ID   NANG2_HUMAN             Reviewed;         232 AA.
AC   Q8N7R0;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   27-MAR-2024, entry version 131.
DE   RecName: Full=Putative homeobox protein NANOG2;
GN   Name=NANOGP1; Synonyms=NANOG2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RC   TISSUE=Embryonic stem cell;
RX   PubMed=15108323; DOI=10.1002/dvdy.20034;
RA   Hart A.H., Hartley L., Ibrahim M., Robb L.;
RT   "Identification, cloning and expression analysis of the pluripotency
RT   promoting Nanog genes in mouse and human.";
RL   Dev. Dyn. 230:187-198(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   GENE FAMILY.
RX   PubMed=15233988; DOI=10.1016/j.ygeno.2004.02.014;
RA   Booth H.A., Holland P.W.;
RT   "Eleven daughters of NANOG.";
RL   Genomics 84:229-238(2004).
RN   [4]
RP   GENE FAMILY.
RX   PubMed=16469101; DOI=10.1186/1471-2148-6-12;
RA   Fairbanks D.J., Maughan P.J.;
RT   "Evolution of the NANOG pseudogene family in the human and chimpanzee
RT   genomes.";
RL   BMC Evol. Biol. 6:12-12(2006).
CC   -!- FUNCTION: Probable transcriptional regulator.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in embryonic stem cells (ES).
CC       {ECO:0000269|PubMed:15108323}.
CC   -!- SIMILARITY: Belongs to the Nanog homeobox family. {ECO:0000305}.
CC   -!- CAUTION: Could be the product of a pseudogene, according to
CC       PubMed:15233988. {ECO:0000305}.
CC   -!- CAUTION: Exists an other tandem duplicated gene (NANOG) and 10 other
CC       NANOG-related nucleotide sequences located on different chromosomes,
CC       all of which are processed pseudogenes lacking introns (NANOGP2 to
CC       NANOGP11); except NANOGP8 which is a retrogene. {ECO:0000305}.
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DR   EMBL; AY455283; AAS57555.1; -; mRNA.
DR   EMBL; AK097770; BAC05167.1; -; mRNA.
DR   AlphaFoldDB; Q8N7R0; -.
DR   SMR; Q8N7R0; -.
DR   GlyGen; Q8N7R0; 1 site, 1 O-linked glycan (1 site).
DR   BioMuta; HGNC:23099; -.
DR   DMDM; 74762537; -.
DR   EPD; Q8N7R0; -.
DR   jPOST; Q8N7R0; -.
DR   MassIVE; Q8N7R0; -.
DR   PeptideAtlas; Q8N7R0; -.
DR   ProteomicsDB; 72319; -.
DR   AGR; HGNC:23099; -.
DR   GeneCards; NANOGP1; -.
DR   HGNC; HGNC:23099; NANOGP1.
DR   neXtProt; NX_Q8N7R0; -.
DR   InParanoid; Q8N7R0; -.
DR   PhylomeDB; Q8N7R0; -.
DR   Pharos; Q8N7R0; Tdark.
DR   Proteomes; UP000005640; Unplaced.
DR   RNAct; Q8N7R0; Protein.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   PANTHER; PTHR24327; HOMEOBOX PROTEIN; 1.
DR   PANTHER; PTHR24327:SF72; HOMEOBOX PROTEIN NANOG2-RELATED; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   5: Uncertain;
KW   DNA-binding; Homeobox; Nucleus; Reference proteome; Repeat; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..232
FT                   /note="Putative homeobox protein NANOG2"
FT                   /id="PRO_0000261423"
FT   REPEAT          123..127
FT                   /note="1"
FT   REPEAT          128..132
FT                   /note="2"
FT   REPEAT          133..137
FT                   /note="3"
FT   REPEAT          143..147
FT                   /note="4"
FT   REPEAT          148..152
FT                   /note="5"
FT   REPEAT          153..157
FT                   /note="6"
FT   REPEAT          158..162
FT                   /note="7"
FT   REPEAT          163..167
FT                   /note="8"
FT   REGION          1..39
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          123..167
FT                   /note="8 X repeats starting with a Trp in each unit"
FT   REGION          123..167
FT                   /note="Sufficient for transactivation activity"
FT                   /evidence="ECO:0000250"
FT   REGION          168..232
FT                   /note="Sufficient for strong transactivation activity"
FT                   /evidence="ECO:0000250"
FT   COMPBIAS        1..22
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        23..39
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   232 AA;  26880 MW;  5C525D1B54F291BA CRC64;
     MDLPIQDSHD SSTSPKGKQP TTAEKSATKK EDKVPVKKQK TRTVFSSTQL CVLNDRFQRQ
     KYLSLQQMQE LSNILNLSYK QVKTWFQNQR MKSKRWQKNN WLKNSNGVTQ GCLVNPTGNL
     PMWSNQTWNN STWSNQTQNI QSWSNHSWNT QTWCTQSWNN QAWNSPFYNC GEESLQSCMQ
     FQPNSPASDL QAALEAAGEG LNVIQQTTRY FNTPQTMDLF LNYSMNMQPE DV
//