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Protein

POM121-like protein 12

Gene

POM121L12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
POM121-like protein 12
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000221900.5
HGNCiHGNC:25369 POM121L12
neXtProtiNX_Q8N7R1

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000221900

Polymorphism and mutation databases

BioMutaiPOM121L12
DMDMi327478566

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003484531 – 296POM121-like protein 12Add BLAST296

Proteomic databases

PaxDbiQ8N7R1
PeptideAtlasiQ8N7R1
PRIDEiQ8N7R1

PTM databases

iPTMnetiQ8N7R1
PhosphoSitePlusiQ8N7R1

Expressioni

Gene expression databases

BgeeiENSG00000221900
GenevisibleiQ8N7R1 HS

Organism-specific databases

HPAiHPA027836

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000386133

Structurei

3D structure databases

ProteinModelPortaliQ8N7R1
SMRiQ8N7R1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the POM121 family.Curated

Phylogenomic databases

eggNOGiENOG410JDK1 Eukaryota
ENOG4111BVZ LUCA
GeneTreeiENSGT00730000110770
HOGENOMiHOG000171786
InParanoidiQ8N7R1
OMAiSCAWEGC
OrthoDBiEOG091G04SC
PhylomeDBiQ8N7R1

Family and domain databases

InterProiView protein in InterPro
IPR026054 Nucleoporin
PANTHERiPTHR23193 PTHR23193, 2 hits

Sequencei

Sequence statusi: Complete.

Q8N7R1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAAAPAESA DLGNFWKAGE PLLQGPDALA APMSRSPSTP QTTPSPQGRQ
60 70 80 90 100
SPWPLRSLTQ SHIQYFQWGR PVPSTHLIEV RPTQDPAKPQ RVVSEGWRRP
110 120 130 140 150
ALPGETALGR DLSCAWEGCM KGGLCRAWNP GRTWSPVTIG IAPPERQESP
160 170 180 190 200
WRSPGQRARP AGRPAAQELL DPCTRETLLG ALSQCPKGSA RFDGPLWFEV
210 220 230 240 250
SDSKGGRRNL QPRPSAFKPL SKNGAVASFV PRPGPLKPSL GPWSLSFCDD
260 270 280 290
AWPSVLVQPA PSAIWDFWEA TTPSCGSCSR VSFALEVTQS AGPFGS
Length:296
Mass (Da):31,848
Last modified:April 5, 2011 - v3
Checksum:i10434551DF3C2FC1
GO

Sequence cautioni

The sequence BAC05166 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAD38744 differs from that shown. Contaminating sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti144P → S in CAD38744 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04618021P → T. Corresponds to variant dbSNP:rs10229800Ensembl.1
Natural variantiVAR_04618164Q → E1 PublicationCorresponds to variant dbSNP:rs11238247Ensembl.1
Natural variantiVAR_046182188G → E. Corresponds to variant dbSNP:rs1689291Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097768 mRNA Translation: BAC05166.1 Different initiation.
AC074397 Genomic DNA No translation available.
AL833888 mRNA Translation: CAD38744.1 Sequence problems.
CCDSiCCDS43584.1
RefSeqiNP_872401.3, NM_182595.3
UniGeneiHs.381970

Genome annotation databases

EnsembliENST00000408890; ENSP00000386133; ENSG00000221900
GeneIDi285877
KEGGihsa:285877
UCSCiuc003tpz.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiP1L12_HUMAN
AccessioniPrimary (citable) accession number: Q8N7R1
Secondary accession number(s): Q8NDI9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: April 5, 2011
Last modified: April 25, 2018
This is version 92 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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