Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

POM121-like protein 12

Gene

POM121L12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
POM121-like protein 12
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:25369. POM121L12.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiPOM121L12.
DMDMi327478566.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 296296POM121-like protein 12PRO_0000348453Add
BLAST

Proteomic databases

PaxDbiQ8N7R1.
PeptideAtlasiQ8N7R1.
PRIDEiQ8N7R1.

PTM databases

iPTMnetiQ8N7R1.
PhosphoSiteiQ8N7R1.

Expressioni

Gene expression databases

BgeeiENSG00000221900.
GenevisibleiQ8N7R1. HS.

Organism-specific databases

HPAiHPA027836.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000386133.

Structurei

3D structure databases

ProteinModelPortaliQ8N7R1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the POM121 family.Curated

Phylogenomic databases

eggNOGiENOG410JDK1. Eukaryota.
ENOG4111BVZ. LUCA.
GeneTreeiENSGT00730000110770.
HOGENOMiHOG000171786.
InParanoidiQ8N7R1.
OMAiSCAWEGC.
OrthoDBiEOG091G04SC.
PhylomeDBiQ8N7R1.

Sequencei

Sequence statusi: Complete.

Q8N7R1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAAAPAESA DLGNFWKAGE PLLQGPDALA APMSRSPSTP QTTPSPQGRQ
60 70 80 90 100
SPWPLRSLTQ SHIQYFQWGR PVPSTHLIEV RPTQDPAKPQ RVVSEGWRRP
110 120 130 140 150
ALPGETALGR DLSCAWEGCM KGGLCRAWNP GRTWSPVTIG IAPPERQESP
160 170 180 190 200
WRSPGQRARP AGRPAAQELL DPCTRETLLG ALSQCPKGSA RFDGPLWFEV
210 220 230 240 250
SDSKGGRRNL QPRPSAFKPL SKNGAVASFV PRPGPLKPSL GPWSLSFCDD
260 270 280 290
AWPSVLVQPA PSAIWDFWEA TTPSCGSCSR VSFALEVTQS AGPFGS
Length:296
Mass (Da):31,848
Last modified:April 5, 2011 - v3
Checksum:i10434551DF3C2FC1
GO

Sequence cautioni

The sequence BAC05166 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAD38744 differs from that shown.Contaminating sequence.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti144 – 1441P → S in CAD38744 (PubMed:17974005).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti21 – 211P → T.
Corresponds to variant rs10229800 [ dbSNP | Ensembl ].
VAR_046180
Natural varianti64 – 641Q → E.1 Publication
Corresponds to variant rs11238247 [ dbSNP | Ensembl ].
VAR_046181
Natural varianti188 – 1881G → E.
Corresponds to variant rs1689291 [ dbSNP | Ensembl ].
VAR_046182

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097768 mRNA. Translation: BAC05166.1. Different initiation.
AC074397 Genomic DNA. No translation available.
AL833888 mRNA. Translation: CAD38744.1. Sequence problems.
CCDSiCCDS43584.1.
RefSeqiNP_872401.3. NM_182595.3.
UniGeneiHs.381970.

Genome annotation databases

EnsembliENST00000408890; ENSP00000386133; ENSG00000221900.
GeneIDi285877.
KEGGihsa:285877.
UCSCiuc003tpz.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097768 mRNA. Translation: BAC05166.1. Different initiation.
AC074397 Genomic DNA. No translation available.
AL833888 mRNA. Translation: CAD38744.1. Sequence problems.
CCDSiCCDS43584.1.
RefSeqiNP_872401.3. NM_182595.3.
UniGeneiHs.381970.

3D structure databases

ProteinModelPortaliQ8N7R1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000386133.

PTM databases

iPTMnetiQ8N7R1.
PhosphoSiteiQ8N7R1.

Polymorphism and mutation databases

BioMutaiPOM121L12.
DMDMi327478566.

Proteomic databases

PaxDbiQ8N7R1.
PeptideAtlasiQ8N7R1.
PRIDEiQ8N7R1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000408890; ENSP00000386133; ENSG00000221900.
GeneIDi285877.
KEGGihsa:285877.
UCSCiuc003tpz.4. human.

Organism-specific databases

CTDi285877.
GeneCardsiPOM121L12.
H-InvDBHIX0006689.
HGNCiHGNC:25369. POM121L12.
HPAiHPA027836.
neXtProtiNX_Q8N7R1.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JDK1. Eukaryota.
ENOG4111BVZ. LUCA.
GeneTreeiENSGT00730000110770.
HOGENOMiHOG000171786.
InParanoidiQ8N7R1.
OMAiSCAWEGC.
OrthoDBiEOG091G04SC.
PhylomeDBiQ8N7R1.

Miscellaneous databases

ChiTaRSiPOM121L12. human.
GenomeRNAii285877.
PROiQ8N7R1.

Gene expression databases

BgeeiENSG00000221900.
GenevisibleiQ8N7R1. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiP1L12_HUMAN
AccessioniPrimary (citable) accession number: Q8N7R1
Secondary accession number(s): Q8NDI9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: April 5, 2011
Last modified: September 7, 2016
This is version 83 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.