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Q8N7Q3

- ZN676_HUMAN

UniProt

Q8N7Q3 - ZN676_HUMAN

Protein

Zinc finger protein 676

Gene

ZNF676

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 2 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri169 – 19123C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri197 – 21923C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri225 – 24723C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri253 – 27523C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri281 – 30323C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri309 – 33123C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri337 – 35923C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri365 – 38723C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri393 – 41523C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri421 – 44323C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri449 – 47123C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri477 – 49923C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri505 – 52723C2H2-type 13PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri533 – 55523C2H2-type 14PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri561 – 58323C2H2-type 15PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_12627. Generic Transcription Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 676
    Gene namesi
    Name:ZNF676
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:20429. ZNF676.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142670477.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 588588Zinc finger protein 676PRO_0000233996Add
    BLAST

    Proteomic databases

    PaxDbiQ8N7Q3.
    PRIDEiQ8N7Q3.

    PTM databases

    PhosphoSiteiQ8N7Q3.

    Expressioni

    Gene expression databases

    BgeeiQ8N7Q3.
    CleanExiHS_ZNF676.
    GenevestigatoriQ8N7Q3.

    Interactioni

    Protein-protein interaction databases

    BioGridi127857. 2 interactions.
    IntActiQ8N7Q3. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N7Q3.
    SMRiQ8N7Q3. Positions 111-584.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 4343KRABPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 15 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 KRAB domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri169 – 19123C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri197 – 21923C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri225 – 24723C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri253 – 27523C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri281 – 30323C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri309 – 33123C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri337 – 35923C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri365 – 38723C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri393 – 41523C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri421 – 44323C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri449 – 47123C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri477 – 49923C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri505 – 52723C2H2-type 13PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri533 – 55523C2H2-type 14PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri561 – 58323C2H2-type 15PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000234617.
    HOVERGENiHBG018163.
    KOiK09228.
    OMAiCGKASNS.
    OrthoDBiEOG7KSX7Q.
    PhylomeDBiQ8N7Q3.
    TreeFamiTF342117.

    Family and domain databases

    Gene3Di3.30.160.60. 16 hits.
    InterProiIPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    SMARTiSM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 14 hits.
    [Graphical view]
    PROSITEiPS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 12 hits.
    PS50157. ZINC_FINGER_C2H2_2. 15 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8N7Q3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLENYRNLVF LGIAAFKPDL IIFLEQGKEP WNMKRHEMVE EPPVICSHFS    50
    QEFWPEQGIE DSFQKMILRR YDKCGHENLH LKISCTNVDE CNVHKEGYNK 100
    LNQSLTTTQS KVFQCGKYAN VFHKCSNSNR HKIRHTGEKG LKCKEYVRSF 150
    CMLSHLSQHE RIYTRENSYK CEENGKAFNW SSTLTYYKSI HTGEKPYKCE 200
    ECGKAFSKFS ILTKHKVIHT GEKPYKCEEC GKAFNRSSIL TKHKIIHTGE 250
    KPYKCEECGK GFSSVSTLNT HKAIHAEEKP YKCEECGKAS NSSSKLMEHK 300
    RIHTGEKPYK CEECGKAFSW SSSLTEHKRI HAGEKPYKCE ECGKAFNRSS 350
    ILTKHKIIHT GEKPYKCEGC GKAFSKVSTL NTHKAIHAEE KPYKCEECGK 400
    ASNSSSKLME HKRIHTGEKP YKCEECGKAF SWSSSLTEHK RIHAGEKPYK 450
    CEECGKAFTW SSSFTKHKRI HAAEKPYKCE ECGKGFSTFS ILTKHKIIHT 500
    GEKRYKCEEC GKAFSWSSIL TEHKIIHTGE KPYKCEECGK AFSRSSSLTR 550
    HKRIHTGEKP YKCEECGKAF KSSSTVSYHK KIHTGENP 588
    Length:588
    Mass (Da):67,624
    Last modified:November 25, 2008 - v2
    Checksum:i662E28DBE1CBB6D6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti180 – 1801W → S in BAC05174. (PubMed:14702039)Curated
    Sequence conflicti183 – 1908TLTYYKSI → NLMEHKRV in BAC05174. (PubMed:14702039)Curated
    Sequence conflicti208 – 22013KFSIL…KVIHT → WSSSLTEHKRIHA in BAC05174. (PubMed:14702039)CuratedAdd
    BLAST

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti27 – 271G → E.
    Corresponds to variant rs8104929 [ dbSNP | Ensembl ].
    VAR_047437
    Natural varianti96 – 961E → K.
    Corresponds to variant rs12986319 [ dbSNP | Ensembl ].
    VAR_047438
    Natural varianti292 – 2921S → W.
    Corresponds to variant rs11671538 [ dbSNP | Ensembl ].
    VAR_047439

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC073539 Genomic DNA. No translation available.
    AK097798 mRNA. Translation: BAC05174.1.
    CCDSiCCDS42539.1.
    RefSeqiNP_001001411.2. NM_001001411.2.
    UniGeneiHs.55452.

    Genome annotation databases

    EnsembliENST00000397121; ENSP00000380310; ENSG00000196109.
    GeneIDi163223.
    KEGGihsa:163223.
    UCSCiuc002nqs.1. human.

    Polymorphism databases

    DMDMi215273918.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC073539 Genomic DNA. No translation available.
    AK097798 mRNA. Translation: BAC05174.1 .
    CCDSi CCDS42539.1.
    RefSeqi NP_001001411.2. NM_001001411.2.
    UniGenei Hs.55452.

    3D structure databases

    ProteinModelPortali Q8N7Q3.
    SMRi Q8N7Q3. Positions 111-584.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 127857. 2 interactions.
    IntActi Q8N7Q3. 1 interaction.

    PTM databases

    PhosphoSitei Q8N7Q3.

    Polymorphism databases

    DMDMi 215273918.

    Proteomic databases

    PaxDbi Q8N7Q3.
    PRIDEi Q8N7Q3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000397121 ; ENSP00000380310 ; ENSG00000196109 .
    GeneIDi 163223.
    KEGGi hsa:163223.
    UCSCi uc002nqs.1. human.

    Organism-specific databases

    CTDi 163223.
    GeneCardsi GC19M022361.
    HGNCi HGNC:20429. ZNF676.
    neXtProti NX_Q8N7Q3.
    PharmGKBi PA142670477.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000234617.
    HOVERGENi HBG018163.
    KOi K09228.
    OMAi CGKASNS.
    OrthoDBi EOG7KSX7Q.
    PhylomeDBi Q8N7Q3.
    TreeFami TF342117.

    Enzyme and pathway databases

    Reactomei REACT_12627. Generic Transcription Pathway.

    Miscellaneous databases

    GenomeRNAii 163223.
    NextBioi 88328.
    PROi Q8N7Q3.

    Gene expression databases

    Bgeei Q8N7Q3.
    CleanExi HS_ZNF676.
    Genevestigatori Q8N7Q3.

    Family and domain databases

    Gene3Di 3.30.160.60. 16 hits.
    InterProi IPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    SMARTi SM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 14 hits.
    [Graphical view ]
    PROSITEi PS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 12 hits.
    PS50157. ZINC_FINGER_C2H2_2. 15 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 180-588.
      Tissue: Testis.

    Entry informationi

    Entry nameiZN676_HUMAN
    AccessioniPrimary (citable) accession number: Q8N7Q3
    Secondary accession number(s): A8MVX5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 2, 2006
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 95 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3