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Q8N7R0

- NANG2_HUMAN

UniProt

Q8N7R0 - NANG2_HUMAN

Protein

Putative homeobox protein NANOG2

Gene

NANOGP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Protein uncertaini
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Probable transcriptional regulator.

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative homeobox protein NANOG2
    Gene namesi
    Name:NANOGP1
    Synonyms:NANOG2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:23099. NANOGP1.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 232232Putative homeobox protein NANOG2PRO_0000261423Add
    BLAST

    Proteomic databases

    PaxDbiQ8N7R0.
    PRIDEiQ8N7R0.

    Expressioni

    Developmental stagei

    Expressed in embryonic stem cells (ES).1 Publication

    Gene expression databases

    GenevestigatoriQ8N7R0.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000323777.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N7R0.
    SMRiQ8N7R0. Positions 18-100.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati123 – 12751
    Repeati128 – 13252
    Repeati133 – 13753
    Repeati143 – 14754
    Repeati148 – 15255
    Repeati153 – 15756
    Repeati158 – 16257
    Repeati163 – 16758

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni123 – 167458 X repeats starting with a Trp in each unitAdd
    BLAST
    Regioni123 – 16745Sufficient for transactivation activityBy similarityAdd
    BLAST
    Regioni168 – 23265Sufficient for strong transactivation activityBy similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the Nanog homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox, Repeat

    Phylogenomic databases

    eggNOGiNOG297592.
    HOGENOMiHOG000236291.
    HOVERGENiHBG058783.
    InParanoidiQ8N7R0.
    PhylomeDBiQ8N7R0.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8N7R0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDLPIQDSHD SSTSPKGKQP TTAEKSATKK EDKVPVKKQK TRTVFSSTQL    50
    CVLNDRFQRQ KYLSLQQMQE LSNILNLSYK QVKTWFQNQR MKSKRWQKNN 100
    WLKNSNGVTQ GCLVNPTGNL PMWSNQTWNN STWSNQTQNI QSWSNHSWNT 150
    QTWCTQSWNN QAWNSPFYNC GEESLQSCMQ FQPNSPASDL QAALEAAGEG 200
    LNVIQQTTRY FNTPQTMDLF LNYSMNMQPE DV 232
    Length:232
    Mass (Da):26,880
    Last modified:October 1, 2002 - v1
    Checksum:i5C525D1B54F291BA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY455283 mRNA. Translation: AAS57555.1.
    AK097770 mRNA. Translation: BAC05167.1.
    UniGeneiHs.635882.

    Polymorphism databases

    DMDMi74762537.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY455283 mRNA. Translation: AAS57555.1 .
    AK097770 mRNA. Translation: BAC05167.1 .
    UniGenei Hs.635882.

    3D structure databases

    ProteinModelPortali Q8N7R0.
    SMRi Q8N7R0. Positions 18-100.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000323777.

    Polymorphism databases

    DMDMi 74762537.

    Proteomic databases

    PaxDbi Q8N7R0.
    PRIDEi Q8N7R0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    GeneCardsi GC12P008028.
    HGNCi HGNC:23099. NANOGP1.
    neXtProti NX_Q8N7R0.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG297592.
    HOGENOMi HOG000236291.
    HOVERGENi HBG058783.
    InParanoidi Q8N7R0.
    PhylomeDBi Q8N7R0.

    Gene expression databases

    Genevestigatori Q8N7R0.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification, cloning and expression analysis of the pluripotency promoting Nanog genes in mouse and human."
      Hart A.H., Hartley L., Ibrahim M., Robb L.
      Dev. Dyn. 230:187-198(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
      Tissue: Embryonic stem cell.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    3. Cited for: GENE FAMILY.
    4. "Evolution of the NANOG pseudogene family in the human and chimpanzee genomes."
      Fairbanks D.J., Maughan P.J.
      BMC Evol. Biol. 6:12-12(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY.

    Entry informationi

    Entry nameiNANG2_HUMAN
    AccessioniPrimary (citable) accession number: Q8N7R0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2006
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Could be the product of a pseudogene. According to PubMed:15233988.Curated
    Exists an other tandem duplicated gene (NANOG) and 10 other NANOG-related nucleotide sequences located on different chromosomes, all of which are processed pseudogenes lacking introns (NANOGP2 to NANOGP11); except NANOGP8 which is a retrogene.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3