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Protein

Zinc finger protein 676

Gene

ZNF676

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri169 – 19123C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri197 – 21923C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri225 – 24723C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri253 – 27523C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri281 – 30323C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri309 – 33123C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri337 – 35923C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri365 – 38723C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri393 – 41523C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri421 – 44323C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri449 – 47123C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri477 – 49923C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri505 – 52723C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri533 – 55523C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri561 – 58323C2H2-type 15PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 676
Gene namesi
Name:ZNF676
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componentsi: Chromosome 19, Unplaced

Organism-specific databases

HGNCiHGNC:20429. ZNF676.

Subcellular locationi

  1. Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670477.

Polymorphism and mutation databases

BioMutaiZNF676.
DMDMi215273918.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 588588Zinc finger protein 676PRO_0000233996Add
BLAST

Proteomic databases

PaxDbiQ8N7Q3.
PRIDEiQ8N7Q3.

PTM databases

PhosphoSiteiQ8N7Q3.

Expressioni

Gene expression databases

BgeeiQ8N7Q3.
CleanExiHS_ZNF676.
GenevestigatoriQ8N7Q3.

Interactioni

Protein-protein interaction databases

BioGridi127857. 2 interactions.
IntActiQ8N7Q3. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8N7Q3.
SMRiQ8N7Q3. Positions 111-584.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 4343KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 15 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri169 – 19123C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri197 – 21923C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri225 – 24723C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri253 – 27523C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri281 – 30323C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri309 – 33123C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri337 – 35923C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri365 – 38723C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri393 – 41523C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri421 – 44323C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri449 – 47123C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri477 – 49923C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri505 – 52723C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri533 – 55523C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri561 – 58323C2H2-type 15PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00780000121856.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8N7Q3.
KOiK09228.
OMAiCGKASNS.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ8N7Q3.
TreeFamiTF342117.

Family and domain databases

Gene3Di3.30.160.60. 16 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 14 hits.
[Graphical view]
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N7Q3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLENYRNLVF LGIAAFKPDL IIFLEQGKEP WNMKRHEMVE EPPVICSHFS
60 70 80 90 100
QEFWPEQGIE DSFQKMILRR YDKCGHENLH LKISCTNVDE CNVHKEGYNK
110 120 130 140 150
LNQSLTTTQS KVFQCGKYAN VFHKCSNSNR HKIRHTGEKG LKCKEYVRSF
160 170 180 190 200
CMLSHLSQHE RIYTRENSYK CEENGKAFNW SSTLTYYKSI HTGEKPYKCE
210 220 230 240 250
ECGKAFSKFS ILTKHKVIHT GEKPYKCEEC GKAFNRSSIL TKHKIIHTGE
260 270 280 290 300
KPYKCEECGK GFSSVSTLNT HKAIHAEEKP YKCEECGKAS NSSSKLMEHK
310 320 330 340 350
RIHTGEKPYK CEECGKAFSW SSSLTEHKRI HAGEKPYKCE ECGKAFNRSS
360 370 380 390 400
ILTKHKIIHT GEKPYKCEGC GKAFSKVSTL NTHKAIHAEE KPYKCEECGK
410 420 430 440 450
ASNSSSKLME HKRIHTGEKP YKCEECGKAF SWSSSLTEHK RIHAGEKPYK
460 470 480 490 500
CEECGKAFTW SSSFTKHKRI HAAEKPYKCE ECGKGFSTFS ILTKHKIIHT
510 520 530 540 550
GEKRYKCEEC GKAFSWSSIL TEHKIIHTGE KPYKCEECGK AFSRSSSLTR
560 570 580
HKRIHTGEKP YKCEECGKAF KSSSTVSYHK KIHTGENP
Length:588
Mass (Da):67,624
Last modified:November 25, 2008 - v2
Checksum:i662E28DBE1CBB6D6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti180 – 1801W → S in BAC05174 (PubMed:14702039).Curated
Sequence conflicti183 – 1908TLTYYKSI → NLMEHKRV in BAC05174 (PubMed:14702039).Curated
Sequence conflicti208 – 22013KFSIL…KVIHT → WSSSLTEHKRIHA in BAC05174 (PubMed:14702039).CuratedAdd
BLAST

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti27 – 271G → E.
Corresponds to variant rs8104929 [ dbSNP | Ensembl ].
VAR_047437
Natural varianti96 – 961E → K.
Corresponds to variant rs12986319 [ dbSNP | Ensembl ].
VAR_047438
Natural varianti292 – 2921S → W.
Corresponds to variant rs11671538 [ dbSNP | Ensembl ].
VAR_047439

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC073539 Genomic DNA. No translation available.
AK097798 mRNA. Translation: BAC05174.1.
CCDSiCCDS42539.1.
RefSeqiNP_001001411.2. NM_001001411.2.
UniGeneiHs.55452.

Genome annotation databases

EnsembliENST00000395385; ENSP00000378783; ENSG00000276219.
ENST00000397121; ENSP00000380310; ENSG00000196109.
GeneIDi163223.
KEGGihsa:163223.
UCSCiuc002nqs.1. human.

Polymorphism and mutation databases

BioMutaiZNF676.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC073539 Genomic DNA. No translation available.
AK097798 mRNA. Translation: BAC05174.1.
CCDSiCCDS42539.1.
RefSeqiNP_001001411.2. NM_001001411.2.
UniGeneiHs.55452.

3D structure databases

ProteinModelPortaliQ8N7Q3.
SMRiQ8N7Q3. Positions 111-584.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127857. 2 interactions.
IntActiQ8N7Q3. 1 interaction.

PTM databases

PhosphoSiteiQ8N7Q3.

Polymorphism and mutation databases

BioMutaiZNF676.
DMDMi215273918.

Proteomic databases

PaxDbiQ8N7Q3.
PRIDEiQ8N7Q3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000395385; ENSP00000378783; ENSG00000276219.
ENST00000397121; ENSP00000380310; ENSG00000196109.
GeneIDi163223.
KEGGihsa:163223.
UCSCiuc002nqs.1. human.

Organism-specific databases

CTDi163223.
GeneCardsiGC19M022361.
HGNCiHGNC:20429. ZNF676.
neXtProtiNX_Q8N7Q3.
PharmGKBiPA142670477.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00780000121856.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8N7Q3.
KOiK09228.
OMAiCGKASNS.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ8N7Q3.
TreeFamiTF342117.

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii163223.
NextBioi88328.
PROiQ8N7Q3.

Gene expression databases

BgeeiQ8N7Q3.
CleanExiHS_ZNF676.
GenevestigatoriQ8N7Q3.

Family and domain databases

Gene3Di3.30.160.60. 16 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 14 hits.
[Graphical view]
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 180-588.
    Tissue: Testis.

Entry informationi

Entry nameiZN676_HUMAN
AccessioniPrimary (citable) accession number: Q8N7Q3
Secondary accession number(s): A8MVX5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: November 25, 2008
Last modified: April 29, 2015
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.