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Q8N7Q3 (ZN676_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 676
Gene names
Name:ZNF676
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length588 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in transcriptional regulation.

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 15 C2H2-type zinc fingers.

Contains 1 KRAB domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityPolymorphism
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 588588Zinc finger protein 676
PRO_0000233996

Regions

Domain1 – 4343KRAB
Zinc finger169 – 19123C2H2-type 1; degenerate
Zinc finger197 – 21923C2H2-type 2
Zinc finger225 – 24723C2H2-type 3
Zinc finger253 – 27523C2H2-type 4
Zinc finger281 – 30323C2H2-type 5
Zinc finger309 – 33123C2H2-type 6
Zinc finger337 – 35923C2H2-type 7
Zinc finger365 – 38723C2H2-type 8
Zinc finger393 – 41523C2H2-type 9
Zinc finger421 – 44323C2H2-type 10
Zinc finger449 – 47123C2H2-type 11
Zinc finger477 – 49923C2H2-type 12
Zinc finger505 – 52723C2H2-type 13
Zinc finger533 – 55523C2H2-type 14
Zinc finger561 – 58323C2H2-type 15

Natural variations

Natural variant271G → E.
Corresponds to variant rs8104929 [ dbSNP | Ensembl ].
VAR_047437
Natural variant961E → K.
Corresponds to variant rs12986319 [ dbSNP | Ensembl ].
VAR_047438
Natural variant2921S → W.
Corresponds to variant rs11671538 [ dbSNP | Ensembl ].
VAR_047439

Experimental info

Sequence conflict1801W → S in BAC05174. Ref.2
Sequence conflict183 – 1908TLTYYKSI → NLMEHKRV in BAC05174. Ref.2
Sequence conflict208 – 22013KFSIL…KVIHT → WSSSLTEHKRIHA in BAC05174. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q8N7Q3 [UniParc].

Last modified November 25, 2008. Version 2.
Checksum: 662E28DBE1CBB6D6

FASTA58867,624
        10         20         30         40         50         60 
MLENYRNLVF LGIAAFKPDL IIFLEQGKEP WNMKRHEMVE EPPVICSHFS QEFWPEQGIE 

        70         80         90        100        110        120 
DSFQKMILRR YDKCGHENLH LKISCTNVDE CNVHKEGYNK LNQSLTTTQS KVFQCGKYAN 

       130        140        150        160        170        180 
VFHKCSNSNR HKIRHTGEKG LKCKEYVRSF CMLSHLSQHE RIYTRENSYK CEENGKAFNW 

       190        200        210        220        230        240 
SSTLTYYKSI HTGEKPYKCE ECGKAFSKFS ILTKHKVIHT GEKPYKCEEC GKAFNRSSIL 

       250        260        270        280        290        300 
TKHKIIHTGE KPYKCEECGK GFSSVSTLNT HKAIHAEEKP YKCEECGKAS NSSSKLMEHK 

       310        320        330        340        350        360 
RIHTGEKPYK CEECGKAFSW SSSLTEHKRI HAGEKPYKCE ECGKAFNRSS ILTKHKIIHT 

       370        380        390        400        410        420 
GEKPYKCEGC GKAFSKVSTL NTHKAIHAEE KPYKCEECGK ASNSSSKLME HKRIHTGEKP 

       430        440        450        460        470        480 
YKCEECGKAF SWSSSLTEHK RIHAGEKPYK CEECGKAFTW SSSFTKHKRI HAAEKPYKCE 

       490        500        510        520        530        540 
ECGKGFSTFS ILTKHKIIHT GEKRYKCEEC GKAFSWSSIL TEHKIIHTGE KPYKCEECGK 

       550        560        570        580 
AFSRSSSLTR HKRIHTGEKP YKCEECGKAF KSSSTVSYHK KIHTGENP 

« Hide

References

[1]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 180-588.
Tissue: Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC073539 Genomic DNA. No translation available.
AK097798 mRNA. Translation: BAC05174.1.
CCDSCCDS42539.1.
RefSeqNP_001001411.2. NM_001001411.2.
UniGeneHs.55452.

3D structure databases

ProteinModelPortalQ8N7Q3.
SMRQ8N7Q3. Positions 111-584.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid127857. 2 interactions.
IntActQ8N7Q3. 1 interaction.

PTM databases

PhosphoSiteQ8N7Q3.

Polymorphism databases

DMDM215273918.

Proteomic databases

PaxDbQ8N7Q3.
PRIDEQ8N7Q3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000397121; ENSP00000380310; ENSG00000196109.
ENST00000577063; ENSP00000460377; ENSG00000262942.
GeneID163223.
KEGGhsa:163223.
UCSCuc002nqs.1. human.

Organism-specific databases

CTD163223.
GeneCardsGC19M022361.
HGNCHGNC:20429. ZNF676.
neXtProtNX_Q8N7Q3.
PharmGKBPA142670477.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000234617.
HOVERGENHBG018163.
KOK09228.
OMACGKASNS.
OrthoDBEOG7KSX7Q.
PhylomeDBQ8N7Q3.
TreeFamTF342117.

Enzyme and pathway databases

ReactomeREACT_71. Gene Expression.

Gene expression databases

BgeeQ8N7Q3.
CleanExHS_ZNF676.
GenevestigatorQ8N7Q3.

Family and domain databases

Gene3D3.30.160.60. 16 hits.
InterProIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 14 hits.
[Graphical view]
PROSITEPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi163223.
NextBio88328.
PROQ8N7Q3.

Entry information

Entry nameZN676_HUMAN
AccessionPrimary (citable) accession number: Q8N7Q3
Secondary accession number(s): A8MVX5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: November 25, 2008
Last modified: July 9, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM