Q8N7Q3 (ZN676_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein 676

Gene names

Name:

ZNF676

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	588 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in transcriptional regulation.
Subcellular location	Nucleus Probable.
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 15 C2H2-type zinc fingers. Contains 1 KRAB domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-templated Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-templated Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 588	588	Zinc finger protein 676		PRO_0000233996
Regions
	Domain	1 – 43	43	KRAB
	Zinc finger	169 – 191	23	C2H2-type 1; degenerate
	Zinc finger	197 – 219	23	C2H2-type 2
	Zinc finger	225 – 247	23	C2H2-type 3
	Zinc finger	253 – 275	23	C2H2-type 4
	Zinc finger	281 – 303	23	C2H2-type 5
	Zinc finger	309 – 331	23	C2H2-type 6
	Zinc finger	337 – 359	23	C2H2-type 7
	Zinc finger	365 – 387	23	C2H2-type 8
	Zinc finger	393 – 415	23	C2H2-type 9
	Zinc finger	421 – 443	23	C2H2-type 10
	Zinc finger	449 – 471	23	C2H2-type 11
	Zinc finger	477 – 499	23	C2H2-type 12
	Zinc finger	505 – 527	23	C2H2-type 13
	Zinc finger	533 – 555	23	C2H2-type 14
	Zinc finger	561 – 583	23	C2H2-type 15
Natural variations
	Natural variant	27	1	G → E. Corresponds to variant rs8104929 [ dbSNP | Ensembl ].		VAR_047437
	Natural variant	96	1	E → K. Corresponds to variant rs12986319 [ dbSNP | Ensembl ].		VAR_047438
	Natural variant	292	1	S → W. Corresponds to variant rs11671538 [ dbSNP | Ensembl ].		VAR_047439
Experimental info
	Sequence conflict	180	1	W → S in BAC05174. Ref.2
	Sequence conflict	183 – 190	8	TLTYYKSI → NLMEHKRV in BAC05174. Ref.2
	Sequence conflict	208 – 220	13	KFSIL…KVIHT → WSSSLTEHKRIHA in BAC05174. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q8N7Q3 [UniParc]. Last modified November 25, 2008. Version 2. Checksum: 662E28DBE1CBB6D6	FASTA	588	67,624
	10 20 30 40 50 60 MLENYRNLVF LGIAAFKPDL IIFLEQGKEP WNMKRHEMVE EPPVICSHFS QEFWPEQGIE 70 80 90 100 110 120 DSFQKMILRR YDKCGHENLH LKISCTNVDE CNVHKEGYNK LNQSLTTTQS KVFQCGKYAN 130 140 150 160 170 180 VFHKCSNSNR HKIRHTGEKG LKCKEYVRSF CMLSHLSQHE RIYTRENSYK CEENGKAFNW 190 200 210 220 230 240 SSTLTYYKSI HTGEKPYKCE ECGKAFSKFS ILTKHKVIHT GEKPYKCEEC GKAFNRSSIL 250 260 270 280 290 300 TKHKIIHTGE KPYKCEECGK GFSSVSTLNT HKAIHAEEKP YKCEECGKAS NSSSKLMEHK 310 320 330 340 350 360 RIHTGEKPYK CEECGKAFSW SSSLTEHKRI HAGEKPYKCE ECGKAFNRSS ILTKHKIIHT 370 380 390 400 410 420 GEKPYKCEGC GKAFSKVSTL NTHKAIHAEE KPYKCEECGK ASNSSSKLME HKRIHTGEKP 430 440 450 460 470 480 YKCEECGKAF SWSSSLTEHK RIHAGEKPYK CEECGKAFTW SSSFTKHKRI HAAEKPYKCE 490 500 510 520 530 540 ECGKGFSTFS ILTKHKIIHT GEKRYKCEEC GKAFSWSSIL TEHKIIHTGE KPYKCEECGK 550 560 570 580 AFSRSSSLTR HKRIHTGEKP YKCEECGKAF KSSSTVSYHK KIHTGENP

References

[1]

"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 180-588. Tissue: Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC073539 Genomic DNA. No translation available. AK097798 mRNA. Translation: BAC05174.1.
RefSeq	NP_001001411.2. NM_001001411.2.
UniGene	Hs.55452.
3D structure databases
ProteinModelPortal	Q8N7Q3.
SMR	Q8N7Q3. Positions 111-588.
ModBase	Search...
MobiDB	Search...
Protein-protein interaction databases
BioGrid	127857. 2 interactions.
IntAct	Q8N7Q3. 1 interaction.
PTM databases
PhosphoSite	Q8N7Q3.
Polymorphism databases
DMDM	215273918.
Proteomic databases
PaxDb	Q8N7Q3.
PRIDE	Q8N7Q3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000397121; ENSP00000380310; ENSG00000196109. ENST00000577063; ENSP00000460377; ENSG00000262942.
GeneID	163223.
KEGG	hsa:163223.
UCSC	uc002nqs.1. human.
Organism-specific databases
CTD	163223.
GeneCards	GC19M022361.
HGNC	HGNC:20429. ZNF676.
neXtProt	NX_Q8N7Q3.
PharmGKB	PA142670477.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5048.
HOGENOM	HOG000234617.
HOVERGEN	HBG018163.
KO	K09228.
OMA	CGKASNS.
OrthoDB	EOG7KSX7Q.
PhylomeDB	Q8N7Q3.
TreeFam	TF342117.
Enzyme and pathway databases
Reactome	REACT_71. Gene Expression.
Gene expression databases
Bgee	Q8N7Q3.
CleanEx	HS_ZNF676.
Genevestigator	Q8N7Q3.
Family and domain databases
Gene3D	3.30.160.60. 16 hits.
InterPro	IPR001909. Krueppel-associated_box. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
SMART	SM00349. KRAB. 1 hit. SM00355. ZnF_C2H2. 14 hits. [Graphical view]
PROSITE	PS50805. KRAB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 12 hits. PS50157. ZINC_FINGER_C2H2_2. 15 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	163223.
NextBio	88328.
PRO	Q8N7Q3.

Entry information

Entry name

ZN676_HUMAN

Accession

Primary (citable) accession number: Q8N7Q3
Secondary accession number(s): A8MVX5

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2006
Last sequence update:	November 25, 2008
Last modified:	April 16, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.