ensembl ].
VAR_033883

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei38 – 10467SHSAL…LGIYL → RHLSSCVLCSLVAVSVVAAV FAVEHLNHHLSRIVGENISR MSRVSLQGQEPNVILEARKI AKMIFKR in isoform 2. 1 PublicationVSP_056967Add
BLAST
Alternative sequencei105 – 18985Missing in isoform 2. 1 PublicationVSP_056968Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097736 mRNA. Translation: BAC05155.1.
AK302239 mRNA. Translation: BAG63591.1.
AC013413 Genomic DNA. Translation: AAY24295.1.
CH471053 Genomic DNA. Translation: EAX00608.1.
CH471053 Genomic DNA. Translation: EAX00609.1.
BC035194 mRNA. Translation: AAH35194.2.
AF368277 mRNA. Translation: AAK60572.1.
CCDSiCCDS1744.1.
RefSeqiNP_775921.1. NM_173650.1.
XP_006712058.1. XM_006711995.1.
XP_006712059.1. XM_006711996.1.
XP_006712060.1. XM_006711997.1.
XP_006712061.1. XM_006711998.1.
UniGeneiHs.116303.

Genome annotation databases

EnsembliENST00000296097; ENSP00000296097; ENSG00000163793. [Q8N7S2-1]
ENST00000402462; ENSP00000384305; ENSG00000163793. [Q8N7S2-1]
ENST00000406962; ENSP00000385533; ENSG00000163793. [Q8N7S2-2]
GeneIDi285126.
KEGGihsa:285126.
UCSCiuc002rjl.1. human. [Q8N7S2-1]

Polymorphism databases

DMDMi50400554.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097736 mRNA. Translation: BAC05155.1 .
AK302239 mRNA. Translation: BAG63591.1 .
AC013413 Genomic DNA. Translation: AAY24295.1 .
CH471053 Genomic DNA. Translation: EAX00608.1 .
CH471053 Genomic DNA. Translation: EAX00609.1 .
BC035194 mRNA. Translation: AAH35194.2 .
AF368277 mRNA. Translation: AAK60572.1 .
CCDSi CCDS1744.1.
RefSeqi NP_775921.1. NM_173650.1.
XP_006712058.1. XM_006711995.1.
XP_006712059.1. XM_006711996.1.
XP_006712060.1. XM_006711997.1.
XP_006712061.1. XM_006711998.1.
UniGenei Hs.116303.

3D structure databases

ProteinModelPortali Q8N7S2.
SMRi Q8N7S2. Positions 11-118.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000296097.

PTM databases

PhosphoSitei Q8N7S2.

Polymorphism databases

DMDMi 50400554.

Proteomic databases

PaxDbi Q8N7S2.
PRIDEi Q8N7S2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000296097 ; ENSP00000296097 ; ENSG00000163793 . [Q8N7S2-1 ]
ENST00000402462 ; ENSP00000384305 ; ENSG00000163793 . [Q8N7S2-1 ]
ENST00000406962 ; ENSP00000385533 ; ENSG00000163793 . [Q8N7S2-2 ]
GeneIDi 285126.
KEGGi hsa:285126.
UCSCi uc002rjl.1. human. [Q8N7S2-1 ]

Organism-specific databases

CTDi 285126.
GeneCardsi GC02P027498.
H-InvDB HIX0029859.
HGNCi HGNC:24844. DNAJC5G.
HPAi HPA035504.
MIMi 613946. gene.
neXtProti NX_Q8N7S2.
PharmGKBi PA134880296.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0484.
GeneTreei ENSGT00760000118947.
HOGENOMi HOG000231969.
HOVERGENi HBG005414.
InParanoidi Q8N7S2.
KOi K09525.
OMAi GIYIYDH.
OrthoDBi EOG7WHHBD.
PhylomeDBi Q8N7S2.
TreeFami TF105164.

Miscellaneous databases

GenomeRNAii 285126.
NextBioi 95281.
PROi Q8N7S2.
SOURCEi Search...

Gene expression databases

Bgeei Q8N7S2.
CleanExi HS_DNAJC5G.
ExpressionAtlasi Q8N7S2. baseline and differential.
Genevestigatori Q8N7S2.

Family and domain databases

Gene3Di 1.10.287.110. 1 hit.
InterProi IPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
[Graphical view ]
Pfami PF00226. DnaJ. 1 hit.
[Graphical view ]
PRINTSi PR00625. JDOMAIN.
SMARTi SM00271. DnaJ. 1 hit.
[Graphical view ]
SUPFAMi SSF46565. SSF46565. 2 hits.
PROSITEi PS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Testis.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  5. "Novel isoforms of the cysteine string protein."
    Tobaben S., Stahl B.
    Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 57-165 (ISOFORM 1).

Entry informationi

Entry nameiDNJ5G_HUMAN
AccessioniPrimary (citable) accession number: Q8N7S2
Secondary accession number(s): B4DY29
, Q53SY5, Q8IYQ4, Q96RJ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: October 1, 2002
Last modified: November 26, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3