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Q8N7R0 (NANG2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative homeobox protein NANOG2
Gene names
Name:NANOGP1
Synonyms:NANOG2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length232 AA.
Sequence statusComplete.
Protein existenceUncertain

General annotation (Comments)

Function

Probable transcriptional regulator.

Subcellular location

Nucleus By similarity.

Developmental stage

Expressed in embryonic stem cells (ES). Ref.1

Sequence similarities

Belongs to the Nanog homeobox family.

Contains 1 homeobox DNA-binding domain.

Caution

Could be the product of a pseudogene. According to Ref.3.

Exists an other tandem duplicated gene (NANOG) and 10 other NANOG-related nucleotide sequences located on different chromosomes, all of which are processed pseudogenes lacking introns (NANOGP2 to NANOGP11); except NANOGP8 which is a retrogene.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
Repeat
   LigandDNA-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtranscription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 232232Putative homeobox protein NANOG2
PRO_0000261423

Regions

Repeat123 – 12751
Repeat128 – 13252
Repeat133 – 13753
Repeat143 – 14754
Repeat148 – 15255
Repeat153 – 15756
Repeat158 – 16257
Repeat163 – 16758
Region123 – 167458 X repeats starting with a Trp in each unit
Region123 – 16745Sufficient for transactivation activity By similarity
Region168 – 23265Sufficient for strong transactivation activity By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8N7R0 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 5C525D1B54F291BA

FASTA23226,880
        10         20         30         40         50         60 
MDLPIQDSHD SSTSPKGKQP TTAEKSATKK EDKVPVKKQK TRTVFSSTQL CVLNDRFQRQ 

        70         80         90        100        110        120 
KYLSLQQMQE LSNILNLSYK QVKTWFQNQR MKSKRWQKNN WLKNSNGVTQ GCLVNPTGNL 

       130        140        150        160        170        180 
PMWSNQTWNN STWSNQTQNI QSWSNHSWNT QTWCTQSWNN QAWNSPFYNC GEESLQSCMQ 

       190        200        210        220        230 
FQPNSPASDL QAALEAAGEG LNVIQQTTRY FNTPQTMDLF LNYSMNMQPE DV 

« Hide

References

« Hide 'large scale' references
[1]"Identification, cloning and expression analysis of the pluripotency promoting Nanog genes in mouse and human."
Hart A.H., Hartley L., Ibrahim M., Robb L.
Dev. Dyn. 230:187-198(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
Tissue: Embryonic stem cell.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[3]"Eleven daughters of NANOG."
Booth H.A., Holland P.W.
Genomics 84:229-238(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: GENE FAMILY.
[4]"Evolution of the NANOG pseudogene family in the human and chimpanzee genomes."
Fairbanks D.J., Maughan P.J.
BMC Evol. Biol. 6:12-12(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: GENE FAMILY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY455283 mRNA. Translation: AAS57555.1.
AK097770 mRNA. Translation: BAC05167.1.
UniGeneHs.635882.

3D structure databases

ProteinModelPortalQ8N7R0.
SMRQ8N7R0. Positions 18-100.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000323777.

Polymorphism databases

DMDM74762537.

Proteomic databases

PaxDbQ8N7R0.
PRIDEQ8N7R0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

GeneCardsGC12P008028.
HGNCHGNC:23099. NANOGP1.
neXtProtNX_Q8N7R0.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG297592.
HOGENOMHOG000236291.
HOVERGENHBG058783.
InParanoidQ8N7R0.
PhylomeDBQ8N7R0.

Gene expression databases

GenevestigatorQ8N7R0.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNANG2_HUMAN
AccessionPrimary (citable) accession number: Q8N7R0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM