ZNF676

Functionⁱ

May be involved in transcriptional regulation.

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	169 – 191	C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	197 – 219	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	225 – 247	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	253 – 275	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	281 – 303	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	309 – 331	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	337 – 359	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	365 – 387	C2H2-type 8PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	393 – 415	C2H2-type 9PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	421 – 443	C2H2-type 10PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	449 – 471	C2H2-type 11PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	477 – 499	C2H2-type 12PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	505 – 527	C2H2-type 13PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	533 – 555	C2H2-type 14PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	561 – 583	C2H2-type 15PROSITE-ProRule annotationAdd BLAST	23

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
metal ion binding Source: UniProtKB-KW

Complete GO annotation...

GO - Biological processⁱ

regulation of transcription, DNA-templated Source: UniProtKB-KW
transcription, DNA-templated Source: UniProtKB-KW

Complete GO annotation...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-212436. Generic Transcription Pathway.

Reactomeⁱ

R-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger protein 676
Gene namesⁱ	Name:ZNF676
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:20429. ZNF676.

HGNCⁱ

HGNC:20429. ZNF676.

Subcellular locationⁱ

Nucleus Curated

GO - Cellular componentⁱ

nucleus Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	163223.
Open Targets More...OpenTargetsⁱ	ENSG00000196109.
PharmGKBⁱ	PA142670477.

Polymorphism and mutation databases

BioMutaⁱ	ZNF676.
DMDMⁱ	215273918.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000233996	1 – 588	Zinc finger protein 676Add BLAST		588

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8N7Q3.
PaxDbⁱ	Q8N7Q3.
PeptideAtlas More...PeptideAtlasⁱ	Q8N7Q3.
PRIDEⁱ	Q8N7Q3.

PTM databases

iPTMnetⁱ	Q8N7Q3.
PhosphoSitePlusⁱ	Q8N7Q3.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000196109.
CleanExⁱ	HS_ZNF676.

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	127857. 1 interactor.
IntActⁱ	Q8N7Q3. 1 interactor.
STRINGⁱ	9606.ENSP00000380310.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8N7Q3.
SMRⁱ	Q8N7Q3.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	1 – 43	KRABPROSITE-ProRule annotationAdd BLAST		43

Sequence similaritiesⁱ

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	169 – 191	C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	197 – 219	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	225 – 247	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	253 – 275	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	281 – 303	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	309 – 331	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	337 – 359	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	365 – 387	C2H2-type 8PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	393 – 415	C2H2-type 9PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	421 – 443	C2H2-type 10PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	449 – 471	C2H2-type 11PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	477 – 499	C2H2-type 12PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	505 – 527	C2H2-type 13PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	533 – 555	C2H2-type 14PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	561 – 583	C2H2-type 15PROSITE-ProRule annotationAdd BLAST	23

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721. Eukaryota. COG5048. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00880000137899.
HOGENOMⁱ	HOG000234617.
HOVERGENⁱ	HBG018163.
InParanoidⁱ	Q8N7Q3.
KEGG Orthology (KO) More...KOⁱ	K09228.
OMAⁱ	FTEMSKL.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02KC.
PhylomeDBⁱ	Q8N7Q3.
TreeFamⁱ	TF342117.

Family and domain databases

Gene3Dⁱ	3.30.40.10. 1 hit.
InterProⁱ	View protein in InterPro IPR001909. KRAB. IPR013087. Znf_C2H2_type. IPR013083. Znf_RING/FYVE/PHD.
SMARTⁱ	View protein in SMART SM00355. ZnF_C2H2. 14 hits.
SUPFAMⁱ	SSF57667. SSF57667. 9 hits.
PROSITEⁱ	View protein in PROSITE PS50805. KRAB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 12 hits. PS50157. ZINC_FINGER_C2H2_2. 15 hits.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8N7Q3-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLENYRNLVF LGIAAFKPDL IIFLEQGKEP WNMKRHEMVE EPPVICSHFS 
        60         70         80         90        100
QEFWPEQGIE DSFQKMILRR YDKCGHENLH LKISCTNVDE CNVHKEGYNK 
       110        120        130        140        150
LNQSLTTTQS KVFQCGKYAN VFHKCSNSNR HKIRHTGEKG LKCKEYVRSF 
       160        170        180        190        200
CMLSHLSQHE RIYTRENSYK CEENGKAFNW SSTLTYYKSI HTGEKPYKCE 
       210        220        230        240        250
ECGKAFSKFS ILTKHKVIHT GEKPYKCEEC GKAFNRSSIL TKHKIIHTGE 
       260        270        280        290        300
KPYKCEECGK GFSSVSTLNT HKAIHAEEKP YKCEECGKAS NSSSKLMEHK 
       310        320        330        340        350
RIHTGEKPYK CEECGKAFSW SSSLTEHKRI HAGEKPYKCE ECGKAFNRSS 
       360        370        380        390        400
ILTKHKIIHT GEKPYKCEGC GKAFSKVSTL NTHKAIHAEE KPYKCEECGK 
       410        420        430        440        450
ASNSSSKLME HKRIHTGEKP YKCEECGKAF SWSSSLTEHK RIHAGEKPYK 
       460        470        480        490        500
CEECGKAFTW SSSFTKHKRI HAAEKPYKCE ECGKGFSTFS ILTKHKIIHT 
       510        520        530        540        550
GEKRYKCEEC GKAFSWSSIL TEHKIIHTGE KPYKCEECGK AFSRSSSLTR 
       560        570        580 
HKRIHTGEKP YKCEECGKAF KSSSTVSYHK KIHTGENP

Length:588

Mass (Da):67,624

Last modified:November 25, 2008 - v2

Checksum:ⁱ662E28DBE1CBB6D6

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	180	W → S in BAC05174 (PubMed:14702039).Curated	1
Sequence conflictⁱ	183 – 190	TLTYYKSI → NLMEHKRV in BAC05174 (PubMed:14702039).Curated	8
Sequence conflictⁱ	208 – 220	KFSIL…KVIHT → WSSSLTEHKRIHA in BAC05174 (PubMed:14702039).CuratedAdd BLAST	13

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_047437	27	G → E. Corresponds to variant dbSNP:rs8104929Ensembl.	1
Natural variantⁱVAR_047438	96	E → K. Corresponds to variant dbSNP:rs12986319Ensembl.	1
Natural variantⁱVAR_047439	292	S → W. Corresponds to variant dbSNP:rs11671538Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC073539 Genomic DNA. No translation available. AK097798 mRNA. Translation: BAC05174.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS42539.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001001411.2. NM_001001411.2.
UniGeneⁱ	Hs.55452.

Genome annotation databases

Ensemblⁱ	ENST00000395385; ENSP00000378783; ENSG00000276219. ENST00000397121; ENSP00000380310; ENSG00000196109.
GeneIDⁱ	163223.
KEGGⁱ	hsa:163223.
UCSC genome browser More...UCSCⁱ	uc002nqs.2. human.

Keywords - Coding sequence diversityⁱ

Polymorphism

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC073539 Genomic DNA. No translation available. AK097798 mRNA. Translation: BAC05174.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS42539.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001001411.2. NM_001001411.2.
UniGeneⁱ	Hs.55452.

3D structure databases

ProteinModelPortalⁱ	Q8N7Q3.
SMRⁱ	Q8N7Q3.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	127857. 1 interactor.
IntActⁱ	Q8N7Q3. 1 interactor.
STRINGⁱ	9606.ENSP00000380310.

PTM databases

iPTMnetⁱ	Q8N7Q3.
PhosphoSitePlusⁱ	Q8N7Q3.

Polymorphism and mutation databases

BioMutaⁱ	ZNF676.
DMDMⁱ	215273918.

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8N7Q3.
PaxDbⁱ	Q8N7Q3.
PeptideAtlas More...PeptideAtlasⁱ	Q8N7Q3.
PRIDEⁱ	Q8N7Q3.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000395385; ENSP00000378783; ENSG00000276219. ENST00000397121; ENSP00000380310; ENSG00000196109.
GeneIDⁱ	163223.
KEGGⁱ	hsa:163223.
UCSC genome browser More...UCSCⁱ	uc002nqs.2. human.

Organism-specific databases

CTDⁱ	163223.
DisGeNET More...DisGeNETⁱ	163223.
GeneCardsⁱ	ZNF676.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:20429. ZNF676.
neXtProtⁱ	NX_Q8N7Q3.
Open Targets More...OpenTargetsⁱ	ENSG00000196109.
PharmGKBⁱ	PA142670477.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1721. Eukaryota. COG5048. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00880000137899.
HOGENOMⁱ	HOG000234617.
HOVERGENⁱ	HBG018163.
InParanoidⁱ	Q8N7Q3.
KEGG Orthology (KO) More...KOⁱ	K09228.
OMAⁱ	FTEMSKL.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02KC.
PhylomeDBⁱ	Q8N7Q3.
TreeFamⁱ	TF342117.

Enzyme and pathway databases

Reactomeⁱ	R-HSA-212436. Generic Transcription Pathway.

Reactomeⁱ

R-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAiⁱ	163223.
Protein Ontology More...PROⁱ	PR:Q8N7Q3.

Gene expression databases

Bgeeⁱ	ENSG00000196109.
CleanExⁱ	HS_ZNF676.

Family and domain databases

Gene3Dⁱ	3.30.40.10. 1 hit.
InterProⁱ	View protein in InterPro IPR001909. KRAB. IPR013087. Znf_C2H2_type. IPR013083. Znf_RING/FYVE/PHD.
SMARTⁱ	View protein in SMART SM00355. ZnF_C2H2. 14 hits.
SUPFAMⁱ	SSF57667. SSF57667. 9 hits.
PROSITEⁱ	View protein in PROSITE PS50805. KRAB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 12 hits. PS50157. ZINC_FINGER_C2H2_2. 15 hits.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZN676_HUMAN
Accessionⁱ	Q8N7Q3Primary (citable) accession number: Q8N7Q3 Secondary accession number(s): A8MVX5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 2, 2006
	Last sequence update:	November 25, 2008
	Last modified:	June 7, 2017
	This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
SIMILARITY comments
Index of protein domains and families

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8N7Q3 (ZN676_HUMAN)

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Zinc finger protein 676

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ