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Protein

Putative homeobox protein NANOG2

Gene

NANOGP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein uncertaini

Functioni

Probable transcriptional regulator.

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative homeobox protein NANOG2
Gene namesi
Name:NANOGP1
Synonyms:NANOG2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:23099. NANOGP1.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 232232Putative homeobox protein NANOG2PRO_0000261423Add
BLAST

Proteomic databases

PaxDbiQ8N7R0.
PRIDEiQ8N7R0.

Expressioni

Developmental stagei

Expressed in embryonic stem cells (ES).1 Publication

Gene expression databases

GenevestigatoriQ8N7R0.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000323777.

Structurei

3D structure databases

ProteinModelPortaliQ8N7R0.
SMRiQ8N7R0. Positions 43-97.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati123 – 12751
Repeati128 – 13252
Repeati133 – 13753
Repeati143 – 14754
Repeati148 – 15255
Repeati153 – 15756
Repeati158 – 16257
Repeati163 – 16758

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni123 – 167458 X repeats starting with a Trp in each unitAdd
BLAST
Regioni123 – 16745Sufficient for transactivation activityBy similarityAdd
BLAST
Regioni168 – 23265Sufficient for strong transactivation activityBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the Nanog homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox, Repeat

Phylogenomic databases

eggNOGiNOG297592.
HOGENOMiHOG000236291.
HOVERGENiHBG058783.
InParanoidiQ8N7R0.
PhylomeDBiQ8N7R0.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N7R0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLPIQDSHD SSTSPKGKQP TTAEKSATKK EDKVPVKKQK TRTVFSSTQL
60 70 80 90 100
CVLNDRFQRQ KYLSLQQMQE LSNILNLSYK QVKTWFQNQR MKSKRWQKNN
110 120 130 140 150
WLKNSNGVTQ GCLVNPTGNL PMWSNQTWNN STWSNQTQNI QSWSNHSWNT
160 170 180 190 200
QTWCTQSWNN QAWNSPFYNC GEESLQSCMQ FQPNSPASDL QAALEAAGEG
210 220 230
LNVIQQTTRY FNTPQTMDLF LNYSMNMQPE DV
Length:232
Mass (Da):26,880
Last modified:October 1, 2002 - v1
Checksum:i5C525D1B54F291BA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY455283 mRNA. Translation: AAS57555.1.
AK097770 mRNA. Translation: BAC05167.1.
UniGeneiHs.635882.

Polymorphism databases

DMDMi74762537.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY455283 mRNA. Translation: AAS57555.1.
AK097770 mRNA. Translation: BAC05167.1.
UniGeneiHs.635882.

3D structure databases

ProteinModelPortaliQ8N7R0.
SMRiQ8N7R0. Positions 43-97.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000323777.

Polymorphism databases

DMDMi74762537.

Proteomic databases

PaxDbiQ8N7R0.
PRIDEiQ8N7R0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiGC12P008028.
HGNCiHGNC:23099. NANOGP1.
neXtProtiNX_Q8N7R0.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG297592.
HOGENOMiHOG000236291.
HOVERGENiHBG058783.
InParanoidiQ8N7R0.
PhylomeDBiQ8N7R0.

Gene expression databases

GenevestigatoriQ8N7R0.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification, cloning and expression analysis of the pluripotency promoting Nanog genes in mouse and human."
    Hart A.H., Hartley L., Ibrahim M., Robb L.
    Dev. Dyn. 230:187-198(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
    Tissue: Embryonic stem cell.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. Cited for: GENE FAMILY.
  4. "Evolution of the NANOG pseudogene family in the human and chimpanzee genomes."
    Fairbanks D.J., Maughan P.J.
    BMC Evol. Biol. 6:12-12(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY.

Entry informationi

Entry nameiNANG2_HUMAN
AccessioniPrimary (citable) accession number: Q8N7R0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: October 1, 2002
Last modified: February 4, 2015
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene. According to PubMed:15233988.Curated
Exists an other tandem duplicated gene (NANOG) and 10 other NANOG-related nucleotide sequences located on different chromosomes, all of which are processed pseudogenes lacking introns (NANOGP2 to NANOGP11); except NANOGP8 which is a retrogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.