ID   ZN676_HUMAN             Reviewed;         588 AA.
AC   Q8N7Q3; A8MVX5;
DT   02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 2.
DT   27-MAR-2024, entry version 160.
DE   RecName: Full=Zinc finger protein 676;
GN   Name=ZNF676;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA   Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA   Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA   Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA   Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA   Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA   Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA   Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA   Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA   McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA   Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA   Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA   She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA   Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 180-588.
RC   TISSUE=Testis;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
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DR   EMBL; AC073539; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AK097798; BAC05174.1; -; mRNA.
DR   CCDS; CCDS42539.1; -.
DR   RefSeq; NP_001001411.2; NM_001001411.2.
DR   AlphaFoldDB; Q8N7Q3; -.
DR   SMR; Q8N7Q3; -.
DR   BioGRID; 127857; 1.
DR   IntAct; Q8N7Q3; 1.
DR   STRING; 9606.ENSP00000380310; -.
DR   GlyGen; Q8N7Q3; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; Q8N7Q3; -.
DR   PhosphoSitePlus; Q8N7Q3; -.
DR   BioMuta; ZNF676; -.
DR   DMDM; 215273918; -.
DR   EPD; Q8N7Q3; -.
DR   jPOST; Q8N7Q3; -.
DR   MassIVE; Q8N7Q3; -.
DR   MaxQB; Q8N7Q3; -.
DR   PaxDb; 9606-ENSP00000380310; -.
DR   PeptideAtlas; Q8N7Q3; -.
DR   ProteomicsDB; 72318; -.
DR   Antibodypedia; 44182; 46 antibodies from 10 providers.
DR   DNASU; 163223; -.
DR   Ensembl; ENST00000395385.7; ENSP00000378783.4; ENSG00000276219.4.
DR   Ensembl; ENST00000397121.3; ENSP00000380310.1; ENSG00000196109.9.
DR   GeneID; 163223; -.
DR   KEGG; hsa:163223; -.
DR   MANE-Select; ENST00000397121.3; ENSP00000380310.1; NM_001001411.3; NP_001001411.2.
DR   UCSC; uc002nqs.2; human.
DR   AGR; HGNC:20429; -.
DR   CTD; 163223; -.
DR   DisGeNET; 163223; -.
DR   GeneCards; ZNF676; -.
DR   HGNC; HGNC:20429; ZNF676.
DR   HPA; ENSG00000196109; Tissue enhanced (parathyroid gland, testis).
DR   neXtProt; NX_Q8N7Q3; -.
DR   OpenTargets; ENSG00000196109; -.
DR   PharmGKB; PA142670477; -.
DR   VEuPathDB; HostDB:ENSG00000196109; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   GeneTree; ENSGT00940000153236; -.
DR   HOGENOM; CLU_002678_44_0_1; -.
DR   InParanoid; Q8N7Q3; -.
DR   OMA; FHECSNS; -.
DR   OrthoDB; 4625752at2759; -.
DR   PhylomeDB; Q8N7Q3; -.
DR   TreeFam; TF342117; -.
DR   PathwayCommons; Q8N7Q3; -.
DR   Reactome; R-HSA-212436; Generic Transcription Pathway.
DR   SignaLink; Q8N7Q3; -.
DR   BioGRID-ORCS; 163223; 299 hits in 1084 CRISPR screens.
DR   GenomeRNAi; 163223; -.
DR   Pharos; Q8N7Q3; Tdark.
DR   PRO; PR:Q8N7Q3; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; Q8N7Q3; Protein.
DR   Bgee; ENSG00000196109; Expressed in primordial germ cell in gonad and 91 other cell types or tissues.
DR   ExpressionAtlas; Q8N7Q3; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IBA:GO_Central.
DR   Gene3D; 3.30.160.60; Classic Zinc Finger; 16.
DR   InterPro; IPR001909; KRAB.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR16515; PR DOMAIN ZINC FINGER PROTEIN; 1.
DR   PANTHER; PTHR16515:SF55; ZINC FINGER PROTEIN 711; 1.
DR   Pfam; PF00096; zf-C2H2; 11.
DR   Pfam; PF13465; zf-H2C2_2; 1.
DR   SMART; SM00355; ZnF_C2H2; 14.
DR   SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 9.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 12.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 15.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..588
FT                   /note="Zinc finger protein 676"
FT                   /id="PRO_0000233996"
FT   DOMAIN          1..43
FT                   /note="KRAB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT   ZN_FING         169..191
FT                   /note="C2H2-type 1; degenerate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         197..219
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         225..247
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         253..275
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         281..303
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         309..331
FT                   /note="C2H2-type 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         337..359
FT                   /note="C2H2-type 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         365..387
FT                   /note="C2H2-type 8"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         393..415
FT                   /note="C2H2-type 9"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         421..443
FT                   /note="C2H2-type 10"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         449..471
FT                   /note="C2H2-type 11"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         477..499
FT                   /note="C2H2-type 12"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         505..527
FT                   /note="C2H2-type 13"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         533..555
FT                   /note="C2H2-type 14"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         561..583
FT                   /note="C2H2-type 15"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   VARIANT         27
FT                   /note="G -> E (in dbSNP:rs8104929)"
FT                   /id="VAR_047437"
FT   VARIANT         96
FT                   /note="E -> K (in dbSNP:rs12986319)"
FT                   /id="VAR_047438"
FT   VARIANT         292
FT                   /note="S -> W (in dbSNP:rs11671538)"
FT                   /id="VAR_047439"
FT   CONFLICT        180
FT                   /note="W -> S (in Ref. 2; BAC05174)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        183..190
FT                   /note="TLTYYKSI -> NLMEHKRV (in Ref. 2; BAC05174)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        208..220
FT                   /note="KFSILTKHKVIHT -> WSSSLTEHKRIHA (in Ref. 2;
FT                   BAC05174)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   588 AA;  67624 MW;  662E28DBE1CBB6D6 CRC64;
     MLENYRNLVF LGIAAFKPDL IIFLEQGKEP WNMKRHEMVE EPPVICSHFS QEFWPEQGIE
     DSFQKMILRR YDKCGHENLH LKISCTNVDE CNVHKEGYNK LNQSLTTTQS KVFQCGKYAN
     VFHKCSNSNR HKIRHTGEKG LKCKEYVRSF CMLSHLSQHE RIYTRENSYK CEENGKAFNW
     SSTLTYYKSI HTGEKPYKCE ECGKAFSKFS ILTKHKVIHT GEKPYKCEEC GKAFNRSSIL
     TKHKIIHTGE KPYKCEECGK GFSSVSTLNT HKAIHAEEKP YKCEECGKAS NSSSKLMEHK
     RIHTGEKPYK CEECGKAFSW SSSLTEHKRI HAGEKPYKCE ECGKAFNRSS ILTKHKIIHT
     GEKPYKCEGC GKAFSKVSTL NTHKAIHAEE KPYKCEECGK ASNSSSKLME HKRIHTGEKP
     YKCEECGKAF SWSSSLTEHK RIHAGEKPYK CEECGKAFTW SSSFTKHKRI HAAEKPYKCE
     ECGKGFSTFS ILTKHKIIHT GEKRYKCEEC GKAFSWSSIL TEHKIIHTGE KPYKCEECGK
     AFSRSSSLTR HKRIHTGEKP YKCEECGKAF KSSSTVSYHK KIHTGENP
//