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UniProtKB - Q8N7Q3 (ZN676_HUMAN)

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Protein

Zinc finger protein 676

Gene

ZNF676

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri169 – 191C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri197 – 219C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri225 – 247C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri253 – 275C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri281 – 303C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri309 – 331C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri337 – 359C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri365 – 387C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri393 – 415C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri421 – 443C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri449 – 471C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri477 – 499C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri505 – 527C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri533 – 555C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri561 – 583C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

Complete GO annotation...

GO - Biological processi

Complete GO annotation...

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 676
Gene namesi
Name:ZNF676
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:20429. ZNF676.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi163223.
OpenTargetsiENSG00000196109.
PharmGKBiPA142670477.

Polymorphism and mutation databases

BioMutaiZNF676.
DMDMi215273918.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002339961 – 588Zinc finger protein 676Add BLAST588

Proteomic databases

MaxQBiQ8N7Q3.
PaxDbiQ8N7Q3.
PeptideAtlasiQ8N7Q3.
PRIDEiQ8N7Q3.

PTM databases

iPTMnetiQ8N7Q3.
PhosphoSitePlusiQ8N7Q3.

Expressioni

Gene expression databases

BgeeiENSG00000196109.
CleanExiHS_ZNF676.

Interactioni

Protein-protein interaction databases

BioGridi127857. 1 interactor.
IntActiQ8N7Q3. 1 interactor.
STRINGi9606.ENSP00000380310.

Structurei

3D structure databases

ProteinModelPortaliQ8N7Q3.
SMRiQ8N7Q3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 43KRABPROSITE-ProRule annotationAdd BLAST43

Sequence similaritiesi

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri169 – 191C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri197 – 219C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri225 – 247C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri253 – 275C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri281 – 303C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri309 – 331C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri337 – 359C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri365 – 387C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri393 – 415C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri421 – 443C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri449 – 471C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri477 – 499C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri505 – 527C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri533 – 555C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri561 – 583C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00880000137899.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8N7Q3.
KOiK09228.
OMAiFTEMSKL.
OrthoDBiEOG091G02KC.
PhylomeDBiQ8N7Q3.
TreeFamiTF342117.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR001909. KRAB.
IPR013087. Znf_C2H2_type.
IPR013083. Znf_RING/FYVE/PHD.
SMARTiView protein in SMART
SM00355. ZnF_C2H2. 14 hits.
SUPFAMiSSF57667. SSF57667. 9 hits.
PROSITEiView protein in PROSITE
PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.

Sequencei

Sequence statusi: Complete.

Q8N7Q3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLENYRNLVF LGIAAFKPDL IIFLEQGKEP WNMKRHEMVE EPPVICSHFS 
        60         70         80         90        100
QEFWPEQGIE DSFQKMILRR YDKCGHENLH LKISCTNVDE CNVHKEGYNK 
       110        120        130        140        150
LNQSLTTTQS KVFQCGKYAN VFHKCSNSNR HKIRHTGEKG LKCKEYVRSF 
       160        170        180        190        200
CMLSHLSQHE RIYTRENSYK CEENGKAFNW SSTLTYYKSI HTGEKPYKCE 
       210        220        230        240        250
ECGKAFSKFS ILTKHKVIHT GEKPYKCEEC GKAFNRSSIL TKHKIIHTGE 
       260        270        280        290        300
KPYKCEECGK GFSSVSTLNT HKAIHAEEKP YKCEECGKAS NSSSKLMEHK 
       310        320        330        340        350
RIHTGEKPYK CEECGKAFSW SSSLTEHKRI HAGEKPYKCE ECGKAFNRSS 
       360        370        380        390        400
ILTKHKIIHT GEKPYKCEGC GKAFSKVSTL NTHKAIHAEE KPYKCEECGK 
       410        420        430        440        450
ASNSSSKLME HKRIHTGEKP YKCEECGKAF SWSSSLTEHK RIHAGEKPYK 
       460        470        480        490        500
CEECGKAFTW SSSFTKHKRI HAAEKPYKCE ECGKGFSTFS ILTKHKIIHT 
       510        520        530        540        550
GEKRYKCEEC GKAFSWSSIL TEHKIIHTGE KPYKCEECGK AFSRSSSLTR 
       560        570        580 
HKRIHTGEKP YKCEECGKAF KSSSTVSYHK KIHTGENP
Length:588
Mass (Da):67,624
Last modified:November 25, 2008 - v2
Checksum:i662E28DBE1CBB6D6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti180W → S in BAC05174 (PubMed:14702039).Curated1
Sequence conflicti183 – 190TLTYYKSI → NLMEHKRV in BAC05174 (PubMed:14702039).Curated8
Sequence conflicti208 – 220KFSIL…KVIHT → WSSSLTEHKRIHA in BAC05174 (PubMed:14702039).CuratedAdd BLAST13

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04743727G → E. Corresponds to variant dbSNP:rs8104929Ensembl.1
Natural variantiVAR_04743896E → K. Corresponds to variant dbSNP:rs12986319Ensembl.1
Natural variantiVAR_047439292S → W. Corresponds to variant dbSNP:rs11671538Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC073539 Genomic DNA. No translation available.
AK097798 mRNA. Translation: BAC05174.1.
CCDSiCCDS42539.1.
RefSeqiNP_001001411.2. NM_001001411.2.
UniGeneiHs.55452.

Genome annotation databases

EnsembliENST00000395385; ENSP00000378783; ENSG00000276219.
ENST00000397121; ENSP00000380310; ENSG00000196109.
GeneIDi163223.
KEGGihsa:163223.
UCSCiuc002nqs.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiZN676_HUMAN
AccessioniPrimary (citable) accession number: Q8N7Q3
Secondary accession number(s): A8MVX5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: November 25, 2008
Last modified: June 7, 2017
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families